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Karakteristik Pasien Pneumotoraks Et Causa Penyakit Paru Obstruktif Kronik (PPOK) di Bangsal Paru RSUP Dr. M. Djamil Padang Angela, Sonnya Morisa; Sabri, Yessy Susanty; Hanum, Fathiya Juwita; Rasyid, Rosfita; Russilawati, Russilawati; Nofendra, Ade
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.986

Abstrak Latar Belakang: Pneumotoraks merupakan kelainan pada paru yang ditandai dengan terdapatnya udara pada rongga pleura. Terdapat beberapa jenis pneumotoraks salah satunya Pneumotoraks Spontan Sekunder (PSS). Pneumotoraks Spontan Sekunder (PSS) terjadi ketika penyakit dasar dengan target organ paru pada seseorang semakin memburuk. Penyakit paru tertinggi pada kasus PSS adalah Penyakit Paru Obstruktif Kronik (PPOK). Objektif: Mengetahui karakteristik pasien penderita pneumotoraks spontan sekunder yang disebabkan PPOK di Bangsal Paru RSUP Dr. M. Djamil Padang pada periode 2018 – 2021 berdasarkan usia, jenis kelamin, status merokok, keluhan utama, komorbid, dan sisi pneumotoraks pasien. Metode: Penelitian ini merupakan penelitian deskriptif retrospektif menggunakan rekam medis pasien pneumotoraks spontan yang disebabkan PPOK. Pengambilan sampel penelitian menggunakan teknik penelitian sensus sesuai kriteria inklusi. Hasil: Terdapat 26 pasien yang memenuhi kriteria inklusi dalam penelitian ini. Terdapat 50% pasien berada pada kelompok usia 55-64 tahun, 96,15% pasien berjenis kelamin laki-laki, 55,85% sebagai bekas perokok, 100% pasien dengan keluhan utama dispnea, komorbid pneumonia komuniti 34,09%, dan 53,85% pasien pneumotoraks sisi kiri. Kesimpulan: Kebanyakan pasien adalah kelompok usia 55-64 tahun, jenis kelamin laki-laki, merupakan bekas perokok, keluhan utama dispnea, komorbid pneumonia komuniti, dan mengenai sisi kiri dada. Kata kunci: karakteristik, penyakit paru obstruktif kronik, pneumotoraks spontan

Continuous Positive Airway Pressure (CPAP) versus Non-Invasive Ventilation (NIV) in Obesity Hypoventilation Syndrome: A Meta-Analysis Meliza Wahyuni; Yessy Susanty Sabri; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1274

Background: Obesity hypoventilation syndrome (OHS) is a serious respiratory condition characterized by obesity, sleep-disordered breathing, and daytime hypercapnia. Both continuous positive airway pressure (CPAP) and non-invasive ventilation (NIV) are commonly used to treat OHS, but their comparative effectiveness remains unclear. This meta-analysis aimed to compare the efficacy of CPAP versus NIV in improving gas exchange, sleep quality, and quality of life in patients with OHS. Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted from 2013 to 2024 to identify randomized controlled trials (RCTs) comparing CPAP and NIV in adults with OHS. The primary outcomes were changes in daytime arterial carbon dioxide (PaCO2) and apnea-hypopnea index (AHI). Secondary outcomes included changes in daytime arterial oxygen (PaO2), sleep efficiency, and quality of life measures. Data were pooled using a random-effects model, and the standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated. Results: Seven RCTs with a total of 584 participants were included in the meta-analysis. Compared to CPAP, NIV was associated with a significantly greater reduction in PaCO2 (SMD -0.45; 95% CI -0.88 to -0.02; p=0.04) and AHI (SMD -0.61; 95% CI -1.17 to -0.05; p=0.03). NIV also showed a trend towards greater improvement in PaO2, although this was not statistically significant (SMD 0.32; 95% CI -0.06 to 0.70; p=0.10). No significant differences were observed between CPAP and NIV in sleep efficiency or quality of life measures. Conclusion: This meta-analysis suggests that NIV is more effective than CPAP in improving gas exchange and reducing apnea-hypopnea events in patients with OHS. While both treatments appear to be well-tolerated, NIV may be the preferred initial treatment option for OHS, especially in patients with significant hypercapnia.

