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All Journal Jurnal Riset Kesehatan Journal of Health (JoH) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Media Ilmu Kesehatan JI-KES (Jurnal Ilmu Kesehatan) Indonesian Journal of Biology Education Jurnal Kesehatan Saelmakers PERDANA (JKSP) Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Kefarmasian AKFARINDO Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Abdi Insani Prosiding Conference on Research and Community Services Jurnal Ilmu Kesehatan MAKIA Jurnal Kesehatan Tambusai Jurnal Pengabdian kepada Masyarakat International Journal of Advanced Health Science and Technology Jurnal Kesehatan Rajawali Jurnal Ilmu Kesehatan MAKIA Varians Jurnal Kesehatan Masyarakat

Sepvianti, Wiwit

STIKES GUNA BANGSA YOGYAKARTA

Author-ID : 3435970

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari Aulia Rahman; Wiwit Sepvianti; Arif Tirtana; Gravinda Widyaswara; Kumara Rahmawati Zain
Jurnal Kesehatan Rajawali Vol 13 No 1 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.159

Thrombocyte concentrate transfusion was one of the important medical treatments in increasing the number of thrombocytes in patients with medical indications of thrombocytopenia. The monitoring of blood product quality from upstream to downstream must be considered in order to obtain a good quality thrombocyte concentrate. Thrombocyte concentrate was prone to change during storage due to significant changes between in vitro and in vivo conditions. The changes in thrombocyte concentrate quality that commonly occur during storage were the decreased platelet levels, increased of acidity (pH) and turbidity, and loss of thrombocyte swirling in the plasma. Therefore, it was necessary to conduct research to determine the quality of thrombocyte concentrates during the 5-day shelf life to find out whether at the end of the shelf life, these blood products were still suitable for transfusion to the patients. Several tools used in this study were Hematology Analyzer, blood scales, and pH meter. The results of successive studies showed that the thrombocyte concentrate product did not meet the basic quality standards because the number of thrombocytes per unit was below the standard that was set by Regulation of the Ministry of Health of the Republic of Indonesia Number 91 Years 2015.

INISIASI PENGEMBANGAN DESA SIAGA DONOR DARAH MELALUI PROGRAM PEMERIKSAAN DAN PENDATAAN GOLONGAN DARAH WARGA DUSUN KALIADEM, SLEMAN, YOGYAKARTA Kumara Rahmawati Zain; Wiwit Sepvianti; Aulia Rahman; Gravinda Widyaswara; Arif Tirtana
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.997

Alert village is a concept of empowerment and community participation at the village level, accompanied by the development of alertness and readiness of the community to maintain their health independently. Residents of Alert Village have the readiness of resources and the ability and willingness to independently prevent and overcome health problems, disasters and health emergencies. The blood donor alert village is expected to be able to accommodate health problems that arise in areas prone to natural disasters, if during a disaster there is the possibility of the route being cut off. The concept of Desa Siaga Donor is to build a system in a village that is responsible for maintaining community health at the village level, it is hoped that it will overcome problems related to maternal mortality so that it can be accommodated, especially those related to meeting the need for blood during childbirth. Collecting residents' blood type data as an initiation of the Village Alert Program for blood donors in Dusun Kaliadem, especially in fulfilling the need for blood during the delivery process. Community service through the Blood Donor Alert Village initiation activity in Kaliadem Hamlet, Kepuharjo Village, Cangkringan District, Sleman Regency involving 14 DIII students of Blood Bank Technology STIKes Guna Bangsa Yogyakarta by running the Donor Alert Village Initiation program. The total number of residents of Kaliadem Hamlet is 215 people, of which 48.83% have their blood type recorded while 51.16% are not recorded. The community empowerment program in Kaliadem Hamlet, Kepuharjo Village, Cangkringan District, Sleman Regency was carried out as part of the Blood Donor Alert Village Initiation Effort by carrying out health education activities as well as data collection and examination of people's blood groups in Kaliadem Hamlet. Based on the results of blood group checking, it was found that 34 residents had blood type A, 30 residents had blood type B, 5 residents had blood type AB and 36 residents had blood type O. Blood checking data for Kaliadem Hamlet residents will be the main data in the Donor Alert Village initiation. The blood group data of Kaliadem Hamlet residents then becomes part of the Kepuharjo Village database.

