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Evaluation of the rationality of drugs use inpatient patients with type 2 diabetes mellitus of 2023 at Hospital Y Depok Khairani, Sondang; Manninda, Reise; Wijayanti, Bitya Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1694

Diabetes mellitus is a chronic disease caused by failure to control blood glucose levels. Type 2 Diabetes Mellitus (T2DM) is a condition of hyperglycemia caused by the failure of insulin to maintain balanced blood sugar levels. If T2DM is not treated it will cause complications. One way to control T2DM is the rational use of antidiabetic drugs. This study aims to look at the demographic data of inpatients with T2DM, patterns of drug use, rationality for drug use, and the relationship between the rationality of drug use and therapeutic outcomes in inpatients with T2DM at Hospital Y Depok for the period 2023. The outcome evaluated is a random blood sugar test. The research method was carried out descriptively and inferentially with a cross-sectional design. There were 122 samples that met the inclusion criteria, women predominantly suffered from type 2 diabetes mellitus (50.89%). The most common age range was 46-65 years (64.56%). As many as 84.31% of patients used the JKN payment method. The most widely used class of type 2 diabetes mellitus medication is insulin. In evaluating the rationality of using type 2 diabetes mellitus drugs, the rationality results were 99.49% correct drug, 100% correct dose, and 98.73% correct administration. The results of statistical tests show that there is a correlation between the rationality of drug use and clinical outcomes p-value 0.001.

Compliance of Outpatient Prescriptions with National Pharmaceutical Standards: A Cross-Sectional Study at Military Hospital in Jakarta Sondang Khairani; Wanda Ditan Arvandi; Safira Nafisa; Desi Nadya Aulena
Indonesian Journal of Administrative and Clinical Pharmacy Vol. 2 No. 1 (2025): IJAClinPharm June In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar

Hospital pharmaceutical services play a crucial role in ensuring the quality of patient care, particularly through prescription screening, which includes administrative and pharmaceutical aspects. This study aimed to evaluate the completeness of BPJS outpatient prescriptions at one of military hospital in Jakartabased on national standards. A retrospective descriptive study was conducted on 367 prescriptions from February to April 2023, selected using simple random sampling. Data were analyzed using descriptive statistics. The results showed full completeness (100%) for patient name, medical record number, diagnosis, physician name, and prescription date in the administrative section. However, gender (6.3%) and physician license number (2.7%) were often missing. For the pharmaceutical section, all indicators were complete except for strength (98.9%), dosage form (99.7%), duration (99.7%), and stability (0%). In conclusion, the pharmaceutical elements of prescriptions mostly complied with national standards, but administrative completeness remains a concern and needs system-level improvements.

Study of The In Vivo Anti-Inflammatory, Antipyretic and Analgesic Effect of The Ethanol Extract Indian Nettle Plant (Acalypha indica Linn) Khairani, Sondang; Ros Sumarny; Yurista Elystra
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6506

The body can experience fever and pain, when inflammation occurs. Indian nettle plant (Acalypha Indica Linn.) are known to contain flavonoid compounds which are thought to have anti-inflammatory, antipyretic, and analgesic effect. This study aims to test the anti-inflammatory, antipyretic, and analgesic effect of the ethanol extract of 70% Indian Nettle plant. Method each test used 5 groups, negative control all given Na CMC 0,5%. Antiinflammatory use rats with Winter method, aspirin 40,43mg/200gBB, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III), antipyretics use rats with Brewer's yeast method, aspirin 21,45mg/200gBW, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III). Analgesic use mice with the Siegmund method, aspirin 3,10mg/20gBB, the test group dose of 10mg/20gBB (I); 20mg/20gBB (II); 40mg/20g BW (III). Results Kruskall Wallis test, the anti-inflammatory effect significant difference to negative control, p value <0,05. Percentage of inhibition positive control edema and test dosage I, II, and III obtained 34,44%; 18,88%; 21,37%, and 29,61%. The Mann Whitney test, the antipretic and analgesic effects significant difference to the negative control, p value <0,05. The decreased percentage of fever in positive control and dosage I, II, and III test preparations was 3,74%; 2,60%; 2,55%; 3,01%. Inhibition percentage of stretching positive control and test dosage I, II, and III obtained 41,05%; 24,46%; 27,78%; and 33,31%. Conclussion: Wriggling inhibition (analgesic) had the highest presentation dose III 33,31% compare to anti-inflammatory and antipyretic activities, lower than aspirin as positive control 41,05% (p<0,05).

