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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy
S.Farm., M.Farm., Apt, Sondang Khairani
Fakultas Farmasi Unniversitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Anti-Inflammatory and Analgesic Effect: an Experimental Study of Purple Leaves (Graptophyllum pictum (L.) Griff) Decoction Sondang Khairani; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8421

Abstract

Purple leaves (Graptophyllum pictum (L.) Griff) are known to contain flavonoid compounds as anti-inflammatory and analgesic properties. This study aims to obtain the efficacy of purple leaf decoction as anti-inflammatory and analgesic. The anti-inflammatory study used the Winter method with Sprague Dawley rat test, were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 8.0208 mg/200g BW, and 3 groups of decoction with doses of 5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW. Anti-inflammatory testing was carried out by measuring the decrease in the volume of edema on the soles of the rat's feet. Analgesic testing using the Siegmund method with Deutche Denken Yoken mice. The mice were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 1.1586 mg/20g BW, and 3 groups of decoction with doses of 1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW. The analgesic study was carried out by calculating the decrease in the number of writhing mice. The results of the percentage of anti-inflammatory effectiveness of purple leaf decoction doses (5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW) were 51.77%, 68.77% and 79.46%, respectively. The results of the percentage of analgesic effectiveness of purple leaf decoction doses (1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW) were 54.03%, 71.62% and 79.73%, respectively. Based on the test results, it can be concluded that purple leaf decoction has an anti-inflammatory and analgesic effect.
Evaluation of the rationality of drugs use inpatient patients with type 2 diabetes mellitus of 2023 at Hospital Y Depok Khairani, Sondang; Manninda, Reise; Wijayanti, Bitya Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1694

Abstract

Diabetes mellitus is a chronic disease caused by failure to control blood glucose levels. Type 2 Diabetes Mellitus (T2DM) is a condition of hyperglycemia caused by the failure of insulin to maintain balanced blood sugar levels. If T2DM is not treated it will cause complications. One way to control T2DM is the rational use of antidiabetic drugs. This study aims to look at the demographic data of inpatients with T2DM, patterns of drug use, rationality for drug use, and the relationship between the rationality of drug use and therapeutic outcomes in inpatients with T2DM at Hospital Y Depok for the period 2023. The outcome evaluated is a random blood sugar test. The research method was carried out descriptively and inferentially with a cross-sectional design. There were 122 samples that met the inclusion criteria, women predominantly suffered from type 2 diabetes mellitus (50.89%). The most common age range was 46-65 years (64.56%). As many as 84.31% of patients used the JKN payment method. The most widely used class of type 2 diabetes mellitus medication is insulin. In evaluating the rationality of using type 2 diabetes mellitus drugs, the rationality results were 99.49% correct drug, 100% correct dose, and 98.73% correct administration. The results of statistical tests show that there is a correlation between the rationality of drug use and clinical outcomes p-value 0.001.
Compliance of Outpatient Prescriptions with National Pharmaceutical Standards: A Cross-Sectional Study at Military Hospital in Jakarta Sondang Khairani; Wanda Ditan Arvandi; Safira Nafisa; Desi Nadya Aulena
Indonesian Journal of Administrative and Clinical Pharmacy Vol. 2 No. 1 (2025): IJAClinPharm June In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hospital pharmaceutical services play a crucial role in ensuring the quality of patient care, particularly through prescription screening, which includes administrative and pharmaceutical aspects. This study aimed to evaluate the completeness of BPJS outpatient prescriptions at one of military hospital in Jakartabased on national standards. A retrospective descriptive study was conducted on 367 prescriptions from February to April 2023, selected using simple random sampling. Data were analyzed using descriptive statistics. The results showed full completeness (100%) for patient name, medical record number, diagnosis, physician name, and prescription date in the administrative section. However, gender (6.3%) and physician license number (2.7%) were often missing. For the pharmaceutical section, all indicators were complete except for strength (98.9%), dosage form (99.7%), duration (99.7%), and stability (0%). In conclusion, the pharmaceutical elements of prescriptions mostly complied with national standards, but administrative completeness remains a concern and needs system-level improvements.
Study of The In Vivo Anti-Inflammatory, Antipyretic and Analgesic Effect of The Ethanol Extract Indian Nettle Plant (Acalypha indica Linn) Khairani, Sondang; Ros Sumarny; Yurista Elystra
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6506

