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Resty Ryadinency
Universitas Mega Buana Palopo
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Journal : Medical Journal of Indonesia

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Effect of zinc supplementation on triglyceride and malondialdehyde levels: study on diabetic Wistar rats induced with streptozotocin Ryadinency, Resty; Hadisaputro, Suharyo; Rachmawati, Banundari
Medical Journal of Indonesia Vol 27, No 2 (2018): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.971 KB) | DOI: 10.13181/mji.v27i2.1417

Abstract

Background: Diabetes mellitus is associated with increased blood glucose and triglyceride levels, which can lead to an oxidative stress. Zinc (Zn) is a micronutrient that has antioxidant properties and involved in lipid and glucose metabolism. This study aimed to evaluate the effect of zinc on the levels of fasting blood glucose (FBG), triglycerides (TG), and malondialdehyde (MDA) in male diabetic Rattus norvegicus Wistar rats.Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 40 mg/kg BW streptozotocin (STZ) and confirmed by FBG level higher than 200 mg/dL after 2 weeks. The rats were randomly divided into three groups: control group (STZ), treatment I (STZ + zinc 5 mg/kg BW), and treatment II (STZ + zinc 10 mg/kg BW). Zinc was administered by oral gavage for 30 days. At the end of the experiment, levels of FBG, TG, and MDA were measured. Data were analyzed using paired t-test or Wilcoxon test as appropriate.Results: Supplementation of 5 mg/kg zinc significantly decreased the levels of FBG (pre-intervention: 328.95±70.90 mg/dL, post-intervention: 144.35±34.27 mg/dL, p<0.05), TG (pre-intervention: 252.48±26.30 mg/dL, post-intervention: 147.90±12.18 mg/dL, p<0.05), and MDA (pre-intervention: 12.11±6.46 nm/mL, post-intervention: 4.75±2.34 nm/mL, p<0.05). Moreover, supplementation of 10 mg/kg zinc decreased the levels of TG (pre-intervention: 275.62±56.25nm/mL, post-intervention: 165.58±22.63 nm/mL, p<0.05) and MDA (pre-intervention: 13.08±6.60 nm/mL, post-intervention: 5.08±2.40 nm/mL, p<0.05).Conclusion: Supplementation of zinc significantly reduced the levels of FBG, TG, and MDA in diabetic rats.
Co-Authors Andira, Putri Arif, Wahyuni Ayu Irawati Banundari Rachmawati Djano, Nur Asphina R. Eksanti Kadir Evi Lusiana Furqani, Dian Hamdan, Dian Furqani Herti, Hertiana Hertiana, Hertiana Izhak Jumraini Jumraini Kadang, Hafsah Citra Lindriani, Lindriani Misnawati, Andi Muaningsih, Muaningsih Nur Asphina R Djano Nur Asphina R. Djano Nurlaeli Nurlaeli Putri Andira Rahma Ayu Kinanti Rismayanti Yamin Rosdiana Rosdiana Sinta Hikma Suharyo Hadisaputro Suriyani Suriyani, Suriyani Suwandi N Suwandi Suwandi Try Ayu Parmawati Uly, Nilawati Wahyu Hidayat Zamli