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All Journal Jurnal Plastik Rekonstruksi Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal ABDIMAS MUTIARA Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Cermin Dunia Kedokteran
Wina Sinaga
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Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Pemberian Nutrisi Terkait Perubahan Metabolisme pada Pasien Penyakit Ginjal Kronik Derajat 5 dengan Hemodialisis Rutin Sinaga, Wina; Dhita Alfara, Lady
Cermin Dunia Kedokteran Vol 43, No 1 (2016): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (761.061 KB) | DOI: 10.55175/cdk.v43i1.12

Abstract

Pasien penyakit ginjal kronik derajat 5 mengalami suatu keadaan ginjal yang sama sekali tidak dapat mempertahankan homeostasis metabolisme tubuh, sehingga membutuhkan terapi pengganti ginjal. Terapi pengganti ginjal yang paling sering dipilih adalah hemodialisis. Gangguan fungsi ginjal dan proses hemodialisis dapat menyebabkan berbagai perubahan metabolisme, sehingga terjadi berbagai masalah nutrisi. Dibutuhkan terapi terintegrasi yang terdiri atas terapi farmakologi, terapi pengganti ginjal, terapi nutrisi, dan dukungan psikologis. Pemberian nutrisi pada pasien PGK dengan hemodialisis bertujuan untuk mengatasi gejala dan mencegah komplikasi.
Peran Tunas Brokoli pada Stres Oksidatif Penyandang Diabetes Sinaga, Wina
Cermin Dunia Kedokteran Vol 43, No 10 (2016): Anti-aging
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.023 KB) | DOI: 10.55175/cdk.v43i10.880

Abstract

Penyandang diabetes mengalami hiperglikemia dan peningkatan kadar asam lemak bebas yang menyebabkan stres oksidatif. Stres oksidatif tersebut dapat menyebabkan komplikasi vaskuler jangka panjang. Pemberian antioksidan diharapkan dapat memperbaiki keadaan stres oksidatif pada penyandang diabetes. Tunas brokoli merupakan brokoli berumur tiga sampai empat hari, mengandung komponen aktif sulforaphane. Sulforaphane bekerja pada enzim fase 2 dan berpotensi sebagai antioksidan kuat. Berbagai penelitian menunjukkan manfaat pemberian tunas brokoli pada perbaikan stres oksidatif penyandang diabetes.Hiperglycemia and elevated free fatty acid cause oxidative stress in diabetes patients which may long term vascular complications. Antioxidant can theoretically reduce oxidative stress in diabetes. Broccoli sprouts is three to four-day old broccoli, contain bioactive component sulforaphane. Sulforaphane is an enzyme, strong inducer and an antioxidant. Researches show benefit of broccoli sprouts in reducing oxidative stress in diabetes.
Splanchnic Hypoperfusion and Enteral Feeding Wina Sinaga; Luciana Budiati Sutanto; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/141201335-38

Abstract

Hypoperfusion or decrease in blood flow is may cause organ failure. When the body experiences hypoperfusion, body perfusion is prioritized to brain and heart, which may cause the hypoperfusion of splanchnic organ. Splanchnic hypoperfusion will cause ischemia of the mucosa, disturbance in the barrier, and increased splanchnic permeability, which in further level mayl cause bacterial and endotoxin translocation to systemic circulation.Enteral feeding in hypoperfusion is beneficial to prevent splanchnic hypoperfusion. However, method of enteral feeding needs to be considered, so that it does not cause harmful adverse effects. Early enteral feeding by slow continuous drip method can prevent splanchnic failure in critically ill patients with high risk of hypoperfusion. Keywords: splanchnic hypoperfusion, enteral feeding, continuous slow drip method
Senam Kaki Diabetik Terhadap Sirkulasi Darah Marbun, Agnes Silvina; Ariyani, Novita; Sipayung, Normi Parida; Ginting, Azwara Andika; Sinaga, Aan Sanita; Sinaga, Wina
Jurnal Abdimas Mutiara Vol. 3 No. 2 (2022): JURNAL ABDIMAS MUTIARA (IN PRESS)
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

