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All Journal International Journal of Public Health Science (IJPHS) HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Majalah Kedokteran Bandung Folia Medica Indonesiana Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease Majalah Kedokteran Gigi Indonesia Universa Medicina Health Notions Molecular and Cellular Biomedical Sciences (MCBS) WICAKSANA: Jurnal Lingkungan dan Pembangunan Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Indian Journal of Forensic Medicine & Toxicology
Yoes Prijatna Dachlan
Faculty Of Medicine, Airlangga University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The Effectiveness of The Malaria Cadres on Drug Intake Supervision, The Use of Mosquito Net and Environmental Modification on Malaria Sufferers at Malaria Endemic Area of Public Health Center of Waipukang, Lembata District, Nusa Tenggara Timur Province Kristina, Ragu Harming; Subekti, Sri; Dachlan, Yoes Prijatna; Martini, Santi
Health Notions Vol 1 No 3 (2017): July-September 2017
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.678 KB)

Abstract

Background & objectives: Environmental risk factors, both physical and biological (e.g. ecology of vegetation/plants, forest), equally serve as the risk factors for Anopheles mosquitos breeding. This study was designed to determine a model of spatial mapping for the ecology of vegetation and the potential habitats for the Anopheles mosquitos. Methods: Descriptive epidemiological research was employed to carry out the project, supported with a cross-sectional design. The research took place in Kupang regency, Oesao village, lasting for 2 months from October to November 2014. The ecology of the vegetation and all habitats of the mosquitos in Oesao village were regarded as the population of the research. They were purposively sampled. Results: The vegetation mapping revealed that the land area for rice fields is 169 ha, coconut and banana tress 56.68 ha, maize 67.03 ha, vegetable plants 59.53 ha, forages 21.52 ha, and forests 16.24 ha. The results of the mapping also revealed that the mosquitos breeding sites entail paddy fields, swamps, irrigation channels, and damps. Interpretation & conclution: The ecology of all types of plants mapped serves as potential habitats for the Anopheles mosquitos breeding sites. Plant ecology is quite varied in the Oesao Village, as well as extensive areas of the plant that are closely linked to inadequate growth and development of mosquitoes  and  specific species of Anopheles,  An. vagus and An. annularis. Keywords:  Ecological vegetation mapping; Breeding sites; Malaria mosquitos
Microscopic-Based Trend in Imported Malaria among Workers of Trenggalek District Returning from Kalimantan Island, Indonesia During 2012 – 2016 Arwati, Heny; Kusmartisnawati, Kusmartisnawati; Yotopranoto, Subagyo; Hidayat, Poppy; Dachlan, Yoes Prijatna
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.01.14

