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All Journal Nusantara Medical Science Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmiah Kesehatan Current Research on Biosciences and Biotechnology Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Makara Journal of Health Research Cermin Dunia Kedokteran
Tricia Dewi Anggraeni
Faculty Of Medicine Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Correlation Between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Patients with Ovarian Cancer at Dr. Cipto Mangunkusumo Hospital Madjid, Veinardi; Calvin, David; Purwoto, Gatot; Utami, Tofan Widya; Anggraeni, Tricia Dewi; Vidiawati, Dhanasari; Winarto, Hariyono
Makara Journal of Health Research Vol. 28, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Nausea and vomiting (NV) remain as side effects of chemotherapy, which has a detrimental effect on patients’ quality of life (QOL) and treatment adherence. This study aimed to determine the effect of chemotherapy-induced NV (CINV) on the QOL of patients with ovarian cancer treated with chemotherapy at Dr. Cipto Mangunkusumo Hospital (CMH). Methods: We conducted a cross-sectional study in patients with ovarian cancer receiving first-line chemotherapy regimens of carboplatin and paclitaxel. The European Organisation for Research and Treatment helped translate the Quality-of-Life Questionnaire-OV28 (QLQ-OV28) into Indonesian and tested it in a preliminary study. The approved Indonesian version of the QLQ-OV28, with the Quality-of-Life Questionnaire-C30 (QLQ-C30), was then used to evaluate QOL before and 1 week after chemotherapy. Results: Several symptom scales increased, whereas function scales decreased. Moreover, 72.5% had an increase in the NV symptom scale, whereas 67.5% had a decrease in patients’ scale after chemotherapy. CINV had a significant partial effect on reducing QOL (p = 0.047 and y = 12.208–0.432). Conclusions: CINV has a significant influence on lowering the QOL of patients with ovarian cancer undergoing first-line chemotherapy regimens with carboplatin and paclitaxel in CMH.
Obesity and Endometrial Cancer: Mechanism and How to Deal with? Tricia Dewi Anggraeni; Raymond Surya; Andrew Pratama Kurniawan
Cermin Dunia Kedokteran Vol 48 No 6 (2021): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i6.85

Abstract

Obesity is strongly associated with development of endometrial cancer more than any other cancer type. The relationship between obesity and endometrial cancer risk is combination of inflammation, insulin resistance, and increased bioavailability of estrogen. Obesity can increase risk to develop endometrial cancer as exogenous estrogen has impact for tumorigenesis. The best method to reduce the risk of endometrial cancer in obese women is through progesterone medication and lifestyle intervention. Obesitas erat kaitannya dengan terjadinya kanker endometrium lebih dari jenis kanker lainnya. Hubungan antara obesitas dan risiko kanker endometrium adalah kombinasi antara inflamasi, resistensi insulin, dan peningkatan bioavailabilitas estrogen. Obesitas dapat meningkatkan risiko terjadinya kanker endometrium karena estrogen eksogen berdampak pada tumorigenesis. Metode terbaik untuk mengurangi risiko kanker endometrium pada wanita yang obese adalah melalui pengobatan progesteron dan intervensi gaya hidup.
Socio-demographic Profiles of Cervical Cancer Patients at Cipto Mangunkusumo Hospital - 2009-2019 and Its Association with Cancer Stages at Diagnosis Fitriyadi Kusuma; Kemal Akbar Suryoadji; Michael Adrian; Tofan Widya Utami; Hariyono Winarto; Tricia Dewi Anggraeni; Kartiwa Hadi Nuryanto; Muhammad Haekal
Cermin Dunia Kedokteran Vol 49 No 5 (2022): Neuro-Kardiovaskular
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i5.227

