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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Buletin Farmatera Narra J
Amru Sofian
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HUBUNGAN TUMOR MARKER CA-125 DENGAN SIFAT DAN TIPE SEL TUMOR OVARIUM DI RSUD ARIFIN ACHMAD PEKANBARU Tryanda Ferdyansyah; Amru Sofian; Fatmawati "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 1, No 2 (2014): Wisuda Oktober Tahun 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Ovarian tumor caused by inflammation or proliferation of ovarian’s ephitelial, germinal, stroma cell and it can be benign and malignant. Ovarian tumor had many tumor markers, the most known is Cancer Antigen 125 (CA-125). The normal concentration of CA-125 is <35 IU/ml. CA-125 could be used to predict a malignancy with cut off value ≥35 IU/ml. However, some benign conditions can be found with value ≥35 IU/ml, and some malignancy conditions with normal CA-125 concentration. The purpose of this research was to know correlation between CA-125 with the ovarians tumor malignancy and cell type. This research used retrospective design which involving 206 samples. The characteristic and cell type was based on histopathologycal examination and the value of CA-125 was based on clinical pathology laboratory test result. From 136 patients with benign ovarian tumor, 80 (57,5%) with CA-125 was still in normal limit and 59 (42,5%) was increased. From 67 patients with malignant ovarian tumor, 23 (34,3%) with CA-125 was still in normal limit and 44 (65,7%) was increased. This research showed there was a significant correlation between tumor marker CA-125 with the ovarians tumor malignancy (p =0,002), ephitelial cell type (p=0,001), and germinal cell type (p=0,001).Key words : ovarian tumor, ovarian tumor marker, Cancer Antigen 125, ovarian tumors malignancy and cell type
HUBUNGAN BODY IMAGE, ASUPAN ENERGI DAN AKTIVITAS FISIK DENGAN STATUS GIZI PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS RIAU ANGKATAN 2014 Vicennia Serly; Amru Sofian; Yanti Ernalia
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Adolescents is one of the groups vulnerable to negative issues regarding health and nutrition. Nutritional problems suffered by many adolescents is caused by various factors, such as body image, energy intake and physical activity. This study was conducted with the cross-sectional design with a sample selected with a total sampling method. Body image was assessed by questionnaire BSQ-34, obtained through food energy intake records 3x24 consecutive hours, physical activity obtained form 3x24 hour record of activity and nutritional status assessed by measuring BMI. Based on this study of 166 samples were obtained 56% of respondents are not satisfied with the sight of his body image, while the category of energy intake can be seen as much as 57.8% of respondents with moderate energy intake based AKE 2012. For the category of physical activity, can be known that 44% of respondents mild physical activity and as much as 43.4% of respondents normal nutritional status, 18.1% of respondents overweight nutritional status, 15.7% of respondents nutritional status as underweight, 13.9% of respondents nutritional status obese I and the remaining 9% of respondents nutritional status of obesity II. From the results of the analysis carried out there was significant relationship between body image and nutritional status (p = 0.000). There was a significant relationship between energy intake and nutritional status (p = 0.000) and there was significant association between physical activity and nutritional status (p = 0.000). So, there is a significant relationship (p <0.05) between body image, energy intake and physical activity with nutritional status on the students of the Faculty of Medicine, University of Riau Class of 2014.Key words: Adolescents, body image, energy intake, physical activity and nutritional status
GAMBARAN PEMERIKSAAN INSPEKSI VISUAL ASETAT SEBAGAI DETEKSI LESI PRAKANKER SERVIKS PADA WANITA PEKERJA SEKSUAL TIDAK LANGSUNG DI HOTSPOT X KECAMATAN MARPOYAN DAMAI PEKANBARU Dyah Astrid Astrid; Wiwit Ade Fidiawati; Amru Sofian
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTCervical cancer is the second most common cancer in women inIndonesia. Early detection of cervical cancer with Visual Inspection with AceticAcid (VIA) is an alternative method that recommended for developing countrysuch as Indonesia. Indirect female sex workers have a higher risk of cervicalcancer. The aim of this study is to describe the characteristic of respondent and todetect dysplastic cervical epithelial cells with VIA. The method of this research isdescriptive observational. The study population was all indirect female sexworkers at hotspot X District Marpoyan Damai Pekanbaru and the samples weretaken with total sampling method. The result showed that among 33 sample, 14people (42%) were diagnosed with positive white appearance (positive VIA).Keywords: Visual inspection with acetic acid, Cervical cancer, Cervicalprecancerous lesion, Indirect Female Sex Workers
GAMBARAN PEMERIKSAAN INPEKSI VISUAL ASETAT SEBAGAI DETEKSI LESI PRAKANKER SERVIKS DI HOTSPOT JALAN TUANKU TAMBUSAI KECAMATAN SUKAJADI PEKANBARU Dhini Aiyulie Novri; Amru Sofian; Wiwit Ade Fidiawati
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 1, No 1 (2014): Wisuda Februari Tahun 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Cervical cancer is the third most frequent cancer in women in Indonesia.Indirect female sex worker are in high risk for having cervical cancer. WorldHealth Organization had recommended an alternative approach for developingcountries with down staging concept of cervical malignancy with visual inspectionwith acetic acid (VIA) to detect cervical precancerous lesion. This research wascarried out at hotspot Tuanku Tambusai Street, Pekanbaru aimed to describe thecharacteritics of respondent and to detect displastic cervical epithelial cells withVIA. The result showed from 31 indirect female sex worker, 52 % were diagnosedwith positive acetowhite appereance (positive VIA). Conclusion of the study thatdisplastic cervical epithelial cells of indirect female sex worker who has high riskfor having cervical cancer should be reffered for further follow up.Keywords: Visual inspection with acetic acid, Cervical cancer, Cervicalprecancerous lesion, Indirect female sex worker.
