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Edukasi Penggunaan Obat Aman dan Rasional Berbasis Kimia Farmasi pada Siswa SMA Negeri 2 Binjai Rahma Yulia; Dea Anggraini; Muzakkir Muzakkir; Salman salman; Meutia Indriana; Desy Natalia Siahaan; Bunga Rimtam Barus
Jurnal Abdi Masyarakat Multidisiplin Vol. 5 No. 01 (2026): April: JURNAL ABDI MASYARAKAT MULTIDISIPLIN
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jammu.v5i01.2977

Kemudahan akses informasi obat melalui media sosial, iklan, keluarga, dan sumber digital perlu diimbangi dengan literasi obat yang memadai agar remaja mampu menggunakan obat secara aman dan rasional. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan edukasi awal mengenai penggunaan obat yang aman dan rasional, membiasakan siswa memperhatikan informasi dan aturan penggunaan obat, mengenalkan risiko penggunaan obat yang tidak tepat, serta mendorong sikap selektif terhadap sumber informasi obat. Kegiatan dilaksanakan pada 14 Oktober 2025 di SMA Negeri 2 Binjai dengan melibatkan 35 siswa. Metode yang digunakan berupa edukasi dengan pendekatan deskriptif-kualitatif melalui penyampaian materi, diskusi, tanya jawab, observasi keterlibatan peserta, dan dokumentasi. Materi meliputi pengenalan obat dan zat aktif, dosis dan aturan pakai, label dan tanggal kedaluwarsa, penyimpanan, efek samping, penggunaan obat rasional, serta swamedikasi bertanggung jawab. Pendekatan kimia farmasi diterapkan menggunakan contoh obat yang familiar, seperti parasetamol, aspirin, CTM, dan antasida, untuk memperkenalkan hubungan sederhana antara zat aktif, struktur kimia, manfaat, risiko, dan aturan penggunaan. Hasil kegiatan menunjukkan keterlibatan peserta melalui perhatian, partisipasi dalam diskusi, serta pertanyaan mengenai aturan pakai, keamanan, efek samping, dan karakteristik zat aktif. Kegiatan ini menunjukkan bahwa pendekatan kimia farmasi dapat digunakan sebagai konteks edukatif yang komunikatif untuk menyampaikan literasi penggunaan obat kepada siswa SMA. Namun, karena evaluasi masih bersifat deskriptif dan tidak menggunakan pre-test dan post-test, hasil kegiatan belum dapat menunjukkan perubahan pengetahuan peserta secara kuantitatif. Kegiatan selanjutnya disarankan menggunakan instrumen evaluasi terstruktur untuk mengukur perubahan pemahaman dan literasi obat secara objektif.

Peningkatan Literasi Kesehatan Diabetes Melitus melalui Edukasi Penggunaan Obat Rasional dan Gaya Hidup Sehat di Puskesmas Langkat Yettrie Simarmata; Salman Salman; Meutia Indriana; Ika Julianti Tambunan; Fenny Hasanah; Sudewi Sudewi; Yessi Febriani
Jurnal Abdi Masyarakat Multidisiplin Vol. 5 No. 2 (2026): Agustus: JURNAL ABDI MASYARAKAT MULTIDISIPLIN
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jammu.v5i2.3031

Diabetes melitus merupakan penyakit kronis yang memerlukan literasi kesehatan yang memadai untuk mendukung penggunaan obat yang tepat, penerapan gaya hidup sehat, dan pencegahan komplikasi. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan literasi kesehatan peserta mengenai diabetes melitus melalui edukasi penggunaan obat yang rasional dan gaya hidup sehat di Puskesmas Langkat. Kegiatan menggunakan desain evaluasi one-group pre-test–post-test dengan melibatkan 30 peserta yang terdiri atas pasien diabetes melitus, keluarga pasien, dan masyarakat berisiko diabetes. Intervensi dilakukan melalui penyuluhan interaktif, pembagian leaflet, diskusi, dan simulasi membaca etiket obat. Pengetahuan dievaluasi menggunakan 10 pertanyaan sebelum dan sesudah intervensi. Hasil menunjukkan bahwa rata-rata skor pengetahuan meningkat dari 56,3 pada pre-test menjadi 84,7 pada post-test, dengan peningkatan sebesar 28,4 poin. Peserta dengan kategori pengetahuan baik meningkat dari 20,0% menjadi 80,0%, sedangkan kategori kurang menurun dari 50,0% menjadi 3,3%. Peningkatan terbesar ditemukan pada pengetahuan mengenai tanda hipoglikemia, kepatuhan penggunaan obat, larangan menghentikan obat tanpa konsultasi, serta komplikasi dan perawatan kaki. Uji Wilcoxon menunjukkan perbedaan yang signifikan antara skor pre-test dan post-test (p < 0,001). Hasil kegiatan menunjukkan bahwa edukasi interaktif yang dikombinasikan dengan informasi praktis mengenai penggunaan obat dapat meningkatkan pengetahuan peserta mengenai pengelolaan diabetes dan berpotensi mendukung kegiatan edukasi kesehatan di pelayanan kesehatan primer.