Evaluasi Kualitas Packed Red Cell (PRC) berdasarkan Kadar pH Darah selama Masa Penyimpanan 36 Hari Sepvianti, Wiwit; Widyaswara, Gravinda; Rahman, Aulia; Zain, Kumaha Rahmawati; Tirtana, Arif; Pebriana, Relita; Kodo, Jemi Arivitriyanto Livingston
Jurnal Kesehatan Rajawali Vol 12 No 2 (2022): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v12i2.149

Packed red cell (PRC) merupakan komponen darah dengan frekuensi penggunaan tertinggi dibandingkan komponen darah lainnya seperti thrombocyte concentrate (TC); cryoprecipitate; dan plasma, sehingga laporan terkait reaksi transfusi akibat penggunaan PRC juga menempati urutan pertama. Secara umum reaksi transfusi dapat dipicu oleh terjadinya reaksi yang bersifat imunologi dan non-imunologi. Reaksi imunologi sendiri berkaitan dengan ketidakcocokan darah donor dan resepien sedangkan reaksi non-imunologi berkaitan dengan infeksi penyakit menular, kontaminasi bakteri, hipotermia, keracunan sitrat, kelebihan zat besi dan asidosis. Adapun kondisi asidosis (penurunan kadar pH) produk darah sejauh ini belum banyak dilaporkan, oleh karena itu penelitian ini dilakukan untuk mengevaluasi kualitas PRC berdasarkan kadar pH darah selama penyimpanan 36 hari. Pengukuran kadar pH darah dilakukan terhadap 5 sampel darah PRC menggunakan alat ukur pH meter Ohaus Starter 3100-F. Interval waktu pengukuran adalah setiap 3 hari, sejak hari penyadapan darah yaitu hari ke-0 hingga akhir masa simpan yaitu hari ke-36. Hasil evaluasi menunjukkan bahwa kadar pH darah terus mengalami penurunan dari hari ke hari dengan kurva yang landai. Persentase penurunan kadar pH darah berada pada kisaran 5,63%- 14,49% dengan nilai kadar pH darah di akhir masa simpan berada pada rentang 6,73- 6,90 dengan rerata 6,82. Nilai tersebut masuk dalam kategori produk darah aman digunakan hingga akhir masa simpan, karena berada pada batas aman kadar pH darah yang ditetapkan dalam regulasi pemerintah yaitu PMK No 91 tahun 2015.

SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KALKON TERHADAP BAKTERI KONTAMINAN PRODUK DARAH GRAM NEGATIF DAN POSITIF Wiwit Sepvianti; Christiyani Kusumaningrum, Serafica Btari
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.112

Background: The development of chalcone-based antibiotics has been widely carried out today, variations in the location and type of functional groups were carried out to find chalcone with the best bacterial inhibitory activity. However, the obstacle faced was that not all variations of chalcone showed good bacterial inhibitory activity. The trend of increasing or decreasing antibacterial activity due to variations in the location and type of substituent in chalcone is difficult to detect, because comparative data on the inhibitory activity of chalcone are not current or are no longer relevant to current conditions where the test bacteria have mutation as a form of adaptation or resistance to antibiotics. Objective: This research was conducted to provide current data on the antibacterial activity of chalcone against gram-positive and gram-negative bacteria. Methods: Chalcone was synthesized by Claisen-Schmidt condensation and activity test by diffusion method. Results: The yield of chalcone obtained in this study was 96.15%, with the percent purity based on the results of GC-MS was 100%. Inhibitory activity of chalcone on gram-negative bacteria Escherichia coli is in the strong category with an inhibitory value of 81.30% while Acinetobacter is weak with a percentage of 43.0%. In gram-positive bacteria Staphylococcus aureus the inhibitory ability is moderate with a percentage of 64.0%, while in Staphylococcus epidermidis and Bacillus sp the inhibitory activity is weak with a percentage of 35.5% and 43.0%, respectively. Conclusion: Chalcone have strong activity on Gram-negative bacteria and tend to be moderate on Gram-positive bacteria.

Identifikasi Kadar Hemoglobin Rendah Pada Calon Pendonor Darah Di Yogyakarta: Identification of Low Hemoglobin Levels in Prospective Blood Donors in Yogyakarta Arif Tirtana; Lusia Peni Lamen; Wiwit Sepvianti; Aulia Rahman; Gravinda Widyaswara; Kumara Rahmawati Zain; Selasih Putri Isnawati Hadi
Journal of Health (JoH) Vol 12 No 1 (2025): Journal of Health (JoH) - January
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n1.1143

Hemoglobin (Hb) is influenced by several factors, including unhealthy lifestyle, age, gender, food and drink. Hb binds and carries oxygen from the lungs to be distributed to all body tissues. Hb deficiency can cause anemia which can cause morbidity and mortality for sufferers. This research is to determine the risk factors for low hemoglobin levels in potential donors. This research method is descriptive observational.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n1.1143