Senam kaki diabetik dapat membantu memperbaiki peredaran darah yang terganggu dan memperkuat otot-otot kecil kaki pada pasien diabetes dengan neuropati. Selain itu dapat memperkuat otot betis dan otot paha, mengatasi keterbatasan gerak sendi dan mencegah terjadinya deformitas. Keterbatasan jumlah insulin pada penderita diabetes melitus mengakibatkan kadar gula dalam darah meningkat hal ini menyebabkan rusaknya pembuluh darah, saraf dan struktur internal lainya. Sehingga pasokan darah ke kaki semakin terhambat, akibatnya pasien diabetes melitus akan mengalami gangguan sirkulasi darah pada kakinya. Pada kegiatan pengabdian masyarakat ini, telah dilakukan senam kaki diabetik pada 19 orang dan hasil menunjukkan bahwa sebelum dilakukan senam kaki memiliki nilai rata-rata sirkulasi darah kaki 2,16 dengan nilai (SD sama dengan 0,602), dan setelah dilakukan senam kaki nilai rata-rata sirkulasi darah kaki meningkat menjadi 2,68 (SD sama dengan 0,478). Berdasarkan uji wilxocon sign rank test dengan taraf kesalahan alpha = 0,05 diperoleh nilai sirkulasi darah kaki p sama dengan 0,002 (p < alpha). Saran untuk praktek keperawatan diharapkan perawat hendaknya membuat prosedur tetap senam kaki diabetik dan sebaiknya menggunakan alat yang lebih akurat untuk mengukur sirkulasi darah kaki seperti Dopller HI-doop.
Nutrition Therapy in Type 2 Diabetic Burn Patient Ramadhania, Dian Araminta; Wardhana, Aditya; Sinaga, Wina; Wulandari, Yohannessa; Daya, Mulianah; Octovia, Lily Indriani
Jurnal Plastik Rekonstruksi Vol. 8 No. 1 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i1.314

Abstract

Summary: Severe burn patients experience pronounced metabolic changes that caused hyperglycemia. Other existing metabolic conditions such as diabetes mellitus may worsen this condition. Early, adequate, and personalized nutrition therapy may result in better glycemic control and prognosis.A 44-year-old male with severe burn injury involving 27,5% total body surface area (TBSA) and type 2 diabetes mellitus (T2DM) was given early and diabetes-specific nutrition therapy to meet the recommended energy and protein needs. Lower carbohydrate contents and higher mono-unsaturated fatty acids (MUFA) were components of diabetes-specific nutrition therapy. Desirable blood glucose levels, a positive trend of albumin levels, and reduced inflammatory markers were achieved while being given this nutrition therapy. Sepsis was not diagnosed in this patient. The patient was discharged from the hospital after an improvement in clinical condition. Hyperglycemia commonly occurs in critically ill patients, especially with pre-existing T2DM. The provision of prompt and personalized nutrition therapy will improve clinical outcomes.
Dietary Soluble Fiber Improved Fecal Consistency in Burned Patients with Diarrhea Setiawan, Evania; Wardhana, Aditya; Sinaga, Wina; Sari, Ayu Diandra; Satyani, Metta; Octovia, Lily Indriani
Jurnal Plastik Rekonstruksi Vol. 8 No. 2 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i2.330

Abstract

Backgrounds: Diarrhea frequently occurs in severely burned patients attributable to impaired intestinal integrity and dysbiosis. Soluble fiber may improve intestinal barrier function, avoid bacterial translocation, then subsequently prevent and treat diarrhea. Soluble fiber is rapidly fermented by commensal bacteria and produces short-chain fatty acids (SCFA). Case Reports: A 51-year-old male with severe burn injury involving 53,5% total body surface area (TBSA) and diarrhea were given soluble fiber as part of his diet. Results: Administration of 6–10 g/d soluble fiber clinically improves stool consistency, assessed by Bristol Stool Scale, in the severely burned patient. The patient was discharged after 19 days of hospitalization with improvement in clinical condition. Summary: SCFA maintains intestinal integrity, supports the growth of commensal bacteria, and inhibits pathogens. There is no specific recommendation regarding fiber intake in burned patients
Increased Nutrition Intake from Day 1 to Day 7 and Its Correlation with LOS in The Burn Unit of Dr. Cipto Mangunkusumo Hospital Jakarta Sinaga, Wina; Nurul Ratna Mutu Manikam; Aditya Wardhana; Nandita Melati Putri; Lily Indriani Octovia; Akhmad Noviandi Syarif
Jurnal Plastik Rekonstruksi Vol. 9 No. 2 (2022): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v9i2.339