Pola Penggunaan Bawang Putih sebagai Obat Tradisional untuk Membantu Mengobati Flu di Desa Sumur Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v2i2.86

The purpose of this study was to determine the pattern of use of garlic in the Sumur Village community and know the effectiveness of garlic as a traditional medicine in helping treat flu: non-experimental/observational research. Data analysis used a descriptive cross-sectional design by measuring LL The use of garlic in treating flu. The study was carried out from July 25 to September 12. This study indicates that the people in Sumur Village are still inseparable from their traditions, including very traditional methods of treating flu. Garlic contains sulfur which gives it a distinctive smell and taste that can increase and speed up the activity of the mucous membranes in the respiratory tract. Garlic is better and safer if before. In consumption, garlic is burned or heated first because the nutritious sulfur content has been released and the ester and protein bonds are in this situation, it will be more practical, and garlic which can disrupt the stomach atmosphere, will be safer for garlic users who have a history of ulcers. Garlic contains essential sulfur compounds and 17 amino acids, including eight amino acids and minerals such as calcium, iron, potassium, germanium, selenium, and zinc. One of these sulfur compounds is Alliin. Alliin is easy to turn into Allicin when fresh garlic is chopped, chopped, or chewed directly. The conversion of Alliin to Allicin is assisted by a particular enzyme called allinase. Allicin has the potential as an anti-bacterial; the workings of Allicin are similar to penicillin antibiotics and their derivatives, for example, Amoxicillin: The way it works is by inhibiting the formation of proteins in the bacterial cell wall so that later it can cause defects in the bacterial cell wall which eventually makes the bacteria die because its metabolic system is disrupted. However, one thing to note is that sprouted garlic is not suitable for consumption because the shoots contain the poison HCN (cyanide).

Aktivitas Ekstrak Etanol Temu Mangga (Curcuma mangga Val.) terhadap Edema Kaki Tikus Putih salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v2i2.83

The rhizome of mango Curcuma is empirically used as a traditional medicine for the treatment of gastric pain, pain, and inflammation due to hemorrhoids, sore throat, bronchitis, and asthma. The aim of this study was to determine the chemical compound content of secondary metabolites and the activity of the ethanol extract of Temu Mango (Curcuma mangga Val.) on the reduction of carrageenan-induced rat paw edema. The results of a preliminary examination of the chemical content of the rhizome of Intersection mango (Curcuma mango Val.) showed the presence of glycosides, flavonoids, saponins, essential oils, and steroids. In general, the suspension of the ethanol extract of Temu Mango at doses of 50, 100, 200 mg/kg BW gave an anti-inflammatory effect that began to appear in the first half-hour and continued to increase with increasing time. An increase of 2 times the dose of the ethanol extract of Temu Mango showed an anti-inflammatory effect that was not significantly different, but with an increased dose of 4 times, it showed a significant difference. Even the ethanol extract of Intersection mango at a dose of 200 mg/kg BW gave almost the same effect as indomethacin.

