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Correlation between Protein-with-Molecular-Weight-53 (p53), Burkit Cell Lymphoma 2 (Bcl2), and Fas Ligand (FasL) and Vascular-Cell-Adhesion-Molecule-1 (VCAM-1) mRNA Expression Levels in a Pathogenesis Study of Preeclampsia Teguh, Mintareja; Karkata, Made Kornia; Wirakusumah, Firman Fuad; Mose, Johanes Cornelius; Satari, Mieke Hemiawati; Septiani, Leri
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To determine the role of protein-with-molecular-weight-53 (p53), burkit cell lymphoma 2 (Bcl2),  Fas ligand (FasL) mRNA, and vascular cell adhesion molecule 1 (VCAM-1), known as the apoptosis-related molecular pathway, in preeclamptic patients.     Methods: Observation on the correlation between the mRNA levels of p53, Bcl2 and FasL and VCAM-1 in 31 subjects at 28-42 weeks gestational age was performed in this study using the real time reverse transcriptase-polymerase chain reaction (RT-PCR).    Results: The results showed that p53 mRNA increased (>1.2350 ng/μL) in the preeclampsia group compared to the normal pregnancy group (p=0.010), Bcl2 mRNA was lower (≤0.9271 ng/μL) in the preeclampsia group than the control group (p=0.041). There was also a tendency of increased FasL mRNA expression (>0.5509 ng/μL) in the preeclampsia group compared to the normal pregnancy group (p=0.300). The level of VCAM-1 elevated (>890.08 ng/mL) in the preeclampsia group compared to the normal pregnancy group (p=0.001). In preeclampsia, the correlation between the Bcl2/p53 ratio and VCAM-1 was r=0.541 (p=0.002), whereas the correlation in normal pregnancy was r=0.099 (p=0.595).     Conclusions: There are correlations between the mRNA expression levels of p53 and Bcl2 as an intrinsic pathway of apoptosis along with the VCAM-1 levels in the incidence of preeclampsia. However, no correlation is found between FasL mRNA expression and the incidence of preeclampsia.Keywords: Bcl2, FasL, p53, Preeclampsia, VCAM-1DOI: 10.15850/ijihs.v2n1.273
Pengaruh Senam Hamil Teratur pada Primigravida terhadap Perubahan Psikofisiologis Ibu dan Berat Badan Lahir Bayi Leri Septiani
Sehat MasadaJurnal Vol 11 No 1 (2017): Jurnal Sehat Masada
Publisher : stikes dharma husada bandung

