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All Journal Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Medicamento Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Info Kesehatan
Hestiary Ratih
Fakultas Farmasi Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PERBAIKAN FLOWABILITY DAN TABLETABILITY FUROSEMID MELALUI KO-KRISTALISASI DENGAN KAFEIN : FLOWABILITY AND TABLETABILITY IMPROVEMENT OF FUROSEMID THROUGH CO-CRYSTALIZATION WITH CAFFEINE Ine Rosmala Dewi; Fikri Alatas; Nadira Cantika Putri Ananda; Diamona Ayu Lestari; Alisha Ramadhanty Ludin; Endah Wahyuni; Hestiary Ratih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.414

Abstract

Furosemid (FUR) adalah obat diuretik kuat yang umum dipakai untuk pengobatan tekanan darah tinggi dan lemah jantung. Bahan baku FUR memiliki kemampuan mengalir (flowability) dan kemampuan untuk dikempa menjadi tablet (tabletability) yang buruk. Pada penelitian memperbaiki flowability dan tabletability furosemid diperbaiki melalui pembentukkan ko-kristal dengan kafein (CAF). Metode Ultrasound Assisted Solution Co-Crystalization (USSC) digunakan untuk menyiapkan ko-kristal FUR-CAF. Morfologi kristal produk USSC diamati dengan mikroskop polarisasi. Karakterisasi produk USSC juga dilakukan dengan metode difraksi sinar-X serbuk dan Differential Scanning Calorimetry (DSC). Pengujian flowability yang dilakukan terdiri dari laju alir, sudut istirahat, dan indeks kompresibilitas, sedangkan pengujian tabletability yang dilakukan terdiri dari tensile strength dan elastic recovery. Produk USSC dari FUR-CAF menunjukkan habit kristal yang berbentuk batang, pola difraktogram khas, dan titik lebur di 223,0°C yang terletak di antara titik lebur FUR dan CAF. Hasil pengujian flowability menunjukkan laju alir, sudut istirahat, dan indeks kompresibilitas ko-kristal FUR-CAF lebih baik daripada FUR murni. Tensile strength dan elastic recovery ko-kristal FUR-CAF juga lebih baik daripada FUR murni. Hasil-hasil ini  menunjukkan flowability dan tabletability furosemid bisa diperbaiki melalui ko-kristalisasi dengan kafein menggunakan metode USSC.
Formulation and Physical Evaluation of Sleeping Mask Gel Preparation of Mahogany Leaf Extract (Swietenia Mahagoni (L.) Jacq) As Antioxidant Ratih, Hestiary; Sutarna, Titta Hartyana; Febrianti, Mia; Alatas, Fikri; Purnamasari, Nira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.265

Abstract

Antioxidants are used to neutralize free radicals. Mahogany leaves (Swietenia mahagoni (L.) Jacq) contain flavonoid chemicals that exhibit antioxidant properties. The purpose of the study was to determine the physical characteristics and antioxidant activity of sleeping mask gel preparations with the addition of mahogany leaf extract. Mahogany leaf extract is made using the maceration process. Determination of antioxidant activity using the DPPH method. The formulation is made by varying the concentration of mahogany leaf extract into 4 formulas, F0 (bases, F1 (0.0195%, IC50), F2 (0.0975%, 5xIC50) and F3 (0.195%, 10xIC50). There were several tests used to evaluate formulas, including homogeneity, dispersion, viscosity, pH, and organoleptic (odor, color, and shape) testing. IC50 value of mahogany leaf extract was 19.48 μg / mL. Mahogany leaf extract antioxidant gel sleeping mask preparations F0, F1, F2 and F3 was evaluated such as organoleptic testing requirements, homogeneity and pH produced between 6.15-6.65 including the skin's normal pH range of 4.0-7.0 during 28-day storage. F2 exhibits the best antioxidant stability, with an inhibition value of 54.59%.
PENANGANAN PERMASALAHAN SIFAT HIGROSKOPIS PADA FORMULASI SEDIAAN TABLET Ratih, Hestiary; Gosepa, Oke Setiawan
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.728

