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All Journal International Journal of Integrated Health Sciences Heart Science Journal Media Penelitian dan Pengembangan Kesehatan
Dewi, Triwedya Indra
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

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Long term radial artery occlusion following distal or proximal transradial artery access in invasive cardiovascular procedures Saboe, Aninka; Ibrahim, Maulana; Pranata, Raymond; Dewi, Triwedya Indra; Yahya, Achmad Fauzi
Heart Science Journal Vol. 6 No. 2 (2025): The Complexity in the Management of Heart Rhythm Disorder
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.02.10

Abstract

Background: Radial artery occlusion (RAO) is one of the most common consequences of transradial artery access (TRA) in invasive cardiovascular procedures; therefore, alternative approaches, such as distal radial artery access (DRA), emerged. This study compares proximal and distal radial access for long-term RAO. Objectives: This study compares long-term RAO incidence with proximal and distal radial access following invasive cardiovascular procedures. Material and Methods: This is a retrospective cohort study. The subjects comprised patients with heart disease who underwent invasive cardiovascular procedures using radial access at Dr. Hasan Sadikin General Hospital Bandung between July 2017 and December 2020. The patients were categorized into two groups based on their access type: proximal and distal. The incidence of long-term RAO was evaluated through Doppler ultrasound at least one-year post-TRA. Results: The study included 107 patients (proximal = 72 patients; distal = 35 patients). The mean age was 58.2 ± 8.26 years, with a predominance of male patients (79.4%) and smokers (65.4%). The majority of procedures were interventional (58.2%). Baseline characteristics were comparable between the two groups, except for selecting the access side, which was more prevalent on the left side in the distal group. Long-term RAO occurred in 8 patients (7.48%), with 7 cases (9.72%) in the proximal group and 1 case (2.86%) in the distal group (p=0.269). Conclusion: The study findings reveal no significant difference in the incidence of long-term RAO between proximal and distal radial access in invasive cardiovascular procedures.
QUALITY OF LIFE IN HEART FAILURE PATIENTS RECEIVING SODIUM GLUCOSE -2 (SGLT2) INHIBITORS: A LITERATURE REVIEW Alfathia, Kinanti; Zakiyah, Neily; Dewi, Triwedya Indra; Puspitasari, Irma Melyani
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3059

Abstract

Gagal jantung merupakan kondisi klinis progresif yang berdampak signifikan terhadap kualitas hidup pasien. Penghambat Natrium Glukosa Co-transporter-2 (SGLT2), yang awalnya dikembangkan untuk terapi diabetes melitus tipe 2, telah menunjukkan manfaat kardiovaskular. Studi ini bertujuan mengevaluasi dampak penggunaan penghambat SGLT2, terhadap kualitas hidup pasien gagal jantung melalui tinjauan sistematis literatur. Penelusuran dilakukan di database PubMed dan EBSCOhost untuk menemukan uji klinis terkontrol secara acak yang melaporkan perubahan kualitas hidup menggunakan instrumen valid seperti Kansas City Cardiomyopathy Questionnaire (KCCQ) dan EuroQol 5-Dimension (EQ-5D). Dari 398 artikel yang diidentifikasi, sebanyak 20 studi memenuhi kriteria inklusi dan dianalisis secara kualitatif. Hasil menunjukkan bahwa terapi penghambat SGLT2 secara konsisten meningkatkan skor KCCQ dan EQ-5D secara bermakna dibandingkan plasebo, mencerminkan perbaikan pada aspek fisik, gejala klinis, dan kesejahteraan emosional. Efektivitas ini tercatat konsisten pada berbagai subpopulasi, terlepas dari status diabetes dan tipe fraksi ejeksi dan mendukung peran SGLT2 inhibitor sebagai terapi komprehensif dalam meningkatkan kualitas hidup pasien gagal jantung.
EFFECTIVENESS OF STATIN AND EZETIMIBE COMBINATION ON ATHEROSCLEROTIC PLAQUE IN PATIENTS WITH CORONARY HEART DISEASE Sumedhi, Herdina Mayangsari; Zakiyah, Neily; Dewi, Triwedya Indra; Sinuraya, Rano Kurnia; Puspitasari, Irma Melyani
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3198