POTENSI ANTIBAKTERI AIR REBUSAN SERBUK, EKSTRAK n-HEKSANA DAN EKSTRAK KLOROFORM CACING TANAH ( Perionyx sp.) TERHADAP BAKTERI Salmonella typhosa Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.89

Earthworms are animals that have many benefits and are easy to find—results of information from people consume boiled water of earthworms three times a day for 7 days is used as a typhus medicine, other information is obtained from electronic media, many people also consume earthworms as a typhoid medicine in powder form which is filled into capsules Which can be found in Chinese drug stores, but until now scientific research on earthworms (Perionyx sp.) as an anti-bacterial has not been done. Extraction is done by maceration. Multilevel maceration using chloroform and n-hexane as solvent. The class of chemical compounds was determined on the ethyl acetate extract and the n-hexane extract of the earthworm Perionyx sp.), including alkaloids, glycosides, steroids/triterpenoids, flavonoids, saponins, and tannins. Testing of antibacterial activity of chloroform extract and n-hexane extract against Salmonella typhosa was carried out in vitro by agar diffusion method using metal buffer at a concentration of 500 mg/ml; 400 mg/ml; 300 mg/ml; 200 mg/ml; 100 mg/ml and 50 mg/ml. The results of determining the class of chemical compounds from the chloroform extract of earthworms (Perionyx sp.) showed the presence of chemical compounds belonging to the alkaloid group, while the n-hexane extract did not indicate the presence of chemical compounds detected. The n-hexane extract of tar h (Perionyx sp.) had an inhibitory effect on the growth of Salmonella typhosa at a minimum inhibitory concentration of 400 mg/ml of 10.9mm, while the chloroform extract had a minimum inhibitory concentration of 300 mg/ml with an inhibitory diameter of 12.87 mm.

PENETAPAN KADAR DILTIAZEM HCI DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETR ULTRAVIOLET salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.84

The rhizome of mango Curcuma is empirically used as a traditional medicine for the treatment of gastric pain, pain, and inflammation due to hemorrhoids, sore throat, bronchitis, and asthma. The aim of this study was to determine the chemical compound content of secondary metabolites and the activity of the ethanol extract of Temu Mango (Curcuma mangga Val.) on the reduction of carrageenan-induced rat paw edema. The results of a preliminary examination of the chemical content of the rhizome of Intersection mango (Curcuma mango Val.) showed the presence of glycosides, flavonoids, saponins, essential oils, and steroids. In general, the suspension of the ethanol extract of Temu Mango at doses of 50, 100, 200 mg/kg BW gave an anti-inflammatory effect that began to appear in the first half-hour and continued to increase with increasing time. An increase of 2 times the dose of the ethanol extract of Temu Mango showed an anti-inflammatory effect that was not significantly different, but with an increased dose of 4 times, it showed a significant difference. Even the ethanol extract of Intersection mango at a dose of 200 mg/kg BW gave almost the same effect as indomethacin.

PEMANFAATAN KULIT BATANG MIMBA SEBAGAI ANTITUBERKULOSIS DIBANDINGKAN DENGAN RIFAMPISIN DAN ETAMBUTOL Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.92

Indonesia ranks third in the number of tuberculosis, after India and China. Treatment of tuberculosis takes a long time, and the lack of discipline in taking medication has caused the Mycobacterium tuberculosis to be resistant to many synthetic drugs that have been used so far. In contrast, the discovery of new synthetic drugs is very slow. Traditionally, neem bark (Azadirachta indica JUSS.) has been used to treat coughing up blood and phlegm, and the results of previous studies show that ethanol extract of neem bark in vitro can inhibit the growth of Mycobacterium tuberculosis. This study was conducted to determine the toxicity of neem bark extract, formulation of neem bark ethanol extract into tablet preparations, and the potential of this tablet preparation as anti-tuberculosis in vivo in animals. Neem bark extract was made by percolation using an ethanol extractor. Toxicity test was carried out in the form of an acute toxicity test on mice to calculate the LD50 value and histopathological observations of the liver, lungs, and intestines. The tablets were made by wet granulation. The potential test of tablet preparations as anti-tuberculosis was performed in vivo on animals infected with Mycobacterium tuberculosis H37Rv using a nebulizer. The results showed LD 50 = 11.85 ± 0.571, including mild toxic. The ethanolic extract of neem bark can be formulated into tablets using a 6% gelatin binder, Manihot starch and primojel as a binder, and a mixture of starch and lactose as a filler. Neem bark extract tablets can cure tuberculosis of experimental animals that have been infected with Mycobacterium tuberculosis H37RV, which is given a dose of 3 times a day two tablets (50 mg/tablet) for six weeks seen tuberculosis bacteria from +3 to negative, and a dose of 3 times a day once a day. Tablet looks from +3 to +1.