Abstract

Malaria in Indonesia remains a significant health problem. Trenggalek District is one of the receptive malaria areas in East Java Province, Indonesia, with mainly imported malaria from outside Java Island. The people of this district accustomed to traveling to outside Java where malaria is endemic for temporary working purposes. Usually, they have acquired malaria infection in the areas where they worked and brought to their homeland during their return to the district. The number of imported malaria cases depend on the returning season of the workers. When no workers return from outside Java malaria case is zero. During the year of 2012-2016 microscopic examination of Microscopic examination of Giemsa-stained thick blood films of the workers have been done in the working activity of Pandean Primary Health Center on their arrival from Kalimantan Island either by active or passive case detection. Microscopically positive data were reported herein to describe the trend of imported malaria in the studied areas. A total number of malaria-infected workers were 118 cases. The trend towards increasing case number yearly between 2012 and 2013 being 1.35%, then decreasing between 2013 and 2016 to only 4 cases in 2016. Different patterns of imported malaria by month were seen in each year but no specific pattern throughout the year. The Plasmodium vivax infection was predominant every year and followed by Plasmodium falciparum and mixed infection of those two species. Trends of imported malaria cases in Trenggalek district were decreased and increased irregularly in each month yearly. However, the number of cases declined annually during 2013 – 2016. Antimalarial prophylaxis and insecticides prevent the workers from malaria infection.
Profil Fenotipik Plasmodium falciparum Galur Papua 2300 Akibat Paparan Antimalaria Artemisinin in Vitro Maslachah, Lilik; Dachlan, Yoes Prijatna; Nidom, Chairul A.; Fitri, Loeki Enggar
Majalah Kedokteran Bandung Vol 47, No 1 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Resistensi parasit P. falciparum dan penurunan efikasi terhadap artemisinin mengakibatkan masalah malaria menjadi semakin  kompleks. Hal ini menjadi salah satu permasalahan kesehatan di dunia  yang belum dapat diselesaikan sampai saat ini karena belum ada obat baru pengganti artemisinin. Penelitian ini untuk membuktikan bahwa paparan obat antimalaria artemisinin berulang in vitro dapat menyebabkan perubahan profil fenotipik P. falciparum galur Papua 2300. Waktu penelitian Februari sampai dengan November 2013. Tempat penelitian di Biomedik Universitas Brawijaya Malang dan Fakultas Kedokteran Hewan Universitas Airlangga. Desain penelitian experimental design dengan post test only control group design. Kultur P. falciparum galur Papua 2300 dipapar artemisinin berulang dengan dosis IC50. Pengamatan dilakukan terhadap viabilitas dan nilai IC50 dengan menggunakan analisis probit. Kelompok kontrol tidak menunjukkan perubahan nilai IC50 juga pada kelompok perlakuan PO1. Nilai IC50 terjadi peningkatan setelah perlakuan PO2. Paparan artemisinin berulang pada PO2, PO3, dan PO4 menyebabkan waktu viabilitas P. falciparum galur Papua 2300 lebih pendek daripada PO1. Viabilitas stabil setelah perlakuan PO3. Simpulan, paparan artemisinin berulang berpengaruh pada perubahan peningkatkan nilai IC50 dan waktu viabilitas P. falciparum galur Papua 2300.  [MKB. 2015;47(1):1–9]Kata kunci: Artemisinin, fenotipik, P. falciparum galur Papua 2300, resistensiPhenotypic Profile of  Plasmodium falciparum Papua 2300 Strain Exposed to in Vitro Antimalarial Artemisinin The presence of the P. falciparum resistance and decreased of efficacy against artemisinin and its derivatives result in increasingly complex malaria issues. Malaria has become one of the currently unresolved world’s health problems due to the lack of  new artemisinin replacement drugs. This study aimed to provide evidence that the repeated exposure of in vitro artemisinin may cause a change in P. falciparum Papua 2300 strain phenotypic. This study was conducted during the period of  February to November 2013 in Biomedics Brawijaya University and the Faculty of Veterinary Medicine, Airlangga University. A post-test control only experimental design was used. In vitro cultures of  P. falciparum Papua 2300 strain were treated by repeated artemisin in IC50 concentration and were observed for their viability and IC50 using probit analysis. The control group did not show any changes after IC50value and PO1 treatment. An increase in IC50 value was occurred after PO2. Repeated exposures of artemisinin in PO2, PO3 and PO4 had shorter viability periods than PO1. The viability of was stable after PO3 in this group. In conclusion, repeated exposures of artemisinin influence changes in  IC50 value and viability period of  P. falciparum Papua 2300 strain. [MKB. 2015;47(1):1–9]Key words: Artemisinin, phenotypic, P. falciparum Papua 2300, resistance DOI: 10.15395/mkb.v47n1.390   
Qualitative Analysis of Cinnamomum burmannii Content using GCMS (Gas Chromatography Mass Spectometry) Method Hayati; Jusak Nugraha; Bambang Purwanto; Hari Basuki Notobroto; Yoes Prijatna Dachlan; Hari Setiono; Idha Kusumawati
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17556

