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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Jurnal Ilmu Bedah Indonesia Journal of Indonesia Vascular Access Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rama Nusjirwan
Department Of Surgery, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Althea Medical Journal

 1 
Bixa Orellana L Leaf infusion as an Anti-inflammatory Agent in Carrageenan-induced Wistar Rats Yusuf, Sabrina Munggarani; Rohmawaty, Enny; Nusjirwan, Rama
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.412 KB)

Abstract

Background: One of the characteristics of inflammation is swelling or edema. Inflammation can be treated with traditional medicine, such as Bixa orellana L. Bixa orellana L leaf  contains flavonoid and tannin responsible for its anti-inflammatory effect. This study was conducted to analyse the ability of Bixa orellana L leaf infusion (BOLI) to suppress paw edema in carrageenan-induced Wistar rats.Methods: This study was conducted in the Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran in October 2012. Bixa orellana L leaves were procured from Lembang, Bandung, and were botanically identified at the Herbarium of Universitas Padjadjaran, Jatinangor. Thirty female Wistar rats were randomly divided into five groups. Group 1 was given 5 mL aquades as a control, three groups received BOLI with 0,09 g; 0,18 g; and 0,36 g dosage respectively; and group 5 was given 0,9 mg diclofenac. At 1 hour after treatment, all rats were induced by carrageenan injection subcutaneously. Paw edema changes were quantified at 0, 1, 2, 3, 4, 5, 6, and 24 hour afterwards. Data were analysed using Kruskal-Wallis and Mann-Whitney testResults: Based on paw edema inhibition percentage, 0.18 g of BOLI was shown most effective (16.97%) compared to 0.09 g (10.96%) and 0.36 g (7.50%). Interestingly, no significant differences of anti-inflammatory effect were observed between groups that were treated with 0,18 g of BOLI and diclofenac (p > 0,005).Conclusions: The BOLI can suppress inflammation comparable to diclofenac. The effective dosage is 0.18 g/200 g BW/day.[AMJ.2014;1(1):7–12]Keywords: anti-inflammatory, Bixa orellana L leaf, paw edema Infusa Daun Kesumba (Bixa Orellana L) sebagai Anti Inflamasi pada Tikus Wistar yang Diinduksi Carrageenan Latar Belakang: Salah satu ciri khas dari peradangan atau inflamasi adalah adanya pembengkakan atau edema. Peradangan dapat diobati  dengan obat tradisional, seperti Kesumba (Bixa orellana). Daun Kesumba diketahui mengandung flavonoid dan tanin yang berfungsi sebagai anti-inflamasi. Penelitian ini dilakukan untuk menganalisis kemampuan infusa daun kesumba (Bixa orellana) (BOLI) dalam mengurangi edema tungkai pada kaki tikus Wistar yang diinduksi Carrageenan.Metode: Penelitian ini dilakukan di Laboratorium Hewan Departemen Farmakologi dan Terapi di Rumah Sakit Umum Dr. Hasan Sadikin Bandung pada bulan Oktober 2012. Daun Kesumba (Bixa Orellana) diperoleh dari Lembang, Bandung, dan diidentifikasi botani di Herbarium Universitas Padjadjaran, Jatinangor. Tiga puluh tikus Wistar betina secara acak dibagi menjadi lima kelompok. Kelompok kontrol negatif diberi 5 mL aquades, tiga kelompok menerima BOLI dengan 0,09 g; 0,18 g; dan masing-masing 0,36 g dosis; sedangkan kelompok kontrol positif diberikan 0,9 mg diklofenak. Pada 1 jam setelah pengobatan, semua tikus diinduksi oleh subkutan injeksi karagenan. Perubahan edema (Paw) yang diukur pada 0, 1, 2, 3, 4, 5, 6, dan 24 jam sesudahnya. Data dianalisis denganmenggunakanKruskal-Wallis dan uji Mann-Whitney.Hasil: Berdasarkan persentase pengurangan edema tungkai, kelompok 0,18g BOLI terlihat paling efektif (16,9%) dibandingkan dengan 0,09 g (10,9%) dan 0,36 g (7,5%). Tidak ada perbedaan yang signifikan dari efek anti-inflamasi yang diamati antara kelompok-kelompok yang diobati dengan 0,18 g BOLI dan diklofenak (p> 0.005).Simpulan: Infusa Daun Kesumba (Bixaorellana) dapat menekan peradangan sama baiknya dengan diklofenak. Dosis efektif adalah 0,18 g /200 g BB / hari.Kata kunci: anti-inflamasi, daun kesumba (Bixaorellana), edema tungkai DOI: 10.15850/amj.v1n2.347
Bixa Orellana L Leaf infusion as an Anti-inflammatory Agent in Carrageenan-induced Wistar Rats Sabrina Munggarani Yusuf; Enny Rohmawaty; Rama Nusjirwan
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.412 KB)