Abstract

Sebagian besar bahan aktif farmasi (BAF) bersifat sangat higroskopis dalam bentuk padatan. Higroskopisitas yang tinggi dapat menimbulkan beberapa permasalahan antara lain terjadinya perubahan sifat fisikokimia pada bahan aktif.  Perubahan sifat fisiko kimia tersebut dapat berdampak pada usia simpan sediaan tablet sehingga menjadi lebih singkat. Kajian literatur ini bertujuan untuk memberikan informasi mengenai penanganan pada proses produksi sediaan tablet yang memiliki sifat padatan bahan baku higroskopis. Metode penyusunan kajian literatur ini bersumber dari 42 artikel yang berasal dari artikel jurnal nasional maupun internasional yang telah terbit pada sepuluh tahun terakhir (2014-2024), artikel yang terkumpul dilakukan seleksi dan identifikasi berdasarkan kriteria inklusi dan eksklusi. Hasil kajian penelusuran pustaka terkait dengan upaya yang dapat dilakukan dalam penanganan permasalahan sifat higroskopis padatan farmasi pada formulasi sediaan tablet, antara lain yaitu, dengan teknik penyalutan film, teknik enkapsulasi (dengan spray-drying/freeze-drying dan koaservasi kompleks), teknik ko-proses (co-process), dan rekayasa kristal (co-crystal). Berdasarkan kajian literatur yang telah dilakukan dapat disimpulkan bahwa beberapa teknik dalam memodifikasi sifat fisik bahan aktif farmasi pada formulasi sediaan tablet dapat menangani permasalahan sifat higroskopis bahan aktif dengan meningkatkan pengendalian higroskopisitas suatu padatan sehingga dapat meningkatkan stabilitas bahan aktif. Kata kunci:  Formulasi, higroskopis, penanganan, sediaan, tablet.   Abstract The majority of active pharmaceutical ingredients (API) are highly hygroscopic in solid form. High hygroscopicity can cause several problems, including changes in the physicochemical properties of active ingredients which can cause difficulties in formulating a preparation such as tablets, so that this can affect the shelf life of tablet preparations which become shorter. This literature review aims to find out the formulation handling in the production process of tablet preparations that have the characteristics of highly hygroscopic solids. The method of preparing this literature review comes from 42 articles originating from national and international journal articles that have been published in the last ten years (2014 - 2024), the collected articles were selected and identified based on the inclusion and exclusion criteria. The results of the literature search review related to efforts that can be made in handling the problem of hygroscopic properties of pharmaceutical solids in tablet dosage formulations, including film coating techniques, encapsulation techniques (by spray-drying/freeze-drying and complex coacervation), co-process techniques, and crystal engineering (co-crystal). Based on the literature review that has been conducted, it can be concluded that several techniques in modifying the physical properties of active pharmaceutical ingredients in tablet formulations can handle the problem of the hygroscopic nature of active ingredients by increasing the control of hygroscopicity of a solid so as to increase the stability of active ingredients. Keywords: Formulation, hygroscopic, handling, preparation, tablets.  
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs Butar-Butar, Maria Elvina Tresia; Wathoni, Nasrul; Ratih, Hestiary; Wardhana, Yoga Windhu
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in which polymers and surfactants can trap drug molecules that are in the amorphous phase. Drugs in a hydrophilic carrier will increase wettability, water absorption capacity, and porosity of particles, so that the drug is released better. This review article will discuss the development of technology in solid-state, how solid dispersion overcomes the lack of solubility and the rate of dissolution of antiviral drugs, and solid dispersion preparation techniques. We also discuss some examples of successful applications of solid dispersion methods to antiviral drugs that have been circulating on the market. Overall, this review article offers information of innovation in the development of antiviral drugs to provide more solid dispersion antiviral drug products.
PENGARUH PENGGUNAAN DUA TIPE ENKAPSULAT PHARMACOAT TERHADAP KARAKTERISTIK MIKROKAPSUL ASAM ASKORBAT Pratiwi, Gladdis Kamilah; Alatas, Fikri; Ratih, Hestiary; Sutarna, Titta Hartyana; Bintary, Dyan; Prianto, Ulla L. F.
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 4 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Asam askorbat, suatu vitamin yang larut dalam air, dapat teroksidasi oleh faktor lingkungan dan pembuatan mikrokapsul dengan enkpasulat yang tepat menjadi sangat penting untuk meningkatkan karakteristiknya. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan dua tipe enkapsulat Pharmacoat terhadap karakteristik mikrokapsul asam askorbat. Mikrokapsul asam askorbat dibuat dengan metode penguapan pelarut dengan menggunakan variasi konsentrasi dua tipe Pharmacoat sebagai enkapsulat, yaitu F1 dan F2 menggunakan Pharmacoat 606 dengan rasio asam askorbat-Pharmacoat 606 berturut-turut 1 : 1 dan 2 : 3, sementara F3 dan F4 menggunakan Pharmacoat 615 dengan rasio asam askorbat : Pharmacoat 615 berturut-turut 1 : 1 dan 2 : 3. Etanol digunakan sebagai pelarut polimer dan asam askorbat, parafin cair sebagai fase minyak, dan Span 80 sebagai emulgator. Karakteristik mikrokapsul yang dievaluasi, meliputi penetapan kadar air, uji perolehan kembali, distribusi ukuran partikel mikrokapsul, uji stabilitas terhadap paparan cahaya, dan morfologi mikrokapsul menggunakan Scanning Electron Microscopy (SEM). Hasil evaluasi menunjukkan seluruh formula mikrokapsul memiliki kadar air adalah sekitar 1-3 %, dan distribusi ukuran partikel mikrokapsul pada rentang 250-500 μm. Efisiensi penjeratan mikrokapsul F1, F2, F3, dan F4 berturut-turut adalah 75,67, 86,88, 82,02, dan, 93,72%. F4 memiliki efektivitas paling naik dalam mengurangi oksidasi asam askorbat dari pararan cahaya. Fotomikrograf SEM menunjukkan F4 memiliki morfologi paling baik. Kesimpulannya, mikrokapsul yang dibuat dengan rasio asam askorbat: Pharmacoat 615 (2 : 3) menunjukkan stabilitas terhadap paparan cahaya dan morfologi paling baik. Kata kunci : asam askorbat, mikrokapsul, Pharmacoat® 606, Pharmacoat® 615 DOI : 10.35990/mk.v7n4.p331-340
Optimasi Konsentrasi BHT untuk Menjaga Stabilitas Pigmen Alami pada Sediaan Cream Blush Ekstrak Hemigraphis colorata Ratih, Hestiary; Sutarna, Titta Hartyana; Al-Hakim, Nur Achsan; Dwijayanti, Anisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1139