Abstract

Introduction : Burn patients as well as the critically ill experience strong oxidative stress, an intense inflammatory response, and a prolonged months-long hypermetabolic and catabolic response that affect nutritional requirements. This study aimed to investigate the nutrition intake in the acute phase from day 1 to day 7 and the correlation with length of stay (LOS) in burn patients in Dr. Cipto Mangunkusumo General Hospital.Method : This cross-sectional study was conducted from January to December 2020 in the Burn Unit of Dr. Cipto Mangunkusumo General Hospital. Research subjects were burns patients who were willing to take part in this research and met the research criteria. The characteristics data included gender, age, burn area, cause of burns, body mass index, and intake analysis were obtained from medical records and were analyzed using Spearman’s correlation and linear regression.Result : A total of 68 subjects were included in this study. There was an increase in energy intake from day 1 to day 7 of 10.81 + 12.73 Kcal/kgBW. There was a significant negative weak correlation between energy changes from day-1 to day-7 and length of stay (r = -0.25, p = 0.03).Conclusion: The higher energy increases within 7 days of treatment, the shorter the LOS of burn patients. Further research is still needed to assess the components that influence nutrition intake and how they impact the clinical outcome of burn patients.
Effect of Zinc Supplementation on Fasting Blood Glucose Control in Burn Injury Patients with Type 2 Diabetes Mellitus: a Case Report Tedjaatmadja, Chintya; Rasyid, Nurhayati M; Wulandari, Yohannessa; Octovia, Lily Indriani; Sinaga, Wina; Wardhana, Aditya
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.194

Abstract

Burn injury is the second leading cause of injury in Indonesia. Patients with burn injury may develop zinc deficiency due to loss of exudate and decreased carrier proteins, leading to impaired glucose regulation and inadequate wound healing. Jayawardena et al. showed that zinc supplementation can help regulate blood glucose in patients with diabetes mellitus. This case aims to see the effect of zinc supplementation on fasting blood glucose control in burn injury patients with type 2 diabetes mellitus. A 47-year-old Male with diabetes mellitus and a history of COVID-19 presented with 34% second to third-degree burn injury. The patient was given short-acting insulin 6 IU thrice a day and long-acting insulin 10 IU once a day. Nutrition was increased gradually until it reached 30 kcal/kgBW with protein 1,2 g/kgBW on the 28th day of hospitalization, referring to a diabetes-specific formula, 6x300 kcal. The patient also received zinc sulfate supplementation, 40 mg per day. The patient’s daily zinc intake was 47 mg/dL, and it was analyzed using Nutrisurvey. Fasting blood glucose in the first 28 days was not well-regulated (92-348 mg/dL). After 28 days of zinc supplementation, the patient's fasting blood glucose was stable. (140-180 mg/dL). Uncontrolled blood glucose leads to bacteremia, decreased skin graft takes, and increased mortality. Zinc deficiency can cause greater insulin resistance that can lead to hyperglycemia. Fasting blood glucose was stable after 28 days of zinc supplementation, similar to the previous study. Supplementation can help to regulate fasting blood glucose in burn patients with diabetes mellitus.
Effect of magnesium supplementation on glycemic control in type 2 diabetes mellitus: evidence-based case report Apriyanti G, Anita Janetthe; Sinaga, Wina
World Nutrition Journal Vol. 8 No. i2 (2025): Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0003

Abstract

Background: Diabetes mellitus is one of the most serious and common chronic diseases, leading to life-threatening, disabling and costly complications, and reducing life expectancy. Poor intracellular magnesium concentration may contribute to insulin resistance, whereas higher magnesium levels are associated with increased insulin sensitivity. This study aimed to investigate the effect of magnesium supplementation on glycemic control in patients with type 2 diabetes. Objective: This study aimed to investigate the effect of magnesium supplementation on glycemic control in patients with type 2 diabetes. Methods: A literature search was conducted using three major databases: PubMed, Cochrane Library, and EBSCOhost. MeSH terms, advanced search, and eligibility criteria were used for title and abstract screening after removing duplicates. Critical assessment tools and levels of evidence of the final articles are based on the Oxford Center for Evidence-Based Medicine. Results: A meta-analysis and two RCTs met the PICO and eligibility criteria. One meta-analysis found that magnesium supplementation significantly reduced fasting blood glucose and HbA1c. One RCT reported that magnesium supplementation significantly improved HbA1c, insulin levels, and HOMA-IR. Another RCT found that there were no differences in HbA1C and continuous glucose monitoring. Conclusion: Magnesium supplementation may have a beneficial effect on glycemic control in patients with type 2 diabetes. However, further research is needed to establish optimal dosage and the most effective form of magnesium supplementation.
Pengaruh Suplementasi Zink Terhadap Mukositis Oral Terkait Radiasi Pasien Kanker Kepala dan Leher: Studi Kasus Dengan Pendekatan Berbasis Bukti Gultom, Yohana Elisabeth; Sinaga, Wina
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1253

