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All Journal Indonesian Journal of Tropical and Infectious Disease Dentino: Jurnal Kedokteran Gigi Indonesian Journal of Cardiology Manuju : Malahayati Nursing Journal Jurnal Farmasi Higea Journal of Telenursing (JOTING) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal Jurnal Locus Penelitian dan Pengabdian Folia Medica Indonesiana
Asmarawati, Tri Pudy
Department Of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Indonesian Society Of Internal Medicine
Religion Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Bloodstream Infections Leading to Sepsis: Clinical and Microbiological Profiling of Bacteremia among Hospitalized Patients in Surabaya, Indonesia Marwasyifa, Nuritsna; Asmarawati, Tri Pudy; Setiawan, Firman; Endraswari, Pepy Dwi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66675

Abstract

Introduction: Bacteremia poses a significant health risk due to its frequently atypical presentation and potential progression to sepsis. Understanding its clinical profiles and causative pathogens is essential for timely diagnosis and effective management. This study examined the characteristics of bacteremia cases in 2022 at Universitas Airlangga Hospital, Surabaya, Indonesia. Methods: A retrospective, descriptive observational study was conducted utilizing hospitalized bacteremia patients' medical records. A total of 107 patients met the inclusion criteria, which required positive blood cultures along with complete data on age (≥19 years), sex, comorbidities, clinical manifestations, bacterial infection diagnosis, outcomes, and pathogen characteristics. Medical records failing to meet these criteria were excluded. The data were categorized and analyzed by variables. Results: Bacteremia predominantly affected patients aged >65 years (36.4%), males (50.5%), and those with diabetes (54.2%) and with pneumonia (79.4%). Key symptoms included tachycardia (55.1%), tachypnea (55.1%), anemia (65.4%), and leukocytosis (71.0%), despite normal vitals observed in numerous cases. Gram-positive bacteria were most prevalent (69.7%), mainly Staphylococcus hominis (18.7%). Escherichia coli (9.3%) was the leading Gram-negative isolate, while extended-spectrum beta-lactamase (ESBL) strains (4.2%) were the primary multidrug-resistant organisms (MDRO). Sepsis and septic shock were equally prevalent (35.5%). Mortality (64.5%) occurred primarily due to septic shock (49.3%). Conclusion: Sepsis and septic shock frequently occur in older males with diabetes and pneumonia. Key symptoms include frequent tachycardia, tachypnea, anemia, and leukocytosis. Septic shock, the leading cause of death in bacteremia patients, frequently occurs alongside infections by Staphylococcus hominis and ESBL-producing Escherichia coli.   Highlights: 1. This study offers fresh perspectives on the clinical profiles of hospitalized bacteremia patients and the characteristics of causative bacteria at Universitas Airlangga Hospital, a topic that has been minimally explored in the Indonesian medical community. 2. It highlights the prevalence of bacteremia, its clinical manifestations, and outcomes to determine the mortality rate of hospitalized bacteremia patients. 3. This study provides valuable data that can help inform future infection control strategies to manage and prevent bloodstream infections, hence enhancing healthcare outcomes by emphasizing the importance of improving clinical data collection and monitoring.
Bacterial Profile and Antibiotic Use in Catheter-Associated Urinary Tract Infection Patients at a Tertiary Referral Hospital in Surabaya, Indonesia Erianto, Ahmad Veri; Asmarawati, Tri Pudy; Widodo, Agung Dwi Wahyu; Rachman, Brian Eka
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • This study examined patients with catheter-associated urinary tract infections (CAUTI) to find the prevalent bacteria and the frequency of antibiotic use. • Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli sensitive to amikacin was found to be the most common pathogen in CAUTI, while ceftriaxone was the most commonly used antibiotic. Abstract Catheter-associated urinary tract infection (CAUTI) is the most typical type of infection associated with healthcare. This infection constitutes a significant health problem due to its complications and frequent recurrence. The high annual incidence of CAUTI leads to infectious complications and a high cost of treatment. Antibiotic-resistant bacteria further complicate the problem because multiresistant pathogenic bacteria are often responsible for these infections. Moreover, the lack of a comprehensive case reporting system in Indonesia hinders the determination of CAUTI incidence. This study aimed to determine the bacterial profile and antibiotic use in CAUTI patients (n=22) at the Internal Medicine Inpatient Unit of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This retrospective descriptive study collected data from patient medical records to describe the incidence, type of bacteria, sensitivity patterns, and antibiotic use in CAUTI patients. The data collection process included collecting medical records, recording information on data collection sheets, and recapitulating and analyzing the data. The criteria for CAUTI diagnosis were a bacterial count of ≥105 CFU/mL and a catheterization that lasted more than 48 hours. Samples were selected using non-probability sampling, also known as saturation sampling. Meanwhile, variables analyzed in this study were the type of pathogenic bacteria, antibiotics used, age, and sex. Descriptive analysis was employed to analyze the data. The findings suggested that the most common bacteria were Escherichia coli, with eight of nine bacteria showing extended-spectrum beta-lactamase (ESBL) production. Female patients aged 35–65 years were the majority of the CAUTI patients. Amikacin was the antibiotic with the highest sensitivity (90.9%), while ceftriaxone was the most common type of antibiotic administered to the patients. In addition, intravenous (IV) administration was the most common route of antibiotic administration, with an average therapy duration of seven days. In conclusion, identifying the type of pathogenic bacteria and performing antibiotic susceptibility testing can help minimize antibiotic resistance and prevent more severe complications in CAUTI patients.
Prevalensi Kelainan Kongenital Janin pada Kehamilan Penderita HIV/AIDS di RSUD Dr. Soetomo Kota Surabaya Rista Elva Riani; Arief Bakhtiar; Dewi Setyowati; Manggala Pasca Wardhana; Tri Pudy Asmarawati
Malahayati Nursing Journal Vol 6, No 10 (2024): Volume 6 Nomor 10 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i10.13807

