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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Jurnal Berkala Epidemiologi Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Epidemiologi Kesehatan Komunitas Medica Hospitalia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Bioscientia Medicina : Journal of Biomedicine and Translational Research Gema Lingkungan Kesehatan Indonesian Journal of Global Health Research
K. Heri Nugroho HS, K. Heri
Division Of Endocrinology, Metabolism And Diabetes, Department Of Internal Medicine, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Effect of Chlorogenic Acid Content in Coffee Can Reduce Malondialdehyde (MDA) and Increase Testosterone Hormone Levels in DM Conditions Eko Naning Sofyanita; Achmad Zulfa Juniarto; Ari Suwondo; Heri Nugroho
Gema Lingkungan Kesehatan Vol. 23 No. 1 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i1.163

Abstract

Hyperglycemia is an uncontrolled condition of DM in the body, which causes a decrease in cell functions due to an increase in free radicals (ROS). This study explored the effects of Chlorogenic Acid found in coffee on mitigating MDA levels and augmenting testosterone in the context of Diabetes Mellitus (DM). Chlorogenic Acid, recognized for its substantial antioxidative properties, may ameliorate cellular impairments resulting from high glucose concentrations, consequently elevating Testosterone levels. The methodology employed was a Randomized Control Posttest Group Design involving 20 male Rattus norvegicus rats, aged 8-12 weeks, divided equally into four distinct groups. DM was simulated by administering 40mg/KgBB of streptozotocin and verifying the onset of Hyperglycemia through blood glucose evaluations three days post-administration. Following the confirmation of Hyperglycemia, a 14-day intervention with Robusta Coffee was initiated, with subsequent blood sampling on the fifteenth day to measure MDA and Testosterone concentrations. Results indicated that the groups KP, KP1, and KP2 exhibited notable variations in their responses when contrasted with KP, achieving statistical relevance Of ANOVA (p<0.05). However, no marked difference was observed in Testosterone levels between KP1 and KP2 (p>0.05). The investigation corroborated that Chlorogenic Acid in coffee plays a crucial role in reducing MDA and increasing testosterone hormone levels in DM conditions.
Effect of Garcinia mangostana Linn. Pericarp Extract Supplementation on Lipid Profile and Glycemic Parameters in Elderly Patients with Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Trial Yosef Purwoko; Heri Nugroho; Siti Setiati; Banundari Rachmawati
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1661

Abstract

Type 2 Diabetes Mellitus (T2DM) in the elderly is frequently accompanied by dyslipidemia, increasing cardiovascular risk. Mangosteen pericarp, derived from Garcinia mangostana Linn., contains xanthones with antioxidant and anti-inflammatory properties that may improve metabolic parameters. The aim of this study is evaluate the effect of mangosteen pericarp extract supplementation on lipid profile, glycemic parameters, and insulin resistance in elderly patients with T2DM. This double-blind randomized controlled trial included 72 elderly T2DM patients allocated into a supplementation group (n=36) and a placebo-controlled group (n=36). Consecutive sampling was used for this study. Baseline and post-intervention assessments included fasting blood glucose, HbA1c, serum insulin, HOMA-IR, total cholesterol, LDL, HDL, and triglycerides. Within-group and between-group analyses were performed using parametric or non-parametric tests as appropriate, with p <0.05 considered statistically significant. Significant differences in baseline HbA1c and LDL levels were observed between groups (p<0.05). After intervention, a significant between-group difference was found only in HDL levels (p<0.05). Delta analysis demonstrated significant improvements in LDL and HDL in the supplementation group compared with controls (p<0.05). No significant differences were observed in fasting glucose, HbA1c, insulin levels, or HOMA-IR. Mangosteen pericarp extract supplementation significantly improved LDL and HDL levels but did not significantly affect glycemic control or insulin resistance.
Co-Authors Abdul Mughni Abdul Mughni Achmad Zulfa Juniarto Agus Layanto Anggoro Teguh Prasetya Anindita, Yohana Prima Ceria Antono Suryoputro Antono Suryosaputro Ari Suwondo Ariawan Soejoenoes Arthur Lelono Arum Kartikadewi Awal Prasetyo Ayudyah Nurani Bagoes Widjanarko Banundari Rachmawati Charles Limantoro Diana Diana Diana Nur Afifah, Diana Nur Djoko Trihadi Lukmono Djoko Trihadi Lukmono Dwi Lestari Partiningrum Eko Naning Sofyanita Fathur Nur Kholis Fransisca Yustika Dewi Siahaan Friska Anggraini Helena Silitonga Gracilaria Puspa Sari Hanifah Ardiani Hanifah Ardiani Henry Setyawan Susanto Henry Setyawan Susanto Hery Djagat Purnomo Ika Vemilia Warlisti Indra Kusuma Adi Putranto Kartika Widyakusuma Agung Putri Kusmiyati Tjahjono Kusmiyati Tjahjono Lestariningsih Lestariningsih Lisyani Budipradigdo Marisa Gita Putri Marisa Gita Putri Mateus Sakundarno Mateus Sakundarno Adi, Mateus Sakundarno Minuljo, Tania Tedjo Muchlis Achsan Udji Sofro Nyoman Suci Widyastiti Pusaka, Semerdanta Rakhma Yanti Hellmi Rakhma Yanti Hellmi Ratnasari Dwi Cahyanti Resna Meiwarnis Rina Rina Roesipin, Sri Wahyuningsih Selamat Budijitno Shofa Chasani Shofia Aji Hidayatillah Silitonga, Marisi Elizabeth R. Siti Setiati Soeharyo Hadisaputro Sofyan Rais Addin Sri Wahyuningsih Sri Wahyuningsih Roesipin Suhartono Suhartono Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Suharyo Hadisaputro Sulistio Rini Tjokorda Gde Dalem Pemayun Tjokorda Gde Dalem Pemayun Tjokorda Gde Dalem Pemayun Yosef Purwoko