Abstract

The use of natural dyes from Hemigraphis colorata Hall. extract as cosmetic dyes faces stability challenges due to oxidative degradation. This study aims to test the effect of Butylated Hydroxytoluene (BHT) antioxidant concentration on the physical stability and color of cream blush formulations. H. colorata leaves were extracted by maceration and lyophilization, then formulated into four cream blush preparations with varying concentrations of BHT: without BHT (F0), 0.0075% (F1), 0.05% (F2), and 0.1% (F3). Physical stability of the formulations was evaluated for 28 days through organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and color stability using UV-Visible spectrophotometry. The results showed that all formulations met the physical standards for topical preparations. However, F2 (0.05%) and F3 (0.1%) successfully maintained color stability with minimal shifts. This study concludes that BHT can effectively maintain the physical stability of cream blush formulations based on H. colorata extract, with 0.05% (F2) being the optimal BHT concentration (the lowest effective concentration), based on considerations of effectiveness, safety, and cost, proven to be optimal in protecting natural pigments from degradation. These results provide important information for the development of safe, high-quality natural cosmetic products with a longer shelf life.
Sediaan Larutan Nanopartikel Dari Fraksi Etil Asetat Daun Sungkai (Peronema Canescens Jack) Hartesi , Barmi; Ratih, Hestiary; Nugraha , Sabina Azahra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1158

Abstract

Sungkai leaves (Peronema canescens Jack) are known to contain secondary metabolite compounds such as alkaloids, polyphenols, flavonoids, quinones, and steroid-triterpenoids, which have potential as immunostimulants. This study aims to determine the effect of the ratio of chitosan and NaTPP on the stability of nanoparticle solutions from the ethyl acetate fraction of sungkai leaves. Sungkai leaves were extracted using the maceration method with 70% ethanol, then fractionated using the liquid-liquid estraction method using n-hexane, ethyl acetate, and n-butanol solvents. The ethyl acetate fraction selected to be made into nanoparticle solutions used the ionic gelation method with variations in the ratio of chitosan:NaTPP consisting of 3 formulas, namely F1 (5:1), F2 (10:1), F3 (20:1). Characterization of the nanoparticle solution was carried out by organoleptic testing, measuring % transmittance, particle size with a Particle Size Analyzer (PSA), and measuring the zeta potential value. The results showed that F3 (Chitosan:NaTPP 20:1) produced an average particle size of 953.6 nm, a polydispersity index of 0,338, and a zeta potential of 43.2 mV, indicating relatively better stability compared to the other formulas. However, the percent transmittance obtained was still below the optimum (80-100%), which was 68.88%. In conclusion, increasing the chitosan:NaTPP ratio affected the environmental stability of the nanoparticles, and formula. F3 was the most stable formula in this study.
Formulasi dan Karakterisasi Nanokristal Meloksikam Menggunakan Kombinasi Penstabil Polimer dan Surfaktan untuk Meningkatkan Kelarutan Al-Hakim, Nur Achsan; Sutarna, Titta Hartyana; Ratih, Hestiary; Azzara, Karina Putriani
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12523