Abstract

ABSTRACT HIV infection in pregnancy is at risk of causing various complications in the mother and fetus, one of which is congenital abnormalities. This study aims to determine the prevalence of congenital abnormalities in pregnancy of women with HIV / AIDS. Retrospective descriptive study with cross-sectional design using medical record data of HIV-positive pregnant women at Dr. Soetomo Surabaya Hospital for the 2020-2022 period. There were 108 pregnant women with HIV, 3 of whom (2.8%) had congenital abnormalities in the fetus in the form of hydrocephalus, Dandy-Walker syndrome, and CPAM. Suspected to be associated with opportunistic infections and embryo-toxic effects of the ARV drug efavirenz. In pregnant women with HIV at Dr. Soetomo General Hospital, 3 (2.8%) pregnant women experience congenital abnormalities in the fetus, for that it is necessary to prevent and early detection of complications during pregnancy, as well as the selection of ARV regimens that are safer for fetal development. Keywords: Pregnancy With HIV/AIDS, HIV/AIDS, Congenital Abnormalities  ABSTRAK Infeksi HIV pada kehamilan berisiko menyebabkan berbagai komplikasi pada ibu dan janin, salah satunya kelainan bawaan. Penelitian ini bertujuan untuk mengetahui prevalensi kelainan bawaan pada kehamilan ibu dengan HIV/AIDS. Studi deskriptif retrospektif dengan desain cross-sectional menggunakan data rekam medis ibu hamil HIV-positif di RSUD Dr. Soetomo Surabaya periode 2020-2022. Ada 108 wanita hamil dengan HIV, 3 di antaranya (2,8%) memiliki kelainan bawaan pada janin berupa hidrosefalus, sindrom Dandy-Walker, dan CPAM. Diduga terkait dengan infeksi oportunistik dan efek toksik embrio dari obat ARV efavirenz. Pada ibu hamil dengan HIV di Rumah Sakit Umum Dr. Soetomo, 3 (2,8%) ibu hamil mengalami kelainan bawaan pada janin, untuk itu perlu dilakukan pencegahan dan deteksi dini komplikasi selama kehamilan, serta pemilihan regimen ARV yang lebih aman bagi perkembangan janin. Kata Kunci: Kehamilan Dengan HIV/AIDS, HIV/AIDS, Kelainan Bawaan
Infeksi pada Lanjut Usia: Epidemiologi, Risiko, dan Pendekatan Klinis Safitri Indah Masithah; Muhammad Rifqo Hafidzudin Farid; Tri Pudy Asmarawati; Erika Marfiani; Andi Ratna Kartika Maharani; Nabilah Nabilah; Dananti Kusumawindani
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 5 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i5.5811

