Article Per Year (5 Year)
p-Index From 2020 - 2025
1.789
P-Index
This Author published in this journals
All Journal International Journal of Integrated Health Sciences Global Medical and Health Communication Majalah Obstetri dan Ginekologi Jurnal Sistem Kesehatan Journal of Midwifery and Nursing Jurnal Riset Kesehatan Poltekkes Depkes Bandung JURNAL MUTIARA NERS Sehat Masada Jurnal WIDYA LAKSMI (Jurnal Pengabdian Kepada Masyarakat) ENDLESS : International Journal of Future Studies
Leri Septiani
STIKes Dharma Husada, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Other

Published : 16 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 16 Documents
Search

 1   2 
The Effectiveness of Referral Back Sheets on Early Detection of High Maternal Risk in the Work Area of Subang Health Department Leri Septiani; Yanti Herawati; Hidayat Wijayanegara; Siti Sugih Hartiningsih
ENDLESS: INTERNATIONAL JOURNAL OF FUTURE STUDIES Vol. 6 No. 2 (2023): ENDLESS: International Journal of Future Studies
Publisher : Global Writing Academica Researching & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Maternal health is an important aspect of the health care system, as the quality of maternal health has a direct impact on the well-being of the mother and her unborn child. High maternal risk refers to conditions that increase the potential for complications during pregnancy, labor and postpartum. Early identification of high maternal risk is crucial to provide appropriate care and reduce the risk of complications that can harm both mother and baby. One tool that can be used to support early detection of high maternal risk is the Pre-Referral Back Sheet (PRBS). PRBS is an instrument that presents a collection of questions or certain parameters that must be filled in by health workers, especially midwives during prenatal examinations. It is designed to identify risk factors and early symptoms that may indicate potential maternal high risk. Although the LBPR has been integrated into maternal health care practice, no in-depth study has specifically evaluated its effectiveness in early detection of maternal high risk. Therefore, this study aimed to evaluate the effectiveness of the Pre-Referral Back Sheet in early detection of maternal high risk and identify the extent to which this tool can improve the quality of maternal health care. This study used an observational method with a cross-sectional approach with a sample of 450 pregnant women who attended prenatal examinations at selected health centers. Of the total 450 respondents, the majority were pregnant women of reproductive age (20-35 years) with an average age of 28 years. 60% of respondents had secondary education, and 80% lived in urban areas. The prevalence of maternal high risk in the Subang Health Office Working Area was found to be 18%, based on the criteria identified by the LBPR. Statistical analysis showed that the use of LBPR significantly improved early detection of maternal high risk. The sensitivity of LBPR reached 75%, with a specificity of 85%. These results indicate that the LBPR can identify most maternal high-risk cases with good accuracy. Based on these findings, it can be concluded that the Pre-Referral Back Sheet (LBPR) is effective in early detection of maternal high risk in the Subang Health Office Working Area. The use of LBPR can improve the quality of maternal health services and contribute positively to efforts to prevent and manage high maternal risk.
Akt–the Mammalian Target of Rapamycin (mTOR) Pathway Inhibition Increases Cervical Cancer Cell Chemosensitivity to Active Form of Irinotecan (SN-38) Leri Septiani; Yudi Mulyana Hidayat; Yusuf Sulaeman Effendi; Tono Djuwantono; Dimas Erlangga Luftimas; Ahmad Faried
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1048.106 KB)