Antibacterial Activity of 4-hydroxychalcone Against Bacterial Contaminant of Packed Red Cells Kusumaningrum, Serafica Btari Christiyani; Sepvianti, Wiwit; Pebrina, Relita; Rahman, Aulia
Indonesian Journal of Biology Education Vol 5, No 2 (2022): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/ijobe.v5i2.7158

The bacterial contamination of blood products is still become a serious problem in consideration, thus it can cause the risk of blood transfusion, namely bacterial sepsis. Packed red cells is blood product and potentially contain bacterial contaminant. The source of bacterial contamination can come from the skin disinfection process in less aseptic during blood collection, donor bacterimia, and blood processing. In response, currently there have been many antibacterial compounds developments purposely to reduce the risk of bacterial contamination of blood products. This study aimed to observe the activity of 4-hydroxychalconecompounds in contaminant bacteria isolated from packed red cells blood products. Bacterial isolates isolated from the packed red cells were Staphylococcus aureusbased on cell morphology, biochemistry and colony shape. The antibacterial activity of 4-hydroxychalchone compound against Staphylococcus aureus isolates used the diffusion method. The results showed, there were antibacterial activity of 4-hydroxychalchone at a concentration of 2.5% 1.25% and 0.625% against packed red cells contaminant bacteria based upon the clear zone formed. In conclusion, the bacteria isolate was obtained from the PRC was gram positive bacteria, Staphylococcus aureus. The 4-hydroxychalcone had successfully synthesized and has antibacterial activity against S. aureus isolated from PRC, with the biggest inhibition power was 71,36% at 5,0% of chalcone concentration.

Pengaruh Konsumsi Jus Buah Bit (Beta vulgaris L) Terhadap Kadar Hemoglobin Mahasiswa Putri di Condongcatur, Sleman Zain, Kumara Rahmawati; Widyaswara, Gravinda; Hae, Shinny Love Laga; Sepvianti, Wiwit; Tirtana, Arif; Sunartono, Sunartono; Arifah, Siti; Rahmawati Zain, Kumara
Journal of Health Vol. 12 No. 2 (2025): Journal of Health (JoH) - July
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Hemoglobin is the main element of red blood cells that functions as a conjugated protein to transport oxygen and carbon dioxide. Hemoglobin levels below normal limits can cause anemia. Indonesia is one of the countries with a fairly high rate of anemia. Anemia is a common health problem among adolescent girls, mainly caused by iron deficiency which is triggered by menstruation and high nutritional needs. Currently, a non-pharmacological approach is an alternative to increase hemoglobin levels in adolescent girls, one of which is by consuming beetroot juice. Indonesia is one of the countries with relatively high anemia rates. Beetroot is rich in iron, folate, and vitamin C which can increase hemoglobin levels in the blood. The type of research used was a quasi-experimental study with a two-group pretest and posttest design, namely providing intervention by giving beetroot juice for 7 days in the morning to students in the eastern region who live in Condongcatur, Depok, Sleman, Yogyakarta. The results of this study were explained using SPSS with a Paired sample t-test with a p value <0.05 and obtained H0 = 0.024 and H7 = 0.001. This means that the sig value <0.05 indicates an effect on hemoglobin levels after the intervention. Before the intervention, the average was 11.1 gr/dl and after the intervention, the average was 12.8 gr/dl. These results indicate that consumption of beetroot juice can significantly increase hemoglobin levels in adolescent girls with anemia.

EVALUASI KUALITAS THROMBOCYTE CONCENTRATE SELAMA MASA SIMPAN LIMA HARI BERDASARKAN VARIASI USIA PENDONOR Bria, Theodosia Claranty Nahak; Mentari, Diani; Sepvianti, Wiwit; Pebriani, Relita; Tirtana, Arif; Nurpratami, Diah
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 2 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Thrombocyte Concentrate (TC) merupakan komponen darah yang digunakan untuk meningkatkan jumlah trombosit pada pasien yang mengalami trombositopenia. Komponen darah TC secara in vitro dapat disimpan selama 5 hari pada platelet agitator. Kontrol kualitas merupakan faktor yang penting untuk menjaga produk TC tetap dalam kondisi baik. Selama penyimpanan TC dapat mengalami berbagai perubahan kualitas. Usia merupakan faktor yang dapat memengaruhi kualitas darah itu sendiri. Semakin bertambahnya usia seseorang maka metabolisme tubuh akan ikut menurun. Hal ini dapat berpengaruh terhadap produksi trombosit. Saat ini, penelitian evaluasi kualitas TC pendonor dengan perbedaan usia belum pernah diteliti. Sampel TC diambil dari pendonor laki-laki berusia ≤ 30 dan > 30 tahun yang telah lolos seleksi donor, selanjutnya TC disimpan selama 5 hari. Sampel dianalisis pada hari ke 1, 3, 5 dengan beberapa parameter yaitu jumlah trombosit yang diukur menggunakan hemotology analyzer, serta swirling dan tingkat kekeruhan yang diukur secara visual. Pengamatan TC secara visual pada hari ke-5 menunjukkan swirling skor 2 dan nampak terjadi kekeruhan pada sampel TC pendonor ≤ 30 tahun. Selain itu jumlah TC yaitu 9 x 109 sel/unit. Pada pendonor usia > 30 tahun jauh lebih baik, dengan swirling skor 3 dan tidak adanya kekeruhan dan jumlah TC yaitu 26 x 109 sel/unit. Sampel darah TC dari pedonor usia > 30 tahun memiliki kualitas yang jauh lebih baik dibandingkan dengan pendonor ≤ 30 tahun. Maka dapat disimpulkan bahwa usia seseorang tidak dapat menentukan kualitas komponen darah TC. Kata kunci: kontrol kualitas, swirling, thrombocyte concentrate, trombosit, usiaDOI : 10.35990/mk.v7n2.p112-123

