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Pralampita, Pulong Wijang
Department Of Clinical Pathology, Faculty Of Medicine, University Of Jember, Jember, Indonesia
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COMPARATIVE STUDY OF LIVER HISTOPATHOLOGY AND TRANSAMINASE LEVELS IN DIABETIC WISTAR RATS INDUCED BY ALLOXAN AND STREPTOZOTOCIN Hidayah, Ainun Nafisa Riski; Purnawati, Ratna Damma; Pralampita, Pulong Wijang; Ismail, Akhmad
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53470

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. Experimental models using male Wistar rats (Rattus norvegicus) induced with alloxan (ALX) or streptozotocin (STZ) are widely applied to explore therapeutic strategies. However, several studies have reported that ALX has greater limitations compared with STZ. Objective: To analyze the differential effects of ALX and STZ as diabetogenic inducers in Wistar rats based on liver histopathology, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT) levels. Methods: A post-test only control group design with simple randomization was employed. Forty-two male Wistar rats weighing ≥200 g were assigned into seven treatment groups. Independent variables included ALX and STZ at graded doses, while dependent variables were liver histopathology, SGOT, and SGPT. Histopathology was assessed using the Manja Roenigk scoring system, and enzyme levels were measured by enzymatic methods. Results: Significant differences were observed between ALX and STZ in liver histopathology (p<0.001) and SGPT levels (p=0.001), but not in SGOT (p=0.199). Histopathological findings between ALX- and STZ-induced groups were relatively comparable at equivalent doses. In contrast, SGOT and SGPT results indicated that ALX may induce resistance. Conclusion: ALX and STZ caused comparable hepatic damage, but STZ exhibited more stable blood biomarker profiles.
Co-Authors . Suryono Aini, Nada Qurrota Akhmad Ismail Aris Prasetyo Bagus Hermansyah Cholis Abrori, Cholis Diana Chusna Mufida Dina Helianti Dini Agustina Erma Sulistyaningsih Hidayah, Ainun Nafisa Riski I Ketut Suada Jauhar Firdaus Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Miftakhul Huda Parawita Dewanti Prasetyo, Aris Ratna Damma Purnawati Rosita Dewi Sa'adah, Ajeng Samrotu Salsabila, Zadia Maheswari Selly Silfana Liensa septa surya wahyudi, septa surya Supangat Supangat Supangat Supangat Wiji Utami Wiwien Sugih Utami