Abstract

Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24–72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103
Pengaruh Senam Hamil Teratur pada Primigravida terhadap Perubahan Psikofisiologis Ibu dan Berat Badan Lahir Bayi Septiani, Leri
Sehat MasadaJurnal Vol 11 No 1 (2017): Jurnal Sehat Masada
Publisher : stikes dharma husada bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tingginya keluhan ketidaknyamanan ibu pada saat hamil terutama pada ibu primigravida dapat meningkatkan kecemasan ibu serta berdampak merugikan bagi bayi yang dilahirkan. Upaya yang dapat dilakukan untuk menurunkan ketidaknyamanan adalah dengan senam hamil teratur. Manfaat melakukan senam hamil dapat memperlancar peredaran darah, mempersiapkan pernapasan serta meningkatkan kepercayaan diri. Tujuan penelitian ini adalah untuk menganalisis pengaruh senam hamil teratur pada primigravida terhadap perubahan psikofisiologis ibu dan berat badan lahir bayi. Penelitian ini menggunakan metode quasi eksperimental dengan rancangan pretest-posttest control group design. Populasi penelitian ini adalah ibu hamil primigravida yang mengikuti senam hamil. Pengambilan sampel dilakukan dengan teknik non-random sampling dengan metode consecutive sampling. Jumlah sampel 50 responden yang dibagi menjadi 25 responden kelompok perlakuan dan 25 responden kelompok kontrol,pengolahan dan analisis data menggunakan uji kai kuadrat,eksak fisher, Mann-whitney dan T-test. Hasil penelitian ini menunjukkan adanya pengaruh senam hamil teratur terhadap penurunan skor kecemasan (nilai p=0,026), perubahan tekanan darah diastolik (nilai p=0,014) dan perubahan pernapasan (nilai p<0,001) yang memperlihatkan adanya perbedaan yang signifikan antara kelompok perlakuan dan kelompok kontrol. Tetapi tidak terdapat perbedaan yang bermakna pada tekanan darah sistolik(p>0,05), penambahan berat badan ibu(p>0,05) dan berat badan lahir bayi (p>0,05). Simpulan dalam penelitian ini adalah senam hamil teratur berpengaruh terhadap penurunan kecemasan, perubahan tekanan darah, dan perubahan pernapasan. Dan tidak terdapat pengaruh senam hamil yang teratur terhadap perubahan Tekanan darah sistolik, penambahan berat badan ibu dan berat badan lahir bayi.
BED PORTABLE MASSAGE OKSITOSIN TERHADAP KELANCARAN DAN PRODUKSI ASI PADA IBU POSTPARTUM Metaliasari, Metaliasari; Septiani, Leri; Sastramihardja, Herri S; Sutisna, Ma’mun; Sugih, Siti; Rowawi, Roni
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2756

Abstract

Pemberian ASI masih menjadi tantangan global, dengan hanya 31 dari 194 negara yang berhasil mencapai target pemberian ASI eksklusif sebesar 50%. Salah satu cara untuk meningkatkan kelancaran dan produksi ASI adalah dengan merangsang hormon prolaktin dan oksitosin melalui perawatan payudara, pemijatan, serta pijat oksitosin. Pijat oksitosin dikenal sebagai metode efektif untuk mengatasi kesulitan menyusui. Penelitian ini bertujuan untuk mengetahui pengaruh bed portable massage oksitosin terhadap kelancaran dan produksi ASI pada ibu postpartum. Penelitian ini menggunakan desain quasi-eksperimental dengan pendekatan non-equivalent control group design. Populasi penelitian adalah ibu postpartum yang melahirkan pada periode 1 Juli – 30 Juli 2024, dengan total 72 orang. Sampel sebanyak 60 responden dipilih menggunakan teknik accidental sampling, yang kemudian dibagi menjadi dua kelompok (intervensi dan kontrol). Pengumpulan data dilakukan dengan observasi langsung terhadap ibu postpartum dari hari ke-1 hingga hari ke-7, dan analisis data menggunakan uji paired t-test. Hasil penelitian menunjukkan bahwa penggunaan Bed Portable Massage Oksitosin meningkatkan frekuensi menyusui (>8–12 kali per hari) dengan nilai p = 0,012 (<0,05), yang menunjukkan perbedaan signifikan. Selain itu, setelah penggunaan bed portable massage oksitosin, hampir seluruh responden (28 dari 30 orang) mengalami produksi ASI penuh, dengan nilai p= 0,001 (<0,05), yang mengindikasikan efek signifikan terhadap kelancaran ASI. Terdapat pengaruh signifikan penggunaan Bed Portable Massage Oksitosin terhadap kelancaran dan produksi ASI pada ibu postpartum.
PRE-REFERRAL PROGRAM DEVELOPMENT Leri Septiani; Hidayat Wijayanegara; Lina Herlina
Jurnal Ilmiah Keperawatan Vol 8 No 1 (2025): Jurnal Mutiara Ners
Publisher : Program Studi Ners UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jmn.v8i1.5836

