Asmarawati, Tri Pudy
Department Of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Indonesian Society Of Internal Medicine

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Bloodstream Infections Leading to Sepsis: Clinical and Microbiological Profiling of Bacteremia among Hospitalized Patients in Surabaya, Indonesia Marwasyifa, Nuritsna; Asmarawati, Tri Pudy; Setiawan, Firman; Endraswari, Pepy Dwi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66675

Abstract

Introduction: Bacteremia poses a significant health risk due to its frequently atypical presentation and potential progression to sepsis. Understanding its clinical profiles and causative pathogens is essential for timely diagnosis and effective management. This study examined the characteristics of bacteremia cases in 2022 at Universitas Airlangga Hospital, Surabaya, Indonesia. Methods: A retrospective, descriptive observational study was conducted utilizing hospitalized bacteremia patients' medical records. A total of 107 patients met the inclusion criteria, which required positive blood cultures along with complete data on age (≥19 years), sex, comorbidities, clinical manifestations, bacterial infection diagnosis, outcomes, and pathogen characteristics. Medical records failing to meet these criteria were excluded. The data were categorized and analyzed by variables. Results: Bacteremia predominantly affected patients aged >65 years (36.4%), males (50.5%), and those with diabetes (54.2%) and with pneumonia (79.4%). Key symptoms included tachycardia (55.1%), tachypnea (55.1%), anemia (65.4%), and leukocytosis (71.0%), despite normal vitals observed in numerous cases. Gram-positive bacteria were most prevalent (69.7%), mainly Staphylococcus hominis (18.7%). Escherichia coli (9.3%) was the leading Gram-negative isolate, while extended-spectrum beta-lactamase (ESBL) strains (4.2%) were the primary multidrug-resistant organisms (MDRO). Sepsis and septic shock were equally prevalent (35.5%). Mortality (64.5%) occurred primarily due to septic shock (49.3%). Conclusion: Sepsis and septic shock frequently occur in older males with diabetes and pneumonia. Key symptoms include frequent tachycardia, tachypnea, anemia, and leukocytosis. Septic shock, the leading cause of death in bacteremia patients, frequently occurs alongside infections by Staphylococcus hominis and ESBL-producing Escherichia coli.   Highlights: 1. This study offers fresh perspectives on the clinical profiles of hospitalized bacteremia patients and the characteristics of causative bacteria at Universitas Airlangga Hospital, a topic that has been minimally explored in the Indonesian medical community. 2. It highlights the prevalence of bacteremia, its clinical manifestations, and outcomes to determine the mortality rate of hospitalized bacteremia patients. 3. This study provides valuable data that can help inform future infection control strategies to manage and prevent bloodstream infections, hence enhancing healthcare outcomes by emphasizing the importance of improving clinical data collection and monitoring.
ESKAPE Pathogens in Hospitalized Patients: A Comprehensive Profiling of Infections and Characteristics at Universitas Airlangga Hospital, Surabaya, Indonesia Dinda Rachma Harlisa; Tri Pudy Asmarawati; Firman Setiawan; Pepy Dwi Endraswari
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.103-112

Abstract

Highlights This study found that ESKAPE pathogenic infections at Universitas Airlangga Hospital were dominated by Gram-negative bacteria, particularly Klebsiella pneumoniae, with sputum as the most commonly collected specimen providing valuable data for infection control strategies. Most patients exhibited significant clinical manifestations involving neurological disorders, with the respiratory system being the most affected information that may enhance the effectiveness of patient management in the hospital.   ABSTRACT Background: Infections pose a significant threat in Indonesia, particularly in healthcare settings where healthcare-associated infections (HAIs) are prevalent. At a hospital in Jakarta, the prevalence of ESKAPE pathogens was reported to be 69.8%. However, detailed data on the infection profiles of these pathogens remain scarce. This underscores the importance of studying ESKAPE pathogenic bacteria to better understand their characteristics. Objective: This study aimed to determine the infection profile of ESKAPE pathogens in hospitalized patients at Universitas Airlangga Hospital, Surabaya, Indonesia in 2022. Material and Method: This descriptive observational study employed a retrospective design using secondary data from non-ICU inpatients at Universitas Airlangga Hospital infected with ESKAPE pathogens in 2022. Total sampling was applied to eligible medical records. Result: The study included 119 specimens from inpatients infected with ESKAPE pathogens that met the inclusion and exclusion criteria. Of these, 78% were Gram-negative bacterial infections, with Klebsiella pneumoniae being the most prevalent (29%). Sputum was the most commonly collected specimen (49%). Most patients were male (57%), aged 56–65 years (29%), and had no comorbidities (46%). Additionally, 63% of patients had used invasive devices during hospitalization. The majority were admitted to low-care inpatient wards. The primary clinical features were neurological complaints (29%) and respiratory disorders (37%), predominantly associated with Klebsiella pneumoniae. Conclusion: ESKAPE infections were primarily caused by Klebsiella pneumoniae, a Gram-negative bacterium, most frequently identified in sputum samples. The predominant clinical manifestations were decreased consciousness and respiratory disorders. Affected patients were mainly male, aged ≥56 years, hospitalized in low-care wards, with a history of invasive device use and no comorbidities.
Bacterial Profile and Antibiotic Use in Catheter-Associated Urinary Tract Infection Patients at a Tertiary Referral Hospital in Surabaya, Indonesia Erianto, Ahmad Veri; Asmarawati, Tri Pudy; Widodo, Agung Dwi Wahyu; Rachman, Brian Eka
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: • This study examined patients with catheter-associated urinary tract infections (CAUTI) to find the prevalent bacteria and the frequency of antibiotic use. • Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli sensitive to amikacin was found to be the most common pathogen in CAUTI, while ceftriaxone was the most commonly used antibiotic. Abstract Catheter-associated urinary tract infection (CAUTI) is the most typical type of infection associated with healthcare. This infection constitutes a significant health problem due to its complications and frequent recurrence. The high annual incidence of CAUTI leads to infectious complications and a high cost of treatment. Antibiotic-resistant bacteria further complicate the problem because multiresistant pathogenic bacteria are often responsible for these infections. Moreover, the lack of a comprehensive case reporting system in Indonesia hinders the determination of CAUTI incidence. This study aimed to determine the bacterial profile and antibiotic use in CAUTI patients (n=22) at the Internal Medicine Inpatient Unit of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This retrospective descriptive study collected data from patient medical records to describe the incidence, type of bacteria, sensitivity patterns, and antibiotic use in CAUTI patients. The data collection process included collecting medical records, recording information on data collection sheets, and recapitulating and analyzing the data. The criteria for CAUTI diagnosis were a bacterial count of ≥105 CFU/mL and a catheterization that lasted more than 48 hours. Samples were selected using non-probability sampling, also known as saturation sampling. Meanwhile, variables analyzed in this study were the type of pathogenic bacteria, antibiotics used, age, and sex. Descriptive analysis was employed to analyze the data. The findings suggested that the most common bacteria were Escherichia coli, with eight of nine bacteria showing extended-spectrum beta-lactamase (ESBL) production. Female patients aged 35–65 years were the majority of the CAUTI patients. Amikacin was the antibiotic with the highest sensitivity (90.9%), while ceftriaxone was the most common type of antibiotic administered to the patients. In addition, intravenous (IV) administration was the most common route of antibiotic administration, with an average therapy duration of seven days. In conclusion, identifying the type of pathogenic bacteria and performing antibiotic susceptibility testing can help minimize antibiotic resistance and prevent more severe complications in CAUTI patients.
LIFESTYLE EDUCATION TO PREVENT CHRONIC DISEASES AMONG INDONESIAN MIGRANT WORKERS IN MALAYSIA: A COMMUNITY EMPOWERMENT Asmarawati, Tri Pudy; Effendy, Lyndia; Jonny; Suidah, Hartin; Thamrin, Husin; Lestari, Kusuma Scorpia; Kunsah, Baterun; Irnandi, Dicky Faizal; Trianto, Heru Fajar
Journal of Public Health Research and Community Health Development Vol. 9 No. 2 (2026): March
Publisher : Fakultas Ilmu Kesehatan, Kedokteran dan Ilmu Alam (FIKKIA), Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jphrecode.v9i2.68666

