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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy
S.Farm., M.Farm., Apt, Sondang Khairani
Fakultas Farmasi Unniversitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Efek Sari Buah Terong Belanda (Solanum betaceum Cav.) terhadap Perubahan Profil Lipid pada Mencit Dislipidemia Ni Made Dwi Sandhiutami; Sondang Khairani; Moordiani Moordiani; Ira Ningtiyas Purpranoto
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.10302

Abstract

Buah terong belanda (Solanum betaceum Cav.) mengandung antosianin, isoflavon, karotenoid, serat, vitamin-vitamin seperti vitamin E, vitamin A, vitamin C dan vitamin B6, banyak digunakan secara empiris untuk tekanan darah tinggi, aterosklerosis, membantu metabolisme, meningkatkan imunitas, sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui efek perubahan profil lipid dari pemberian sari buah terong belanda terhadap mencit dislipidemia. Pengujian efek perubahan profil lipid dilakukan dengan cara mengiduksi mencit dengan pemberian kuning telur, sukrosa dan lemak hewan sehingga mencit mengalami dislipidemia. Setelah 14 hari, penginduksian dihentikan dan dilanjutkan dengan pemberiaan sediaan uji setiap hari selama 7 hari (i) kontrol positif (atorvastatin dosis 2,6 mg/kgBB), sari buah terong belanda (ii) dosis 14 g/kgBB, (iii) dosis 21 g/kgBB dan (iv) dosis 28 g/kgBB, (v) kontrol normal dan (vi) kontrol negatif. Pemeriksaan kadar kolesterol total, trigliserida, LDL dan HDL pada darah mencit dilakukan dengan metode kalorimetri enzimatik pada hari ke-0, ke-14, dan ke-21. Sari buah terong belanda dosis 14, 21, 28 g/kgBB dapat menurunkan kadar kolesterol total dengan persentase penurunan secara berturut-turut sebesar 21,08; 25,50; dan 29,94%. menurunkan kadar trigliserida sebesar 20,28; 31,69; dan 38,54%; menurunkan kadar LDL sebesar 28,43; 28,76; dan 42,83%; dan meningkatkan kadar HDL sebesar 16,67; 17,50; 30,13%. Sari buah terong belanda dengan dosis 28 g/kgBB perhari efektif menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan kadar HDL mencit dislipidemia.
Faktor Resiko Penyebab Multidrug Resistant Tuberkulosis: Sistematik Review Mita Restinia; Sondang Khairani; Reise Manninda
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 1 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.775 KB) | DOI: 10.15408/pbsj.v3i1.20049

Abstract

Indonesia merupakan negara kedua dengan jumlah kasus tuberkulosis terbanyak di dunia. Pengobatan Tuberkulosis di Indonesia semakin sulit dengan munculnya Multidrug Resistant Tuberculosis (MDR-TB). Penelitian dilakukan untuk mengetahui faktor resiko yang menyebabkan terjadinya MDRT-TB di Indonesia. Sistematik review dilakukan terhadap artikel dengan studi case control. MDR-TB sebagai kelompok kasus dan Non MDR-TB sebagai kelompok kontrol. Artikel yang dipilih adalah artikel yang dipublikasikan pada tahun 2015-2020. Artikel dicari  melalui database google schoolar dan dianalisa menggunakan Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Terdapat 9 original artikel yang memenuhi kriteria inklusi untuk dianalisa. Faktor resiko terjadinya MDR-TB dibagi menjadi tiga kelompok yaitu karakteristik responden, Riwayat TB dan pengobatan, dan komorbiditas. Karakteristik responden yang signifikan mempengaruhi terjadinya MDR TB adalah dukungan keluarga, pengetahuan, usia, dan akses ke fasilitas kesehatan. Tidak patuh minum obat, adanya riwayat pengobatan TB, tidak aktif pengawas minum obat, efek samping obat dan adanya komorbiditas juga merupakan faktor resiko terjadinya MDR-TB.  Hasil yang diperoleh dapat disimpulkan bahwa identifikasi faktor resiko terjadinya MDR TB perlu dilakukan dengan baik. Selain itu, Pasien TB yang memiliki faktor resiko perlu diberikan edukasi yang lebih komprehensif dan pengawasan minum obat secara lebih ketat  untuk mencegah terjadinya MDR TB.
E-Health Literacy and Adherence to Health Protocols Among Self-Quarantined Patients with COVID-19 in a Sub-district in West Java Hesty Utami Ramadaniati; Sondang Khairani; Nurul Azizah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004176

