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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Komunitas Jurnal Respirologi Indonesia Unri Conference Series: Community Engagement Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Eduvest - Journal of Universal Studies Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Yessy Susanty Sabri
Universitas Andalas
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Association Between Comorbidities and Outcome of COVID-19 Patients at dr. M. Djamil General Hospital Padang Nova Indriyani; Yessy Susanty Sabri; Afriani Afriani
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.59

Abstract

Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality estimated up to 20%. This number will increase with the presence of comorbidities. Comorbidities were associated with complex clinical management and impacted on COVID-19 disease outcomes. This study aims to determine the association between comorbidities and the outcome of COVID-19 patients at Dr. M. Djamil Hospital. Method: We conducted an observational study with a retrospective cohort design on COVID-19 patients treated at Dr. M. Djamil Hospital. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients was analyzed by Chi-Square or Fisher Exact Test. Results: The majority patientss were female (56.4%) and ages above 50 years old (64.3%) were the majority of patients. The most common was hypertension (36.56%). The longest length of stay of COVID-19 patients was more than 21 days (52.9%).  The outcomes of COVID-19 patients were recovered (59.5%), recovered with sequelae (5.7%), and died (34.8%). Diabetes mellitus affected the end of treatment outcome. There was no relationship of type of comorbidity with length of stay. The more co-morbidities a patient suffers, the condition when infected with COVID-19 will get worse. Conclusion: The number of comorbidities affects the outcome of COVID-19 patients. Diabetes mellitus is most common that affects the end of treatment outcome for COVID-19 patients at Dr. M. Djamil Hospital.
Association of the Vaccination Status of Health Workers of COVID-19 Survivors with The Outcomes of Treatment of COVID-19 At General Hospital in Padang City Kornelis Aribowo; Masrul Basyar; Yessy Susanty Sabri
Jurnal Respirologi Indonesia Vol 43, No 3 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i3.351

Abstract

Background: Health workers are on the front lines of treating and fighting the COVID-19 pandemic. Health workers face COVID-19 patients at work. Health workers are at increased risk of infection if they are not properly protected. Increased risk for health workers can be caused by contact with patients without personal protective equipment (PPE) and surfaces contaminated with the virus. Infected health workers can infect other people around them and will increase the workload of other health workers. One of the efforts to reduce the risk of transmission to health workers is vaccination. Vaccines against COVID-19 are considered very important to prevent and control COVID-19. The aim is to determine the relationship between the COVID-19 vaccine status and the outcomes of healthcare workers treated for confirmed COVID-19 at hospitals throughout Padang.Methods: This observational study was conducted using a retrospective cohort method. The study was conducted from August 2021 to May 2022 in hospitals across Padang by completing a questionnaire in the form of a Google form link. Results: Vaccination status of health workers who survived COVID-19 who were treated at Padang City General Hospital (66.97%) were not vaccinated, aged 26–35 years (57.80%), female (80.73%), worked as paramedics (63, 55%), symptom onset 3 to 7 days (44.95%), number of symptoms 3 (55.96%), most fever (24.68%), number of comorbid 1 to 2 (66.06%), obesity (66.67%), length of stay <21 days (84.40%), and mild clinical (55.96%) and recovered (92.66%). The highest degree of COVID-19 severity for health workers who were not vaccinated was moderate clinical, 42 samples (57.53%), and vaccinated, predominantly mild clinical, 34 samples (94.44%). The duration of stay of health workers vaccinated was higher than that who were not vaccinated (97.22% vs. 78.08%).Conclusion: The vaccination status of health workers who have survived COVID-19 relates to a clinical degree, length of stay, and outpatient treatment.
Differences in IL-6 Levels Based on Clinical Severity and Outcome of COVID-19 Patients at Dr. M. Djamil Hospital Chicy Widya Morfi; Yessy Susanty Sabri; Dessy Mizarti
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.94