Abstract

Objective: To determine the socio-demographic profile of cervical cancer patients at Cipto Mangunkusumo Hospital in 2009-2019 based on educational level, parity, age, residence, and employment status and their relationship to cervical cancer stage at diagnosis. Methods: Comparative analytical study was conducted retrospectively based on medical records in Cipto Mangunkusumo Hospital. The selection was based on data completeness: cervical cancer stages, sociodemographic profiles consisting of education level, parity, age, Java or non-Java Island resident, and occupation. Multivariate analysis calculated the association between socio-demographic factors and cervical cancer stages. Data were analyzed using SPSS v.22.0 and Microsoft Excel. Results: This study included 4,584 patients with complete data. Only 19.3% patients were in the early stage, 63.3% had less than three parities, 82.8% of patients had formal primary school education or less, 80.9% patients were aged 18-65 years, 88.3% patients resided in Java Island, and 80.5% didn’t have the occupation. There was a significant association (p <0.05) between cervical cancer stage and educational level (aOR= 0.86; 95% CI= 0.78-0.94) and age (aOR= 1.46; 95% CI= 1.18-1.40). There is no significant association (p >0.05) between cervical cancer stage and parity, residence, and employment status. Conclusion: Low education and old age (> 65-year-old) were associated with the advanced stage of cervical cancer at diagnosis. Tujuan: Mengetahui profil sosiodemografi pasien kanker serviks di Rumah Sakit Cipto Mangunkusumo tahun 2009-2019 berdasarkan tingkat pendidikan, jumlah paritas, usia, status kependudukan, pekerjaan, serta hubungannya terhadap stadium kanker serviks saat diagnosis. Metode: Penelitian analitik komparatif retrospektif berdasarkan data rekam medis Rumah Sakit Cipto Mangunkusumo. Pemilihan sesuai kelengkapan data: stadium kanker serviks, profil status sosiodemografi yang terdiri atas tingkat pendidikan, paritas, usia, penduduk pulau Jawa atau non-Jawa, dan status pekerjaan. Hubungan antar variabel dianalisis multivariat untuk mencari hubungan berbagai faktor sosiodemografi terhadap stadium kanker serviks. Analisis data menggunakan program SPSS versi 22.0 dan Microsoft Excel. Hasil : Terdapat 4.584 pasien kanker serviks yang memenuhi kriteria inklusi. Sebanyak 19,3% pasien dengan stadium awal. Selanjutnya 82,8% pasien memiliki pendidikan formal sekolah dasar atau kurang, 63,3% pasien memiliki jumlah paritas kurang dari tiga, 80,9% pasien berusia antara 18-65 tahun, 88,3% pasien berdomisili di pulau Jawa, dan 80,5% tidak bekerja. Didapatkan asosiasi bermakna (p<0,05) antara stadium kanker serviks dan tingkat pendidikan (aOR = 0,86; 95% CI= 0,78-0,94) dan usia (aOR= 1,46; 95% CI= 1,18-1,40). Tidak ditemukan asosiasi bermakna (p>0,05) antara stadium kanker serviks dengan paritas, domisili kependudukan, dan status pekerjaan. Simpulan: Tingkat pendidikan rendah dan usia lanjut (>65 tahun) berasosiasi dengan stadium lanjut kanker serviks saat diagnosis.
Upaya Menurunkan Angka Kematian Ibu akibat Perdarahan Pasca-Persalinan di Indonesia melalui Inovasi Sistem Pelayanan Kesehatan Muhammad Alifian Remifta Putra; Edward Christopher Yo; Jason Phowira; Tricia Dewi Anggraeni
Cermin Dunia Kedokteran Vol 47 No 10 (2020): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i10.556