Abstract

To identify the bioactive compounds in Cinnamomum burmannii and their biological activity. Cinnamonbark originating from Batu Malang, East Java, which was located 700-1300 meters above sea level, wasprocessed into dry extract by maceration method with 96% ethanol solvent. Furthermore, cinnamonethanol extract was analyzed using the GCMS method to look at the content of the bioactive componentfor further testing biological activity with the server Way2Drug PASS. GCMS results showed 40 activecompounds such as trans-cinnamaldehyde, trans-anethole, cinnamyl acetate, calacorene, cadina-1,4-diene, delta-cadinene. Furthermore, of the 40 compounds, the biological activity potential was testedfor 29 bioactive compounds based on PA (probable to be active) values predicted by the Way2DrugPASS server. Cinnamomum was tested against the potential as anti-fungi, anti-bacterial, anti-oxidant,anti-inflammatory, anti-diabetic, anti-neoplastic. Trans-cinnamaldehyde showed PA 0,583 as antiinflammatory, L-limonene PA0,818 as anti neoplastic, Tans-anethole PA 0,614 as anti neoplastic,Cinnamyl acetate PA 0,669 as anti inflammatory, calacorene PA 0,698 as anti inflammatory, DeltacadinenePA 0,651 as anti neoplastic, , Cathechin PA 0,828 as anti oxidant, alpha.-Cubebene PA 0,888 asanti inflammatory and PA 0,837 as anti neoplastic, melilotin PA 0,929 as anti neoplastic, CaryophyllenePA0,915 as anti neoplastic. Cinnamomum burmannii had biological potency based on potential activity(PA) 0,432 (+0,117) as antifungi, PA 0,335 (+0,090) as antibacterial, PA 0,304 (+0,199) as antioxidan,PA 0,561 (+0,190) as anti inflammatory, PA 0,373 (+0,170) as antidiabetic, PA 0,584 (+0,234) asantineoplastic.
Sensitivity and Specificity of Rapid Diagnostic Test with Microscopic Gold Standard to Identify Plasmodium Species Sahrir Sillehu; Heny Arwati; Yoes Prijatna Dachlan; Sudjajadi Keman
International Journal of Public Health Science (IJPHS) Vol 5, No 4: December 2016
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.104 KB) | DOI: 10.11591/ijphs.v5i4.4829

Abstract

Malaria is a main health problem in islands area which is under developed and isolated. Nation-wide, in 2014 Maluku province was recorded to have Annual Malaria Incident (AMI) value of 30.4%, positive incidents of 13.30%, ABER 3.76%, SPR 21.50%, and Annual Paracite Incident (API) 8.10%, while South Buru Regency has a value of Annual Malaria Incident (AMI) of 14.49%, 494 positive incidents, ABER 1.12%, SPR 60.91%, and Annual Paracite Incident (API) 6.86%. The purpose of this study was to identify Plasmodium species in malaria incidents in NamroleSubdistrict, South Buru Regency, Maluku Province. Observational research with a sample of 64 respondents for symptomatic and asymptomatic malaria. The instrument for the research was Rapid Diagnostic Test (RDT) and microscopic Gold Standard. Result: Malaria examination by using RDT suggested 3 kinds of parasites, i.e., P. falciparum, P. Vivax, and a mix between P. falciparum and P. vivax. Most parasites found were P. falciparum 56.3%. The accuracy of RDT examination was proven with microscopic test and the result suggested that the RDT sensitivity was 100% and the specifivity was 63.3%. Positive predictive value was 92.9% and negative predictive value was 100%, both were for positive likelihood ration of 2.75%. While for negative likelihood ration of 0%, the value of degree of conformity (Kappa) between RDT and microscopic is 0%. RDT has one benefit that it can be use to conduct malaria diagnosis rapidly, particularly in isolated areas. The benefit of Rapid Diagnostic Test (RDT) was that it could be used in remote and isolated areas to conduct diagnosis. RDT is highly effective and efficient.
Immune Response to Burn Injury: Hyperinflammation and Immunosuppression Septin Mauludiyana; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro; Muhaimin Rifa’i
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15936