Abstract

ground: A cytokine storm is defined by elevated levels of proinflammatory cytokines such as interleukin-6 (IL-6). In COVID-19 infection, IL-6 is superior to C-reactive protein (CRP) and other inflammatory markers in predicting respiratory failure. The IL-6 is the main cytokine triggered by T cells when a cytokine storm occurs. IL-6 is the most important driver of immune dysregulation and ARDS in COVID-19 infection. The purpose of this study is to assess differences of IL-6 levels based on clinical severity and outcomes in COVID-19 patients at Dr. M. Djamil Hospital. Method: The study took place at Dr. M. Djamil Hospital from November 2021 to November 2022. This is a retrospective cohort study in which patients were tested for IL-6 levels between January 1st, 2021 and December 31, 2021. The distribution of the frequency and proportion of each variable is included in univariate analysis; bivariate analysis determines the correlation between the independent variables (clinical severity, length of stay, and final status of hospitalization) and the dependent variable (IL-6 levels in COVID-19 patients). Results: Patients' characteristics in this study, the majority of patients aged 18-49 years. Women and patients with moderate disease were more common. The majority of patients were treated for less than 14 days, and the final status of hospitalization the patients showed that most of the patients recovered. IL-6 levels with median (min-max) was 32.00 (1.50-589.00). The IL-6 levels were higher in clinically critical COVID-19 patients (77.20 mg/L), in patients with a shorter length of stay (14 days) (36.00 mg/L), and at final status of hospitalization were death (58.90 mg/L). Conclusion: There were differences of IL-6 level based on clinical severity and final hospitalization status of COVID-19 patients, but not from the length of stay in COVID-19 patients at Dr. M. Djamil Hospital.
HUBUNGAN DERAJAT MEROKOK TERHADAP PENURUNAN FUNGSI PARU :SEBUAH KAJIAN LITERATUR Vildania, Nisrina; Sabri, Yessy Susanty; Ermayanti, Sabrina
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 2 (2025): SINERGI : Jurnal Riset Ilmiah, February 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i2.885

Abstract

Rokok merupakan gulungan tembakau seukuran jari kelingking yang dibungkus dengan daun nipah atau kertas. Asap rokok mengandung lebih dari 4.000 zat kimia, dengan 40 di antaranya diketahui sebagai penyebab kanker pada berbagai organ tubuh manusia. Sebanyak delapan dari sepuluh penelitian menunjukkan bahwa merokok dapat mengurangi fungsi paru, termasuk kapasitas vital paksa, volume ekspirasi paksa dalam satu detik, VEP1 / KVP, dan aliran ekspirasi paksa pada 25-75%. Studi literatur ini merupakan tinjauan naratif yang membahas berbagai literatur primer dengan desain penelitian observasional mengenai hubungan antara derajat merokok dan penurunan fungsi paru. Penulis melakukan pencarian literatur di enam basis data, yaitu PubMed NCBI, ProQuest, Google Scholar, Elsevier, ResearchGate, dan European Respiratory Journal. Dari 1.545 literatur yang ditemukan, hanya 15 literatur yang memenuhi kriteria inklusi. Sebelas dari lima belas literatur tersebut menyatakan adanya penurunan fungsi paru yang signifikan seiring dengan peningkatan derajat merokok, sementara tidak ditemukan perbedaan signifikan pada empat literatur lainnya. Kesimpulan dari studi ini adalah adanya hubungan antara derajat merokok dengan penurunan fungsi paru, dengan sebagian besar perokok mengalami penurunan fungsi paru yang signifikan. Beberapa faktor yang berhubungan dengan penurunan fungsi paru antara lain usia, jenis kelamin, aktivitas fisik, durasi merokok, serta jumlah batang rokok yang dihisap setiap harinya  
Karakteristik Pasien Pneumotoraks Et Causa Penyakit Paru Obstruktif Kronik (PPOK) di Bangsal Paru RSUP Dr. M. Djamil Padang Angela, Sonnya Morisa; Sabri, Yessy Susanty; Hanum, Fathiya Juwita; Rasyid, Rosfita; Russilawati, Russilawati; Nofendra, Ade
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.986

Abstract

Abstrak Latar Belakang: Pneumotoraks merupakan kelainan pada paru yang ditandai dengan terdapatnya udara pada rongga pleura. Terdapat beberapa jenis pneumotoraks salah satunya Pneumotoraks Spontan Sekunder (PSS). Pneumotoraks Spontan Sekunder (PSS) terjadi ketika penyakit dasar dengan target organ paru pada seseorang semakin memburuk. Penyakit paru tertinggi pada kasus PSS adalah Penyakit Paru Obstruktif Kronik (PPOK). Objektif: Mengetahui karakteristik pasien penderita pneumotoraks spontan sekunder yang disebabkan PPOK di Bangsal Paru RSUP Dr. M. Djamil Padang pada periode 2018 – 2021 berdasarkan usia, jenis kelamin, status merokok, keluhan utama, komorbid, dan sisi pneumotoraks pasien. Metode: Penelitian ini merupakan penelitian deskriptif retrospektif menggunakan rekam medis pasien pneumotoraks spontan yang disebabkan PPOK. Pengambilan sampel penelitian menggunakan teknik penelitian sensus sesuai kriteria inklusi. Hasil: Terdapat 26 pasien yang memenuhi kriteria inklusi dalam penelitian ini. Terdapat 50% pasien berada pada kelompok usia 55-64 tahun, 96,15% pasien berjenis kelamin laki-laki, 55,85% sebagai bekas perokok, 100% pasien dengan keluhan utama dispnea, komorbid pneumonia komuniti 34,09%, dan 53,85% pasien pneumotoraks sisi kiri. Kesimpulan: Kebanyakan pasien adalah kelompok usia 55-64 tahun, jenis kelamin laki-laki, merupakan bekas perokok, keluhan utama dispnea, komorbid pneumonia komuniti, dan mengenai sisi kiri dada. Kata kunci: karakteristik, penyakit paru obstruktif kronik, pneumotoraks spontan
Continuous Positive Airway Pressure (CPAP) versus Non-Invasive Ventilation (NIV) in Obesity Hypoventilation Syndrome: A Meta-Analysis Meliza Wahyuni; Yessy Susanty Sabri; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1274