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Abstract

Tingginya keluhan ketidaknyamanan ibu pada saat hamil terutama pada ibu primigravida dapat meningkatkan kecemasan ibu serta berdampak merugikan bagi bayi yang dilahirkan. Upaya yang dapat dilakukan untuk menurunkan ketidaknyamanan adalah dengan senam hamil teratur. Manfaat melakukan senam hamil dapat memperlancar peredaran darah, mempersiapkan pernapasan serta meningkatkan kepercayaan diri. Tujuan penelitian ini adalah untuk menganalisis pengaruh senam hamil teratur pada primigravida terhadap perubahan psikofisiologis ibu dan berat badan lahir bayi. Penelitian ini menggunakan metode quasi eksperimental dengan rancangan pretest-posttest control group design. Populasi penelitian ini adalah ibu hamil primigravida yang mengikuti senam hamil. Pengambilan sampel dilakukan dengan teknik non-random sampling dengan metode consecutive sampling. Jumlah sampel 50 responden yang dibagi menjadi 25 responden kelompok perlakuan dan 25 responden kelompok kontrol,pengolahan dan analisis data menggunakan uji kai kuadrat,eksak fisher, Mann-whitney dan T-test. Hasil penelitian ini menunjukkan adanya pengaruh senam hamil teratur terhadap penurunan skor kecemasan (nilai p=0,026), perubahan tekanan darah diastolik (nilai p=0,014) dan perubahan pernapasan (nilai p<0,001) yang memperlihatkan adanya perbedaan yang signifikan antara kelompok perlakuan dan kelompok kontrol. Tetapi tidak terdapat perbedaan yang bermakna pada tekanan darah sistolik(p>0,05), penambahan berat badan ibu(p>0,05) dan berat badan lahir bayi (p>0,05). Simpulan dalam penelitian ini adalah senam hamil teratur berpengaruh terhadap penurunan kecemasan, perubahan tekanan darah, dan perubahan pernapasan. Dan tidak terdapat pengaruh senam hamil yang teratur terhadap perubahan Tekanan darah sistolik, penambahan berat badan ibu dan berat badan lahir bayi.
Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review Leri Septiani; Yudi Mulyana Hidayat; Mutakin Mutakin; Rizky Abdulah; Ahmad Faried; Hiroshi Koyama
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To analyze the role of selenium and glutathione peroxidase (GPx) in cervical cancer.Methods: Serum selenium concentrations and GPx activities of 19 women with cervical cancer along with their healthy counterparts (control group) were obtained. Selenium concentration were measured fluorometrically and GPx activities were measured spectrophotometrically based on the quantity of NADPH used in the reduction of glutathione. Results: The mean of serum selenium concentrations in cervical cancer group was significantly lower than that in the control group, 67.24±15 ng/mL and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the cervical cancer group was also significantly lower than that in the control group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04), respectively. Multivariate analysis in the cervical cancer patients showed that the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) staging score (early vs. advanced) was inversely correlated with serum selenium concentration (p=0.027).Conclusions: Serum selenium concentration and GPx activity was significantly lower in the cervical cancer patients. Our results demonstrate that selenium and GPx activity may have an important role in the carcinogenesis of cervical cancer. Keywords: Cervical cancer, glutathione peroxidase activity, selenium DOI: 10.15850/ijihs.v4n2.833
The effect of sitting and soaking therapy with binahong leaf (Anredera cordifolia) decoction on perineal wound healing Daini Zulmi; Leri Septiani; Suryani Soepardan
Majalah Obstetri dan Ginekologi Vol. 27 No. 1 (2019): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.094 KB) | DOI: 10.20473/mog.V27I12019.28-33

Abstract

Objective: To analyze the effect of sitting and soaking therapy with the decoction of Anredera cordifolia on the perineal wound healing in postpartum period mothers.Materials and Methods: The research method used is the Quasi-Experiment with pretest-posttest control group design, a sample of 62 primiparous postpartum period mothers with 2nd-grade perineal rupture. The sampling technique used is purposive sampling to obtain 31 respondents treated by 31 respondents. The wound healing variable was observed using the REEDA scale. The characteristic analysis is tested using Mann-Whitney statistical test, while to test the effect analysis is tested using the Wilcoxon test.Results: The results of this study in the intervention group showed 52.71% was cured after getting treatment for perineal wounds sitting and soaking therapy with the decoction of Anredera cordifolia. On the other hand, in the control group, using only clean water shows 27.90% recovered. Analysis data effect of using the decoction of Anredera cordifolia 25% containing on perineal wound healing showed results with Wilcoxon Test with value (p<0.05).Conclusion: Based on this result there is an effect of sitting and soaking therapy with the decoction of Anredera cordifolia on perineal wound healing for postpartum mothers.
Pengaruh Kombinasi Akupresur Pada Titik Sp6 (San Yin Ciau) Dan Gb21 (Jian Jing) Terhadap Pemendekan Kala I Fase Laten Pada Primigravida Muayah Muayah; Leri Septiani; Udin Sabarudin; Hidayat Wijayanegara; Herri Sastramihardja; Tania Novy
Jurnal Sistem Kesehatan Vol 6, No 1 (2021): Volume 6 Nomor 1 September 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jsk.v6i1.35635

