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Journal : JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan

Xanthone Protective Effects Against Spermatozoa Morphology of Mice Induced by 2-Methoxyethanol (2-ME) Ernawati Ernawati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 14 No 4 (2022): EDISI SPESIAL
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v14i4.874

Abstract

Antioxidants can be used to protect against oxidative stress which is one of the important mechanisms of 2-methoxyethanol (2-ME) -induced testicular toxicity . This research was conducted to find out normal and abnormal morphology of spermatozoa cells in mice induced by 2-Methoxyethanol . The study used 35 male mice which were divided into 5 groups, namely: the control group (the mice were given purified water every day by distillation); the 2-ME group (the mice were given 2-ME 200 mg /kg BW daily orally once a day for 35 days); and the treatment group (the mice were given xanthones 60 mg , 120 mg , and 240 mg /kg BW orally once a day for 38 days, and on the 3rd day, 2-ME 200 mg /kg BW were given one hour after. Xanthones were given). After 38 days, next sperm mice will conducted inspection morphology . The results showed that the administration of 2-ME could influence abnormality spermatozoa morphology . However, xanthone treatment significantly shows _ enhancement normality spermatozoa morphology . Conclusion From the results of this study indicate that xanthones are able to increase spermatozoa morphology in mice that were given 2-ME.
Co-Authors Achmad, Abdul Kholid Agus Maulana Ramadhan Ahmad Arif Badruz Zaman Ahmad Fikri Ramadhan Ahmad Nur Kholis Ainul Mufidah Alkusani, Alkusani Ambarwati Eka Lestari Ana Malikah Syarifatin Andi Rahmad Rahim Anita Handayani Anita Sari Aries Kurniawan Arin Widi Kustantri Arya Setya Nugroho Atikotul Fauziyah Ayunda Sayyidatul Ifadah Bagus Hariyanto Beni Dwi Komara Citra Ayu Putriningtyas Diah Fauzia Zuhroh Diah Jerita Eka Sari Dian Agnesia Dian Indah Sari Dwi Faqihatus Syarifah Has Eka Permady Faerul Falaq Farichatul Ainiyah Firdah Vebriyanti Ganis Irham Fanani Hanifah Rahmawati Hendriyan Aji F Heni Indapratiwi Heru Baskoro Hilda Rodhotul Ainiyah Imam Wahyu Ramadhan Indra Irawan Indro Kirono Iqnatia Alfiansyah Julianti Puji Kartika Keziah Frydha Putri Arwantini M. Gerri Setia B Mar’atus Sholihah Mas'udatus Saniyah Ma’had Wicaksono Mochammad Hafizh Maulana Moh Fachrudin Moh Faiqul Humam Moh. Adhim Moh. Dian Kurniawan Muhammad Aufa Muhammad Faris Kamaaluddin Muhammad Iqbal Ash Shidiq Muhammad Wahyu Mutahro Mutahro Nabila Anjani Eka Putri Nadia Putri Liani Pradini Nanang Khoirul Umam Ninik Anadiyah Nitha Pramestia Dhevi Noor Amirrudin Noor Amiruddin Nur Layli Fitria Nyimas Wardatul Afiqoh Parianti Parianti Pujianto Nur Romadlon Rahmat Agus Santoso Riris Dia Mariati Rizky Bagus Kuncoro Santya Dian Pratiwi Silviana Putri Indah Sari Slamet Asari Soffiana Agustin, Soffiana Sukaris Suwandi, S. Syaiful Syaiful Tri Yuli Ardiansyah Trias Fitri Ariza Yanuar Pandu Negoro Yusuf Hermansyah