Abstract

Perdarahan pasca-persalinan (PPP) adalah komplikasi persalinan yang menyebabkan 35% seluruh kematian ibu di dunia. Meskipun PPP mulai jarang ditemui di negara maju, kondisi ini masih merupakan salah satu penyebab utama kematian ibu di negara berkembang seperti Indonesia. Hal ini antara lain akibat infastruktur kesehatan yang kurang optimal, sehingga terlambat mengidentifikasi faktor risiko PPP, merujuk, serta memberikan intervensi tepat waktu. Kajian pustaka ini mengamati adanya hubungan signifikan antara penurunan kematian ibu akibat PPP dan implementasi sistem peringatan dini obstetri, manajemen efektif, dan optimalisasi alur rujukan. Namun, karena tiap wilayah memiliki aspek sosioekonomis dan geografis yang berbeda, studi lanjutan diperlukan untuk menentukan pendekatan yang tepat bagi masing-masing wilayah di Indonesia. Postpartum hemorrhage (PPH) is a life-threatening condition that contributes to 35% of all maternal deaths worldwide. Although the risk of PPH has greatly declined in developed countries, it remains a leading cause of maternal mortality in developing countries like Indonesia. This issue could mainly be attributed to poor healthcare system and infrastructure leading to delay in identifying risk factors, referring mothers-at-risk to health centers, and appropriate intervention. We observed a notable relationship between decrease in maternal deaths due to PPH and the implementation of early warning system, effective PPH management, and optimization of referral system. These healthcare innovations showed promising potential in reducing the burden of PPH. However, since there is no single health policy that can be universally implemented, further research is needed to decide the best approach for each area depending on individual, socio-economic and geographic aspects.
Higher HIF-1alpha Level in Cervical Cancer Worsen the Outcome of Radiotherapy in Stage IIIB Squamous Cell Carcinoma of the Cervix Malano, Yoarva; Fitriyadi Kusuma; Prijanti, Ani Retno; Winarto, Hariyono; Anggraeni, Tricia Dewi; Utami, Tofan Widya; Adiyarianni, Ghina
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.1871

Abstract

Prevalensi Infeksi Human Papilloma Virus Risiko Tinggi Pada Wanita dengan Positif Human Immunodeficiency Virus di Dunia: Tinjauan Sistematis Berdasarkan Studi Terkini Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Abdullah, Muhammad Raoul Taufiq; Fauzi, Ahmad; Ridwan, Alifaturrasyid Syafaatullah; Purwoto, Gatot; Winarto, Hariyono; Anggraeni, Tricia Dewi; Utami, Tofan Widya
Jurnal Ilmiah Kesehatan Vol 22 No 02 (2023): Jurnal Ilmiah Kesehatan terbitan Agustus Volume 22 Nomor 02 Tahun 2023
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikes.v22i02.2652

Abstract

Tipe Human Papilloma Virus (HPV) risiko tinggi merupakan etiologi dari kanker serviks yang menjadi kanker kedua terbesar pada wanita. Infeksi Human Immunodeficiency Virus (HIV) menjadi salah satu faktor risiko infeksi HPV. Pada pasien dengan HIV terjadi penurunan sistem imun yang dapat menyebabkan peningkatan risiko infeksi terlebih jika kadar CD4+ rendah. Untuk menelusuri seberapa banyak wanita dengan HIV yang terinfeksi virus HPV risiko tinggi pada berbagai penelitian terkini. Penelusuran dilakukan dengan metode systematic review menggunakan database Pubmed, Cochrane, dan ScienceDirect. Digunakan kata kunci “((HPV Positive) AND (HIV) AND (Cervical Cancer))”.Dalam systematic reviews ini, didapatkan hasil akhir 3 penelitian yang memenuhi kriteria inklusi. Di antaranya penelitian di Kenya tahun 2012 menunjukkan 52,6% dari 498 wanita dengan HIV terinfeksi HPV risiko tinggi, penelitian di Nigeria pada 2017 menunjukkan 29% dari 449 wanita dengan HIV terinfeksi HPV risiko tinggi dan juga terdapat hubungan signifikan antara HIV pada pasien wanita dengan infeksi HPV risiko tinggi dibandingkan dengan pasien wanita tanpa HIV dengan dengan OR 3,38 (95% CI 2,34–4,87, p < 0,001), dan penelitian di Nigeria tahun 2014 menunjukkan prevalensi HPV risiko tinggi lebih besar pada pasien dengan HIV positif (24,5%) dibandingkan HIV negatif (15,9%) secara bermakna (P<0,005; OR=1,7; 95% CI=1,1-2,7), serta terdapat penurunan dari prevalensi infeksi HPV risiko tinggi pada wanita dengan HIV positif apabila jumlah CD4 pasien lebih dari 500 sel/mm3 (OR = 0,7; 95% CI: 0,5-0,8). Prevalensi yang besar dan hubungan signifikan antara infeksi HPV risiko tinggi dengan HIV pada pasien wanita menunjukkan diperlukannya skrining HPV tipe risiko tinggi pada pasien wanita dengan HIV sebagai strategi pencegahan yang lebih awal terhadap kanker serviks dan dibutuhkan pemberian terapi yang rutin kepada wanita dengan HIV positif untuk memiliki angka CD4 >500 sel/mm3.
Clinicopathological Profile and Disease-Free Survival in Stage I-II Endometrial Cancer at Cipto Mangunkusumo Hospital Muhammad Rizkinov Jumsa; Nuryanto, Kartiwa Hadi; Tricia Dewi Anggraeni; Tantri Hellyanti
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.48383