Abstract

Akupresur titik SP6 dan GB21 merangsang produksi hormon endorfin yang dapat mengelola nyeri persalinan dan merangsang peningkatan hormon oksitosin dalam tubuh secara alami sehingga dapat mempersingkat waktu persalinan. Penelitian bertujuan menganalisis pengaruh kombinasi akupresur titik SP6 dan GB21 terhadap pemendekan kala I fase laten pada primigravida. Metode rancangan penelitian menggunakan quasi eksperimen dengan posttest only design with nonequivalent groups. Tehnik pengambilan sampel menggunakan consecutive sampling dengan jumlah sampel 62 primigravida, kontrol (n=31) dan intervensi (n=31). Penelitian dilaksanakan Juni - Juli 2019 di wilayah kerja Puskesmas Kronjo dan Puskesmas Mekar Baru Kabupaten Tangerang. Penekanan Akupresur dimulai dari SP6 kemudian GB21 masing-masing 15 kali selama 15 menit dengan cara pemberian 30 detik kemudian jeda 30 detik (1 kali). Cara pengukuran lama kala I fase laten menggunakan lembar observasi. Analisis statistik menggunakan Independent T-Test. Hasil penelitian menunjukkan bahwa rata-rata durasi kala I fase laten kelompok kontrol dan intervensi (403,03 dan 337,9 menit) dengan nilai p 0,016, sehingga kelompok intervensi lebih singkat 66,13 menit (1 jam 1 menit) dibanding kelompok kontrol. Simpulan terdapat pengaruh kombinasi akupresur titik SP6 dan GB21 terhadap pemendekan kala I fase laten pada primigravida.Kata kunci: Akupresur, kala I fase laten, primigravida, titik SP6, titik GB21.
Influence of Adolescent Reproductive Health Promotion Media Booklet on Knowledge and Attitude of Adolescents Living in Work Area of Ibrahim Adjie Public Health Center in 2018 Sri Hennyati Amiruddin; Sri Komalaningsih; Ma&#039;mun Sutisna; Hidayat Wijayanegara; Leri Septiani; Herry Garna
Global Medical & Health Communication (GMHC) Vol 8, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.419 KB) | DOI: 10.29313/gmhc.v8i2.4962

Abstract

Adolescent period is a critical period that requires quality health services. The aim of this study was to analyze the effect of health education through booklet media on the knowledge and attitude towards reproductive health among adolescents. This was a quasi-experimental case control study with nonequivalent two group design conducted on 282 students of SMP Negeri 37, a public junior high school, in the work area of Ibrahim Adjie Public Health Center in Bandung city during December 2018–May 2019. Subjects were divided into two groups, intervention and control groups, with 141 subjects in each group. Data collected were tested for normality and homogeneity using Kolmogorov-Smirnov and Levene tests, respectively, followed by a bivariate analysis using Wilcoxon test to determine the difference. Knowledge of all students in both groups was poor during pre-test with an increase found in 135 subjects (95.7%) in the intervention group (p=0.001) and 63 subjects (44.7%) in the control group (p=0.003) based on the post-test results. Negative attitude was also seen in both groups during pre-test, with a shift towards positive attitude was evident in 134 students (95.0%) in the intervention group (p=0.001) and 117 students (83.0%) in the control group (p=0.002) based on post-test results. This presence that health information conveyed through booklet has a probability of giving 0.995 times stronger influence leaflet. Thus, the use of booklet can improve knowledge and attitude towards adolescent reproductive health. PENGARUH BOOKLET MEDIA PROMOSI KESEHATAN REPRODUKSI REMAJA TERHADAP PENGETAHUAN DAN SIKAP REMAJA YANG BERTEMPAT TINGGAL DI WILAYAH KERJA PUSKESMAS IBRAHIM ADJIE TAHUN 2018Masa remaja merupakan masa kritis yang membutuhkan pelayanan kesehatan yang berkualitas. Tujuan penelitian ini adalah menganalisis pengaruh pendidikan kesehatan melalui media booklet terhadap pengetahuan dan sikap remaja tentang kesehatan reproduksi. Penelitian ini merupakan penelitian quasi-experimental case control dengan rancangan nonequivalent two group yang dilaksanakan terhadap 282 siswa/i SMP Negeri 37 di wilayah kerja Puskesmas Ibrahim Adjie Kota Bandung selama Desember 2018–Mei 2019. Subjek dibagi menjadi dua kelompok, yaitu kelompok intervensi dan kontrol dengan 141 subjek di setiap kelompok. Data yang terkumpul diuji normalitas dan homogenitasnya masing-masing menggunakan Uji Kolmogorov-Smirnov dan Levene, dilanjutkan dengan analisis bivariat menggunakan Uji Wilcoxon untuk mengetahui perbedaannya. Pengetahuan semua siswa pada kedua kelompok kurang saat pre-test dengan peningkatan pengetahuan 135 subjek (95,7%) pada kelompok intervensi (p=0,001) dan 63 subjek (44,7%) pada kelompok kontrol (p=0,003) berdasar atas hasil post-test. Sikap negatif juga terlihat pada kedua kelompok selama pre-test dengan pergeseran ke arah sikap positif 134 siswa (95,0%) pada kelompok intervensi (p=0,001) dan 117 siswa (83,0%) pada kelompok kontrol (p=0,002) berdasar atas hasil post-test. Informasi kesehatan yang disampaikan melalui media booklet ini berpeluang memberikan pengaruh 0,995 kali lebih kuat daripada media leaflet. Dengan demikian, penggunaan booklet dapat meningkatkan pengetahuan dan sikap remaja terhadap kesehatan reproduksi. Simpulan, terdapat pengaruh pendidikan kesehatan melalui media booklet terhadap pengetahuan dan sikap remaja tentang kesehatan reproduksi.
Noviemeter Diagnostic Test as a Head Circumference Measurement Device for Under-Five Children Novita Ayu Indraswati; Ma’mun Sutisna; Achmad Suardi; Hidayat Wijayanegara; Leri Septiani; Herry Garna
Global Medical & Health Communication (GMHC) Vol 9, No 3 (2021)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.054 KB) | DOI: 10.29313/gmhc.v9i3.7741

