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All Journal Jurnal Ilmu Dasar Journal of Pharmaceutics and Pharmacology Indonesian Journal of Cancer Chemoprevention Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Journal of Sylva Indonesiana Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM)
Julia Reveny
Department Of Formulation Technology, Faculty Of Pharmacy, Universitas Sumatera Utara
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation

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Antibacterial Potential Of Ethanol Extract Of Tamarind Seed Bark (Tamarindus indica L.) And Formulation Of Anti-Acne Nanogel Amalyuri, Annisa Ghassani; Reveny, Julia; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.522

Abstract

Acne is a skin disease that affects a large number of sufferers. Acne occurs due to active oil glands under the skin. This activity is stimulated by androgen hormones. The active compound content of proanthocyanidin is the main compound in the ethanolic extract of tamarind seed bark, which can inhibit the growth of acne-causing bacteria, namely Propionibacterium acnes and Staphylococcus epidermidis. The purpose of this study was to formulate a nanogel from tamarind seed bark extract and test the antibacterial potential of an ethanol extract of tamarind seeds against acne-causing bacteria. The antibacterial potency test consisted of variations in concentration and was 0.5, 1, 5, 25, 50, 75, 100, 125, 150, and 300 (in mg/mL). The concentration of the formulated nanogel preparations was 2.5%, 5%, and 7.5%. The MIC results showed that the minimum inhibitory concentration (MIC) was at a concentration of 1 mg/mL with a zone of inhibition of 6.50 ± 0.44 mm (Propionibacterium acnes) and 6.40 ± 0.10 mm (Staphylococcus epidermidis). The minimum bactericidal concentration (MBC) was at a concentration of 25 mg/mL with a percentage reduction of 98.18% (Propionibacterium acnes) and 98.06% (Staphylococcus epidermidis). The results of the nanogel formulations showed that the particle sizes were 49.88 ± 0.11 nm (Formula I), 51.92 ± 0.09 nm (Formula II), and 59.13 ± 0.10 nm (Formula III). Conclusion The ethanolic extract of tamarind seed bark has effectiveness in inhibiting the growth of acne-causing bacteria and can be formulated as an anti-acne nanogel.
Formulation And Evaluation Of Nanoemulgel Clove Leaf Oil (Sygyzium Aromaticum) (L.) Merr & Perry As Anti-Acne Dasawanti, Yoan; Reveny, Julia; Sumaiyah, Sumaiyah
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.681

Abstract

Acne also known as acne vulgaris, is an inflammatory condition of the polysebaceous layer that is brought on by the buildup of keratin. Active oil glands under the skin cause acne. Androgen hormones function as a stimulant for this activity. Cloves are herbal plants that contain essential oil chemicals. The chemical composition of clove leaf oil is mainly composed of eugenol. Eugenol has pharmacological effects as antibacterial, analgesic and anti-inflammatory. Nanoemulsion is a nanocarrier that gets a lot of attention, because of its small particle size so that it can be thermodynamically stable and can increase drug penetration. Recent advances in nanoemulsion research have created new prospects in a number of industries, including pharmaceuticals, biotechnology, food, and cosmetics. This research was conducted by formulating clove leaf oil into nanoemulgel preparations, followed by evaluation of the preparations and testing of antibacterial activity against acne-causing bacteria. The result of the nanoemulgel formulation is yellow, smells of clove leaf oil, is transparent and homogeneous. Nanoemulgel viscosity 3434-3109 M.Pas, pH 6.15-6.41 and particle size 12.3-13.3 nm. Physical studies of nanoemulgel been carried out for three cycles and there is no change in color, change in odor and phase separation. The results of the antibacterial activity of Staphylococcus epidermidis at NEG1 12.03 mm, NEG2 16.93 mm, NEG3 18.96 mm and EG 18.03 mm. The results of the antibacterial activity of Propionibacterium acnes at NEG1 11.50 mm, NEG2 16.16 mm, NEG3 18.03 mm and EG 17.33 mm. The results of the study concluded that clove leaf oil nanoemulgel with a concentration of 7% was the best formula, because it is stable during storage and has the greatest antibacterial activity compared to emulgel.
Aktivitas Antibakteri Minyak Habbatusauda (Nigella Sativa L.) dalam Menghambat Pertumbuhan Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Darmanta Bukit; Julia Reveny; Masfria Masfria
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47399