Abstract

Introduction: This study aimed to describe the clinicopathological profile and evaluate the disease-free survival (DFS) of patients with FIGO 2009 stage I–II endometrioid endometrial cancer, and to determine the prognostic value of key factors, emphasizing lymphovascular space invasion (LVSI) and tumor grade. Methods: A retrospective cohort of 111 patients treated between January 2017 and December 2022 was analyzed. Variables included age, menopausal status, BMI, depth of myometrial invasion, LVSI, and tumor grade. Survival was estimated using the Kaplan–Meier method; associations were assessed with Fisher’s exact test, and independent prognostic factors were identified using multivariate Cox regression analysis Results: The median follow-up for the 111 patients was 32 months. Most were stage IB (42.4%), aged 45–60 years (46.8%), postmenopausal (73%), and obese (63%). Stage-specific DFS rates were: Stage IA – 94.6% (1-year), 87.8% (2-year), 87.8% (3-year); Stage IB – 93.6% (1-year), 91.0% (2-year), 91.0% (3-year); Stage II – 92.6% (1-year), 88.9% (2-year), 88.9% (3-year). LVSI positivity (15.3%) and high tumor grade emerged as the strongest prognostic factors. Multivariate analysis confirmed LVSI as an independent predictor across all stages, with hazard ratios ranging from 3.85 in stage IA to 4.25 in stage IB and 12.5 in stage II (p<0.05). In stage II, LVSI-positive patients showed a 57.1% 3-year DFS versus 100% in LVSI-negative patients. Conclusions: LVSI and tumor grade are independent, interrelated prognostic markers in early-stage endometrial carcinoma. Their integration into risk stratification refines adjuvant therapy guidance. Implementation requires standardized pathological reporting and efficient referral systems to improve long-term surveillance adherence.
Co-Authors Abdullah, Muhammad Raoul Taufiq Adiyarianni, Ghina Aldri Frinaldi Andrew Pratama Kurniawan Ani Retno Prijanti Antonius, Puja Agung Calvin, David Christopher Yo, Edward Dhanasari Vidiawati Dinda Shezaria Edward Christopher Yo Edward Christopher Yo Fauzi Ahmad Muda Fitriyadi Kusuma Fransisca Dela Verna Gatot Purwoto Hariyono Winarto Hariyono Winarto Jason Phowira Jason Phowira Kartiwa Hadi Nuryanto Kemal Akbar Suryoadji Lady Feren Pangjaya Madjid, Veinardi Malano, Yoarva Michael Adrian Muhammad Alifian Remifta Putra Muhammad Alifian Remifta Putra Muhammad Haekal Muhammad Haekal Muhammad Rizkinov Jumsa Phowira, Jason Pratama Kurniawan, Andrew Radiana Dhewayani Antarianto Raymond Surya Raymond Surya Raymond Surya Remifta Putra, Muhammad Alifian Ridwan, Alifaturrasyid Syafaatullah Sanya Khaerunnisa Suryoadji, Kemal Akbar Tantri Hellyanti Tofan Widya Utami Tofan Widya Utami Utami, Tofan Widya Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono