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All Journal e-GIGI e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Kesehatan Journal of Dentistry Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Padjadjaran Journal of Dental Researchers and Students Cakradonya Dental Journal Odonto dental journal
Depi Praharani
Fakultas Kedokteran Gigi Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : e-Journal Pustaka Kesehatan

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Jumlah Trombosit pada Mencit Diabetes setelah Pemberian Ekstrak Rumput Laut Merah (Rhodophyceae) Dahna Maudita Kartikasari; Didin Erma Indahyani; Depi Praharani
Pustaka Kesehatan Vol 7 No 3 (2019): Volume 7 No.3, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i3.11350

Abstract

Oxidative stress in diabetes mellitus triggers activation and increases in platelet counts that play a role in the formation of platelet plugs in the blood clotting process. If excessive blood clots occur, there is a risk of cardiovascular disease. Red seaweed extract contains carotenoids, phenols and their derivatives, fikobilin pigments, polysaccharide sulfates, and vitamins. The biggest phenol compound is flavonoids which are compounds that can produce platelet antia-gregation effects. The purpose of this study was to examine the effect of giving red seaweed extract to platelet counts in diabetic mice. The study group consisted of the treatment group of red seaweed extract, normal control, positive control and negative controls. The dosage of seaweed extract as much as 10 mg / 20 grBB is given in condition. The calculation of platelet count is carried out directly with the Brecher Cronkite method using a calculated room Improved Neubauer. The One Way ANOVA test results showed a significance value (p <0.05), that is, the group of diabetic mice given red seaweed extract had a lower platelet count of 280000 μl compared to diabetic mice given metformin as much as 379000 μl. The decrease is due to flavonoids, saponins, alkaloids, β carotene, vitamins and minerals able to stabilize the production of megakaryocytes and platelets, prevent the destruction of pancreatic β cells and prevent free radicals. It was concluded that red seaweed extract can reduce platelet counts of diabetic mice near normal values.
Daya Antibakteri Infusa Daun Asam Jawa (Tamarindus indica Linn) terhadap Streptococcus mutans (Antibacterial Activity of Asam Jawa Leaf Infuse (Tamarindus indica Linn) against Streptococcus mutans Anggi Faradiba; Achmad Gunadi; Depi Praharani
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Dental caries is a mouth diseases caused by the interaction of host, microorganisms, substrate and time. One of the microorganisms that had played a role in occurrence dental caries is Streptococcus mutans bacteria. Infection caused by S. mutans can be treated with an natural antibacterial or synthetic antibacterial, but synthetic antibacterial has side effects in long term use so we need to do some research to find out natural materials that can be used as an antibacterial to minimize the side effects. Asam jawa leaf (Tamarindus indica L) is one of medicinal plants that have been known contains antibacterial compound namely flavonoid, saponin, alkaloid, vitamin C, chlorine and tanin. Objective: Determined the antibacterial activity of asam jawa leaf infuse against S. mutans. Methods: Laboratories experimental with post test only control group design research. Samples in this research divided into 2 control groups that is negative control (sterile aquadest), positive control (chlorhexidine) and 3 treated groups that is 25%, 50% and 100% asam jawa leaf infuse with 5 total samples for each groups. The antibacterial test was paper disc diffusion method. Antibacterial activity showed by the inhibition zone around the paper disc that indicated there is no bacterial growth. Result and Conclusion: Asam jawa leaf infuse had antibacterial activity against S. mutans and the effective concentration of the asam jawa leaf infuse which had antibacterial activity was 100%. Keywords : Antibacterial, asam jawa leaf infuse, S. mutans.
Daya Hambat Ekstrak Daun Pepaya (Carica papaya L.) terhadap Adhesi Bakteri Porphyromonas gingivalis pada Neutrofil (Inhibition of Papaya (Carica papaya L.) Leaves Extract on Adhesion of Porphyromonas gingivalis Bacteria to Neutrophils) Ermita Windya Pratiwi; Depi Praharani; Yuliana Mahdiyah Da'at Arina
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Adhesion process of Porphyromonas gingivalis on neutrophils significantly play a role in the onset of periodontal infection. Papaya leaves contain several active substances that might impact to bacterial adhesion. This study was aimed to determine inhibition potency of papaya leaf extract (PLE) to adhesion of Porphyromonas gingivalis to neutrophils and at different concentration. This was an experimental laboratories in vitro study on neutrophils cells from peripheral blood. Samples divided into 5 group: group I/control (without PLE), group II (PLE 25%), group III (PLE 50 %), group IV (PLE 75%), and group V (PLE 100%). Isolated neutrofil was incubated by PLE in 3 hours, then incubated to the P. gingivalis in 2.5 hours. The index of adhesion was determined by calculating average number of P. gingivalis on 100 neutrophils. The result found that inhibition potency of PLE was significantly different to all groups. The conclusion was PLE inhibited P. gingivalis adhesion on neutrophils; and there were differences of inhibition potency of bacterial adhesion of P. gingivalis bacteria among PLE at 25%, 50%, 75% and 100% concentration, which higher concentration had higher inhibition effect.   Keywords: adhesion, neutrophils, papaya leaf, Porphyromonas gingivalis
Level Glukosa Darah pada Mencit Diabetes Setelah Pemberian Ekstrak Rumput Laut Coklat (Phaeophyta) Mega Bintang Bella Pertiwi; Didin Erma Indahyani; Depi Praharani
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.12165