Abstract

Infeksi merupakan penyebab utama morbiditas, mortalitas, dan rawat inap pada populasi lanjut usia. Peningkatan usia harapan hidup menyebabkan proporsi individu ?65 tahun dengan multimorbiditas dan kerentanan terhadap infeksi semakin tinggi. Penelitian ini bertujuan untuk mengkaji secara komprehensif epidemiologi, faktor risiko, patofisiologi, manifestasi klinis, serta pendekatan diagnosis, tatalaksana, dan pencegahan infeksi pada pasien geriatri. Metode yang digunakan adalah studi literatur dengan menelaah berbagai publikasi ilmiah terkait infeksi pada lanjut usia di berbagai setting pelayanan kesehatan, termasuk komunitas, rumah sakit, dan fasilitas perawatan jangka panjang. Hasil kajian menunjukkan bahwa infeksi yang paling umum pada lanjut usia meliputi pneumonia, infeksi saluran kemih, sepsis, serta infeksi kulit dan jaringan lunak. Faktor risiko utama mencakup imunosenesens, inflamaging, malnutrisi, frailty, komorbiditas kronik, serta paparan lingkungan medis seperti penggunaan alat invasif dan antibiotik spektrum luas. Manifestasi klinis sering bersifat atipikal sehingga berpotensi menyebabkan keterlambatan diagnosis. Tatalaksana memerlukan pendekatan individual dengan mempertimbangkan perubahan farmakokinetik dan farmakodinamik pada lanjut usia, serta pentingnya antimicrobial stewardship. Kesimpulannya, infeksi pada geriatri merupakan kondisi kompleks yang memerlukan pendekatan multidisiplin, deteksi dini, serta strategi pencegahan yang komprehensif guna menurunkan beban penyakit dan meningkatkan kualitas hidup pasien.
Co-Authors Agung Dwi Wahyu Widodo Ahmad Veri Erianto Alsagaff, Mochamad Yusuf Anudya Kartika Ratri Ardhena Ekasari Bakhtiar, Arief Bramanton Bramantono Bramantono, Bramantono Dahlia Riyanto Desiana Radithia, Desiana Dewi Setyowati Dinda Monika Nusantara Ratri Erianto, Ahmad Veri Erika Marfiani Hana Hanunnisa, Nadhifa Heri Krisnata Ginting Hermina Novida, Hermina Isnin Anang Marhana Juniastuti Juniastuti Khanfar, Sarah Amjad Abdel-Raouf Kusumawindani, Dananti Lestari, Kristanti Maharani, Andi Ratna Kartika Mareta Rindang Andarsari Marwasyifa, Nuritsna Masithah, Safitri Indah Mochamad Yusuf Alsagaff Monita, Syafira Putri Muhammad Rifqo Hafidzudin Farid Muhammad Vitanata Arfijanto, Muhammad Vitanata Musofa Rusli Nabilah Nabilah Nasronudin Nasronudin Nursalam, Nursalam Pepy Dwi Endraswari, Pepy Dwi Rachman, Brian Eka Ratri, Anudya Kartika Rindang Tanjungsari Rista Elva Riani S. Ugroseno Yudho Bintoro Setiawan, Firman Sholichah, Aminatush Usman Hadi Wardani, Erlisa Pramodya Wardhana, Manggala Pasca