Survei Indeks Massa Tubuh dan Konsumsi Zat Gizi pada Masyarakat Desa Kepuharjo, Cangkringan, Sleman, Daerah Istimewa Yogyakarta sebagai Syarat Kelayakan Donor Darah : Sebuah Studi Spasial Ikrimah Nafilata; Widyaswara, Gravinda; Rahman, Aulia; Sepvianti, Wiwit; Tirtana, Arif; Zain, Kumara Rahmawati; Sunartono, Sunartono; Arifah, Siti; Fauzi, Ahmad
Varians Jurnal Kesehatan Masyarakat Vol. 3 No. 2 (2025): Desember 2025
Publisher : Varians Statistik Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63953/vjkm.v3i2.60

Konsumsi zat gizi dapat mempengaruhi IMT seseorang, seperti pada Dusun Kaliadem dan Petung yang merupakan dusun terdampak erupsi gunung Merapi pada tahun 2010. Kebijakan pasca erupsi harus merelokasi kedua dusun tersebut ke area yang lebih aman yaitu Hunian Tetap (Huntap), sehingga perlu adanya survei mengenai status gizi masyarakat serta pemetaan titik household, kaitannya dengan kelayakan syarat donor darah sukarela sebagai bagian pembentukan Desa Siaga Donor Darah. Penelitian merupakan survei observasional dengan desain cross-sectional pada 331 responden yang diambil berdasarkan tujuan estimasi proporsi. Pengumpulan data berupa wawancara, pengukuran tinggi badan, berat badan dan pengambilan titik household. Analisis data secara univariat dan persebaran household kategori IMT digambarkan menggunakan QGIS. Didapatkan hasil IMT kategori Normal mendominasi dibandingkan dengan kategori IMT Sangat kurus (3,3%), kurus (6,3%), overweight (14,8%), obesitas (22,4%), serta secara pemetaan persebaran kategori IMT yang bermasalah berdekatan karena masih dalam satu area Huntap. Disarankan agar instansi kesehatan setempat dapat melakukan edukasi mengenai konsumsi gizi berdasarkan titik household permasalahan kategori IMT, kaitannya dengan syarat kelayakan donor darah untuk pembentukan Desa Siaga Donor Darah.

Co-Authors Ana Nur ‘Aini Andriyani, Yuni Arif Tirtana Arif Tirtana Arif Tirtana Arum Sari Arum Sari Arum Sari Aulia Rahman Aulia Rahman Bria, Theodosia Claranty Nahak Btari C.K, Serafica Christiyani Kusumaningrum, Serafica Btari Diani Mentari Fauzi Ahmad Muda Gravinda Widyaswara Gravinda Widyaswara Hae, Shinny Love Laga Ikrimah Nafilata Ikrimah Nafilata Ikrimah Nafilata Kodo, Jemi Arivitriyanto Livingston Kumara Rahmawati Zain Kusumaningrum, Serafica Btari Christiyani Lusia Peni Lamen Meyta Wulandari Mohd Nazil Salleh Nafilata, Ikrimah Nurpratami, Diah Pebriana, Relita Pebriani, Relita Pebrina, Relita Relita Pebrina Relita Pebrina RIfail Rizkia Anggini Selasih Putri Isnawati Hadi Siti Arifah Sunartono Sunartono sunartono sunartono Taib Djafar Tirtana, Arif Widyaswara, Gravinda Zain, Kumaha Rahmawati

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