Asmarawati, Tri Pudy
Department Of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Indonesian Society Of Internal Medicine

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Acute Pericarditis in Patient with Systemic Lupus Erythematosus: A Case Report Ratri, Anudya Kartika; Alsagaff, Mochamad Yusuf; Asmarawati, Tri Pudy
Indonesian Journal of Cardiology Vol 39 No 1 (2018): January - March 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.30701/ijc.v39i1.793

Abstract

Acute pericarditis is a common disorder caused by inflammation of the pericardium and can occur as an isolated entity or as a manifestation of an underlying systemic disease. The diagnosis of acute pericarditis is established when a patient has at least two of the following symptoms or signs: chest pain consistent with pericarditis, pericardial friction rub, typical ECG changes, or a pericardial effusion of more than trivial size. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune systemic disorder with unknown etio-pathogenesis. Upon the susceptible genetic, hormonal and abnormal immunologic background, the environmental factors may play role as trigger to permit disease development. Cardiovascular complications occur in more than half of the patients with SLE. Pericarditis is the most studied cardiovascular manifestation, although often not evident clinically, and it is included in the American College of Rheumatology (ACR) classification criteria for SLE. We report a clinical case of initially unremarkably findings which progressed to SLE complicated by full-blown acute pericarditis. A brief review of acute pericarditis, including etiology, clinical presentation, ECG criteria, echocardiographic manifestation, and treatment is presented.   Abstrak Perikarditis akut adalah penyakit yang disebabkan oleh inflamasi dari perikard, dapat terjadi sebagai entitas penyakit primer maupun sekunder sebagai manifestasi dari penyakit sistemik yang mendasarinya. Diagnosis perikarditis akut ditegakkan saat pasien mengalami setidaknya dua dari tanda atau gejala berikut: nyeri dada spesifik perikarditis, pericardial friction rub, perubahan EKG tipikal, atau adanya efusi perikard dengan ukuran lebih dari trivial. Lupus Eritematosus Sistemik (LES) adalah penyakit autoimun sistemik kronis dengan etiopatogenesis yang belum diketahui. Adanya kepekaan genetik, latar belakang imunologis abnormal dan hormonal, serta faktor lingkungan memegang peran sebagai pemicu perkembangan penyakit. Komplikasi kardiovaskular terjadi pada lebih dari setengah pasien dengan SLE. Perikarditis merupakan manifestasi kardiovaskular yang paling sering dijumpai, meskipun jarang ditemukan patognomonis secara klinis, dan termasuk dalam kriteria klasifikasi LES menurut American College of Rheumatology (ACR). Berikut kami laporkan kasus dengan presentasi klinis febris dan takikardia yang kemudian mengarah pada LES dengan komplikasi perikarditis akut. Kami sertakan juga ulasan tentang perikarditis akut, termasuk etiologi, presentasi klinis, kriteria EKG, manifestasi ekokardiografis, dan terapi.
Relationship between Neutrophil-Lymphocyte Ratio and Disease Severity in COVID-19 Patients in Isolation Ward of Dr. Soetomo General Teaching Hospital Heri Krisnata Ginting; M. Vitanata Arfijanto; Tri Pudy Asmarawati; S. Ugroseno Yudho Bintoro
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17558

Abstract

This study was conducted to prove the relationship between the neutrophil-lymphocyte ratio and theseverity of COVID-19. A retrospective cohort study using medical record data of inpatients from Juneto July 2020. Analysis of the NLR relationship and the degree of severity using the Mann Whitney testif the data had an abnormal distribution. Significant if p<0.05 and 95% confidence interval. If there weresignificant results, we try to measure the cut-off of NLR value to predict severe and non-severe clinicalsymptoms. Total study subjects were 110 patients, with a male as many as 65 (59.1%), the median agewas 53.5 years (range 20-88). Most of the comorbidities were diabetes mellitus (35.5%), followed byhypertension (30%). The severity of clinical symptoms was 50% in the non-severe and severe groups,respectively. The NLR value was higher in the severe group. Mann-Whitney test showed significantdifferences in the value of NLR between the severe group and the not severe group with the p-value<0.001. Receiver operating characteristic (ROC) curve analysis area under the curve (AUC) of NLRon day-1 was 0.716 (CI 95%: 0.605 - 0.826), and the cut-off point of the prediction severity diseaseat day-7 was ≥ 6.14 with a sensitivity of 71% and a specificity of 69.1%. The neutrophil-lymphocyteratio value with severe symptoms was higher than the neutrophil ratio value for lymphocytes with nonseveresymptoms in patients with COVID-19.
Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia Usman Hadi; Bramanton; Tri Pudy Asmarawati; Musofa Rusli; Nasronudin; Brian Eka Rachman; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17659