Anthrax: Deadly Bioterrorism Threat and Prevention Challenges in Indonesia Serly, Vicennia; Sabri, Yessy Susanty
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50301

Anthrax is a disease caused by the bacterium Bacillus anthracis. The disease can be a threat to bioterrorism because it causes a high mortality rate and is easy to spread. The characteristics of sport anthrax are resistance to extreme environmental conditions. Furthermore, the Vegetative form of anthrax bacteria can form biofilms. This characteristic causes the bacteria to become a potential biological weapon agent because it is persistent and resistant to some antimicrobial agents. Antibiotic therapy is still considered the main treatment choice for anthrax disease. Antibiotic recommendations vary depending on the location, severity of the disease, and level of antimicrobial sensitivity that should be tested through bacterial culture. Anthrax prevention and control procedures in Indonesia are still limited in monitoring the entry of animals from anthrax-free areas and administering vaccines to animals in endemic or enzootic areas. The high rate of death, illness, and economic burden due to anthrax outbreaks requires health workers to increase medical vigilance against clinical anthrax. Early detection efforts and policy-making to prevent the spread of anthrax, especially against the possibility of its use as bioterrorism, should be a concern

Cystic Fibrosis Lung Disease: A Narrative Literature Review Putra, Rizki Amrika; Masrul Basyar; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.967

Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cystic fibrosis transmembrane conductance regulator (CFTR) which is located on chromosome seven. The CFTR protein under normal conditions acts as a chloride channel and helps the movement of sufficient electrolytes and water across the membrane. Mutations in CFTR cause abnormalities in chloride ion transport through epithelial cells and impaired sodium and water transport resulting in viscous secretions with low water content. This thick and sticky secretion will inhibit the normal function of various organs, although pulmonary complications are the most common cause of death. Cystic fibrosis has wide genotypic and phenotypic variations. There are six categories of mutations based on their effect on the CFTR protein, where these categories are not only used to predict the phenotype but also to determine better therapeutic strategies based on the identified mutations.

Analysis of Bioterrorism Studies on Lung Health: A Meta-Analysis Nutari, Hasbi; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1083

Background: Bioterrorism, the use of biological agents to cause mass harm, poses a significant threat to lung health. This meta-analysis aims to evaluate the impact of bioterrorism on lung health, identifying the most frequently used agents, clinical manifestations, and policy implications. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases from 2018 to 2024. Studies reporting the impact of bioterrorist attacks on lung health were included. Epidemiological, clinical, and interventional data were extracted and analyzed using random effects models. Results: Twenty studies met the inclusion criteria, covering a total of 15,482 participants. The most common bioterrorism agent was Bacillus anthracis (43.5%), followed by Yersinia pestis (21.7%) and Francisella tularensis (17.4%). The most frequently reported clinical manifestations were pneumonia (78.3%), acute respiratory failure (39.1%), and sepsis (26.1%). Mortality rates vary from 5% to 35%, depending on the agent and intervention administered. Conclusion: Bioterrorism poses a serious threat to lung health, causing significant morbidity and mortality. Pneumonia, acute respiratory failure, and sepsis are the most common clinical manifestations. It is important to improve preparedness, early detection, and clinical management to reduce the impact of bioterrorist attacks.

Cystic Fibrosis Lung Disease: A Narrative Literature Review Putra, Rizki Amrika; Masrul Basyar; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.967

Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cystic fibrosis transmembrane conductance regulator (CFTR) which is located on chromosome seven. The CFTR protein under normal conditions acts as a chloride channel and helps the movement of sufficient electrolytes and water across the membrane. Mutations in CFTR cause abnormalities in chloride ion transport through epithelial cells and impaired sodium and water transport resulting in viscous secretions with low water content. This thick and sticky secretion will inhibit the normal function of various organs, although pulmonary complications are the most common cause of death. Cystic fibrosis has wide genotypic and phenotypic variations. There are six categories of mutations based on their effect on the CFTR protein, where these categories are not only used to predict the phenotype but also to determine better therapeutic strategies based on the identified mutations.

Analysis of Bioterrorism Studies on Lung Health: A Meta-Analysis Nutari, Hasbi; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1083

Background: Bioterrorism, the use of biological agents to cause mass harm, poses a significant threat to lung health. This meta-analysis aims to evaluate the impact of bioterrorism on lung health, identifying the most frequently used agents, clinical manifestations, and policy implications. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases from 2018 to 2024. Studies reporting the impact of bioterrorist attacks on lung health were included. Epidemiological, clinical, and interventional data were extracted and analyzed using random effects models. Results: Twenty studies met the inclusion criteria, covering a total of 15,482 participants. The most common bioterrorism agent was Bacillus anthracis (43.5%), followed by Yersinia pestis (21.7%) and Francisella tularensis (17.4%). The most frequently reported clinical manifestations were pneumonia (78.3%), acute respiratory failure (39.1%), and sepsis (26.1%). Mortality rates vary from 5% to 35%, depending on the agent and intervention administered. Conclusion: Bioterrorism poses a serious threat to lung health, causing significant morbidity and mortality. Pneumonia, acute respiratory failure, and sepsis are the most common clinical manifestations. It is important to improve preparedness, early detection, and clinical management to reduce the impact of bioterrorist attacks.

