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All Journal Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Human Care Journal Jurnal Endurance: Kajian Ilmiah Problema Kesehatan International Journal of Medicine and Health Inovasi Kesehatan Global
Sukarsi Rusti
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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Uncaria gambir in Dermatology: Phytochemistry, Therapeutic Evidence, and Translational Challenges Refa Rahmaddiansyah; Sukarsi Rusti
Inovasi Kesehatan Global Vol. 3 No. 3 (2026): Agustus: Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v3i3.3362

Abstract

Background: Uncaria gambir (gambir) is an Indonesian medicinal plant rich in catechins, procyanidins, tannins, and indole alkaloids. Its antioxidant, anti-inflammatory, antimicrobial, angiogenic, and extracellular-matrix-modulating activities have prompted interest in topical dermatology, although the evidence has not been critically integrated. Objective: To synthesize direct gambir evidence relevant to skin disease, distinguish it from broader catechin-class extrapolation, and define priorities for clinical translation. Methods: A structured narrative search of PubMed/MEDLINE, Google Scholar, Crossref-linked publisher records, and reference lists was conducted through 29 July 2026. Dermatology-related gambir studies were organized by indication and appraised according to chemical characterization, model relevance, dose-response assessment, controls, and human evidence. Findings: The evidence remains predominantly preclinical and heterogeneous. The most coherent signal concerns keloid biology, with linked computational, fibroblast, and ex vivo findings involving TGF-β1, AKT1, PDGF-related signaling, collagen, cytoglobin, proliferation, and migration. Wound findings are mixed, psoriasis evidence is limited to early formulation and animal studies, and acne, pigmentation, photoprotection, and photoaging data are mainly laboratory based. Implication: Gambir is a promising development candidate, but clinical use is not justified without botanical authentication, marker-based standardization, dermal safety testing, delivery studies, and phased human trials.
Co-Authors Dessy Arisanty Destri Suari Fettriwanti Fettriwanti Fettriwanti Fettriwanti Helda Helda Helda Helda Mira Maryani Latifa Nurmiati Nurmiati Nursal Asbiran Rauza Sukma Rita Refa Rahmaddiansyah Refa Rahmaddiansyah Refa Rahmaddiansyah Refa Rahmaddiansyah Renti Mahkota Sudarto Ronoatmodjo Wahida Rahmi Welly Femelia Zainal Abidin