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All Journal Jurnal Respirologi Indonesia Respiratory Science Indonesian Journal of Cancer
Sita Laksmi Andarini
Department Of Pulmonology And Respiratory Medicine Faculty Of Medicine, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : respiratory science

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Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta Astari Pranindya Sari; Ratnawati Ratnawati; Wahju Aniwidyaningsih; Sita Laksmi Andarini; Faisal Yunus
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.38

Abstract

Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status. Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed. Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation. Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.
The Role of miRNA in Non-Small Cell Lung Carcinoma Ahmad Arfan; Sita Laksmi Andarini
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.39

Abstract

Micro Ribonucleic Acids, or miRNAs, are short non-coding RNAs. Their length, on average, is 22 nucleotides, and they function in post-transcriptional regulation of gene expression. MiRNAs have their own nomenclature, and the same miRNAs can be found across different species. MiRNAs play important roles in many physiological and pathological processes in the human body. Regarding cancer, miRNAs are involved in carcinogenesis. MiRNAs work by binding completely or incompletely with messenger RNAs (mRNAs). Complete binding with mRNA produces mRNA degradation, while incomplete binding produces translational inhibition. Eventually, miRNAs decreased gene expression. In cancer, miRNAs show unique and different expression profiles. Based on their role in activating or deactivating intracellular signaling pathways, miRNAs can be classified as oncomiR or tumor suppressor miRNA. In non-small cell lung cancer (NSCLC), miRNAs are associated with gene mutation status, and they have important roles as diagnostic, prognostic, and predictive biomarkers.  
Co-Authors Agus Dwi Susanto Ahmad Arfan Ahmad Hudoyo Aniwidyaningsih, Wahju Anna Yusrika Astari Pranindya Sari Budhi Antariksa Damayanti, Triya Dea Putri Audina Dewi Yenita Faisal Yunus Faisal Yunus Faisal, Hana Khairina Putri Farhan Hilmi Taufikulhakim Flora Ekasari Herawati Hidajat Isbaniah, Fathiyah Muhammad Ilyas Nurlinah Jalil Prasenohadi Raden Rara Diah Handayani Ratnawati Ratnawati Ririn Astuty Ningsih Samoedro, Erlang Soehardiman, Dicky Sri Wening Pamungkasningsih Taufik, Feni Fitriani Tomu Juliani Wahyu Aniwidyaningsih Widhy Yudistira Nalapraya Zaini, Jamal