Abstract

Background: Low solubility in water is a major obstacle for Meloxicam (MLX) and has implications for its limited bioavailability. Nanocrystallization techniques show potential for improving drug solubility, but nanoparticles tend to aggregate, suggesting the use of a combination of Hydroxypropyl Methylcellulose (HPMC) and Decyl Glucoside (DG) as stabilizers to overcome this problem.Objective: This study aims to develop and characterize meloxicam nanocrystals (MLX-NC) with a combination of HPMC and DG in an effort to improve solubility. MLX-NC was synthesized using ultrasonication and dried by lyophilization.Methods: The resulting formulation exhibited excellent physical stability over 28 days, as evidenced by consistent particle size (~11 nm) and polydispersity index (<0.3). Physical evaluation and characterization were performed, including particle size analysis (DLS), zeta potential, particle morphology (SEM), thermal analysis (DSC), X-ray diffraction (XRD), and saturated solubility testing.Results: The MLX-NC formulation showed a more than 200-fold increase in solubility compared to pure MLX, from 0.005 mg/mL to 1.064 mg/mL. XRD and DSC analyses confirmed that the nanocrystallization process converted the crystalline phase of MLX into an amorphous phase. These results indicate that induced amorphization can significantly improve solubility.Conclusion: The solubility of MLX can be significantly improved using ultrasonication combined with HPMC and DG. This approach has the potential to overcome the solubility limitations of BCS Class II drugs.
Formulation Strategy to Prevent Sticking in Calcium Carbonate–Cholecalciferol Chewable Tablets: The Role of Citric Acid Ratih, Hestiary; Gosepa, Oke Setiawan; Alatas, Fikri; Sutarna, Titta Hartyana
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2325

Abstract

The sticking phenomenon is a critical issue in the production of calcium carbonate–cholecalciferol (vitamin D3) chewable tablets, primarily driven by the hygroscopicity and reactivity of citric acid, which is used as a flavor-masking agent. This study aims to evaluate and determine the optimal method for mitigating sticking by modifying citric acid excipients using two approaches: granulation with mannitol (F1: 0.5%, F2: 1%) and coating with HPMC (F3: 0.5%, F4: 1%). The evaluation was conducted on the properties of the granule mass and quantitatively measured the percentage of sticking in industrial-scale modifications for 24 hours. The results showed that the control formula (F0), without modification, had the lowest sticking percentage (10.88%) and the highest moisture content (3.36%), as indicated by a "passable" flow property with a compressibility index of 21.47%. The 1% HPMC coating modification method (F4) was successful in eliminating stickiness to 0%, supported by moisture-control data (2.25%) and a significant improvement in powder-flow properties to “fair,” with a compressibility index of 17.06%. Although the 1% mannitol granulation method (F2) is relatively effective in reducing stickiness (0.85%), the 1% HPMC coating (F4) is more effective at physically isolating citric acid. This study concludes that the HPMC coating method is superior to the granulation method for physically isolating citric acid, yielding stable, non-sticking calcium carbonate–cholecalciferol chewable tablets.      
Co-Authors Abilyo Ramadan Akhirul Kahfi Syam Alisha Ramadhanty Ludin Azzara, Karina Putriani Barmi Hartesi Bella Dewinta Saraswati Bintary, Dyan Dadan Suryasaputra Diamona Ayu Lestari Dini Tereslina Dwijayanti, Anisa Endah Wahyuni Erina Sifa Mutmainah Faizal Hermanto Fani Wahyuni Fani Wahyuni, Fani Farah Salsabilla Saidah Azhar Febrianti, Mia Fikri Alatas Gladdis Kamilah Pratiwi Gosepa, Oke Setiawan Hartyana Sutarna, Titta Hesti Kurnia Ine Rosmala Dewi Jessie Sofia Pamudji Maria Elvina Tresia Butar-Butar Meyra Pratami Dewilestari Mia Agustin Nabila Anis Nadira Cantika Putri Ananda Nasrul Wathoni Nira Purnamasari, Nira Nugraha , Sabina Azahra Nur Achsan Al-Hakim Pratiwi, Gladdis Kamilah Prianto, Ulla L. F. Purwoko, Agus Rani Sugandi Rani Sugandi, Rani Renata Ananda Marthasedana Rini Agustin Riskia Putri Peratiwi Riskia Putri Peratiwi, Riskia Putri Sheila Nur Hasanah Sri Restu Andriyani Sundani Nurono Soewandhi Wulan Anggraeni Yoga Windhu Wardhana Yoga Windu Wardhana