Abstract

Penyakit jantung koroner mengacu pada kondisi penyumbatan pembuluh darah arteri yang dikenal dengan istilah aterosklerosis. Statin bekerja dengan mengurangi produksi kolesterol di hati serta menjaga stabilisasi plak pada pasien dengan penyakit jantung koroner. Namun demikian pemberian statin tidak dapat ditoleransi dengan baik pada pasien tertentu, sehingga dipertimbangkan penggunaan kombinasi statin dengan ezetimibe. Tinjauan artikel ini bertujuan untuk mengetahui efektivitas kombinasi statin dan ezetimibe terhadap plak aterosklerosis pada pasien dengan penyakit jantung koroner. Penelusuran pustaka dilakukan menggunakan basis data PubMed dan EBSCO (MEDLINE Ultimate) pada bulan Februari 2025 dengan menggunakan kata kunci “Ezetimibe”, “Hydroxymethylglutaryl-CoA Reductase Inhibitors”,“Atherosclerotic Plaque” dan “Coronary Artery Disease”. Artikel dipilih berdasarkan kriteria inklusi yaitu artikel berbahasa Inggris, diterbitkan dalam sepuluh tahun terakhir, penelitian pada manusia, dan merupakan randomized controlled trial pada pasien jantung koroner dengan atau tanpa penyakit penyerta. Kriteria eksklusi meliputi: tinjauan/review, studi protokol, editorial, tinjauan sistematis dan meta analisis, dan topik/hasil yang tidak relevan. Penelusuran awal menghasilkan 34 artikel dengan 10 duplikasi dan 14 kriteria eksklusi, sehingga diperoleh 10 artikel penelitian yang berfokus di Jepang, Korea, dan Cina. Hasil tinjauan artikel menunjukkan bahwa kombinasi statin dengan ezetimibe lebih efektif dalam menurunkan low density lipoprotein-cholesterol (LDL-C), mengurangi respon inflamasi, serta menghasilkan regresi plak aterosklerosis yang lebih besar dibandingkan monoterapi statin. Dengan demikian, penggunaan kombinasi statin dosis rendah hingga sedang dan ezetimibe dapat menjadi terapi pilihan bagi pasien dengan penyakit jantung koroner yang berisiko tinggi.
In-Hospital Outcomes Comparison Between Off-Pump and On-Pump CABG: Indonesian Tertiary Center Experience Dewi, Triwedya Indra; Jungjunan, Ridho; Raharjo, Pradana Pratomo; Rezkita, Aliya Rahmadewi; Hidayat, Syarief; Martha, Januar Wibawa; Nusjirwan, Rama; Akbar, Mohammad Rizki
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4119

Abstract

Background: Coronary artery disease (CAD) often requires revascularization. Coronary artery bypass grafting (CABG) is a cornerstone intervention that improves patients’ survival. Both on-pump and off-pump CABG have their own advantages and limitations, with reported outcomes vary across studies.Objective: to investigate the differences in the outcomes of patients undergoing off-pump and on-pump CABG.Methods: A retrospective cohort study was performed on 186 patients aged ≥18 years undergoing on-pump or off-pump CABG between June 2020 and December 2023. Outcomes included were all-cause mortality, postoperative acute renal failure, length of postoperative stay, and complete revascularization rate. Comparative analysis was conducted using Chi-Square test and independent T-test. Multivariate analysis, including logistic regression tests, was carried out to identify independent predictors associated with each outcome.Results: The on-pump group presented more diabetes (42.9% vs. 28.4%; P=0.040) and lower left ventricular ejection fraction (LVEF) values (43 [IQR 16–79] vs. 53 [23–75]; P=0.001). Patients in this group also had higher rates of postoperative renal failure (61.5% vs. 24.2%; P<0.001), longer stays (64.8% vs. 41.1%; P=0.001), and better complete revascularization (98.9% vs. 92.6%; P=0.035), but no significant difference in mortality (16.5% vs. 13.7%; P =0.594). Multivariate analysis identified diabetes, LVEF ≤40%, and postoperative renal failure as predictors of mortality.Conclusions: On-pump CABG is associated with higher rates of complete revascularization. However, the adoption of this technique is linked to a higher risk of postoperative acute kidney failure and prolonged hospital stays. No difference in mortality is observed between those with off-pump and on-pump.
Co-Authors Achmad Fauzi Yahya, Achmad Fauzi Akbar, Mohammad Rizki Alfathia, Kinanti Ibrahim, Maulana Irma Melyani Puspitasari Januar Wibawa Martha Jungjunan, Ridho Pranata, Raymond Raharjo, Pradana Pratomo Rama Nusjirwan RANO KURNIA SINURAYA Rezkita, Aliya Rahmadewi Saboe, Aninka Sumedhi, Herdina Mayangsari Syarief Hidayat Zakiyah, Neily