Abstract

Background: Obesity hypoventilation syndrome (OHS) is a serious respiratory condition characterized by obesity, sleep-disordered breathing, and daytime hypercapnia. Both continuous positive airway pressure (CPAP) and non-invasive ventilation (NIV) are commonly used to treat OHS, but their comparative effectiveness remains unclear. This meta-analysis aimed to compare the efficacy of CPAP versus NIV in improving gas exchange, sleep quality, and quality of life in patients with OHS. Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted from 2013 to 2024 to identify randomized controlled trials (RCTs) comparing CPAP and NIV in adults with OHS. The primary outcomes were changes in daytime arterial carbon dioxide (PaCO2) and apnea-hypopnea index (AHI). Secondary outcomes included changes in daytime arterial oxygen (PaO2), sleep efficiency, and quality of life measures. Data were pooled using a random-effects model, and the standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated. Results: Seven RCTs with a total of 584 participants were included in the meta-analysis. Compared to CPAP, NIV was associated with a significantly greater reduction in PaCO2 (SMD -0.45; 95% CI -0.88 to -0.02; p=0.04) and AHI (SMD -0.61; 95% CI -1.17 to -0.05; p=0.03). NIV also showed a trend towards greater improvement in PaO2, although this was not statistically significant (SMD 0.32; 95% CI -0.06 to 0.70; p=0.10). No significant differences were observed between CPAP and NIV in sleep efficiency or quality of life measures. Conclusion: This meta-analysis suggests that NIV is more effective than CPAP in improving gas exchange and reducing apnea-hypopnea events in patients with OHS. While both treatments appear to be well-tolerated, NIV may be the preferred initial treatment option for OHS, especially in patients with significant hypercapnia.
Cystic Fibrosis Lung Disease: A Narrative Literature Review Putra, Rizki Amrika; Masrul Basyar; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.967

Abstract

Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cystic fibrosis transmembrane conductance regulator (CFTR) which is located on chromosome seven. The CFTR protein under normal conditions acts as a chloride channel and helps the movement of sufficient electrolytes and water across the membrane. Mutations in CFTR cause abnormalities in chloride ion transport through epithelial cells and impaired sodium and water transport resulting in viscous secretions with low water content. This thick and sticky secretion will inhibit the normal function of various organs, although pulmonary complications are the most common cause of death. Cystic fibrosis has wide genotypic and phenotypic variations. There are six categories of mutations based on their effect on the CFTR protein, where these categories are not only used to predict the phenotype but also to determine better therapeutic strategies based on the identified mutations.
Analysis of Bioterrorism Studies on Lung Health: A Meta-Analysis Nutari, Hasbi; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1083

Abstract

Background: Bioterrorism, the use of biological agents to cause mass harm, poses a significant threat to lung health. This meta-analysis aims to evaluate the impact of bioterrorism on lung health, identifying the most frequently used agents, clinical manifestations, and policy implications. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases from 2018 to 2024. Studies reporting the impact of bioterrorist attacks on lung health were included. Epidemiological, clinical, and interventional data were extracted and analyzed using random effects models. Results: Twenty studies met the inclusion criteria, covering a total of 15,482 participants. The most common bioterrorism agent was Bacillus anthracis (43.5%), followed by Yersinia pestis (21.7%) and Francisella tularensis (17.4%). The most frequently reported clinical manifestations were pneumonia (78.3%), acute respiratory failure (39.1%), and sepsis (26.1%). Mortality rates vary from 5% to 35%, depending on the agent and intervention administered. Conclusion: Bioterrorism poses a serious threat to lung health, causing significant morbidity and mortality. Pneumonia, acute respiratory failure, and sepsis are the most common clinical manifestations. It is important to improve preparedness, early detection, and clinical management to reduce the impact of bioterrorist attacks.
Meta-Analysis of Effective Management Strategies for Malignant Central Airway Obstruction Putri, Septriana; Yessy Susanty Sabri; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1108