Abstract

The current typical practice for measuring the head circumference of under-five children is by using a measuring tape. However, it may create some difficulties as children cry and move during measurement, leading to less accurate results. Accurate head circumference measurement is essential for assessing brain development and early detection of brain development disorders. Therefore, a more accurate device to measure head circumference is needed. Noviemeter is a non-touch digitalized head circumference measuring device that enables easier measurement in under-five children. As a new tool, noviemeter’s accuracy, sensitivity, and specificity must be determined. This study aimed to analyze the difference in the head of under-five children circumference measurement results between a typical measuring tape as the gold standard and noviemeter and determine the accuracy, sensitivity, and specificity of the noviemeter. It was a cross-sectional analytical study using cluster random sampling on 72 under-five children in the work area of Guntung Payung Public Health, South Kalimantan, during August 2020. The measurement was performed twice, first using a measuring tape and, second, using a noviemeter. Data were analyzed statistically using the dependent t test and diagnostic test. No significant difference was found between the results of the two measuring devices (p=0.257). The sensitivity, specificity, and accuracy of the noviemeter were 87.0%, 88.4%, and 91.8%, respectively. Thus, noviemeter has good sensitivity, specificity, and accuracy as an easier alternative device to measure head circumference in under-five children. UJI DIAGNOSTIK NOVIEMETER SEBAGAI ALAT PENGUKUR LINGKAR KEPALA BALITAPraktik pengukuran lingkar kepala balita yang umum dilakukan saat ini adalah dengan menggunakan pita ukur. Akan tetapi, hal itu dapat menimbulkan beberapa kesulitan karena anak menangis dan bergerak selama pengukuran yang menyebabkan hasil yang kurang akurat. Pengukuran lingkar kepala yang akurat sangat penting untuk menilai perkembangan otak dan deteksi dini gangguan perkembangan otak. Oleh karena itu, diperlukan alat yang lebih akurat untuk mengukur lingkar kepala. Noviemeter merupakan alat pengukur lingkar kepala digital non-sentuh yang memungkinkan pengukuran lebih mudah pada anak balita. Sebagai alat baru, akurasi, sensitivitas, dan spesifisitas noviemeter harus ditentukan. Penelitian ini bertujuan menganalisis perbedaan hasil pengukuran lingkar kepala balita antara pita ukur tipikal sebagai baku emas dan noviemeter serta mengetahui akurasi, sensitivitas, dan spesifisitas dari noviemeter tersebut. Jenis penelitian ini adalah cross-sectional analytical dengan menggunakan cluster random sampling pada 72 balita di wilayah kerja Puskesmas Guntung Payung Kalimantan Selatan selama bulan Agustus 2020. Pengukuran dilakukan dua kali, pertama menggunakan pita pengukur dan kedua menggunakan noviemeter. Data dianalisis secara statistik menggunakan uji t dependen dan uji diagnostik. Tidak ditemukan perbedaan yang signifikan antara hasil kedua alat ukur (p=0,257). Sensitivitas, spesifisitas, dan akurasi noviemeter masing-masing adalah 87,0%; 88,4%; dan 91,8%. Dengan demikian, noviemeter memiliki sensitivitas, spesifisitas, dan akurasi yang baik sebagai alat alternatif yang lebih mudah untuk mengukur lingkar kepala pada anak balita.
Effect of Zilgrei Method and Lumbal Massage Combination on Labor Progress During Latent Phase of First Stage of Labor in Primigravida Melati Yuliandari; Leri Septiani; Roni Rowawi; Sri Komalaningsih; Herry Garna
Global Medical & Health Communication (GMHC) Vol 8, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2480.888 KB) | DOI: 10.29313/gmhc.v8i2.5083

