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All Journal ADITYA - Pendidikan Bahasa dan Sastra Jawa Jurnal EMPATI Kodifikasia: Jurnal Penelitian Islam ODONTO Dental Journal JOIN (Jurnal Online Informatika) Seminar Nasional Keperawatan TEKNOKOM : Jurnal Teknologi dan Rekayasa Sistem Komputer Odonto dental journal HIKMAH: Jurnal Ilmu Dakwah dan Komunikasi Islam Social Science Academic
Dewi Yunita Sari
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Religion Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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Journal : ODONTO Dental Journal

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THE CYTOTOXIC AND PROLIFERATIVE ACTIVITY OF COCOA POD HUSK EXTRACT (THEOBROMA CACAO L.) ON PERIODONTAL LIGAMENT FIBROBLASTS Rahayu, Yani Corvianindya; Triwahyuni, Iin Eliana; Kusumawardani, Banun; Sari, Dewi Yunita
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.46-52

Abstract

Background: Theobroma cacao was considered agricultural wastes. Cocoa pod husk contain various bioactive compounds as natural antioxidants,antibacterial and anti-inflammatory. A good biomaterial must be non-toxic and have no detrimental effect on the biological environment. The aim of research was to determine the cytotoxicity and proliferative activity of cocoa pod husk extract on primary cells of periodontal ligament fibroblasts. Method: This experimental laboratory used primary cell culture of periodontal ligament fibroblasts. The cytotoxicity and proliferative activity were analyzed by MTT assay [2-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]. Extraction of cacao pods were obtained using the ultrasonic homogenizer method with ethanol 70%. The cytotoxicity test was observed for 24 hours and the doubling time proliferative test was observed for 24, 48, and 72 hours. Result: Cocoa pod husk extract showed there were no cytotoxic effects with viability of primary cells of periodontal ligament fibroblasts at the concentration of 1.56 pg/ml, 3.125 pg/ml, 6.25 pg/ml, 12.5 pg/ml, 25 pg/ml, 50 pg/ml, and 100 pg/ml. The proliferation test showed increasing of fibroblasts at 24 and 48 hours. Kruskal Wallis analysis obtained a significance value (p<0.05) Conclusion: Cytotoxicity and proliferation assays of Cocoa pod husk extract increased cell viability and cell proliferation of periodontal ligament fibroblast.
COWHIDE GELATIN NANOPARTICLES AND TITANIUM-PREPARED PLATELET-RICH FIBRIN POTENTIAL IN PERIODONTITIS HEALING PROCESS Kurniawati, Atik; Saputra, Dwi Riski; Sari, Dewi Yunita; Amanitha, Indhi Cinthiya; Masruroh Hariyati, Siti Nurul
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.73-81

Abstract

Introduction: Based on epidemiological data, the periodontitis prevalence in Indonesia reached 96.58%. Periodontitis is a periodontal disease caused by specific microorganisms causing attachment loss, alveolar bone resorption, and periodontal pocket. The pocket which is more than 6 mm couldn’t be carried out using standard care. Therefore bone grafting is needed to fix the bone defect. Cowhide Gelatin nanoparticle (GNPs) combined with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) is an innovative healing of periodontitis. Objective: To review the potential of cowhide gelatin nanoparticles combined with titanium-prepared platelet-rich fibrin (T-PRF) as an innovation in the healing of periodontitis defects. Literature review: Cowhide GNPs are the main ingredients for the bone replacement, which are nano-sized, biocompatible, bioactive, osteoconductive, non-toxic, and have a porous structure that supports the drug-delivery process. T-PRF contains platelets, fibrin, growth factors that can stimulate bone regeneration. Discussion: GNPs support the attachment and proliferation of osteoblast cells and the formation of mineralized bone matrix. The contents of T-PRF, which are fibrin, platelets, and growth factors, one of TGF-β1 will produce bone formation and periodontal healing in the large number. Moreover, T-PRF has leukocyte-fibrin, which may give an antibacterial effect. Thus, GNPs combined with T-PRF have more potent properties that support each other in carrying out their functions to stimulate the healing process. Conclusion: The combination of cowhide gelatin nanoparticles (GNPs) and titanium-prepared platelet-rich fibrin (T-PRF) has the potential to be effective in bone regeneration in periodontitis defects.
Co-Authors Ahrori, Moh. Hazim Al Aliby, Melky Rama Amanitha, Indhi Cinthiya Atik Kurniawati, Atik Azzery, Yasep Banun Kusumawardani Dedeh Husnaniyah Depi Yulyanti Iin Eliana Triwahyuni Jayanto, Arik Dwi Masruroh Hariyati, Siti Nurul Misbahuddin, M. Muhammad Khoirul Fikri Musari, Fajar Sidik Prasetyo, Ady Riski Maulana Saputra, Dwi Riski Setiawan, Yoga Nur Tamrin Fathoni Tarkawi Tarkawi Taufik Hidayat Tri Puji Astuti Yani Corvianindya Rahayu