Abstract

During the Coronavirus Disease-2019 (COVID-19) pandemic, valid information was crucial and electronic health literacy (EHL) plays a significant role in public adherence to health protocols. This study aimed to evaluate the pattern of COVID-19 information-seeking, and the association between EHL, COVID-19 knowledge, and health protocol adherence among patients with COVID-19 during self-quarantine. Data were collected through an online survey sent to self-quarantined COVID-19 patients during March – December 2020 in a sub-district in West Java. Spearman tests were used to evaluate the relationship between EHL with COVID-19 knowledge, and EHL with health protocol adherence. There were 56 respondents with more than half being female (58.9%), university graduates (64.3%) and having good health status level (57.1%). Social media were the commonest online sources. During self-isolation, the frequency of Internet use increased (i.e., every day) with information on vitamins and supplements as the most commonly searched. Respondents had high scores on EHL (mean= 20.0), knowledge (mean = 8.89/10, SD = 1.796), and adherence (mean = 26.98/30, SD = 3.066). This study found significant relationships between EHL and knowledge (p-value = 0.001, r = 0.436), and the adherence (p-value = 0.011, r = 0.339). In conclusion, EHL had a modest influence on COVID-19 knowledge and minor relationship with adherence to health protocols among self-quarantined patients with COVID-19.
INCREASING ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE AND DECREASING MALONDIALDEHYD LEVELS FROM Ethanol Extract of Radish (Raphanus Sativus L.) LEAVES IN SWIMMING MICE Sondang Khairani; Ni Made Dwi Sandhiutami; Ika Permata Sari
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i1.8261

Abstract

Daun lobak (Raphanus sativus L.) mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek antioksidan ekstrak etanol 70% daun lobak (Raphanus sativus L.) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Penelitian menggunakan mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal (I), kelompok kontrol negative (II), kelompok kontrol positif (III) (vitamin C 2,6 mg/20 gBB), dan 3 kelompok (IV,V,VI)dosis ekstrak etanol 70% daun lobak (Raphanus sativus L.) (5,6; 11,2; 22,4 mg/20 gBB). Pengukuran kadar MDA dilakukan dengan metode Wills dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay dan Analisa menggunakan uji ANOVA. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5,6 mg/20 gBB; 11,2 mg/20 gBB; 22,4 mg/20 gBB secara berturut-turut adalah 2,1617 nmol/mL; 5,3075 nmol/mL; 2,3331 nmol/mL; 4,5583 nmol/mL; 3,5957 nmol/mL; 2,6702 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD hati mencit adalah 124,2383 U/mL; 65,64 U/mL; 176,7583 U/mL; 106,045 U/mL; 134,34 U/mL; 153,53 U/mL. Kesimpulan penelitian ini adalah terdapat perbedaan bermakna antara kelompok III dengan kelompok IV,V,VI  dalam peningkatan aktivitas SOD dan penurunan kadar MDA (p<0,05) yaitu memiliki potensi antioksidan yang sama seperti vitamin C.
Edukasi Penggunaan Antibiotik secara Tepat sebagai Upaya Melindungi Masyarakat dari Bahaya Resistensi Esti Mulatsari; Reise Manninda; Sondang Khairani; Shirly Kumala; Fauzia Noprima Okta
Jurnal Pengabdian Masyarakat Indonesia Vol 3 No 3 (2023): JPMI - Juni 2023
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.1081