Abstract

Burn is an injury to the skin or other tissue. Mostly, it caused by contacting with hot liquids, solids, and flames. The important thing that should be consider in burn incident is the severity of burn and it based on the depth and area of the burn injury. The severity of burns will cause differences of pathophysiological responses. This was a literature review study. Various articles were collected from online database including reports, journals, and published in the last 10 years. The articles were from the scholar journals. The systemic inflammatory response in severe level of burns was not given good response to disappear of lesion burn and initiating tissue repair. Moreover, it was given an organ failure to the patient. The body responded to this incident by releasing antiinflammatory mediators. This response is very strong and prolonged, so it caused immunosuppression and increase the risk of secondary infection to the patients. Burns affects the patient’s immune system. The ratio between pro and antiinflammatory mediators are determining the patient’s subsequent status.
The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model Waode Fifin Ervina; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15995

Abstract

The Effectiveness of The Malaria Cadres on Drug Intake Supervision, The Use of Mosquito Net and Environmental Modification on Malaria Sufferers at Malaria Endemic Area of Public Health Center of Waipukang, Lembata District, Nusa Tenggara Timur Province, Indonesia Ragu Harming Kristina; Sri Subekti; Yoes Prijatna Dachlan; Santi Martini
Health Notions Vol 1, No 3 (2017): July-September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.678 KB) | DOI: 10.33846/hn.v1i3.60

Abstract

Malaria was a disease that caused many mortalities in developing countries. In solving this problem, it was needed a focused and directed mentoring continuously. This study aimed to determine the effectiveness of malaria cadres on drug intake supervision, the use of mosquito net and environmental modification on malaria sufferers at Public Health Center of Waipukang. This research was analytic observational research with cross sectional study design. The results showed that the average knowledge of malaria cadres was still low. Malaria cadres in Public Health Center of Waipukang were less effective in monitoring the consuming of malaria drugs, mosquito nets usage, and environmental modification in their areas. Furthermore, there were 78% of people who used mosquito net properly and 54% of families obediently did environmental modification efforts. Keywords: Malaria, Malaria cadre, Drug intake supervision, Environmental development, Mosquito net
Korelasi Jumlah Streptococcus mutans (S. mutans) dan Level Ekspresi Interlukin 8 (IL-8) pada Severe Early Childhood Caries Muhammad Luthfi; Retno Indrawati; Ira Arundina; Yoes Prijatna Dachlan
Majalah Kedokteran Gigi Indonesia Vol 1, No 2 (2015): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.441 KB) | DOI: 10.22146/majkedgiind.9227

Abstract

Correlation of Streptococcus mutans (S. mutans) Level and Interleukin 8 (IL-8) Expressions of Salivary Neutrophils in Severe Early Childhood Caries. Early childhood caries is a very serious health problem because it is a chronic infectious disease that is contagious. Dental caries begins after the primary teeth grow and develop on the tooth surface very quickly and progressively. In recent years the views of neutrophils have changed dramatically. Neutrophils not only act as a microbe killer through phagocytosis, the release of reactive oxigen species (ROS) and its antimicrobial peptide, but neutrophil activation also helps regulate the immune response. To analyze the relationship between the amount S. mutans and IL-8 expression of salivary neutrophils in severe early Childhood caries. Two groups, namely Isolation of S. mutans were performed on saliva samples taken from 20 caries-free and 20 severe early childhood caries and samples Nacl 1,5% mouthwash results of 20 caries-free and 20 severe early childhood caries salivary neutrophils that were analysis of IL-8 expression by flow cytometry. Based on the average value, it is known that S. mutans level in early Childhood caries-free is lower (513.500,00 +185.565,28 CFU/ml) in comparison to the severe early Childhood caries (977.000,00 +222.500,15 CFU/ml), but the expression of IL-8 neutrophil salivary neutrophils in early Childhood caries-free is higher (3,31+0,50) in comparison to the severe early Childhood caries (2,95+0,56). The increased S. mutans level is probably caused by the decrease in the expression of IL-8 salivary neutrophils in severe early childhood caries.
Ekspresi mRNA Interleukin-10 (IL-10) dalam Kaitannya dengan Patogenesis Malaria Berat Pada Mencit Strain BALB/C yang Diinfeksi Plasmodium yoelli 17XL Sri Wijayanti Sulistyawati; Sukmawati Basuki; Yoes Prijatna Dachlan
Jurnal Biosains Pascasarjana Vol. 20 No. 3 (2018): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.27 KB) | DOI: 10.20473/jbp.v20i3.2018.170-179