Anti-Inflammatory and Analgesic Effect from Decoction of Itchy Leaves (Laportea decumana (Roxb.) Wedd.) Khairani, Sondang; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7371

Itchy leaves have the ability as analgesics, anti-inflammatory, asthma, antimalaria and antihypertension. Empirically in Maluku and Papua, itchy leaves are used topically to treat pain and inflammation. This study aims to examine the antiinflammatory and analgetic effects orally of an Itchy leaves decoction. Anti-inflammatory testing using the Winter method, rats were divided 5 groups negative control given aquadest, positive control given sodium diclofenac 1.8 mg/200 g BW rats, the test group given an infusion of itchy leaves dose 0.3 g/Kg BW (I), 0.6 g/Kg BW (I) and 1.2 g/Kg BW (III). Analgesics testing using Siegmund method, mice were divided 5 groups, negative control given aquadest, positive control given sodium diclofenac 0.26 mg/20 g BW mice, the test group given decoction of itchy leaves dose 0.4 g/Kg BW (I), 0.8 g/Kg BW (II) and 1.6 g/Kg BW (III). Results of Mann-whitney test, infusion of itchy leaves had a significant anti-inflammatory and analgesic effect on the negative control group, p value <0.05. Precentage of positive control edema inhibition and the test group dosage I, II, III was obtained by 27.94%; 15.97%; 25.89%; and 26.86%, percentage inhibition of positive control and the test group dosage I, II, III was obtained by 59.42%; 43.93%; 45.70% and 80.22%. Itchy leaves decoction has a lower anti-inflammatory effect than diclofenac sodium. The analgesics effect of decoction of Itchy leaves at doses of 0.4 g/Kg BW and 0.8 g/Kg BW was lower, dose of 1.6 g/Kg BW was higher than diclofenac sodium.

Evaluasi Penggunaan Antibiotik dengan Metode Kuantitatif pada Pasien Pneumonia Rawat Inap di Rumah Sakit Nusa Tenggara Barat Khairani, Sondang; Ramadaniati, Hesty Utami; Sarnianto, Prih; Kristin, Erna; Anggriani, Yusi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1449

Abstract Overuse of antibiotics is a public health challenge that can lead to antimicrobial resistance. To reduce the occurrence of antibiotic resistance, it is necessary to evaluate the use of antibiotics to determine the rational use of drugs using quantitative methods, namely the ATC /DD method. The purpose of the study was to determine the use of antibiotics and describe the pattern of antibiotic use in inpatients at West Nusa Tenggara Hospital using the ATC /DD method and DU90%. The research method is a cross-sectional study design with retrospective data collection on adult pneumonia patients hospitalized in the period Januari-December 2019 and 2022, data obtained from medical records. The results of the study met the inclusion criteria of 218 patients with the majority being male 117 (53.67%) and the most age > 65, namely 66 (30.28%). Antibiotic use has a total DDD value of 185.56 DDD/100 days of care with the highest antibiotic DDD value being ceftriaxone which is 104.00 DDD/100 days of hospitalization while antibiotics that are included in the DU 90% are ceftriaxone, levofloxacin, cefoperazon and meropenem. Conclusion the most antibiotics used were ceftriaxone 104.00 DDD/100 days of length of stay.

Evaluation of Drug Interactions in Polypharmacy: A Case Study of Patients with Heart Failure Hospitalized at Tangerang District Hospital Khairani, Sondang; Manninda, Reise Reise Manninda; Ariani, Lusiana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0010033

Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's metabolic needs. It is a clinical syndrome with signs and symptoms caused by abnormalities in the structure and/or function of the heart. Heart failure occurs when the heart can't pump enough blood to meet the body's needs. It is caused by problems with the structure or function of the heart. This can lead to polypharmacy, where several medications are often taken by patients with heart failure to manage their condition. This study aims to identify patient characteristics, treatment accuracy based on Indonesian Heart Association (PERKI) 2023 guidelines, and the relationship between drug interactions and polypharmacy in adult patients diagnosed with heart failure with or without comorbidities at Tangerang Regency Hospital in 2023. The research was conducted descriptively using a cross-sectional study design. A total of 78 samples specimens met the inclusion criteria, with a male majority of 37 (52.86%) patients. The most common age group was 56-65 years old with 25 (35.71%) patients. The most common length of stay was 1-5 days with 48 (68.57%) patients. Evaluation of the treatment accuracy showed that the appropriate drug class was achieved in 78 (100%) patients, the appropriate dose in 55 (70.51%) patients and the appropriate frequency in 45 (57.69%) patients. Statistical tests showed a correlation between polypharmacy and drug-drug interactions with p-value 0.05. Accordingly, it is important to enhance monitoring and assessment of drug interactions in heart failure patients to optimize treatment management and prevent the risk of complications

Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Frimayanti, Neni; Peng-Wei, Ching; Khairani, Sondang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine, showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.

