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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Dinamika Pengabdian (JDP) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)

Syahrul Rauf

Faculty ofMedicine University of Hasanuddin/ Dr. Wahidin Sudiro Husodo Hospital Makassar

Author-ID : 358779

Decision Sciences, Operations Research & Management Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 18 Documents Claim Missing Document

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Sensitivity and Specificity of the SelfAdministered HPV Testing in Detecting Precancerous Conditions of the Cervix and Cervical Cancer Nyngsi, Erny M; Rauf, Syahrul; Moeljono, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the sensitivity and specificity of selfadministered Human Papilloma virus (HPV) test in detecting pre-cancerous lesions and high degree cervical cancer. Methods: A case control study design was used in this study. This study was conducted at Dr. Wahidin Sudirohusodo Hospital and its affiliate hospitals during the period of October 2014 to May 2015. Measurement data using HPV self test grant from the Dutch School Netherlands, Evalyn Brush. Collecting data used questionnaires before and after doing HPV self test. Laboratory tests are carried out in Kalbe Genomic using HPV Genotyping capable detect 35 types of the HPV virus. Results: A total of 101 subjects were involved in this study. The subjects were divided into two groups, the case and the controls (n = 50/51). Level of sensitivity and specificity were obtained for HPV self test (56% vs 98%). The level of acceptance of new tests by 62.37% (63 out of 101 respondents) of them admitted that the new test is simple / easy enough to do. The acuracy rate of diagnostic test of this examination is 79%. Conclusion: Self-administered HPV test could be used as an alternative or primary screening for cervical cancer. [Indones J Obstet Gynecol 2017; 5-3: 173-179] Keywords: HPV, self, specificity, the sensitivity

Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients Akbar, Willy; Rauf, Syahrul; S. Riu, Deviana; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective : To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients. Methods :A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fluid of 77 patients with cervical cancer performed with PCR method. Results : The prevalence of HPV type 18 infection both in the cervical and the oral fluid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The aggreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042). Conclusion : HPV type 16 and 18 could infect both cervix and oral cavity although type-specific concordance is low. Keywords :Human papillomavirus,servix, oral cavity   Abstrak Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks. Metode: Penelitian cross sectional ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR. Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042). Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah. Kata kunci : Human papillomavirus, serviks, kavum oral

Conformity of Human Papillomavirus between Self-examination of Vaginal Fluid and Cervical Specimen with Fluid-Based Cytology in Precancerous Lesions Anwar, Rahmawaty; Rauf, Syahrul; Moeljono, Eddy R.
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: To determine the conformity of human papillomavirus between self-examination of vaginal specimen and cervical specimen with fluid-based cytology in precancerous lesions. Methods: A cross-sectional study performed on cervical and vaginal fluid from 90 pre-cancerous lesions patients from April to September 2016. Cytological examination performed with self-examination and liquid-based cytology technique. HPV genotyping performed with PCR technique. Data were analyzed with SPSS. Results: Most of the women aged >35 years (89%), 78% (71/90) multiparity and 74.4% (67/90) do not know about HPV screening. High risk type found in both vaginal and cervical fluid was type 16, 18, 33 and 45 whereas type 35 found only in vaginal fluid. The most prevalent high-risk HPV for both specimens were type 16 and 18. HPV type 42 and 53 were the low risk HPV found in the vaginal and cervical specimens (table 2). Cohen’s kappa for inter-test agreement shows a strong correlation (r=0.864). Conclusion: The HPV self-examination method can be used as a primary examination of cervical cancer lesions detection in addition to fluid-based cytology with the similar results. Keywords: Human papillomavirus, self-examination, fluid-based cytology, cervical cancer   Abstrak Tujuan: Untuk mengetahui tingkat kesesuaian antara pemeriksaan HPV mandiri dari spesimen vagina dan hasil pemeriksaan sitologi berbasis cairan dari spesimen serviks. Metode: Penelitian cross-sectional dilakukan pada cairan serviks dan vagina dari 90 pasien lesi pra-kanker pada April sampai September 2016. Pemeriksaan sitologi dilakukan dengan pemeriksaan diri dan teknik sitologi berbasis cairan. Pemeriksaan genotip HPV dilakukan dengan teknik PCR. Data dianalisis dengan SPSS. Hasil: Sebagian besar wanita dalam penelitian iniaberusia >35 tahun (89%), 78% (71/90) multiparitas dan 74,4% (67/90) tidak mengetahui tentang skrining HPV. Tipe HPV risiko tinggi yang ditemukan pada cairan vagina dan serviks adalah tipe 16, 18, 33 dan 45 sedangkan tipe 35 hanya ditemukan pada cairan vagina. Tipe HPV risiko tinggi yang dominan untuk kedua spesimen adalah tipe 16 dan 18. HPV tipe 42 dan 53 adalah HPV risiko rendah yang ditemukan pada baik spesimen vagina maupun serviks. Kappa Cohen untuk tingkat kesesuaian antara pemeriksaan mandiri dan sitologi berbasis cairan menunjukkan korelasi kuat (r = 0,864). Kesimpulan: Metode pemeriksaan HPV secara mandiri sendiri dapat digunakan sebagai pemeriksaan primer deteksi lesi kanker serviks selain sitologi berbasis cairan dengan hasil yang sama.