Abstract

Introduction: World Health Organization had identified COVID-19 in January 2019. This disease is caused by SARS-CoV-2, which spread throughout the world and became a pandemic on March 20, 2020. COVID-19 is still a health problem because it has not clear whether the patients will be cured and survive from the disease or not. This study aims to determine the predictors of mortality from COVID-19 at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia.Method: This study was conducted in Dr. Soetomo General Academic Hospital (referral hospital for COVID-19, 1500 beds) and Universitas Airlangga Hospital (Referal Hospital for COVID-19, 600 beds). The study used data on patients with confirmed COVID-19 who were hospitalized at these two referral hospitals. Predictors of mortality were analyzed using logistic regressions.Result: There were 247 COVID-19 patients enrolled in this study, all patients were tested positive PCR SARS-CoV-2. The main complaints were cough, nasal congestion, dyspnea, and fever. Significant predictor mortality in this study were age >60 years old (OR: 3.24, 95% CI, 1.36 - 7.70), chronic kidney disease (OR: 5.71, 95% CI, 2.05 - 15.89), obesity (OR: 8.22, 95% CI,1.5 - 54.17), malignancy (OR: 6.025, 95% CI, 1.1- 33.00), coronary heart disease (OR: 5.31, 95% CI, 1.28 - 21.98) , and C-reactive protein >10 mg/L (OR 4.603, 95% CI, 2.03 - 10.44).Conclusions: Obesity and the presence of malignancy, chronic kidney disease, heart disease and age >60 yearsold are the strongest predictors of mortality in people with COVID-19, despite high CRP results.
ORAL CANDIDIASIS IN HIV PATIENT SUFFERING PNEUMOCYSTIC CARINII PNEUMONIA Dahlia Riyanto; Rindang Tanjungsari; Tri Pudy Asmarawati; Desiana Radithia
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8126

Abstract

Background: HIV/AIDS infection provoked opportunistic infection systhemically and intraorally. Pneumocystic carinii pneumonia (PCP) and Oral candidiasis (OC) is the most prevalent opportunistic infection among HIV/AIDS patient and may serve as indicator of low CD4 count in HIV infection. Objective: This paper reports management of oral candidiasis in pneumocystic carinii pneumonia that affects a patient with HIV. Case: A 39 year-old man was hospitalized for pneumocystic carinii pneumonia with weakness of gait and emaciated posture. He was also diagnosed of HIV/AIDS infection through CD4 count and HIV rapid test. Intraoral white patches was reported occured within 2 days being hospitalized. Several tests were ordered resulting, metabolic acidosis, CD4 count were 10 cells/μL, HIV rapid test (ICT) was reactive for 3 methods, and microbiologic examination was positif to C.albicans from the smear of white plaque. The patient also diagnosed with OC pseudomembranous type. Case Management: Patient was treated using intravenous fluconazole 100 mg/day for five days and antiseptic mouthwash. Recovery was achieved within 3 weeks follow-up along with given anti retroviral (ARV) treatment by the internist. Conclusion: Management of OC in HIV/AIDS patient with PCP infection in this case were used systemic antifungal and antiseptic mouthwash. The multidiciplinary approach in managing this case obtained successful therapy.
Acute Pericarditis in Patient with Systemic Lupus Erythematosus: A Case Report Anudya Kartika Ratri; Mochamad Yusuf Alsagaff; Tri Pudy Asmarawati
Jurnal Kardiologi Indonesia Vol 39 No 1 (2018): January - March 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i1.793