Abstract

Penggunaan obat yang tidak rasional sudah menjadi masalah dunia, berkisar 50% obat-obatan diresepkan, didistribusikan, dijual dan digunakan pasien secara tidak tepat. Penggunaan obat yang tidak rasional menjadi fokus perhatian adalah penggunaan antibiotik yang tidak sesuai baik dari jenis obat, dosis, lama pemberian dan penggunaan yang berlebihan pada penyakit non infeksi bakteri. Kondisi ini memicu terjadinya resistensi terhadap antibiotik. Masyarakat banyak menggunakan antibiotik untuk mengatasi penyakit non infeksi seperti batuk, flu, demam tanpa resep dokter dan dijual bebas pada beberapa fasilitas kesehatan yang tidak paham tentang regulasi di Indonesia. Tujuan kegiatan ini memberikan informasi kepada masyarakat tentang bahaya penggunaan antibotik yang tidak tepat. Kegiatan pengabdian kepada masyarakat ini dilakukan dalam bentuk penyuluhan dan pemutaran video DAGUSIBU penggunaan antibiotik. Pengukuran keberhasilan kegiatan dilakukan dengan memberikan pretest dan postets kepada masyarakat peserta kegiatan. Perhitungan persentasi total masyarakat yang dapat menjawab soal dengan tepat. Dari hasil pengolahan data, diketahui bahwa terjadi peningkatan pemahaman dan pengetahuan masyarakat terkait resistensi antibiotik setelah diberikan penyuluhan.
Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo Ni Made Dwi Sandhiutami; Sondang Khairani; Rika Sari Dewi; Zainur Rahman Hakim; Anita Rahmi Pradani
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3169

Abstract

Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.
Evaluasi Penggunaan Antibiotik dengan Metode Kuantitatif pada Pasien Pneumonia Rawat Inap di Rumah Sakit Nusa Tenggara Barat Sondang Khairani; Hesty Utami Ramadaniati; Prih Sarnianto; Erna Kristin; Yusi Anggriani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1449

Abstract

Abstract Overuse of antibiotics is a public health challenge that can lead to antimicrobial resistance. To reduce the occurrence of antibiotic resistance, it is necessary to evaluate the use of antibiotics to determine the rational use of drugs using quantitative methods, namely the ATC /DD method. The purpose of the study was to determine the use of antibiotics and describe the pattern of antibiotic use in inpatients at West Nusa Tenggara Hospital using the ATC /DD method and DU90%. The research method is a cross-sectional study design with retrospective data collection on adult pneumonia patients hospitalized in the period Januari-December 2019 and 2022, data obtained from medical records. The results of the study met the inclusion criteria of 218 patients with the majority being male 117 (53.67%) and the most age > 65, namely 66 (30.28%). Antibiotic use has a total DDD value of 185.56 DDD/100 days of care with the highest antibiotic DDD value being ceftriaxone which is 104.00 DDD/100 days of hospitalization while antibiotics that are included in the DU 90% are ceftriaxone, levofloxacin, cefoperazon and meropenem. Conclusion the most antibiotics used were ceftriaxone 104.00 DDD/100 days of length of stay.
Survei Rumah Tangga terhadap Profil Obat pada Responden dengan Jaminan Kesehatan Nasional di Jakarta Timur Restinia, Mita; Anggriani, Yusi; Khairani, Sondang; Wijaya, Rulliani Bianca
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.158-163.2020