PENENTUAN KADAR PARASETAMOL DALAM SEDIAAN TABLET DAN LARUTAN ORAL SECARA KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.85

According to RI Law no. 36 of 2009, determining the level of efficacious substances from a drug preparation is one of the requirements that must be carried out to ensure the quality of the drug preparation. Drug preparations of good quality will provide the expected effect and one of the parameters is the level of the active substance of the drug must meet the level requirements listed in the Indonesian Pharmacopeia or other standard books. The purpose of this study was to determine the levels of Paracetamol in tablet preparations and oral solution by high-performance liquid chromatography. The determination of the concentration was carried out by the HPLC method using a 2.5 mm x 25 cm VP-ODS shim pack column with water-methanol as a mobile phase (3:1), a flow rate of approximately 1.5 ml/minute, and the detection was carried out at a wavelength of 243 nm. The advantage of the HPLC method is the separation system with high speed and efficiency because it is supported by advances in column technology, high-pressure pump systems, and highly sensitive and diverse detectors so that they are able to analyze various samples qualitatively and quantitatively, back in single or mixed components. The results showed that all the specified samples met the content requirements according to the Indonesian Pharmacopeia IV edition 1995, namely not less than 90.0% and not more than 110.0% of the amount stated on the label. The results of the Validation test method carried out obtained a recovery percent of 99.96% with an RSD (Relative Standard Deviation) of 1.81% so that it can be concluded that this method has good sensitivity and accuracy, with a LOD (limit of detection) 0.76 g/ml and LOQ (limit of quantitation) 2.56 g/ml.

PENGARUH INTERESTERIFIKASI LEMAK SAPI TERHADAP PROFIL LIPIDA MARMUT Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i1.91

Properties of fats are determined by the composition and position (sn-1,2,3) of fatty acids in the fat molecule. Palmitic acid is one of the most atherogenic fatty acids in the sn-2. Interesterification will change the position of palmitic acid in the fat molecule. This study aimed to determine the effect of interesterification on the atherogenic properties of fat. The fat used was beef, extracted by dry rendering, and chemically interesterified using a Na-methoxide catalyst for 20, 30, 60, 90, and 120 minutes. The melting point of the fat was measured using a melting point apparatus then given to guinea pigs. For 21 days, the propyl lipid was measured using the enzymatic method using a micro lab 300 spectrophotometers. The melting point of beef fat from interesterification for 60 minutes was constant, meaning the reaction was complete. Interesterification of beef fat showed an increase in atherogenicity seen from the increase in total cholesterol, triglyceride, LDL and decreased HDL levels after interesterification, respectively 69.20 ± 20.24; 68.60 ± 18.81; 40.43 ± 15.18; 14.33 ± 3.01 mg/dl compared with no interesterification 62.27 ± 16.02; 62.87 ± 14.08; 37.84 ± 13.41; 11.80 ± 2.15 mg/dl (ANOVA, P < 0.05).

SKRINING FITOKIMIA DAN UJI KEMAMPUAN SEBAGAI ANTIOKSIDAN DARI DAUN JAMBU BIJI salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i1.87

Free radicals are molecules that have free electrons, very harmful to health. One of the efforts to overcome it is with antioxidants. Naturally, in the body, there are antioxidants, namely superoxide dismutase, glutathione, and catalase, but depending on food intake, especially containing phenolics and flavonoids. Traditionally, guava leaves are used to treat diarrhea, dysentery, lower cholesterol, irregular menstruation, wounds, and canker sores. Judging from these various properties, it is possible that guava leaves contain chemical compounds that have the potential as antioxidants, especially phenolic compounds, the authors tested the ability of guava leaves as antioxidants. Guava leaves were prepared into ethanol extract, fractionated with n-hexane, ethyl acetate, and water, and phytochemical screening was carried out on the ethanol extract and each fraction. Antioxidant testing was carried out using the Radical Scavenger using 1,1-diphenyl-2-picrylhydrazyl. The test results showed that the ethanol extract contained alkaloids, tannins, flavonoids, steroids, saponins, and glycosides. The n-hexane fraction contains alkaloids and glycosides. the ethyl acetate fraction contains tannins. the water fraction contains tannins and glycosides. As antioxidants, ethanol extract and water fraction were categorized as strong with IC50 ethanol = 42.06 g/ml, water fraction = 49.41 g/mL, n-hexane and ethyl acetate fractions were categorized as medium with IC50 fraction n-hexane = 58.15 g /mL, ethyl acetate fraction = 51.60 g/ml.

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