Abstract

Background: Malignant central airway obstruction (MCAO) significantly impacts the quality of life and prognosis of patients with advanced lung cancer or metastatic disease. This meta-analysis aims to evaluate the effectiveness and safety of various management strategies for MCAO. Methods: A systematic search of PubMed, Embase, and Cochrane databases from 2018 to 2024 was conducted to identify randomized controlled trials (RCTs) and observational studies comparing different MCAO management approaches. Primary outcomes included improvement in airway patency, dyspnea scores, and survival. Secondary outcomes included procedural complications and quality-of-life measures. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: A total of 25 studies (15 RCTs, 10 observational studies), encompassing 3456 patients, were included in the meta-analysis. Interventions assessed were rigid bronchoscopy with various modalities (e.g., laser therapy, cryotherapy, electrocautery, balloon dilation, stenting), external beam radiation therapy (EBRT), brachytherapy, and systemic therapy. Rigid bronchoscopy: Significantly improved airway patency and dyspnea scores compared to supportive care alone (OR 2.86, 95% CI 1.95-4.18; p<0.001). Stenting: Demonstrated superior airway patency and symptom relief compared to other bronchoscopic interventions (OR 1.73, 95% CI 1.21-2.48; p=0.003). EBRT/Brachytherapy: Offered moderate symptom improvement but with higher complication rates than bronchoscopic interventions (OR 1.39, 95% CI 1.05-1.85; p=0.021). Systemic therapy (chemotherapy/immunotherapy): Provided limited benefit in terms of airway patency but may impact overall survival in specific tumor types. Conclusion: Rigid bronchoscopy, particularly with stenting, is the most effective initial management strategy for MCAO, providing rapid symptom relief and airway recanalization. EBRT/brachytherapy can be considered as adjuncts or alternatives in select cases. Further research is needed to determine the optimal combination and sequencing of therapies for different tumor types and stages.
Does Long-Term Oxygen Therapy Reduce Exacerbations in Chronic Obstructive Pulmonary Disease? A Meta-Analysis Rizki, Fitri Amelia; Yessy Susanty Sabri; Afriani, Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1150

Abstract

Background: Chronic obstructive pulmonary disease (COPD) exacerbations contribute significantly to morbidity, mortality, and healthcare costs. While long-term oxygen therapy (LTOT) is a standard treatment for severe resting hypoxemia in COPD, its impact on exacerbations remains unclear. This meta-analysis aimed to evaluate the effect of LTOT on the frequency and severity of COPD exacerbations. Methods: A systematic search of PubMed, Embase, and Cochrane Library was conducted (January 2018 to December 2023) for randomized controlled trials (RCTs) comparing LTOT to no LTOT in COPD patients. The primary outcome was the rate of moderate to severe COPD exacerbations. Secondary outcomes included hospitalization due to exacerbations and all-cause mortality. The risk of bias was assessed using the Cochrane Risk of Bias tool. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs with 2,949 participants were included. LTOT was associated with a statistically significant reduction in the rate of moderate to severe exacerbations (Rate Ratio [RR] 0.72; 95% Confidence Interval [CI] 0.67 to 0.78; p < 0.000001), representing an estimated 28% reduction. LTOT also significantly reduced hospitalization for exacerbations (RR 0.69; 95% CI 0.61 to 0.79; p < 0.000001) and all-cause mortality (RR 0.71; 95% CI 0.57 to 0.89; p = 0.003). Conclusion: LTOT significantly reduces the frequency of moderate to severe COPD exacerbations, related hospitalizations, and all-cause mortality. These findings support LTOT use in eligible COPD patients to improve clinical outcomes.
Co-Authors Afriani Afriani Afriani Afriani Afriani Sandra Afriwardi Afriwardi Amanda Besta Rizaldy Angela, Sonnya Morisa Chicy Widya Morfi Defi Eka Kartika Dessy Mirzati Dessy Mizarti Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dimas Bayu Firdaus Dimas Bayu Firdaus Elsa Purnama Sari Ermayanti, Sabrina Ermayanti, Sabrina Fadhilla Annisa Efendi Fanny Permata Andriani Fenty Anggraini Fenty Anggrainy Fenty Anggrainy Hanum, Fathiya Juwita Herman, Deddy Ilham Ilham Irvan Madison Irvan Medison Irvan Medison Kornelis Aribowo Kornelis Aribowo Lusi Agustini Arda M. Hari Nandi Pinto Masrul Basyar Masrul Basyar Masrul Basyar Mega Senja Meliza Wahyuni Miftah Irramah Muhammad Raihan Nofendra, Ade Nova Indriyani Nova Indriyani Nutari, Hasbi Oea Khairsyaf Putra, Rizki Amrika Reni Prima Gusty Rizki, Fitri Amelia Rosfita Rasyid Rosi Maulini Russilawati, Russilawati Septriana Putri, Septriana Vicennia Serly Vildania, Nisrina Yulia Helexandra Yuniar Lestari Yusrizal Chan Zurayya Fadila