Abstract

The first stage of labor starts from the onset of cervical dilatation and divided into latent and active phases. The latent phase is a more prolonged phase of labor, which allows various interventions performed. Interventions and the latent phase's length may lead to anxiety and restlessness, which might contribute to prolonged labor when experienced by women in labor. A combination of the Zilgrei method and lumbar massage used to reduce labor pain. This method combines movement, change of position, breathing exercise, and the light massage performed since the first stage of labor. It expected that the work of interrelated pelvic muscles becomes harmonized; hence, the cervix will be softer, and the uterine muscles may push the fetus towards the birth canal. This study aimed to determine the effect of the Zilgrei method and lumbar massage combination on the latent phase of the first stage of labor progress in primigravida. It is a quantitative quasi-experimental study on 66 women who underwent the latent phase of the first stage of labor in independent practice of midwife the work area of Citarip Public Health Center during May–July 2019, who were divided equally into control and intervention groups. The statistical analysis used was univariate and bivariate analyses with an independent t test. The mean duration of labor in the latent phase of the first stage of labor in the control group and intervention group was 368 minutes and 307 minutes, respectively, with a difference of 61 minutes (p=0.002). Therefore, the Zilgrei method and lumbar massage combination significantly affect labor progress in the latent phase of the first stage of labor in primigravida. PENGARUH KOMBINASI METODE ZILGREI DAN PEMIJATAN LUMBAL TERHADAP PROSES KEMAJUAN PERSALINAN PADA PRIMIGRAVIDAKala I persalinan merupakan tahap serviks terbuka yang terdiri atas fase laten dan fase aktif. Fase laten mempunyai durasi persalinan lebih panjang sehingga memungkinkan banyak intervensi. Intervensi dan lama fase laten dapat menimbulkan kecemasan dan kegelisahan, apabila dialami ibu in partu dapat menjadi faktor persalinan lama. Kombinasi Metode Zilgrei dan pemijatan lumbal menjadi metode mengurangi rasa nyeri persalinan yang menggabungkan gerakan, perubahan posisi, latihan pernapasan, dan pijatan ringan yang dipersiapkan sejak kala I persalinan. Diharapkan kerja otot panggul saling berkaitan menjadi selaras sehingga serviks tidak kaku dan terdapat potensi otot rahim mendorong janin menuju jalan lahir. Tujuan penelitian ini mengetahui pengaruh kombinasi Metode Zilgrei dan pemijatan lumbal terhadap kemajuan proses persalinan kala I fase laten pada primigravida. Penelitian ini merupakan penelitian kuasi eksperimental kuantitatif pada 66 wanita yang menjalani fase laten persalinan kala I di bidan praktik mandiri (BPM) wilayah kerja Puskesmas Citarip periode Mei–Juli 2019 yang dibagi rata menjadi kelompok kontrol dan intervensi. Analisis statistik menggunakan analisis univariat dan bivariat dengan uji t independen. Durasi persalinan kala I fase laten rerata kelompok kontrol dan intervensi adalah 368 menit dan 307 menit masing-masing dengan selisih waktu 61 menit (p=0.002). Simpulan. kombinasi Metode Zilgrei dan pemijatan lumbal berpengaruh terhadap kemajuan proses persalinan kala I fase laten pada primigravida.
Influence Breast Care Massage Methods To Increase Production Oketani mother's milk (ASI) On Mother Post Partum In Puskesmas Gunungsitoli-Nias: Influence Breast Care Massage Methods To Increase Production Oketani mother's milk (ASI) On Mother Post Partum In Puskesmas Gunungsitoli-Nias Jernihati Krisniat Harefa; Anita Deborah Anwar; Tania Novi; Hidayat Wijayanegara; Leri Septiani; Herry Garna
Journal of Midwifery and Nursing Vol. 2 No. 1 (2020): Health Science
Publisher : Institute Of Computer Science (IOCS)