Abstract

Malaysia is a prominent destination for Indonesian migrant workers in Southeast Asia. Despite their economic importance, migrant workers are susceptible to chronic diseases, particularly hypertension and diabetes, due to constrained access to healthcare, unhealthy behaviors, and demanding working environments. The objective of this community service initiative included the assessment of the health status of Indonesian migrant workers and the promotion of awareness through screening and educational activities. This community service program was conducted in May 2024 at Sekolah Indonesia Kuala Lumpur, in collaboration with the NGO Sharing Organization and the Indonesian Embassy. A total of 113 migrant workers participated in the event. Screening included blood pressure measurement, random blood sugar testing, eye, and reproductive health examinations. Doctoral medical students delivered a mini seminar on chronic disease prevention and management. The majority of participants were women (57%) and within the productive age group (25-55 years). Hypertension was highly prevalent (54%). The mean random blood sugar was 138 ±62.5 mg/dL). Domestic work was the most common occupation. The participants demonstrated a strong interest in health education, and feedback indicated that regular health programs would be welcomed. Indonesian migrant workers in Malaysia show a high burden of hypertension and diabetes but limited disease awareness. Routine health screening, culturally appropriate education, and stronger collaboration between employers, health providers, and the Indonesian Embassy are essential to improve chronic disease prevention and sustain worker productivity.
DEVELOPMENT OF E-TIBI+ AS EARLY DETECTION AND SYSTEMATIC MANAGEMENT OF TUBERCULOSIS CASES IN PLHIV Erwin Astha Triyono; Feriawan Tan; Lilis Masyfufah; Sulvy Dwi Anggraini; Maria Lucia Inge Lucida; Soedarsono; Merita Arini; Tri Pudy Asmarawati; Ariani Permatasari; Rosita Dwi Yuliandari
Journal of Vocational Health Studies Vol. 9 No. 3 (2026): March 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I3.2026.199-207

Abstract

Background: HIV and TBC combinations have received global public attention in recent years. Current collaborative tuberculosis and HIV elimination strategy is not enough to eradicate these two infectious diseases. Therefore, an innovative elimination approach leveraging advancements in digital technology is urgently needed. Purpose: To evaluate the tuberculosis elimination by optimizing case finding and monitoring treatment completion through the Early Detection and Management of Tuberculosis Application System + (E-TIBI+) application based on self-assessment in the HIV population. Method: This observational cohort study was conducted in Surabaya city, East Java Province, Indonesia in the period of September - October 2024. The study population consisted of adult PLHIV who completed the E-TIBI+ self-assessment. The E-TIBI+ application is a web-based platform. Data analysis included univariate analysis in the form of frequencies for each variable and crosstab analysis with the Kendall tau-b test in E-TIBI+ application acceptance data. Result: From a total of 386 patients screened, 61 (15.80%) PLHIV were suspected of having TBC. From the 61 patients, there were 17 patients who sought diagnosis at the health facility of their choice. User acceptance of the E-TIBI+ application by PLHIV patients tends to be positive and statistically significant. Conclusion: The E-TIBI+ application demonstrates strong potential to enhance early detection and systematic monitoring of tuberculosis case management among PLHIV through digital technology.