Abstract

The body can experience fever and pain, when inflammation occurs. Indian nettle plant (Acalypha Indica Linn.) are known to contain flavonoid compounds which are thought to have anti-inflammatory, antipyretic, and analgesic effect. This study aims to test the anti-inflammatory, antipyretic, and analgesic effect of the ethanol extract of 70% Indian Nettle plant. Method each test used 5 groups, negative control all given Na CMC 0,5%. Antiinflammatory use rats with Winter method, aspirin 40,43mg/200gBB, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III), antipyretics use rats with Brewer's yeast method, aspirin 21,45mg/200gBW, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III). Analgesic use mice with the Siegmund method, aspirin 3,10mg/20gBB, the test group dose of 10mg/20gBB (I); 20mg/20gBB (II); 40mg/20g BW (III). Results Kruskall Wallis test, the anti-inflammatory effect significant difference to negative control, p value <0,05. Percentage of inhibition positive control edema and test dosage I, II, and III obtained 34,44%; 18,88%; 21,37%, and 29,61%. The Mann Whitney test, the antipretic and analgesic effects significant difference to the negative control, p value <0,05. The decreased percentage of fever in positive control and dosage I, II, and III test preparations was 3,74%; 2,60%; 2,55%; 3,01%. Inhibition percentage of stretching positive control and test dosage I, II, and III obtained 41,05%; 24,46%; 27,78%; and 33,31%. Conclussion: Wriggling inhibition (analgesic) had the highest presentation dose III 33,31% compare to anti-inflammatory and antipyretic activities, lower than aspirin as positive control 41,05% (p<0,05).
Anti-Inflammatory and Analgesic Effect from Decoction of Itchy Leaves (Laportea decumana (Roxb.) Wedd.) Khairani, Sondang; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7371

Abstract

Itchy leaves have the ability as analgesics, anti-inflammatory, asthma, antimalaria and antihypertension. Empirically in Maluku and Papua, itchy leaves are used topically to treat pain and inflammation. This study aims to examine the antiinflammatory and analgetic effects orally of an Itchy leaves decoction. Anti-inflammatory testing using the Winter method, rats were divided 5 groups negative control given aquadest, positive control given sodium diclofenac 1.8 mg/200 g BW rats, the test group given an infusion of itchy leaves dose 0.3 g/Kg BW (I), 0.6 g/Kg BW (I) and 1.2 g/Kg BW (III). Analgesics testing using Siegmund method, mice were divided 5 groups, negative control given aquadest, positive control given sodium diclofenac 0.26 mg/20 g BW mice, the test group given decoction of itchy leaves dose 0.4 g/Kg BW (I), 0.8 g/Kg BW (II) and 1.6 g/Kg BW (III). Results of Mann-whitney test, infusion of itchy leaves had a significant anti-inflammatory and analgesic effect on the negative control group, p value <0.05. Precentage of positive control edema inhibition and the test group dosage I, II, III was obtained by 27.94%; 15.97%; 25.89%; and 26.86%, percentage inhibition of positive control and the test group dosage I, II, III was obtained by 59.42%; 43.93%; 45.70% and 80.22%. Itchy leaves decoction has a lower anti-inflammatory effect than diclofenac sodium. The analgesics effect of decoction of Itchy leaves at doses of 0.4 g/Kg BW and 0.8 g/Kg BW was lower, dose of 1.6 g/Kg BW was higher than diclofenac sodium.
Evaluasi Penggunaan Antibiotik dengan Metode Kuantitatif pada Pasien Pneumonia Rawat Inap di Rumah Sakit Nusa Tenggara Barat Khairani, Sondang; Ramadaniati, Hesty Utami; Sarnianto, Prih; Kristin, Erna; Anggriani, Yusi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1449

Abstract

Abstract Overuse of antibiotics is a public health challenge that can lead to antimicrobial resistance. To reduce the occurrence of antibiotic resistance, it is necessary to evaluate the use of antibiotics to determine the rational use of drugs using quantitative methods, namely the ATC /DD method. The purpose of the study was to determine the use of antibiotics and describe the pattern of antibiotic use in inpatients at West Nusa Tenggara Hospital using the ATC /DD method and DU90%. The research method is a cross-sectional study design with retrospective data collection on adult pneumonia patients hospitalized in the period Januari-December 2019 and 2022, data obtained from medical records. The results of the study met the inclusion criteria of 218 patients with the majority being male 117 (53.67%) and the most age > 65, namely 66 (30.28%). Antibiotic use has a total DDD value of 185.56 DDD/100 days of care with the highest antibiotic DDD value being ceftriaxone which is 104.00 DDD/100 days of hospitalization while antibiotics that are included in the DU 90% are ceftriaxone, levofloxacin, cefoperazon and meropenem. Conclusion the most antibiotics used were ceftriaxone 104.00 DDD/100 days of length of stay.
Quality and Potency of Government-subsidized Antibiotics in Hospitals Across Jakarta, Indonesia Khairani, Sondang; Ramadaniati, Hesty Utami; Sarnianto, Prih; Kristin, Erna; Anggriani, Yusi
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301198