Abstract

Background: Indonesia's healthcare system is designed with tiered referrals, involving primary, secondary, and tertiary services that work synergistically to provide optimal care. The pre-referral stage is an important element in this system, where patients receive initial treatment at primary health facilities before being referred to higher levels. This stage aims to ensure proper initial care as well as quick and effective referrals according to the patient's condition. However, the implementation of pre-referral programs often faces obstacles such as limited primary health facilities, lack of coordination between facilities, and difficulty accessing supporting information technology. Objective: to analyze the development of a pre-referral program to improve the effectiveness of patient referrals. Research method: Participatory Action Research (PAR) approach, involving Community Health Center and hospitals under the coordination of the Subang Health Office for six months (November 2023-April 2024). The sample consisted of three Community Health Center and five hospitals selected based on their capacity to handle obstetric cases. Data were collected through a Likert scale questionnaire to measure the feasibility of pre-referral media. Results: The results showed that the pre-referral back sheet had high validity (99.6%) and could be used. Interviews revealed problems such as delays in the referral process due to incomplete medical information and inconsistent documentation standards. Conclusion: The importance of periodic evaluation of this program to ensure its sustainability and effectiveness is emphasized. Health worker feedback as well as evaluation of patient care outcomes should be used for continuous improvement in the obstetric referral system.
PENGUATAN KESEHATAN IBU: IMPLEMENTASI PROGRAM PRARUJUKAN Leri Septiani; Lina Herlina
Jurnal Widya Laksmi: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2025): Jurnal WIDYA LAKSMI (Jurnal Pengabdian Kepada Masyarakat)
Publisher : Yayasan Lavandaia Dharma Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59458/jwl.v5i2.205

Abstract

This community service program aimed to strengthen maternal health through the implementation of the Pre-Referral Flipchart (LBPR) as an effort for early detection and management of high-risk maternal cases in the working area of Ciasem Health Center, Subang Regency. The activity was motivated by the high maternal and infant mortality rate, largely caused by delays in referral and low compliance of health workers in using pre-referral instruments. The program was implemented through training for village midwives, Polindes midwives, and maternal and child health (MCH) coordinators on the use of LBPR, preparation and distribution of guidelines and SOPs, the establishment of internal monitoring teams and champion midwives, as well as regular evaluations. Data were collected through observation, interviews, pre-test and post-test, and analyzed descriptively to assess compliance, knowledge improvement, and skills. The results showed an increase in midwives’ understanding of the function and content of LBPR, improved compliance in using the document during referral processes, and the establishment of a simple monitoring system for monthly evaluation. This program succeeded in improving referral flow, enhancing health workers’ readiness in handling high-risk pregnancies, and encouraging collaboration among health facilities. In conclusion, this educational and systematic intervention proved effective in increasing compliance with LBPR use and has the potential to reduce delays in maternal referrals
Co-Authors Achmad Suardi Ahmad Faried Anita Deborah Anwar Daini Zulmi Delvira Andini Dimas Erlangga Luftimas Firman Fuad Wirakusumah Hartiningsih, Siti Sugih Herri S. Sastramihardja Herry Garna Hidayat Wijayanegara Hiroshi Koyama Jernihati Krisniat Harefa Johanes C. Mose Lina Herlina Ma&#039;mun Sutisna Made Kornia Karkata Ma’mun Sutisna Melati Yuliandari Metaliasari, Metaliasari Mieke Hemiawati Satari Mintareja Teguh Muayah Muayah Mutakin Mutakin Novita Ayu Indraswati Rizky Abdulah Rowawi, Roni Sri Hennyati Amiruddin Sri Komalaningsih Sugih, Siti Suryani Soepardan Sutisna, Ma’mun Tania Novi Tania Novy Tono Djuwantono Udin Sabarudin Yanti Herawati Yudi Mulyana Hidayat Yusuf Sulaeman Effendi