Abstract

Abstrak Latar Belakang: Mukositis oral merupakan efek samping radiasi kanker kepala leher yang paling sering, khususnya pada dosis radiasi lebih dari 30 Gray (Gy). Patofisiologi mukositis oral terkait radiasi dapat disebabkan oleh inflamasi dan reactive oxygen species (ROS) yang dihasilkan oleh radiasi pengion. Zink merupakan kofaktor dari sintesis, DNA, protein, polimerasi RNA, dan transkriptase terbalik sehingga memiliki kemampuan penyembuhan luka sekaligus meningkatkan pertumbuhan sel dan sistem imunitas tubuh. Objektif: Mengetahui efek pemberian suplementasi zink terhadap mukositis oral terkait radiasi pasien kanker kepala dan leher Metode: Pencarian literatur dilakukan dengan advanced searching pada Pubmed, Embase, dan Cochrane dengan kriteria eligibilitas yang ditentukan oleh penulis. Hasil: Terdapat 2 artikel yang relevan dengan pertanyaan klinis dan kriteria eligibilitas yang sudah ditetapkan, terdiri dari 1 Randomized Clinical Trial (RCT) dan 1 Systematic Review/Meta-Analysis (SR/MA). Penelitian RCT menyimpulkan suplementasi zink dapat bermanfaat dalam menangani mukositis oral dan penelitian SR/MA menyimpulkan bahwa tidak terdapat manfaat suplementasi zink terhadap mukositis oral pasien kanker kepala leher yang menjalani kemoradiasi. Kesimpulan: Berdasarkan tinjauan kritis yang telah dilakukan dalam studi RCT dan SR/MA, suplementasi zink tidak mempengaruhi mukositis oral terkait radiasi kanker kepala dan leher. Kata kunci: suplementasi zink, mukositis oral, orofaringeal mukositis, kanker kepala leher, radiasi, radioterapi Abstract Background: Oral mucositis is the most frequent radiation side effect of head and neck cancer, particularly at radiation doses greater than 30 Gy. The pathophysiology of radiation-related oral mucositis can be caused by inflammation and reactive oxygen species (ROS) generated by ionizing radiation. Zinc is a cofactor of synthesis, DNA, protein, RNA polymerization, and reverse transcriptase so that it has the ability to heal wounds while increasing cell growth and the body's immune system. Objective: To determine the effect of zinc supplementation on radiation-related oral mucositis in head and neck cancer patients. Methods: Literature search was conducted by advanced searching on Pubmed, Embase, and Cochrane with eligibility criteria determined by the author. Results: There were 2 articles relevant to the clinical question and eligibility criteria that had been set, consisting of 1 Randomized Clinical Trial (RCT) and 1 Systematic Review/Meta-Analysis (SR/MA). The RCT study concluded that zinc supplementation could be beneficial in managing oral mucositis and the SR/MA study concluded that there was no benefit of zinc supplementation on oral mucositis in head and neck cancer patients undergoing chemoradiation. Conclusion: Based on a critical review of RCT and SR/MA studies, zinc supplementation does not affect head and neck cancer radiation-related oral mucositis. Keywords: zinc supplementation, oral mucositis, oropharyngeal mucositis, head and neck cancer, radiation, radiotherapy
Co-Authors Aditya Wardhana Akhmad Noviandi Syarif Andayani, Diyah Eka Apriyanti G, Anita Janetthe Ari Fahrial Syam Ariyani, Novita Daya, Mulianah Dhita Alfara, Lady Diana Sunardi Ginting, Azwara Andika Gultom, Yohana Elisabeth Lily Indriani Octovia Luciana Budiati Sutanto Luciana Budiati Sutanto Marbun, Agnes Silvina Nandita Melati Putri Nurul Ratna Mutu Manikam Octovia, Lily Indriani Purwantini, Dian Ramadhania, Dian Araminta Rasyid, Nurhayati M Sari, Ayu Diandra Satyani, Metta Setiawan, Evania Sinaga, Aan Sanita Sipayung, Normi Parida Sutanto, Krisadelfa Tedjaatmadja, Chintya Wardhana, Aditya Wulandari, Yohannessa