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All Journal METAMORFOSA Journal of Biological Sciences Agrointek Biogenesis: Jurnal Ilmiah Biologi Natural B Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional JIMR - Journal of Islamic Medicine Research Community Development Journal: Jurnal Pengabdian Masyarakat JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Inovasi Penelitian Berkala Penelitian Hayati Pharmademica: Jurnal Kefarmasian dan Gizi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Matematika Dan Ilmu Pengetahuan Alam LLDikti Wilayah 1 (JUMPA) Journal Community Service Consortium Hexagon
Sentot Joko Raharjo
Akademi Analis Farmasi Dan Makanan Putra Indonesia Malang
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Journal : METAMORFOSA Journal of Biological Sciences

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Mekanisme Kerja Antibiotik Ceftriaxone, Clarithromycin, dan Senyawa Aktif Quercetin pada Streptococcus pneumoniae dengan Metoda Docking In Silico Irma Damayanti; Yan Ramona; Sentot Joko Raharjo
Metamorfosa: Journal of Biological Sciences Vol 9 No 1 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i01.p01

Abstract

Pneumolysin is a protein that plays an important role in cell death and bacterial colonization of Streptococcus pneumoniae. Ceftriaxone, clarithromycin, dan quercetin has been proven (in vivo and in vitro) to prevent the action of pneumolysin. The purpose of this study was to identify interactions between ceftriaxone, clarithromycin, and quercetin in inhibiting the pneumolysin activity through in silico. The 3D structure of pneumolysin was downloaded via RCSB PDB (PDB ID:PQQA), while 3D structure of ceftriaxone (ID:5479530), clarithromycin (ID:84029), and quercetin (ID:5280343) were downloaded via PubChem. Protein preparations were done with Discovery Studio, while ligands were prepared with OpenBabel. The docking process used HEX 8.0.0 and visualization analysis with Discovery Studio. Pneumolysin-ceftriaxone interaction produces 4 hydrogen bonds, 5 hydrophobic bonds, 1 electrostatic bond, and 2 unfavorable residue bonds with a bond energy value -329.98kJ/mol. Pneumolysin-clarithromycin interaction produces 3 hydrogen bonds, 1 electrostatic bond, and 3 unfavorable residue bonds with a bond energy value -311.12kJ/mol. Pneumolysin-quercetin interaction produces 2 hydrogen bonds, 4 hydrophobic bonds, and 2 electrostatic bonds with a bond energy value -246.52kJ/mol. Keyword: pneumolysin, ceftriaxone, clarithromycin, quercetin, in silico.
Pengaruh Metode Pengeringan Kering Angin dan Oven Terhadap Karakteristik Simplisia Bunga Kecombrang (Etlingera elatior) Audry Regita Ayu Fardi; Sentot Joko Raharjo
Metamorfosa: Journal of Biological Sciences Vol 9 No 2 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i02.p17

Abstract

Pengeringan merupakan salah satu proses pasca panen yang dapat mempengaruhi standar mutu simplisia bunga kecombrang. Tujuan penelitian ini adalah untuk mengetahui pengaruh metode pengeringan kering angin dan oven terhadap karakteristik simplisia bunga kecombrang. Metode penelitian ini meliputi pembuatan simplisia teh herbal bunga kecombrang dengan menggunakan metode pengeringan kering angin dan oven, serta pengujian karakteristik meliputi organoleptik, makroskopik, mikroskopik, kadar air, kadar sari larut air, kadar sari larut etanol, kromatografi lapis tipis, dan kadar flavonoid total. Hasil menunjukkan bahwa simplisia bunga kecombrang pada pengeringan kering angin dan oven memenuhi persyaratan yang meliputi beberapa parameter organoleptik, mikroskopik, maksroskopik, kadar air, kadar sari larut air, kadar flavonoid total. Pada pengeringan oven dalam pembuatan simplisia bunga kecombrang menghasilkan karakteristik yang terbaik yaitu organoleptik, makroskopik, kadar air dan kadar flavonoid total, sedangkan pada pengeringan kering angin menunjukkan kadar sari larut air dan etanol tertinggi. Kesimpulan penelitian ini adalah bahwa terdapat pengaruh antara metode pengeringan kering angin dan oven terhadap karakteristik simplisia bunga kecombrang yang meliputi kadar air, kadar sari larut air, dan kadar flavonoid total.
Co-Authors Ambar Fidyasari Andini Andini Andini, Andini Anneke, Anneke Audry Regita Ayu Fardi Ayu Ristamaya Yusuf Azizah, Devita Nur Chanif Mahdi Erik Widarto Ernanin Dyah Wijayanti Fadli Muhammad Fatchiyah Fatchiyah Irma Damayanti Istiana, Meiria izza, Aqidatul Karina Tria Amanda Kiantoro Andiek Setiawan Mahisa Ayyuna Nailufar Meiria Istiana Sari Melani Setyowati Misgiati, Misgiati Mukarromah, Milda Lailatul Nurdiana Nurdiana Paini Sri Widyati Rahayu Wahyu Ningsih Rurini Retnowati Sari, Meiria Istiana Soebiantoro Soebiantoro Syarifah, Anisa Lailatusy Tarsisius Dwi Wibawa Budianta Wolfgang Nellen Yan Ramona