Abstract

Several pharmaceutical companies have long complained that the price of medicines that win the e-catalogue tender is too low, in some cases even below the cost of production. However, it should not be a concern that only pharmaceutical products with regulation of Indonesian food and drug (BPOM) distribution licenses are eligible for the price tender, as they are of good quality. This study aims to determine the quality and potency of three antibiotic drugs based on their highest utilization (DU 90%) in pneumonia patients at two hospitals, A (ceftriaxone, azithromycin tablet) and B (ceftriaxone, levofloxacin infusion) compared to brand name. The quality of the samples was evaluated following the Indonesian Pharmacopoeia 6th Edition (FI-VI). Antibiotic potency was assessed using the Plate-Cylinder Method with K. pneumonia from human and S. pneumonia ATCC 10015 as the test bacteria evaluated following CLSI. All samples meet the criteria of FI-VI antibiotic content, weight uniformity, dissolution. Antibiotic potency all samples test S.pneumonia and K.pneumonia were sensitive but ceftriaxone test with K.pneumonia was resistance. All antibiotic tablets and injections studied met the requirements of the Indonesian Pharmacopoeia Edition 6 for active medicinal ingredient content, dosage weight uniformity, and dissolution. All drugs from hospitals (INN) have lower antibiotic potency than branded drugs. This highlight the importance of conducting microbiological testing on antibiotic preparations.
Evaluation of Drug Interactions in Polypharmacy: A Case Study of Patients with Heart Failure Hospitalized at Tangerang District Hospital Khairani, Sondang; Manninda, Reise Reise Manninda; Ariani, Lusiana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0010033

Abstract

Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's metabolic needs. It is a clinical syndrome with signs and symptoms caused by abnormalities in the structure and/or function of the heart. Heart failure occurs when the heart can't pump enough blood to meet the body's needs. It is caused by problems with the structure or function of the heart. This can lead to polypharmacy, where several medications are often taken by patients with heart failure to manage their condition. This study aims to identify patient characteristics, treatment accuracy based on Indonesian Heart Association (PERKI) 2023 guidelines, and the relationship between drug interactions and polypharmacy in adult patients diagnosed with heart failure with or without comorbidities at Tangerang Regency Hospital in 2023. The research was conducted descriptively using a cross-sectional study design. A total of 78 samples specimens met the inclusion criteria, with a male majority of 37 (52.86%) patients. The most common age group was 56-65 years old with 25 (35.71%) patients. The most common length of stay was 1-5 days with 48 (68.57%) patients. Evaluation of the treatment accuracy showed that the appropriate drug class was achieved in 78 (100%) patients, the appropriate dose in 55 (70.51%) patients and the appropriate frequency in 45 (57.69%) patients. Statistical tests showed a correlation between polypharmacy and drug-drug interactions with p-value 0.05. Accordingly, it is important to enhance monitoring and assessment of drug interactions in heart failure patients to optimize treatment management and prevent the risk of complications
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Frimayanti, Neni; Peng-Wei, Ching; Khairani, Sondang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine, showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Co-Authors Anggriani, Yusi Anita Rahmi Pradani Antasya, Vaylia Ariani, Lusiana BENNI ISKANDAR Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Ika Permata Sari Ira Ningtiyas Purpranoto Isti Atika Ita Rahmawati Kurnia, Mala Lestari Rahayu Manninda, Reise Reise Manninda Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Nasution, Musyirna Rahmah Neni Frimayanti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Peng-Wei, Ching Raharjo, Lalu Joko Ramadaniati, Hesty Utami Reise Manninda Rika Sari Dewi RIKA SARI DEWI Rina Rosdiana Ros Sumarny ROS SUMARNY Rulliani Bianca Wijaya Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sarnianto, Prih Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Zainur Rahman Hakim