Leptin Expression in High-grade Serous Ovarian Carcinoma: The Controversy of Leptin Paradox in Ovarian Cancer Ham, Jonathan; Masadah, Rina; Nasser, Andi Sitti Halija Diawanti; Rauf, Syahrul; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Mardiati; Tawali, Suryani
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2373

Objectives : To analyse the characteristics and expression patterns of Leptin in high-grade serous epithelial ovarian carcinoma (HGSC), and to compare them with the overall serous ovarian carcinoma population. Methods : This was a cross-sectional study. A total of 77 paraffin-embedded tissue samples were collected from patients at the Wahidin Sudirohusodo Hospital over a period of 3 years. Immunohistochemical staining was performed using a polyclonal Leptin antibody. Data were analyzed using SPSS version 22.0. Results: Among HGSC patients, the majority (64.3%) were over 50 years old, and a significant portion (39.3%) were obese. Leptin showed strong cytoplasmic expression in 69.6% of HGSC tumor cells and in 100% of LGSC tumor cells (p-value = 0.004). There was no correlation between lymphovascular space invasion and leptin expression. Interestingly, leptin expression in overall serous ovarian carcinoma patients exhibited a protective effect against metastasis (p-value = 0.047), suggesting a leptin paradox exists in this type of cancer. However, this association was no longer significant when the analysis excluded the LGSC group (p-value = 0.193). Conclusion : This study suggest that leptin expression may not be a significant prognostic factor in HGSC. The appearance of the pseudo-leptin paradox phenomenon in several previous studies was confounded by sample populations with heterogeneous tumor morphology. Keywords: high-grade serous carcinoma, leptin paradox, immunohistochemistry, leptin, obesity

Reducing Women’s Cancer Rates: Early Detection of Breast Cancer and Cervical Cancer Through Self-Breast Exams (SADARI) and Pap Smears in Pinrang Regency, South Sulawesi Masadah, Rina; Nelwan, Berti Julian; Ham, Jonathan; Raharja, Siska Putri Wulandari; Gosal, Steffy Rebecca; Rauf, Syahrul
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 11, No 1 (2025): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.99065

Breast and cervical cancer constitute the two most prevalent cancer types globally, with a disproportionately high mortality rate among women. While cervical cancer ranks eighth in terms of incidence, it remains a significant public health concern. A common challenge is the community’s delay in seeking healthcare attributed to a dearth of information, consequently leading to delayed treatment. The Pinrang Regency Health Department and the Family Empowerment and Welfare Team (TP-PKK) of South Sulawesi identified a high incidence of breast and cervical cancer among women in the Pinrang region. A primary obstacle to addressing this issue is the absence of public awareness regarding breast and cervical cancer, including early warning signs, symptoms, and associated risks. This problem is compounded by the district’s lack of an anatomical pathology specialist, hindering public education efforts and diagnostic capabilities. The objective of this activity was to enhance awareness of early detection for these two gynecological cancers in order to reduce mortality and morbidity rates associated with cancer. The method comprised an educational session on breast and cervical cancer, practicing SADARI, attended by 145 participants, followed by Pap smear tests for 45 volunteers. Program effectiveness was evaluated through pretest and posttest. A Wilcoxon signed-rank test was conducted to compare pretest and posttest scores. The results revealed a highly significant increase in scores p = 0.000 (p<0.005), suggesting that the educational program was successful in improving participants’ knowledge. A significant proportion of participants (57.8%) reported undergoing a Pap smear for the first time, highlighting the need for enhanced awareness and knowledge-sharing efforts regarding early detection of cervical cancer. The Pinrang Regency Health Department and TP-PKK provided essential support and participation. The Institute for Research and Community Service (LPPM) funds this community service project. The project was executed under contract number 0031/UN.4.22/PM.01.01.2024.