Abstract

Diabetes mellitus (DM) is a disorder of hyperglycemia and glucose intolerance caused by insulin deficiency or insulin disorder. Insulin hormone functions in the formation of glucose as an energy source. Consequently, glucose accumulates in the blood in DM patients and affects increased free radicals within the cell and oxidative stress. In DM patients with an imbalance of oxidants and antioxidants in his plasm, therefore, patients with DM require a large amount of antioxidants intake. One alternative treatment is seaweed. Brown seaweed contains bioactive components such as polyphenols and carotenoids, which exhibit antioxidants and reduce blood glucose levels. The study aimed to analyze the effect of brown seaweed extract on the blood glucose levels in diabetic mice. The study used a research design of pre and post-test control group design. The study was divided into 4 sample groups, namely the normal group, negative controls (diabetic mice), positive control (diabetic mice + 1.3 mg / 20 gr BB metformin), P1 (diabetic mice + brown seaweed extract). The seaweed dose of 10mg / 20grBB is given daily for 21 days. Blood glucose level checks using Glucometer and strip test (Autocheck™). Brown seaweed extract has an effect on reducing blood glucose levels in diabetic mice.
Kemampuan Pasta Gigi yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora) dalam Menghambat Pertumbuhan Bakteri Fusobacterium nucleatum Vindy. W, Imaniar Fitriatasya; Pujiastuti, Peni; Praharani, Depi
Pustaka Kesehatan Vol. 13 No. 1 (2025): Volume 13 No. 1, 2025
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Fusobacterium nucleatum is a gram-negative obligate anaerobic bacterium that is most dominantly found in the oral cavity and plays an important role in periodontitis pathology. Periodontitis can be prevented by controlling plaque, namely, brushing teeth. Therefore, toothpaste needs to be optimized by adding an antibacterial substance. The robusta coffee (Coffea canephora) contains caffeine, phenols, trigonelline, chlorogenic acid, saponins, tannins, and triterpenoids, which have proven to be antibacterial. This study aimed to assess the ability of toothpaste containing robusta coffee bean extract to inhibit the growth of F. nucleatum. Robusta coffee beans were extracted using the maceration method and formulated into toothpaste with concentrations of 12.5%, 25%, and 50%. Antibacterial tests were carried out by the well diffusion method on MHA media that had been inoculated with F. nucleatum and the measured the diameter of the inhibition zone. The result showed that there was a significant difference in the inhibition zone diameter between the group positive control, the negative control, and toothpaste containing robusta coffee bean extract 12.5%, 25%, and 50%. The largest inhibition zone formed consecutively was in toothpaste containing robusta coffee bean extract 50%, 25%, and 12,5%. It can be concluded that toothpaste containing robusta coffee bean extract with concentrations of 12.5%, 25%, and 50% can inhibit the growth of F. nucleatum.
Co-Authors Achmad Gunadi Achmad Gunadi Anggi Faradiba Arina, Yuliana Mahdiyah Da'at Banun Kusumawardani Daat Arina, Yuliana Mahdiyah Dahna Maudita Kartikasari Desi S. Sari Desi Sandra Sari Dewi Kristiana Dewi Maya Dyaningsih Dewi Maya Dyaningsih, Dewi Maya Didin Erma Indahyani Dwi Prijatmoko Dyah Setyorini Elyda Akhya Afida Misrohmasari Ermita Windya Pratiwi Favinas Octa Nuri Tsalats Handian E Kurniawati Handian E Kurniawati, Handian E I Dewa Ayu Ratna Dewanti I Dewa Ayu Susilawat I Dewa Ayu Susilawati Iga Nadya Putri Inneke Dwi Lestari Izzata Barid Luh Putu Ratna Sundari Mega Bintang Bella Pertiwi Melok A. Wahyukundari Melok Aris Wahyukundari Melok Aris Wahyukundari Melok Aris Wahyukundari, Melok Aris Miftakhur Rizki Nadie Fatimatuzzahro Nafisah Nafisah Neira N. Sakinah Neira Najatus Sakinah Niken Probosari Niken Probosari Peni Pujiastuti Perdana, Mohammad Daffa Duta Prastifa, Febi Zulaikha Purwanto Purwanto , Putu Sadaka Putri Rahayu Rahardyan Parnaadji Raissa Salma Hardiani Rendra Chriestedy Prasetya Rusliyana Nuarita Rusliyana Nuarita, Rusliyana Sakinah, Neira Najatus Sita Amelia Sonya Cut Yumita Putri Sri Lestari SULISTIYANI SULISTIYANI Sumono, Agus Tantin Ermawati Vindy. W, Imaniar Fitriatasya Yuliana Mahdiyah Daat Arina Yuliana Mahdiyah Da’at Arina