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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Plastik Rekonstruksi World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal ABDIMAS MUTIARA Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Cermin Dunia Kedokteran
Wina Sinaga
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Peran Citicoline Oral Sebagai Terapi Tambahan dalam Pengobatan Glaukoma Sinaga, Wina
Cermin Dunia Kedokteran Vol 51 No 3 (2024): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i3.1051

Abstract

Glaucoma is the second-leading global cause of blindness. Lowering intraocular pressure can prevent the worsening of open-angle glaucoma, but alternative neuroprotective therapies are needed; citicoline is supposed to have neuroprotective potential. This evidence-based case report was to review the effectiveness of oral citicoline as an adjunct therapy for glaucoma. From 22 studies identified through PubMed, Scopus, Cochrane, EBSCO Host, and Google Scholar, three articles were selected for critical review. Lanza M. found the RNFL and GCC of the citicoline group 500 mg were significantly higher, 70.39 and 71.19 Pm, p<0,01 compared to controls, after 12 months. Sahin A, et al, showed that the RNFL was significantly higher in the third month than baseline in the oral citicoline 250 mg group, p = 0.038. Putri VC, et al, found that after 60 days, based on sub-group analysis, there was a significant difference in RNFL and GCIPL thickness changes after citicoline 500 mg intervention in the mild glaucoma group and after citicoline 1,000 mg in the moderate-severe glaucoma group. Oral citicoline supplementation prevents significant worsening of glaucoma, it can be given as an adjunct therapy.
The Role Of Synbiotic Supplementation In Improving Bowel Movement Frequency In A Burn Patient With 32% Total Body Surface Area And Constipation: A Case Report Cindy Herno Chrysela; Wina Sinaga; Aditya Wardhana; Diyah Eka Andayani
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 7 No 1 (2026): IJCNP
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v7i1.260

Abstract

Background: Severe burns cause microbiota dysbiosis, impaired intestinal motility, and constipation, worsening patient conditions and prolonging hospitalization. Research Objective: To evaluate the effectiveness of synbiotic supplementation in improving bowel movement frequency in burn patients. Case Illustration: A study conducted in the Burn High Care Unit at RSUPN Cipto Mangunkusumo involved a 42-year-old male patient with 32% TBSA burns and a history of kidney transplantation. Treatments included debridement, skin grafts, electrolyte correction, and synbiotic supplementation starting on day 6. During 29 days, energy intake, fiber intake, bowel movement frequency, and clinical status were monitored, showing significant improvements until discharge. Discussion: The 42-year-old male patient with 32% TBSA burns experienced impaired intestinal motility and constipation consistent with microbiota dysbiosis and decreased SCFA due to severe burns. The patient received enteral nutrition and Rillus® synbiotic supplementation from day 6, theoretically enhancing beneficial bacterial colonization and intestinal motility. Bowel movement frequency improved from day 7, indicating synbiotic-related benefits. Micronutrient supplementation according to ESPEN supported wound healing and immunity. Clinical condition and nutritional status improved with significant wound healing until discharge on day 30. Conclusion: Synbiotic supplementation effectively increased bowel movement frequency and improved intestinal function in severe burn patients with constipation. Keywords: Severe burn, microbiota dysbiosis, synbiotic, constipation, intestinal motility, bowel movement frequency.
THE ROLE OF VITAMIN D3 SUPPLEMENTATION ON MYASTHENIA GRAVIS COMPOSITE SCALE: A CASE REPORT Mardhiani, Meidistya Ayu; Wina Sinaga; Diyah Eka Andayani
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v13i2.931

Abstract

Myasthenia Gravis (MG) is a rare chronic autoimmune disorder triggered by pathogenic IgG autoantibodies and complement activation. Common clinical manifestations include ocular muscle weakness, dysphagia, dysarthria, dysphonia, limb muscle weakness, generalized skeletal muscle weakness, and respiratory muscle involvement. A 47-year-old female presented with unilateral ptosis, bilateral diplopia, dysphagia, dysphonia, dysarthria, and paresis of both upper and lower extremities. The Myasthenia Gravis Composite Scale (MGCS) score was 31. Electromyography confirmed the diagnosis of myasthenia gravis, and laboratory evaluation revealed 25-hydroxyvitamin D deficiency. During hospitalization, the patient received cholinesterase inhibitors, corticosteroids, and vitamin D3 supplementation at 5,000 IU once daily for 9 days. The MGCS score decreased to 19, indicating improved functional capacity. Conclusion: Vitamin D3 supplementation at a dose of 5,000 IU/day may provide potential clinical benefits, as reflected by a reduction in MGCS score, and may also reduce the future risk of osteoporosis secondary to 25-hydroxyvitamin D deficiency. However, the clinical improvement observed in this patient was likely also influenced by the concurrent administration of cholinesterase inhibitors and corticosteroids.
Co-Authors Aditya Wardhana Akhmad Noviandi Syarif Apriyanti G, Anita Janetthe Ari Fahrial Syam Ariyani, Novita Cindy Herno Chrysela Daya, Mulianah Dhita Alfara, Lady Diyah Eka Andayani Ginting, Azwara Andika Gultom, Yohana Elisabeth Lily Indriani Octovia Luciana Budiati Sutanto Luciana Budiati Sutanto Marbun, Agnes Silvina Mardhiani, Meidistya Ayu Nandita Melati Putri Nurul Ratna Mutu Manikam Octovia, Lily Indriani Ramadhania, Dian Araminta Rasyid, Nurhayati M Sari, Ayu Diandra Satyani, Metta Setiawan, Evania Sinaga, Aan Sanita Sipayung, Normi Parida Tedjaatmadja, Chintya Wardhana, Aditya Wulandari, Yohannessa