Abstract

ABSTRACTAcne is a common skin disorder associated with the proliferation of Propionibacterium acnes and Staphylococcus aureus. This study aims to evaluate the antibacterial activity of Nigella sativa (black seed) oil against these two bacteria and investigate its mechanism of action. The methods included disc diffusion assay for inhibition zone measurement, determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), and analysis of ion leakage and intracellular content release using spectrophotometry. The results revealed that black seed oil demonstrated antibacterial activity, with the highest inhibition zone at 100% concentration: 16.16 mm for P. acnes and 16.43 mm for S. aureus. MBC values were determined at 12.5% for P. acnes and 6.25% for S. aureus. The oil also induced leakage of Ca²⁺ and K⁺ ions, as well as nucleic acids and proteins from bacterial cells, indicating membrane disruption as its primary mechanism. These findings support the potential use of black seed oil as a natural therapeutic agent for acne treatment. Keywords: black seed oil, acne, antibacterial, Propionibacterium acnes, Staphylococcus aureus.
Aktivitas Antibakteri Minyak Jarak (Castor Oil) dalam Menghambat Pertumbuhan Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Yuni Angelia Simbolon; Julia Reveny; Masfria Masfria
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47407

Abstract

Abstract Acne is a skin disorder caused by chronic inflammation of the pilosebaceous follicles, commonly associated with increased sebum, bacterial colonization, and local inflammation. The primary bacteria involved are Propionibacterium acnes and Staphylococcus aureus. Long-term use of synthetic antibiotics can lead to bacterial resistance, thus encouraging the search for natural-based alternatives. This study aimed to evaluate the antibacterial activity of castor oil against both bacterial species. The research applied a disc diffusion method to assess the inhibition zones, followed by tests for minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cellular leakage analysis using UV-Vis spectrophotometry and atomic absorption spectroscopy (AAS). Results demonstrated that castor oil exhibits moderate antibacterial activity, with the highest inhibition observed at 100% concentration: 12.86 mm for P. acnes and 10.3 mm for S. aureus. Furthermore, castor oil induced leakage of Ca²⁺, K⁺, protein, and nucleic acids from bacterial cells. These findings confirm the potential of castor oil as a natural topical antibacterial agent for acne treatment.Keywords: castor oil, antibacterial, acne, Propionibacterium acnes, Staphylococcus aureus
Phytoconstituents and Antioxidant Profiling of Avicennia marina (Forsk.) Vierh. Heartwood Extract Sourced from Bagan Kuala: A Novel Natural Source for Radical Scavenging Applications Reveny, Julia; Rahayu, Firdha Sekar; Yuandani
Journal of Sylva Indonesiana Vol. 9 No. 01 (2026): Journal of Sylva Indonesiana
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jsi.v9i01.20826

Abstract

Avicennia marina (Forssk.) Vierh., commonly known as 'api-api' or white mangroves, are woody shrubs and tropical plants that inhabit mangrove ecosystems, which occur at the interface between terrestrial and marine environments. Salinity is a critical environmental factor in mangrove habitats. Plants growing in such extreme conditions exhibit elevated concentrations of specific antioxidant compounds. Various parts of plants, including heartwood, are known to contain an abundance of extractive components compared to sapwood. Objective: This study was the first to evaluate the antioxidant activity of A. marina heartwood extract. Method: The applied method of sample extraction comprises ethanol-based maceration, qualitative phytochemical analysis based on observable visual changes, and the assessment of antioxidant activity employing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay using UV-Vis Spectrophotometry. Result: heartwood extract of Avicennia marina exhibits phytochemical constituents that comprise alkaloids, tannins, saponins, triterpenoids, and flavonoids. The antioxidant capacity of the extract showed strong antioxidant activity with an IC50 value of 61.50 µg/mL (R2 = 0,9962). Conclusion: The current study confirms the promising antioxidant activities of Avicennia marina heartwood sourced from Bagan Kuala. These marine biological resources can be explored further as an ailment for degenerative disease induced by Reactive Oxidative Stress (ROS), which can be made into an oral supplement or topical preparations, thus generating a greater economic value.
Co-Authors Amalyuri, Annisa Ghassani Aminah Dalimunthe Arianto, Anayanti Arianto Darmanta Bukit Dasawanti, Yoan Dharmawan, Hariyadi Ervina Syahfitri Lubis Fajriah, Nurul Fitri, Raissa Hafid Syahputra Herawaty Ginting Juanita Tanuwijaya Juwita, Nur Aira Lely Sari Lubis Maha, Hetty Lendora Masfria Masfria Masfria Muchlisyam Nasri Nazliniwaty Nazliniwaty* Rahayu, Firdha Sekar Rohani, Ade Sri Sudarmi Sumaiyah, Sumaiyah Surjanto Surjanto Suwarso, Edy Urip Harahap Wiryanto Wiryanto Yuandani Yuni Angelia Simbolon Zulmai Rani