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All Journal Journal of Food and Pharmaceutical Science Journal of Epidemiology and Public Health Indonesian Journal of Medicine PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Indonesian Journal of Global Health research Medical Sains : Jurnal Ilmiah Kefarmasian Ahmad Dahlan Medical Journal Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacology and Therapy
Widea Rossi Desvita
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Mental Health Screening for University Students in the Special Region of Yogyakarta Astuti, Fardhiasih Dwi; Heriyanto, M. Junaidy; Desvita, Widea Rossi; Rokhmayanti , Rokhmayanti; Hastuti, Siti Kurnia Widi; Utami, Budi Barata Kusuma; Azka, Arlina
Journal of Epidemiology and Public Health Vol. 9 No. 3 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.03.08

Abstract

Background: Mental health disorders occur a lot among students. Failure to overcome mental health conditions during this period can have a serious impact on their academic condition even on their physical and mental health in adulthood. This study aims to screen mental health in students at Muhammadiyah and Aisyiyah Universities located in the Special Region of Yogyakarta.Subjects and Method: This was a cross-sectional study. A sample of 251 students of Muhammadiyah and Aisyiyah Universities in the Special Region of Yogyakarta were selected by accidental sampling. The study variable was emotional mental disorders which were measured using the Self Rating Questionnaire-20 instrument. Respondents who experienced more than seven symptoms were indicated to have a mental-emotional disorder and needed psychological help. The data were analyzed descriptively.Results: The screening results revealed that 104 students (41.43%) were experiencing mental and emotional disorders and required psychological assistance. In terms of the underlying factors of these disorders, 87.50% of students reported feeling easily fatigued (low energy), 70.19% had difficulty making decisions (cognitive), 52.88% felt unhappy (depression), 55.77% experienced abdominal discomfort (physiological), and 79.81% reported feeling nervous, tense, and worried (anxiety).Conclusion: it is recommended that schools provide accessible psychological counseling and implement stress management programs to help students cope with fatigue, anxiety, and decision-making difficulties
Cytotoxicity of quercetin and curcumin combination against HeLa cells line Agitohutomo, Muhammad; Edityaningrum, Citra Ariani; Utari, Dina; Desvita, Widea Rossi; Aristiani, Windi; Nurani, Laela Hayu
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11488

Abstract

Curcumin and quercetin combination are potential candidates for anticancer. Previous studies reported this combination active against several cancer cells including breast cancer, myeloid leukemia, and melanoma. However, the activity of this combination against cervical cancer has not been reported, yet. This study aimed to evaluate the cytotoxicity of the combination of curcumin and quercetin against HeLa and Vero cells. MTT assay was applied to evaluate cell growth inhibition. The inhibitory 50% concentration (IC50) of curcumin and quercetin on HeLa and Vero cells was determined and the selectivity index (SI) was then calculated. Combination index (CI) was calculated after evaluation of the cytotoxicity of the curcumin and quercetin combination at various concentration of 1 IC50, ½ IC50, and ¼ IC50. The IC50 of the curcumin against the HeLa and Vero cells were 26.57 ± 2.00 μM and 73.89 ± 12.93 μM with a SI of 2.78. Whereas the IC50 of the quercetin against the HeLa and Vero cells were 149.52 ± 21.09 μM and 1094.47 ± 15.68 μM with a SI of 7.32. The CI of combinations of curcumin and quercetin at concentrations of ¼ IC50 was 0.78 indicating a mild-moderate synergistic effect, whereas the combination at a concentration of 1 IC50 or ½ IC50, the CI value was >0.9 indicating an antagonistic effect.
Co-Authors Agitohutomo, Muhammad Akrom Akrom, Akrom Any Guntarti Aristiani, Windi Aristiani, Windy Arlina Azka Astiti, Chairunnisa Citra Ariani Edityaningrum, Citra Fardhiasih Dwi Astuti Fikri Achmad Arif Fikri, Muhammad Ali Hastuti, Siti Kunia Widi Hastuti, Siti Kurnia Widi Heriyanto, M. Junaidy Isabella Meliawati Sikumbang Khayatulisma, Dika Laela Hayu Nurani Muhammad Fikri Rokhmayanti , Rokhmayanti Rokhmayanti, Rokhmayanti Rosyidah Rosyidah, Rosyidah Rulianawati, Viandika Sukmatama, Pradisa Ryan Sumarno, Andhira Setya Yudha Tri Ani Marwati Triantoro Safaria Utami, Budi Barata Kusuma Utari, Dina Wibowo, Rena Anjeli Wiwara Awisarita Yuniasih, Dewi