Meta-Analysis of Effective Management Strategies for Malignant Central Airway Obstruction Putri, Septriana; Yessy Susanty Sabri; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1108

Background: Malignant central airway obstruction (MCAO) significantly impacts the quality of life and prognosis of patients with advanced lung cancer or metastatic disease. This meta-analysis aims to evaluate the effectiveness and safety of various management strategies for MCAO. Methods: A systematic search of PubMed, Embase, and Cochrane databases from 2018 to 2024 was conducted to identify randomized controlled trials (RCTs) and observational studies comparing different MCAO management approaches. Primary outcomes included improvement in airway patency, dyspnea scores, and survival. Secondary outcomes included procedural complications and quality-of-life measures. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: A total of 25 studies (15 RCTs, 10 observational studies), encompassing 3456 patients, were included in the meta-analysis. Interventions assessed were rigid bronchoscopy with various modalities (e.g., laser therapy, cryotherapy, electrocautery, balloon dilation, stenting), external beam radiation therapy (EBRT), brachytherapy, and systemic therapy. Rigid bronchoscopy: Significantly improved airway patency and dyspnea scores compared to supportive care alone (OR 2.86, 95% CI 1.95-4.18; p<0.001). Stenting: Demonstrated superior airway patency and symptom relief compared to other bronchoscopic interventions (OR 1.73, 95% CI 1.21-2.48; p=0.003). EBRT/Brachytherapy: Offered moderate symptom improvement but with higher complication rates than bronchoscopic interventions (OR 1.39, 95% CI 1.05-1.85; p=0.021). Systemic therapy (chemotherapy/immunotherapy): Provided limited benefit in terms of airway patency but may impact overall survival in specific tumor types. Conclusion: Rigid bronchoscopy, particularly with stenting, is the most effective initial management strategy for MCAO, providing rapid symptom relief and airway recanalization. EBRT/brachytherapy can be considered as adjuncts or alternatives in select cases. Further research is needed to determine the optimal combination and sequencing of therapies for different tumor types and stages.

Does Long-Term Oxygen Therapy Reduce Exacerbations in Chronic Obstructive Pulmonary Disease? A Meta-Analysis Rizki, Fitri Amelia; Yessy Susanty Sabri; Afriani, Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1150

Background: Chronic obstructive pulmonary disease (COPD) exacerbations contribute significantly to morbidity, mortality, and healthcare costs. While long-term oxygen therapy (LTOT) is a standard treatment for severe resting hypoxemia in COPD, its impact on exacerbations remains unclear. This meta-analysis aimed to evaluate the effect of LTOT on the frequency and severity of COPD exacerbations. Methods: A systematic search of PubMed, Embase, and Cochrane Library was conducted (January 2018 to December 2023) for randomized controlled trials (RCTs) comparing LTOT to no LTOT in COPD patients. The primary outcome was the rate of moderate to severe COPD exacerbations. Secondary outcomes included hospitalization due to exacerbations and all-cause mortality. The risk of bias was assessed using the Cochrane Risk of Bias tool. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs with 2,949 participants were included. LTOT was associated with a statistically significant reduction in the rate of moderate to severe exacerbations (Rate Ratio [RR] 0.72; 95% Confidence Interval [CI] 0.67 to 0.78; p < 0.000001), representing an estimated 28% reduction. LTOT also significantly reduced hospitalization for exacerbations (RR 0.69; 95% CI 0.61 to 0.79; p < 0.000001) and all-cause mortality (RR 0.71; 95% CI 0.57 to 0.89; p = 0.003). Conclusion: LTOT significantly reduces the frequency of moderate to severe COPD exacerbations, related hospitalizations, and all-cause mortality. These findings support LTOT use in eligible COPD patients to improve clinical outcomes.

Quantifying the Pulmonary Risks of Volcanic Gas Inhalation: A Meta-Analysis Putri, Septriana; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1185

Background: Volcanic eruptions release a complex mixture of gases and particulate matter, posing significant respiratory health risks. This meta-analysis aims to quantify the association between volcanic gas inhalation and adverse pulmonary effects. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted for studies published between 2013 and 2024 investigating the respiratory effects of volcanic gas exposure. Studies reporting quantitative data on lung function, respiratory symptoms, or disease prevalence were included. Random-effect models were used to pool effect estimates, and heterogeneity was assessed using the I² statistic. Results: Six studies (n = 2,215 participants) met the inclusion criteria. Volcanic gas exposure was associated with a significant decrease in FEV1 (forced expiratory volume in 1 second) (standardized mean difference [SMD] = -0.55, 95% CI: -0.67 to -0.42, I² = 51%), increased prevalence of asthma (odds ratio [OR] = 3.31, 95% CI: 1.84 to 5.96, I² = 76%), and chronic bronchitis (OR = 2.86, 95% CI: 1.97 to 4.15, I² =0%). Subgroup analysis revealed a stronger association between gas exposure and respiratory effects in children and individuals with pre-existing lung conditions. Conclusion: This meta-analysis provides compelling evidence that volcanic gas inhalation is detrimental to respiratory health. Public health interventions should prioritize vulnerable populations during and after volcanic eruptions.

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