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Abstract

Oketani massage method can stimulate the pectoral muscle strength mayoruntuk increase milk production and makes the breasts become soft and elastic, making it easier for the baby to suckle. Breast care massage method Oketani this method does not provide pain and discomfort to the mother's breast that is different from the conventional massage. This study aimed to analyze the effect of breast care massage Oketani method to increase milk production in postpartum mothers with indicators of infant weight gain. The method used is quasi-experimental with two group design approach pretest posttest control group design with a sample of 82 mothers postpartum primiparous spontaneous and have a baby. The experiment was conducted in Puskesmas Kota Gunung Sitoli-Nias May to July 2019. Sampling consecutive sampling to obtain each 41 respondents mothers and babies the treatment group and the control group. Variable Methods breast care and breast care massage Oketani conventionally measured by observation sheet, whereas to measure the milk production with the baby weighing indicator. Analysis of the characteristics of respondents were tested using the chi-square test, the mean differences with the Mann-Whitney test, and the difference between the intervention and control by Friedman test. The results showed an average weight infants in the intervention group showed an increase Oketani massage method of infant weight at day 14 as much as 3.35% of birth weight whereas the control group declined 1.3% of birth weight. The result of the difference between the two groups showed no significant difference between before and after the intervention, p = 0.000. In conclusion, there is the effect of breast care massage Oketani method to increase milk production (milk) in the mother post partum.
Peningkatan Pengeluaran ASI Dilihat Dari Indikator Kenaikan Berat Badan Bayi Pada Ibu Nifas Dengan Menggunakan Baju Pijat Oksitosin di Bidan Praktik Mandiri Hj. Siti Aisyah SG., M.Tr.Keb., CHE Delvira Andini; Udin Sabarudin; Leri Septiani
Jurnal Sistem Kesehatan Vol 6, No 2 (2021): Volume 6 Nomor 2 Desember 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jsk.v6i2.48526

Abstract

Beratnya keluhan, ketidak percayaan diri, dan perasaan khawatir mengakibatkan hormon oksitosin terhambat. Upaya yang dilakukan untuk melancarkan pengeluaran ASI di antaranya adalah metode Pijat Oksitosin. Tujuan penelitian ini adalah menganalisis pengeluaran ASI dilihat dari indikator kenaikan berat badan bayi dengan melakukan pijat oksitosin pada ibu nifas yang menggunakan baju pijat oksitosin. Metode penelitian pre eksperimen dengan pendekatan one group pretest-posttest design. Jumlah sampel 30 ibu nifas primipara. Penelitian dilaksanakan pada tanggal 01 Juni sampai 03 Juli 2020 di Bidan Praktik Mandiri Hj. Siti Aisyah SG.,M.Tr.Keb., CHE Jakarta Timur. Pengambilan sampel menggunakan consecutive sampling. Variabel pengeluaran ASI dilihat dari indikator kenaikan berat badan bayi. Analisis perubahan dan selisih berat badan bayi terhadap peningkatan pengeluaran ASI menggunakan uji t berpasangan. Hasil penelitian menunjukkan terjadi penurunan berat badan bayi pada hari ke-4 sebesar 2,23% dan mengalami kenaikan pada hari ke-7 sebesar 2,61% dari berat badan hari ke-1. Selisih rerata perubahan berat badan bayi hari ke-1 dengan hari ke-7 sebesar 98,667g dengan standar deviasi 58,689g, hasil uji statistik didapat p 0,00. Pijat oksitosin dengan baju pijat oksitosin menunjukkan t hit sebesar 9,224 g dan ttab sebesar 1,699 g (thit > ttab). Simpulan, penggunaan baju pijat oksitosin pada ibu nifas dapat mengakibatkan pengeluaran ASI lebih banyak dilihat dari indikator kenaikan berat badan bayi pada hari ke-7.Kata Kunci : Baju pijat oksitosin, Berat badan bayi, Pengeluaran ASI