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All Journal Jurnal Sain Veteriner ARSHI Veterinary Letters Journal of Parasite Science Sibatik Journal : Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan
Ira Sari Yudaniayanti
Departemen Klinik Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Computer Science & IT Economics, Econometrics & Finance Education Immunology & microbiology Social Sciences Veterinary

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Journal : Jurnal Sain Veteriner

 1 
Ekspresi IL – 1β pada Proses Kesembuhan Fraktur Os Femur Tikus Putih (Rattus norvegicus) Ovariektomi yang Diterapi dengan Ekstrak Cikal Tulang (Cissus quadrangularis) Ira Sari Yudaniayanti; Bambang Sektiari Lukiswanto; M. Zainal Arifin
Jurnal Sain Veteriner Vol 35, No 1 (2017): Juni
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2018.61 KB) | DOI: 10.22146/jsv.29296

Abstract

This study aims to determine the potential of the Cissus quadrangularis extract to decreased the expression of IL-1 β so that it can to inhibit bone resorption and osteoporosis fracture healing is not delayed union. Forty rats adapted for 1 week, and then divided into four groups with 10 replications. P0 (sham-operated + Osteotomy + CMC Na); P1 (ovariectomy + Osteotomy + CMC Na); P2 (ovariectomy + Osteotomy + Raloxifene 5.4 mg /kg); P3 (ovariectomy + Osteotomy + CQ 750 mg / kg). Osteoporosis induced is made by bilateral ovariectomy in rats, then to make sure that osteoporosis is already happened, 8 weeks post-ovariectomy performed radiology examinations on the femur, then the osteotomy action. IL1-β expression observations performed in at the 2nd week and 6th week after osteotomy through the immunohistochemistry examination. The results of immunohistochemistry examination in the 2nd week showed an increased expression of IL1-β in all groups of rat that did ovariectomy (P1, P2 and P3) were significantly different (p <0.05) with a rat group that didn’t ovariectomy, as well P2 dan P3 were significantly different with P1. The Results of immunohistochemistry examination in the 6th week showed the samepattern with the 2nd week and there is increased IL1-β expression in all groups of rat compared with the results of the examination in the 2nd week. Based on these results it can be concluded that Cissus quadrangularis extract andRaloxifen can decreased the expression of IL-1 β, and the results that don’t significantly different, so that these both materials can to inhibit bone resorption and osteoporosis fracture healing don’t get delayed union.
Analisis Scanning Electron Microscope (SEM) Mikroarsitektur Daerah Metafisis Os Femur Tikus Putih (Rattus novergicus) Ovariohisterektomi dengan Pemberian Madu Lebah (Apis dorsata) Hutan Sumbawa Samsi Yordan; Abdullah Hasib; Muhammad Huda Ramadhan Ibrahim; Siti Nur Rohmah; Salsabilla Abani; Ira Sari Yudaniayanti
Jurnal Sain Veteriner Vol 36, No 1 (2018): Juni
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9095.229 KB) | DOI: 10.22146/jsv.38446

Abstract

The aims of this study to determine the effect of honey bees (Apis dorsata) to prevent the decrease of femur density in  ovariohysterctomized rats as animal model of osteoporosis by Scanning Electron Microscope (SEM). This study used 20 adult female white rats (Rattus norvegicus) with body weight 300 gr. Divided into 5 groups, negative control group (P0-), not in ovariohysterectomy,  only given aquadest 1.5 ml/day ; Positive control group (P0 +), in ovariohysterectomy,  only given aquadest 1.5 ml/day; Treatment group 1 (P1), in ovariohysterectomy and given honey 1 gram / kg BB + 1.5 ml aquadest; Treatment group 2 (P2), in ovariohysterectomy and given honey 2 grams / kg BB + 1.5 ml aquadest; Treatment group 3 (P3), in ovariohysterectomy and given honey 4 grams / kg BB + 1.5 ml aquadest. After 12 weeks, all rats were sacrified for removal of the femur and performed by SEM. Analysis of SEM showed that mice administered honey with a dose of 4 grams / kg BW (P3) showed bone density approaching negative control treatment (P0-), ie, ovariohysterectomized rats. P3 showed the most less bone porosity than other treatment groups. The largest and most uniformly distributed porosity was shown by the positive control group (P0 +). The best results with the smallest quantity and size of the porosity of femur is in P3 group. In conclusion, honey (Apis dorsata) can prevent the decrease in bone density of the femur by Scanning Electron Microscope (SEM).
Co-Authors Abdullah Hasib Aisyah Novasari Amalia Rosydinasari Rosydinasari Bambang Sektiari Lukiswanto Dewi Mariyam Endah Paraswati Imam Mustofa Inggarsetya Syah Audini Koesnoto Supranianondo Kuncoro Puguh Santoso M. Zainal Arifin Moh Anam Al Arif Mufasirin Muhammad Huda Ramadhan Ibrahim Nunuk Dyah Retno Lastuti Salsabilla Abani Samsi Yordan Sarmanu, Sarmanu Setiawan Koesdarto Setiawati Sigit Siti Nur Rohmah Sofyan, Miyayu Soneta Sri Hidanah Sri Mumpuni Sosiawati Sunarso, Agus Widya Paramita Winda Ayu Puteri Sumartono