Abstract

Acute pericarditis is a common disorder caused by inflammation of the pericardium and can occur as an isolated entity or as a manifestation of an underlying systemic disease. The diagnosis of acute pericarditis is established when a patient has at least two of the following symptoms or signs: chest pain consistent with pericarditis, pericardial friction rub, typical ECG changes, or a pericardial effusion of more than trivial size. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune systemic disorder with unknown etio-pathogenesis. Upon the susceptible genetic, hormonal and abnormal immunologic background, the environmental factors may play role as trigger to permit disease development. Cardiovascular complications occur in more than half of the patients with SLE. Pericarditis is the most studied cardiovascular manifestation, although often not evident clinically, and it is included in the American College of Rheumatology (ACR) classification criteria for SLE. We report a clinical case of initially unremarkably findings which progressed to SLE complicated by full-blown acute pericarditis. A brief review of acute pericarditis, including etiology, clinical presentation, ECG criteria, echocardiographic manifestation, and treatment is presented. Abstrak Perikarditis akut adalah penyakit yang disebabkan oleh inflamasi dari perikard, dapat terjadi sebagai entitas penyakit primer maupun sekunder sebagai manifestasi dari penyakit sistemik yang mendasarinya. Diagnosis perikarditis akut ditegakkan saat pasien mengalami setidaknya dua dari tanda atau gejala berikut: nyeri dada spesifik perikarditis, pericardial friction rub, perubahan EKG tipikal, atau adanya efusi perikard dengan ukuran lebih dari trivial. Lupus Eritematosus Sistemik (LES) adalah penyakit autoimun sistemik kronis dengan etiopatogenesis yang belum diketahui. Adanya kepekaan genetik, latar belakang imunologis abnormal dan hormonal, serta faktor lingkungan memegang peran sebagai pemicu perkembangan penyakit. Komplikasi kardiovaskular terjadi pada lebih dari setengah pasien dengan SLE. Perikarditis merupakan manifestasi kardiovaskular yang paling sering dijumpai, meskipun jarang ditemukan patognomonis secara klinis, dan termasuk dalam kriteria klasifikasi LES menurut American College of Rheumatology (ACR). Berikut kami laporkan kasus dengan presentasi klinis febris dan takikardia yang kemudian mengarah pada LES dengan komplikasi perikarditis akut. Kami sertakan juga ulasan tentang perikarditis akut, termasuk etiologi, presentasi klinis, kriteria EKG, manifestasi ekokardiografis, dan terapi.
Bacterial Profile and Antibiotic Use in Catheter-Associated Urinary Tract Infection Patients at a Tertiary Referral Hospital in Surabaya, Indonesia Ahmad Veri Erianto; Tri Pudy Asmarawati; Agung Dwi Wahyu Widodo; Brian Eka Rachman
Folia Medica Indonesiana Vol. 59 No. 2 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v59i2.39919

Abstract

Highlights: This study examined patients with catheter-associated urinary tract infections (CAUTI) to find the prevalent bacteria and the frequency of antibiotic use. Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli sensitive to amikacin was found to be the most common pathogen in CAUTI, while ceftriaxone was the most commonly used antibiotic. Abstract Catheter-associated urinary tract infection (CAUTI) is the most typical type of infection associated with healthcare. This infection constitutes a significant health problem due to its complications and frequent recurrence. The high annual incidence of CAUTI leads to infectious complications and a high cost of treatment. Antibiotic-resistant bacteria further complicate the problem because multiresistant pathogenic bacteria are often responsible for these infections. Moreover, the lack of a comprehensive case reporting system in Indonesia hinders the determination of CAUTI incidence. This study aimed to determine the bacterial profile and antibiotic use in CAUTI patients (n=22) at the Internal Medicine Inpatient Unit of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This retrospective descriptive study collected data from patient medical records to describe the incidence, type of bacteria, sensitivity patterns, and antibiotic use in CAUTI patients. The data collection process included collecting medical records, recording information on data collection sheets, and recapitulating and analyzing the data. The criteria for CAUTI diagnosis were a bacterial count of ≥105 CFU/mL and a catheterization that lasted more than 48 hours. Samples were selected using non-probability sampling, also known as saturation sampling. Meanwhile, variables analyzed in this study were the type of pathogenic bacteria, antibiotics used, age, and sex. Descriptive analysis was employed to analyze the data. The findings suggested that the most common bacteria were Escherichia coli, with eight of nine bacteria showing extended-spectrum beta-lactamase (ESBL) production. Female patients aged 35–65 years were the majority of the CAUTI patients. Amikacin was the antibiotic with the highest sensitivity (90.9%), while ceftriaxone was the most common type of antibiotic administered to the patients. In addition, intravenous (IV) administration was the most common route of antibiotic administration, with an average therapy duration of seven days. In conclusion, identifying the type of pathogenic bacteria and performing antibiotic susceptibility testing can help minimize antibiotic resistance and prevent more severe complications in CAUTI patients. 
Pengembangan Instrumen Surveilans Ventilator-Associated Events (VAE) Berbasis Algoritme National Healthcare Safety Network (NHSN) Ardhena Ekasari; Nursalam Nursalam; Tri Pudy Asmarawati
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7552

