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All Journal Jurnal Jamu Indonesia ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal EduHealth Journal of Public Health and Pharmacy Journal of Tropical Pharmacy and Chemistry
Niluh Puspita Dewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves Magfirah Magfirah; Indah Kurnia Utami; I Dewa Ayu Nurllya K.D; Niluh Puspita Dewi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38469

Abstract

Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmittance, drug loading, emulsification time, particle size, index polydispersity, zeta potential, dissolution test, Scanning electron microscopy (SEM ) and validation of the analysis method including linearity, precision, accuracy, LOD, and LOQ. Result: The results showed the ratio of surfactant, co-surfactant, and olive oil which produced the optimum formula for SNEDDS, namely 26 ml; 17.5 ml; and 6.5 ml,% transmittance 85.90, drug loading 45.36, emulsification time for AGF, AIF, and aqua dest was 15-16 seconds, particle size 404.1 nm, index polydispersity 0.840, zeta potential -31.4 mV, dissolution test 92.13%, SEM in the form of spherical chunks, and the result of the validation test of the analytical method with a linearity of r = 0.9902, precision 0.436%, accuracy 103.738%, LOD 1.87 µ / ml and LOQ 5.57 µ / ml. SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant provide optimal nanoemulsion characteristics and validation of the analytical method meets the requirements. Conclusion: Formula 1 SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant is an optimal formula that provides good nanoemulsion characteristics and validation of analytical methods meets the requirements
Determination of Total Levels of Secondary Metabolites and Oral Acute Toxicity Testing of Purple Leaf Ethanol Extract (PLEE) in Wistar Rats Niluh Puspita Dewi; Miranti, Miranti; Magfirah, Magfirah; Kurnia Kasim, Athia; Dipayana, I Made
Journal of Public Health and Pharmacy Vol. 4 No. 2: JULY 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i2.5131

Abstract

Introduction: The use of traditional medicines derived from the active ingredients of several types of plants is preferred by the community in treating several types of diseases. One of the plants that has been used by the community as medicine is purple leaves with the Latin name Grapthophylum pictum (L.) Griff. These leaves are traditionally used to treat rheumatism, menstruation, hemorrhoids, urinary tract infections, scabies, swelling, wounds, dermatitis, ear diseases, laxatives, and cancer. The aim of this study was to determine the total levels of secondary metabolites from purple leaf extract ethanol (PLEE) and evaluate the effect of administering PLEE on acute toxicity (LD50) in Wistar rats. Methods: This research is a laboratory experiment with a post test only controlled group design. The research subjects were 20 male Wistar rats, divided into 1 control group and 3 treatment groups, each consisting of 5 rats. The control group only received distilled water, the Treatment I group (P1) was given a suspension of the purple leaf extract test preparation at a dose of 500 mg/kg. Treatment group II (P2), received a suspension of the test preparation at a dose of 2,000 mg/kg, while Treatment group III (P3) received a suspension of the test preparation at a high dose of 5,000 mg/kg of mice. The test preparation was given orally with only one administration at the beginning of the research period and observation was carried out for 14 days. Data was obtained if the rats died after being given treatment. Results: The results showed that the total secondary metabolite content of purple leaves was alkaloids (24,725.99 mg/g), saponins (89.191 mg/g), flavonoids (6.332 mg/g) and tannins (0.884 mg/g), while based on toxicity the PLEE classification was mildly toxic with an LD50 value of 3,890 mg/kg in accordance with BPOM RI's acute toxicity potential at toxicity level 4 (oral LD50 500 – 5,000 mg/kg). Conclusion: PLEE showed the highest total content of secondary metabolites in alkaloids, and consumption of PLEE in high doses caused the death of rats with a mild toxic classification.
Antioxidant Activity Test of Effervescent Granules Morinda citrifolia L Leaf Extract with DPPH Free Radical Absorption Method Muthmainah Tuldjanah; Niluh Puspita Dewi; Dian Rahmawati
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.285