Abstract

Background: One of the characteristics of inflammation is swelling or edema. Inflammation can be treated with traditional medicine, such as Bixa orellana L. Bixa orellana L leaf  contains flavonoid and tannin responsible for its anti-inflammatory effect. This study was conducted to analyse the ability of Bixa orellana L leaf infusion (BOLI) to suppress paw edema in carrageenan-induced Wistar rats.Methods: This study was conducted in the Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran in October 2012. Bixa orellana L leaves were procured from Lembang, Bandung, and were botanically identified at the Herbarium of Universitas Padjadjaran, Jatinangor. Thirty female Wistar rats were randomly divided into five groups. Group 1 was given 5 mL aquades as a control, three groups received BOLI with 0,09 g; 0,18 g; and 0,36 g dosage respectively; and group 5 was given 0,9 mg diclofenac. At 1 hour after treatment, all rats were induced by carrageenan injection subcutaneously. Paw edema changes were quantified at 0, 1, 2, 3, 4, 5, 6, and 24 hour afterwards. Data were analysed using Kruskal-Wallis and Mann-Whitney testResults: Based on paw edema inhibition percentage, 0.18 g of BOLI was shown most effective (16.97%) compared to 0.09 g (10.96%) and 0.36 g (7.50%). Interestingly, no significant differences of anti-inflammatory effect were observed between groups that were treated with 0,18 g of BOLI and diclofenac (p > 0,005).Conclusions: The BOLI can suppress inflammation comparable to diclofenac. The effective dosage is 0.18 g/200 g BW/day.[AMJ.2014;1(1):7–12]Keywords: anti-inflammatory, Bixa orellana L leaf, paw edema Infusa Daun Kesumba (Bixa Orellana L) sebagai Anti Inflamasi pada Tikus Wistar yang Diinduksi Carrageenan Latar Belakang: Salah satu ciri khas dari peradangan atau inflamasi adalah adanya pembengkakan atau edema. Peradangan dapat diobati  dengan obat tradisional, seperti Kesumba (Bixa orellana). Daun Kesumba diketahui mengandung flavonoid dan tanin yang berfungsi sebagai anti-inflamasi. Penelitian ini dilakukan untuk menganalisis kemampuan infusa daun kesumba (Bixa orellana) (BOLI) dalam mengurangi edema tungkai pada kaki tikus Wistar yang diinduksi Carrageenan.Metode: Penelitian ini dilakukan di Laboratorium Hewan Departemen Farmakologi dan Terapi di Rumah Sakit Umum Dr. Hasan Sadikin Bandung pada bulan Oktober 2012. Daun Kesumba (Bixa Orellana) diperoleh dari Lembang, Bandung, dan diidentifikasi botani di Herbarium Universitas Padjadjaran, Jatinangor. Tiga puluh tikus Wistar betina secara acak dibagi menjadi lima kelompok. Kelompok kontrol negatif diberi 5 mL aquades, tiga kelompok menerima BOLI dengan 0,09 g; 0,18 g; dan masing-masing 0,36 g dosis; sedangkan kelompok kontrol positif diberikan 0,9 mg diklofenak. Pada 1 jam setelah pengobatan, semua tikus diinduksi oleh subkutan injeksi karagenan. Perubahan edema (Paw) yang diukur pada 0, 1, 2, 3, 4, 5, 6, dan 24 jam sesudahnya. Data dianalisis denganmenggunakanKruskal-Wallis dan uji Mann-Whitney.Hasil: Berdasarkan persentase pengurangan edema tungkai, kelompok 0,18g BOLI terlihat paling efektif (16,9%) dibandingkan dengan 0,09 g (10,9%) dan 0,36 g (7,5%). Tidak ada perbedaan yang signifikan dari efek anti-inflamasi yang diamati antara kelompok-kelompok yang diobati dengan 0,18 g BOLI dan diklofenak (p> 0.005).Simpulan: Infusa Daun Kesumba (Bixaorellana) dapat menekan peradangan sama baiknya dengan diklofenak. Dosis efektif adalah 0,18 g /200 g BB / hari.Kata kunci: anti-inflamasi, daun kesumba (Bixaorellana), edema tungkai DOI: 10.15850/amj.v1n2.347
Hemoglobin Level Decrease after Open Heart Surgery in a Tertiary Hospital in Indonesia Anabella Nifulea; Reza Sudjud Widianto; Rama Nusjirwan
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1924

Abstract

Background: Open heart surgery is usually performed by connecting the heart to a cardiopulmonary bypass (CPB) machine. The use of the CPB machine may decrease the hemoglobin level and a very low hemoglobin levelcould cause seriouscomplications.This study aimed to explore the decrease in hemoglobin level after open heart surgery.Methods: A cross-sectional retrospective descriptive study was conducted on medical records of patients underwent coronary artery bypass graft (CABG) surgery and heart valve surgery in a tertiary hospital in Indonesia in  2018. The total sampling method was deployed to all medical records of patients underwent CABG surgery (n=25) and patients underwent heart valve surgery (n=3).Results: The decrease in hemoglobin level among young-adult female patients after heart valve surgery was 6.8 g/dl. The average decrease in mid-adult male and female patients after CABG surgery were 6 g/dl and 5.8 g/dl, respectively, and, after the heart valve surgery, the levels were 8.5 g/dl and 5.4 g/dl, respectively. The average decrease in Hb level among late-adult male and female patients after CABG surgery was 6.1 g/dl and 5.4 g/dl, respectively.Conclusion: Hemoglobin level decreases after an open heart surgery. Therefore, observation on the hemoglobin level to prevent complications and to facilitate early treatment is necessary.
Co-Authors Akbar, Mohammad Rizki Anabella Nifulea Aulia Novariza Fahman Dewi, Triwedya Indra Dionisius Panji Wijanarko Enny Rohmawaty Euis Maryani Gideon Setiawan Hapsari, Putie Hendro, Immanuel Immanuel Hendro Januar Wibawa Martha Jungjunan, Ridho Murni, Tri Wahyu Navy Laksmono Nazir, Arnengsih Putie Hapsari Putie Hapsari Rachim Sobarna Raharjo, Pradana Pratomo Ratna Astri Andhini Reza Widianto Sudjud Rezkita, Aliya Rahmadewi Sabrina Munggarani Yusuf Sabrina Munggarani Yusuf Setiawan, Gideon Sobarna, Rachim Syarief Hidayat Teguh Marfen Djajakusumah Tri Wahyu Murni Wijaya, Sergio Aldira