Abstract

This research aims to develop a Ventilator-Associated Events (VAE) surveillance instrument based on the National Healthcare Safety Network (NHSN) in the intensive care unit (ICU). The method used is Research and Development with stages including literature study, observation evaluation, validity and reliability testing, and focus group discussions (FGD). The research results show that the development of an NHSN-based VAE surveillance instrument in the ICU consists of two sheets, namely the first sheet (patient identity, minimum daily PEEP, and FiO2) and the second sheet (IVAC PVAP criteria). The I-CVI test result is 1.00, and the KR 20 test is 0.96, which means it is valid and reliable. In conclusion, developing an NHSN-based VAE surveillance instrument in the ICU can be applied in hospitals to refine Ventilator-Associated Pneumonia (VAP) surveillance. This can objectively detect complications from using a ventilator due to infection or non-infection. Keywords: Infection, Instruments, Surveillance, VAE, VAP
The Clinical Outcome of COVID-19 Infection on Chronic Diabetic Complications Patients Wardani, Erlisa Pramodya; Tri Pudy Asmarawati; Isnin Anang Marhana; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.51748

Abstract

Introduction: COVID-19 is an infectious disease resulting from the SARS-CoV-2 virus. The virus targets the respiratory system and leads to a significant number of fatalities worldwide. Consequently, it was officially classified as a pandemic in 2020. The Covid varians is now being monitored by the World Health Organization. Diabetes mellitus is one of the disorders that might deteriorate following an infection. Diabetes mellitus and its associated comorbidities continue to pose a significant health challenge in Indonesia, while it is also a focus of concern of the Sustainable Development Goals (SDGs). The study was aimed to assess the risks and outcomes associated with COVID-19 infection and the long-term consequences of diabetes mellitus.Methods: This was a descriptive study using a retrospective design. Research data were taken from the medical records of patients confirmed positive for COVID-19 infection and also had chronic complications of diabetes mellitus who were treated at Dr Soetomo General Academic Hospital, Surabaya, Indonesia in 2021. There were 156 patients who met the criteria of this research.Results: There were 156 patients (97 males, 59 females). The average age of the patients was 58, while most of the patients (84%) died and the rest of the patients (16%) survived. Most of the patients with fatality (55.8%) were those with critical severity level and complications of microangiopathy, while the patients who survived (10.3%) were those with moderate severity level and complications of microangiopathy. Conclusion: COVID-19 patients with diabetes and comorbidities had a higher mortality rate than those who recovered, while most of the patients with fatality were those with significant COVID-19 and diabetic microangiopathy complications.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID Andarsari, Mareta Rindang; Hanunnisa, Nadhifa; Lestari, Kristanti; Sholichah, Aminatush; Ratri, Dinda Monika Nusantara; Asmarawati, Tri Pudy
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.584