Abstract

Morinda citrifolia. L leaf is a plant that has the potential as an antioxidant due to the presence of compounds in the form of flavonoids and other phenolic compounds that can function as natural antioxidants. In connection with this, research was carried out to Morinda citrifolia. L formulate leaf extract in the form of effervescent granules. Morinda citrifolia leaf extract was macerated with ethanol 96% as solvent. Phytochemical screening showsthat the extract contains flavonoids, tannins, saponins and alkaloids. The extract was formulated with various concentrations of F1 (20%), F2 (25%), F3 (4%). Determination of antioxidant activity using the DPPH free radical immersion method. The results showed that the concentration in the granules influenced antioxidant activity with IC50 values of 109.05 ppm, 101.33 ppm and 73.28 ppm, respectively
Antioxidant Activity Of Effervescent Granule Of Red Dragon Fruit Peel Extract (Hylocereus Polyrhizus W.) Using The DPPH Method Toding, Ficanata Adhiguna; Niluh Puspita Dewi; Dermiati T; Shinta Widya Wulandari
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Red Dragon Fruit Peel (Hylocereus polyrhizus W.) contains chemicals such as alkaloids, flavonoids, saponins, phenols, and steroids. Flavonoids and phenols are compounds that have antioxidant properties. Red Dragon Fruit Peel extract is formulated in effervescent granule dosage form with different concentrations of 0%, 20%, 25%, and 30% based on its antioxidant activity. The purpose of this study was to determine the effect of concentration differences on the antioxidant activity of effervescent granules produced. The research method uses a completely randomized design (CRD) which includes sampling, sample processing, phytochemical testing, extract preparation, effervescent granule preparation, effervescent granule physical quality testing, effervescent granule testing, antioxidant activity testing, and data analysis. Data from physical quality testing and the IC50 value of effervescent granules were analyzed descriptively using the Analysis of Variance (ANOVA) method with a 95% confidence level. The results obtained show that Red Dragon Fruit Peel extract can be formulated into effervescent granules, and the physical quality test results meet the physical quality requirements for all concentrations. The effervescent granule formulations produced at all concentrations have a very strong antioxidant effect (<50 ppm). The variation of Red Dragon Fruit Peel extract concentration in effervescent granule formulation has a significant effect on its antioxidant activity
Uji Ekstrak Alkohol Daun Mengkudu (Morinda Citrifolia L) terhadap Konsentrasi Kreatinin dan Ureum Tikus Putih Jantan (Rattus Norvegicus) Nefropati Diabetes Tandi, Joni; Yana Novika R; Debora Rislianti Lakiu; Magfirah; Niluh Puspita Dewi
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.241

Abstract

Diabetic nephropathy is one of the microvascular complications of diabetes mellitus (DM). One of the clinical signs of diabetic nephropathy is an increase in urea and creatinine levels. The use of medicinal plants containing antioxidants is one of the therapeutic strategies to prevent complications of DM. The noni plant (Morinda citrifolia L), especially the leaves, contains active substances that have the potential as antioxidants to be used as supportive therapy for DM. This study aims to identify the content of active substances in noni leaf extract and determine the potential of noni leaf extract to reduce creatinine, and urea levels in diabetic nephropathy rats. Noni leaf extract was obtained by maceration using 96% ethanol, and animal models of diabetic nephropathy were obtained by induction of streptozotocin 40 mg/kg BW. The test animals were divided into six groups, namely normal control, negative control, positive control, treatment 1, 2, and 3, each given extract doses of 250, 500, and 750 mg/kg BW. The results indicated the presence of flavonoids, alkaloids, steroids, saponins, and tannins in the noni leaf extract. Giving noni leaf extract can reduce, urea and creatinine levels significantly compared to negative controls. In conclusion, noni leaf extract can potentially prevent complications of diabetic nephropathy with an effective dose of 250 mg/kg BW.
The Effect of Adjuvant Therapy on Metabolic Syndrome in Schizophrenia Patients at Madani Hospital Kurnia Utami, Indah; Yasinta Rakanita; Patricia Novina Nurak; Niluh Puspita Dewi
Journal of Public Health and Pharmacy Vol. 4 No. 3: NOVEMBER 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i3.5900

Abstract

Background: Schizophrenia is a mental disorder that impacts behavior, emotions, and communication. In recent years, atypical antipsychotics have been increasingly prescribed because they significantly reduce both positive and negative symptoms. However, the long-term effects of atypical can cause metabolic syndrome. Additional therapy is provided to maximize the primary therapy and reduce the side effects. Method: This study used a quasi-experimental design with a single-blind, pretest-posttest approach. Patients who had been using atypical antipsychotics, either monotherapy or combination therapy, for more than 3 were examined pretest to determine metabolic syndrome levels. Group A received adjuvant therapy, while Group B did not receive adjuvant therapy. Based on this data, an analysis of the reduction in metabolic syndrome categories was conducted. Result: The percentage of schizophrenia patients by gender was dominated by males (60%). By age, the majority were adults (87%). In Group A, the incidence of metabolic syndrome decreased from 53% in the pretest to 40% in the posttest after being given vitamin A, B, and folic acid therapy. The most commonly used other medication was THP (38%). Conclusion: The administration of adjuvant therapy with vitamins A, B, E, and folic acid can reduce the value of one or two of the five metabolic syndrome criteria for schizophrenia patients (p = 0.052) compared to the group of patients who did not receive vitamins A, B, E, and folic acid adjuvant therapy. Future research should use a longer duration to observe the effects of vitamins A, B, E, and folic acid and evaluate their therapeutic doses. Additionally, it should narrow down the criteria for medication use, focusing solely on the atypical antipsychotic’s clozapine or olanzapine.
Co-Authors Debora Rislianti Lakiu Dermiati T DIAN RAHMAWATI Dipayana, I Made I Dewa Ayu Nurllya K.D Indah Kurnia Utami Joni Tandi, Joni Kurnia Kasim, Athia Kurnia Utami, Indah Magfirah Magfirah Magfirah, Magfirah Miranti Miranti Muthmainah Tuldjanah Patricia Novina Nurak Shinta Widya Wulandari Toding, Ficanata Adhiguna Yana Novika R Yasinta Rakanita