Abstract

Household surveys are one of the methods to obtain accurate information on medicine utilization in society. The study was carried out to identify the access of medicine and medicine utilization profile. A survey using convenient sampling method was conducted in 30 households with national health insurance (JKN) diagnosed with chronic diseases in East Jakarta. Each family was observed once a week for 8 weeks to analyse their diseases, medication used, and medicine access. About 19 (63.3%) respondents enrolled in this study were male. The mean ± SD of age was 55.87±12.486 years old. About 23(76.7%) respondent had access of medicine through hospital and 7(23.3%) by pharmacy directly. The most common chronic diseases identified were cardiovascular and endocrine disorder. Cardiovascular, alimentary tract and metabolism, and nervous system were medications most commonly used. Most of respondents used about 1-3 kind of medications in a month. About 101 kind of drugs used, 74 kinds of drug among of them were generic and 27 were non generic. About 12 (40%) respondents used vitamin and 8 (26.67%) used supplement. This study highlights respondent access of medicine through hospital and cardiovascular medicines were the most commonly used.
Polypharmacy and the occurrence of potential drug interactions in geriatric Covid-19 patients in Karawang General Regional Hospital, Indonesia Khairani, Sondang; Manninda, Reise; Sarah, Mutia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1662

Abstract

The management of COVID-19 treatment continues to evolve by involving various types of drugs both symptomatic and supportive therapy. COVID-19 infection with comorbid conditions in geriatric patients can have an effect on increasing drug use and the potential for drug interactions. The purpose of the study was to determine whether there is a relationship between the level of polypharmacy and the incidence of potential drug interactions at Karawang Regency Hospital for the period January to December 2021. The research method used was a cross-sectional study design. The data collected was hospital secondary data with retrospective data type and statistical analysis using Spearman Rho. The research material used was medical record data from 182 samples using the total sampling method. Based on the results of the study, it was found that as many as 108 (59.3%) patients received treatment with a total of 5-9 types of drugs. Potential drug interactions were experienced by 148 (81.3%) patients with a total of 764 events. There is a relationship between the level of polypharmacy and the potential incidence of drug interactions (r: 0.537, p: <0.001).
Cost effectiveness analysis of ceftriaxone with cefoperazon in thypoid patients at X Mataram Hospital Khairani, Sondang; Manninda, Reise; Widodo, Akhmad Fajri; Raharjo, Lalu Joko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1585

Abstract

Typhoid is the third most common cause of hospitalisation in Indonesia, affecting 100,000 people every year. Typhoid fever, with an average case fatality rate of 2.45% at X Mataram Hospital, was among the top 10 most common inpatient illnesses in 2019 and 2020. Antibiotics are effective in reducing typhoid infection, lowering body temperature, shortening the length of hospitalisation, and reducing mortality. The aim study to determine the cost-effectiveness of using ceftriaxone and cefoperazone antibiotics for typhoid patients at X Mataram Hospital. Method a compares two groups of antibiotics and evaluates direct costs and clinical outcomes clinic (length of stay and time free of fever). This research is using ACER's cost-effectiveness analysis. The study included 63 samples with an average direct cost of Rp 3,645,106 for cefoperazon and Rp 3,168,106 for ceftriaxone. According to the ACER analysis results, hospitalisation with ceftriaxone is more cost-effective a lower cost of Rp 704,023 and based on fever-free time, cefoperazone is more cost-effective at Rp. 1,024,094. No correlation between antibiotic effectiveness and fever-free time, no correlation between antibiotic effectiveness and length of hospitalisation (p-value >0.05).
Co-Authors Anggriani, Yusi Anita Rahmi Pradani Ariani, Lusiana Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Hesty Utami Ramadaniati Hesty Utami Ramadaniati Ika Permata Sari Ira Ningtiyas Purpranoto Isti Atika Ita Rahmawati Kurnia, Mala Lestari Rahayu Manninda, Reise Manninda, Reise Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Prih Sarnianto Raharjo, Lalu Joko Reise Manninda RIKA SARI DEWI Rika Sari Dewi Rina Rosdiana Ros Sumarny ROS SUMARNY Rulliani Bianca Wijaya Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Yusi Anggriani Zainur Rahman Hakim