Abstract

Demam tifoid merupakan penyakit infeksi yang disebabkan oleh bakteri yang salah satu pengobatannya dengan diberikan terapi antibiotik. Untuk mencapai keberhasilan terapi adalah dengan melakukan pemilihan antibiotik. Hal yang perlu diperhatikan dalam memilih antibiotik yaitu dengan melihat efektivitas biaya. Cara mengetahui antibiotik yang paling cost-effective adalah dengan cost-effectiveness analysis (CEA). Analisis ini dapat dihitung dengan nilai ACER (Average Cost-Effectiveness Ratio) yang dilihat dari biaya pengobatan langsung dan efektifitas terapi. Efektivitas terapi dapat dilihat dari data klinis dan laboratorium pasien meliputi suhu, nadi, RR dan leukosit pasien saat keluar dari rumah sakit. Hasil penelitian ini adalah nilai ACER kloramfenikol sebesar Rp1.700.501 (berdasarkan data suhu, nadi, dan RR) dan cefixime sebesar Rp. Rp2.335.650 (berdasarkan data suhu, nadi, RR dan leukosit) pada tahun 2020. Sedangkan cefixime memiliki nilai ACER pada tahun 2021 sebesar Rp4.852.897 (berdasarkan data suhu, nadi, dan RR) dan Rp5.349.785 (berdasarkan data suhu, nadi, RR dan leukosit). Kesimpulan dari penelitian ini adalah kloramfenikol dan sefiksim merupakan antibiotik yang cost-effective berdasarkan nilai ACER terendah untuk pasien rawat inap di Rumah Sakit Universitas Airlangga
Prevalensi Kelainan Kongenital Janin pada Kehamilan Penderita HIV/AIDS di RSUD Dr. Soetomo Kota Surabaya Riani, Rista Elva; Bakhtiar, Arief; Setyowati, Dewi; Wardhana, Manggala Pasca; Asmarawati, Tri Pudy
Malahayati Nursing Journal Vol 6, No 10 (2024): Volume 6 Nomor 10 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i10.13807

Abstract

ABSTRACT HIV infection in pregnancy is at risk of causing various complications in the mother and fetus, one of which is congenital abnormalities. This study aims to determine the prevalence of congenital abnormalities in pregnancy of women with HIV / AIDS. Retrospective descriptive study with cross-sectional design using medical record data of HIV-positive pregnant women at Dr. Soetomo Surabaya Hospital for the 2020-2022 period. There were 108 pregnant women with HIV, 3 of whom (2.8%) had congenital abnormalities in the fetus in the form of hydrocephalus, Dandy-Walker syndrome, and CPAM. Suspected to be associated with opportunistic infections and embryo-toxic effects of the ARV drug efavirenz. In pregnant women with HIV at Dr. Soetomo General Hospital, 3 (2.8%) pregnant women experience congenital abnormalities in the fetus, for that it is necessary to prevent and early detection of complications during pregnancy, as well as the selection of ARV regimens that are safer for fetal development. Keywords: Pregnancy With HIV/AIDS, HIV/AIDS, Congenital Abnormalities  ABSTRAK Infeksi HIV pada kehamilan berisiko menyebabkan berbagai komplikasi pada ibu dan janin, salah satunya kelainan bawaan. Penelitian ini bertujuan untuk mengetahui prevalensi kelainan bawaan pada kehamilan ibu dengan HIV/AIDS. Studi deskriptif retrospektif dengan desain cross-sectional menggunakan data rekam medis ibu hamil HIV-positif di RSUD Dr. Soetomo Surabaya periode 2020-2022. Ada 108 wanita hamil dengan HIV, 3 di antaranya (2,8%) memiliki kelainan bawaan pada janin berupa hidrosefalus, sindrom Dandy-Walker, dan CPAM. Diduga terkait dengan infeksi oportunistik dan efek toksik embrio dari obat ARV efavirenz. Pada ibu hamil dengan HIV di Rumah Sakit Umum Dr. Soetomo, 3 (2,8%) ibu hamil mengalami kelainan bawaan pada janin, untuk itu perlu dilakukan pencegahan dan deteksi dini komplikasi selama kehamilan, serta pemilihan regimen ARV yang lebih aman bagi perkembangan janin. Kata Kunci: Kehamilan Dengan HIV/AIDS, HIV/AIDS, Kelainan Bawaan