Abstract

AbstrakPatogenesis malaria berat masih belum diketahui menyeluruh. Episode malaria berat dapat disebabkan oleh dua keadaan, produksi tinggi pada fase awal IL-10 dan atau kurangnya produksi IL-10 pada fase transisi. Peran IL-10 pada malaria masih belum jelas diketahui. Penelitian ini bertujuan untuk menganalisis ekspresi IL-10 dalam kaitannya dengan patogenesis malaria berat pada mencit strain BALB/c yang diinfeksi P. yoelii 17XL.Penelitian eksperimental laboratoris dengan rancangan “post test only control group design” dilakukan, dan menggunakan 24 mencit strain BALB/c, betina, usia 7-8 minggu, yang dibagi menjadi 4 kelompok. Mencit BALB/c diinfeksi secara intraperitoneal dengan 1x105 P. yoelii 17XL, dan dikorbankan pada hari ke-3 dan ke-6 pasca infeksi. Parasitemia dan kadar hemoglobin diperiksa setiap hari. Jaringan limpa diambil untuk isolasi RNA. Ekspresi mRNA IL-10, TNFα, dan IFNγ dianalisis dengan RT-PCR. Mencit BALB/c dinfeksi dengan 1x105 P. yoelii 17XL menunjukan infeksi letal, yang ditandai dengan peningkatan parasitemia sejalan dengan penurunan kadar hemoglobin, terjadi setelah hari ke-3 pasca infeksi. Ekspresi mRNA IL-10, begitu pula dengan TNFα dan IFNγ pada hari ke-3 paska infeksi menunjukan peningkatan dibandingkan pada kontrol dan hari ke-6 paska infeksi. Tidak adanya ekspresi IL-10 pada H6, menunjukkan kemungkinan adanya kegagalan regulator mengontrol malaria berat pada infeksi P. yoelii 17XL pada mencit BALB/c.   Kata kunci— mRNA IL-10, RT-PCR, patogenesis malaria berat, mencit BALB/c yang diinfeksi P. yoelii 17XL
Co-Authors Anwar Ma'aruf Apsari, Putu Indah Budi Apsari, Putu Indah Budi Aryati Audrey Gracelia Riwu Bambang Purwanto Budiutari, Ni Nyoman Chairul A. Nidom Chairul A. Nidom Cyuzuzo Callixte Dusabimana Jean Damascene Dyah Ayu Febiyanti Eka Nora Vitaloka Aprilia Putri Winthoko Hari Basuki Notobroto Hari Setiono Heny Arwati Hidayat, Poppy Idha Kusumawati Insani Budiningsih Ira Arundina Iswinarno Doso Saputro Jaap M. Middeldorp Jusak Nugraha Kusmartisnawati Kusmartisnawati Kusmartisnawati Kusmartisnawati, Kusmartisnawati Lilik Maslachah Loeki Enggar Fitri Muhaimin Rifa’i Muhammad Luthfi Ndayisaba Daniel Ni Wayan Winianti Nugaraha, Jusak Nur Hayati Nurdianto, Arif Rahman Poppy Hidayat putu indah budi apsari Ragu Harming Kristina Ragu Harming Kristina Raudatul Jannah Retno Indrawati Roestamadji Santi Martini Sensusiati, Anggraini Dwi Septin Mauludiyana Sillehu, Sahrir Sri Subekti Sriwijayanti Sulistyawati Subagyo Yotopranoto Subagyo Yotopranoto Sudjajadi Keman Sukmawati Basuki Suprapto Maat Usman Hadi Waode Fifin Ervina