Evaluation of the rationality of drugs use inpatient patients with type 2 diabetes mellitus of 2023 at Hospital Y Depok Khairani, Sondang; Manninda, Reise; Wijayanti, Bitya Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1694

Diabetes mellitus is a chronic disease caused by failure to control blood glucose levels. Type 2 Diabetes Mellitus (T2DM) is a condition of hyperglycemia caused by the failure of insulin to maintain balanced blood sugar levels. If T2DM is not treated it will cause complications. One way to control T2DM is the rational use of antidiabetic drugs. This study aims to look at the demographic data of inpatients with T2DM, patterns of drug use, rationality for drug use, and the relationship between the rationality of drug use and therapeutic outcomes in inpatients with T2DM at Hospital Y Depok for the period 2023. The outcome evaluated is a random blood sugar test. The research method was carried out descriptively and inferentially with a cross-sectional design. There were 122 samples that met the inclusion criteria, women predominantly suffered from type 2 diabetes mellitus (50.89%). The most common age range was 46-65 years (64.56%). As many as 84.31% of patients used the JKN payment method. The most widely used class of type 2 diabetes mellitus medication is insulin. In evaluating the rationality of using type 2 diabetes mellitus drugs, the rationality results were 99.49% correct drug, 100% correct dose, and 98.73% correct administration. The results of statistical tests show that there is a correlation between the rationality of drug use and clinical outcomes p-value 0.001.

Analysis of Antibiotic Therapy Accuracy and Drug Interaction in Pneumonia Inpatients at The Islamic Hospital Jakarta Cempaka Putih Khairani, Sondang; Manninda, Reise; Ariani, Lusiana; Iskandar, Benni; Hidayati, Nabila Nur
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404456

Polypharmacy may increase the risk of drug interactions affecting toxicity and therapeutic efficacy in pneumonia patients. This study aimed to analyse evaluation of pneumonia management, polypharmacy, relationship between polypharmacy and occurrence of drug-drug interactions, and relationship between drug-drug interactions and length of hospital stay of pneumonia patients. The study design used a quantitative descriptive approach with cross-sectional and retrospective data collection and a total sample of 113 samples that met the criteria. Analyses were performed using Spearman's rho correlation test to assess the association of polypharmacy with drug interactions, and the association of drug interactions with length of hospital stay. Medication accuracy was measured using PDPI (The Indonesian Lung Doctors Assosiaciation) guidelines, drug interactions using drugs.com and/or Medscape.com. Results showed 59.29% of patients were female, with the majority aged over 65 (55.65%). Most patients (91.15%) paid with BPJS, 62.61% were hospitalised for 1-5 days and 81.74% had comorbidities. Treatment accuracy in this study was 49.56%. 106 drug interactions were identified in a total of 226 cases. 66% of the interactions were pharmacodynamic with moderate severity (79%), such as the interaction between combivent and ondansetron. Mild pharmacokinetic interactions were common, especially between ranitidine and paracetamol (22 cases). There is a correlation between polypharmacy and drug interactions with a p-value 0.000 and there is a correlation between the number of drug interactions and length of hospitalisation with p-value 0.000. Conclusion of this study is polypharmacy increases the risk of drug interactions and affects the length of hospital stay in pneumonia patients.

Analysis of the Rationality of Antibiotic Use in Pediatric Bronchopneumonia Patients and its Impact on Clinical Outcomes and Costs at RS Columbia Asia Pulomas Jakarta Period April 2024–April 2025 Yuwono, Wahyu Agung; Khairani, Sondang; Lizikri, Assajadda; Sandhiutami, Ni Made Dwi
Enrichment: Journal of Multidisciplinary Research and Development Vol. 3 No. 11 (2026): Enrichment: Journal of Multidisciplinary Research and Development
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/enrichment.v3i11.612

Bronchopneumonia is one of the leading causes of morbidity and mortality in the pediatric population, especially in developing countries such as Indonesia. This condition also imposes a considerable economic burden due to the long duration of treatment and the frequent use of antibiotics, which are often inappropriate. This study aimed to evaluate the rationality of antibiotic administration in pediatric patients hospitalized with a diagnosis of bronchopneumonia at Columbia Asia Pulomas Hospital Jakarta during the period from April 2024 to April 2025, and to analyze its effect on clinical outcomes and treatment costs. This study used a retrospective cross-sectional design with a total sampling approach of 164 patients through a review of medical records and cost data. The rationality of antibiotic therapy was assessed using the Gyssens method, and the relationship between variables was analyzed using bivariate statistical tests. The study found that 71.9% of rational antibiotic use correlated with a higher clinical improvement rate of 80.5% compared to 52.2% for irrational antibiotic use (p = 0.000). However, there was no significant difference in the duration of hospitalization between rational antibiotic use (4.70 ± 0.82 days) and irrational antibiotic use (5.41 ± 2.25 days) (p = 0.612), nor in the total cost of hospitalization (rational use: Rp 15,956,032.66 ± Rp 5,568,892.10 vs. irrational use: Rp 18,801,283.94 ± Rp 11,292,810.87) (p = 0.658). These results emphasize the importance of antibiotic rationality analysis as an effort to improve clinical outcomes without having a significant impact on cost efficiency or treatment duration.

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