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All Journal Jurnal Kesehatan Holistic Faletehan Health Journal Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) CHMK Applied Scientific Journal Jurnal Kesehatan Madani Medika Jurnal Health Sains Jurnal Fisioterapi dan Ilmu Kesehatan Sisthana (JUFDIKES) Medika Respati : Jurnal Ilmiah Kesehatan Medicor : Journal of Health Informatics and Health Policy Jurnal Ilmiah Ilmu Kesehatan
Anindini Winda Amalia
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Mekanisme Molekuler Imunomodulasi oleh Huangqi (Astragali Radix) Menggunakan Sistem Farmakologi Jejaring Raymond Rubianto Tjandrawinata; Anindini Winda Amalia; Hartati Tuna; Viedya Novalinda Said; Santi Tan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1301

Abstract

Astragali Radix (Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, also known as Huangqi) has been used to improve stamina and immunity for thousands of years. However, the bioactive components and their mechanisms are still unclear, limiting its clinical application. In this research, for the first time, network pharmacology was used to investigate the molecular mechanisms of Huangqi and its bioactive components that play an important role in improving the immune system. An amount of 1,430 immunomodulation-related target proteins was collected from the human genome database, with 171 target proteins from 20 bioactive components, and resulted in 60 intersection target proteins. Subsequently, the networks of common target and protein-protein interaction (PPI) were analyzed. The results showed that Huangqi influenced the modulations of lymphocytes (B cells and T cells), natural killer cells, macrophages, cytokines, immunoglobulins, and immune signal transduction. To a certain limit, this study revealed the potential bioactive components and pharmacological mechanisms of Huangqi in immunomodulation. It was able to direct novel drug development for treating immune system deficiency.
Co-Authors . HERNAYANTI Alfian , RM Alfian, RM Alpiah, Dini Nur Arjuni , Defi Atmira Sariwati Defi Arjuni Dewi Atika Putri Dini Nur Alpiah Dwi Ratna Sari Handayani Hafna Rosyita Hafna Rosyita Hafna Rosyita Handayani, Dwi Ratna Sari Hari Iskandar Hartati Tuna, Hartati Hernayanti Hernayanti Hernayanti Hernayanti Husen Husen husen husen Imam Waluyo ISMIY NOER WAHYUNI Iwan Kusnawirawan Iwan, Setiawan Ekawidjaja Jessi Suryani Setiawan Jessi Suryani Setiawan Jessi, Suryani Setiawan Koniasari Koniasari Koniasari Koniasari Koniasari, Koniasari Kusnawirawan, Iwan Lim Lia Harumiaty Paramita Ratna Gayatri Purba , Yunita Sari Ratna Ratna Raymond R. Tjandrawinata RM Alfian RM Alfian Rosyita , Hafna Rosyita, Hafna Sahuri , Sahuri Sahuri Sahuri Saidi, Viedya Novalinda Santi Tan Sari Handayani, Dwi Ratna Setiawan, Jessi Suryani Subu, Muhammad Arsyad Sulaiman, Yandy Viedya Novalinda Said Yunita Sari Purba