SERVIKSKU SEHAT: UPAYA PENCEGAHAN DAN DETEKSI DINI PENYAKIT KANKER MULUT RAHIM Masadah, Rina; Hasanah, Huswatun; Manule, Yolanda; Rauf, Syahrul
Jurnal Dinamika Pengabdian Vol. 4 (2018): JURNAL DINAMIKA PENGABDIAN VOL. 4 NO. (EDISI KHUSUS) NOVEMBER 2018
Publisher : Departemen Budidaya Pertanian Fakultas Pertanian UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jdp.v4iK.5435

Kanker mulut rahim (kanker serviks) merupakan jenis kanker pada wanita yang mempunyai angka kejadian kedua tertinggi di dunia setelah kanker payudara, dimana terdapat sekitar 529.828 kasus baru setiap tahunnya. Di antara tumor ganas ginekologi, kanker serviks menduduki peringkat pertama terbanyak di Indonesia. Umur penderita yang tersering adalah 45-50 tahun, dengan harapan hidup 5 tahun hanya 40-50%. Tingginya angka kejadian kanker serviks karena belum maksimalnya upaya pencegahan dan deteksi dini pada pasien, akibat masih kurangnya pengetahuan mengenai penyakit ini, serta rasa malu untuk memeriksakan diri karena membuka pakaian dalam dan memeriksakan alat kelamin. Pada umumnya pasien datang sudah dalam stadium lanjut sehingga angka kematian penyakit ini masih sangat tinggi. Penyuluhan mengenai penyakit kanker serviks dan pemeriksaan sel serviks secara rutin sangat penting dilakukan untuk menurunkan angka kesakitan dan kematian wanita akibat penyakit ini di Indonesia. Dilakukan penyuluhan terhadap 95 ibu-ibu masyarakat kelurahan Antang yang berlokasi di Rumah Tahfidz Antang, dan pemeriksaan sel mulut rahim (Pap smear) pada 95 ibu tersebut. Penyuluhan dilakukan dengan menampilkan gambar interaktif, dilanjutkan dengan tanya jawab. Sebelum dan setelah penyuluhan dilakukan pre-test dan post-test; dan sebelum dilakukan Pap smear, ibu diwawancara dan dicatat mengenai keluhannya. Hasil post-test menunjukkan 80% ibu meningkat pemahamannya mengenai kanker mulut rahim. Hanya 3 ibu yang hasil Pap smearnya normal. Terdapat 91 ibu menderita infeksi berbagai macam mikroorganisme, dan 1 ibu menderita penyakit pre-kanker serviks. Hasil pemeriksaan Pap smear diberikan kembali ke ibu melalui ketua Yayasan, dan ibu yang menderita kelainan dirujuk ke Puskesmas.Kata kunci: Kanker serviks, pap smear, penyuluhan.

A Retrospective Comparative Study of Clinicopathological Features in High-Grade and Low-Grade Serous Ovarian Carcinoma Ham, Jonathan; Nasser, Andi S.H.D.; Masadah, Rina; Rauf, Syahrul; Nelwan, Berti J.; Miskad, Upik A; Cangara, Muhammad H; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1558

Backgroud: Ovarian carcinoma is the third most common malignancy in Indonesian women after breast and cervical cancer. Serous ovarian carcinoma is the most frequent subtype, divided into low-grade and high-grade types, each with distinct genetic and biological characteristics. Objective:This study aims to compare the clinicopathological features of high-grade and low-grade serous ovarian carcinoma. Methods: A retrospective cross-sectional study was conducted using 77 paraffin-embedded samples of serous ovarian carcinoma. Clinical and pathological data including age, body mass index (BMI), age at menarche, and parity were collected and analyzed using the chi-square test. Results: Patients aged >50 years accounted for most cases, with 64.3% presenting high-grade serous carcinoma (HGSC). Overweight/obesity was observed in 40.3% of cases. Early menarche (<13 years) was reported in 78%, and 42.7% were multiparous. No significant differences were found in clinical variables between HGSC and low-grade serous carcinoma (LGSC). Histopathologically, HGSC showed more pronounced cytologic atypia, necrosis, and metastasis. Conclusion: High-grade serous carcinoma demonstrates greater aggressiveness compared to its low-grade counterpart. Histopathological assessment plays a critical role in diagnosis, treatment decisions, and prognosis evaluation.

HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes Ridwan, Steven; Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Salima, Siti; Rauf, Syahrul; Hidayat, Yudi Mulyana
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.882

Objective: To evaluate the diagnostic utility of PHAL (Platelet, Hemoglobin, Albumin, and Lymphocyte), SII (Systemic Immune Inflammation Index), and SIRI (Systemic Inflammatory Response Index) for both epithelial and non-epithelial ovarian cancer.Methods: A cross-sectional study of 156 patients with ovarian masses was conducted using preoperative laboratory data to calculate PHAL, SII, and SIRI scores. Histopathology confirmed diagnoses. Population I included all ovarian cancer types and benign tumors, while Population II included only non-epithelial ovarian cancer and benign tumors. Statistical analysis using SPSS 25.0, involved ROC curve and validity testing to assess diagnostic performance.Result: SII showed the best performance in the overall population (AUC 0.738; sensitivity 71.25%; specificity 72.37%; accuracy 71.79%; LR+ 2.58; LR– 0.40). In the subgroup of non-epithelial ovarian cancer versus benign tumors, PHAL had the highest diagnostic accuracy (AUC 0.819; sensitivity 81.81%; specificity 73.68%; accuracy 75.51%; LR+ 3.11; LR– 0.25).Conclusion: PHAL and SII are effective, accessible, and low-cost biomarkers that can support ovarian cancer diagnosis through routine blood tests.PHAL dan SII: Biomarker Inovatif untuk Diagnosis Kanker Ovarium Subtipe Epitel dan Non-Epitel Abstrak Tujuan: Penelitian ini bertujuan untuk mengevaluasi nilai diagnostik dari PHAL (Platelet, Haemoglobin, Albumin, dan Limfosit), SII (Systemic Immune Inflammation Index), dan SIRI (Systemic Inflammatory Response Index) pada kanker ovarium epitelial dan non-epitelial. Metode: Penelitian dengan metode potong lintang ini melibatkan 156 pasien dengan massa ovarium. Data laboratorium pra-operatif digunakan untuk menghitung skor PHAL, SII, dan SIRI. Diagnosis ditegakkan melalui pemeriksaan histopatologi. Populasi I mencakup semua jenis kanker ovarium dan tumor jinak, sedangkan Populasi II hanya mencakup kanker ovarium non-epitelial dan tumor jinak. Analisis statistik dilakukan menggunakan SPSS 25.0, termasuk analisis kurva ROC dan uji validitas untuk menilai kinerja diagnostik. Hasil: Hasil penelitian menyimpulkan bahwa SII memiliki performa terbaik pada seluruh populasi (AUC 0,738; sensitivitas 71,25%; spesifisitas 72,37%; akurasi 71,79%; LR+ 2,58; LR– 0,40). Pada subkelompok kanker ovarium non-epitelial dibandingkan dengan tumor jinak, PHAL menunjukkan akurasi diagnostik tertinggi (AUC 0,819; sensitivitas 81,81%; spesifisitas 73,68%; akurasi 75,51%; LR+ 3,11; LR– 0,25). Kesimpulan: PHAL dan SII merupakan biomarker yang efektif, mudah diakses, dan berbiaya rendah yang dapat mendukung diagnosis kanker ovarium melalui pemeriksaan darah rutin. Kata kunci: Kanker ovarium, Skor PHAL (Platelet-Hemoglobin-Albumin-Limfosit), Systemic Immune-Inflammation Index, Systemic Inflammatory Response Index

Co-Authors A.W., Gatot Nyarumenteng Akbar, Willy Andi Kurniadi, Andi Anwar, Rahmawaty Cangara, Husni Cangara, Muhammad H Chandra, Richard Dodi Suardi Eddy Hartono Eddy R. Moeljono Efendi Lukas Farid, Retno B Gosal, Steffy Rebecca Ham, Jonathan Huswatun Hasanah Kemala Isnainiasih Mantilidewi Maharani, Risma Maharani, Risma Manule, Yolanda Mardiati Moeljono, Eddy Nasser, Andi S.H.D. Nasser, Andi Sitti Halija Diawanti Nelwan, Berti J. Nelwan, Berti Julian Nyngsi, Erny M Raharja, Siska Putri Wulandari Rina Masadah Rusmardiani, Andhinna S. Riu, Deviana Salima, Siti Steven Ridwan, Steven Sulfiana, Isah T Chalid, St Maisuri T. Chalid, St. Maisuri Tawali, Suryani Umar Malinta Upik A Miskad UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yudi Mulyana Hidayat

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