DESCRIPTION OF THE RESULT OF THE EXAMINATION OF PAP SMEAR AFTER RADIATION THERAPY ON CERVICAL CANCER PATIENTS BASED ON THE TYPE OF CELL AT ARIFIN ACHMAD GENERAL HOSPITAL PEKANBARU IN THE PERIOD 2009-2013 Trigen Yulis Rahmat Yulis; Amru Sofian; Mardhiah Gaffar
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 1, No 2 (2014): Wisuda Oktober Tahun 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Cervical cancer is the second most for women in the world. Cervical cancer most often found in advanced stage. The main therapy for advanced stage cervical cancer is radiation therapy. Radiation is also used as therapy for early stage of cervical cancer patient who is not eligible for surgery. Radiation is divided into two, externa radiation and internal radiation. In RSUD Arifin Achmad Pekanbaru is only using externa radiation caused by limitation of the tools on interna radiation. After the complete radiation, patients will do pap smear as follow up to analyse the cell cancer. This research has been done in Radiotherapy Installation, Pathology Anatomic Installation, and Medical Record Installation in RSUD Arifin Achmad. This research uses a descriptive retrospective design by taking a patient's medical record of cervical cancer in RSUD Arifin Achmad period 2009-2013. The result showed that squamous cell carcinoma is the most histhopathology in cervical cancer. 30 of 78 cervical cancer patients who had been in radiation therapy continue to follow up pap smear. The result of pap smear test showed that there are non-malignant cell in 26 patients and the type of cell is squamous cell carcinoma and adenocarcinoma in 2 patients. And in 2 adenocarcinoma patient is found malignant cells. There is a cervical cancer patient with squamosa cell carcinoma who experienced recurrence at 7-9 months after radiation.Keyword : cervical cancer, radiation, pap smear
GAMBARAN HASIL PEMERIKSAAN SITOLOGI SERVIKS WANITA PEKERJA SEKSUAL TIDAK LANGSUNG PADA HOTSPOT X KECAMATAN PAYUNG SEKAKI PEKANBARU Putri Deas H; Wiwit Ade Fidiawati; Amru Sofian
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTCervical cancer is most common gynecology malignancy in the world. Cervical cance is second place in deadly high cancer on female after breast cancer. Indirect female sex workers have high risk to get cervical cancer. Pap smear screening is used to identify pracancers lesion. The number of cervical cancer cases can be reduced with Pap smear screening. The purpose of this study was to know the result of cervical smear cytology examination toward indirect female sex workers at hotspot X Payung Sekaki Pekanbaru. This study was descriptive study. The population of this study were all of indirect female sex workers at hotspot X Payung Sekaki and the samples were taken with total sampling method. The result showed that there were 31 people consist 10% diagnosed with negative intraepithelial lesion or malignancy (Bacterial vaginosis), 35% diagnosed with ASCUS and 55% diagnosed with LSIL. The conclusion is LSIL was the most common intraepithelial lesion of cervical cancer.Key words: cervical smear, Pap smear, cervical cancer, indirect female sex workers, hotspot X Payung Sekaki.
GAMBARAN PEMERIKSAAN INSPEKSI VISUAL ASETAT SEBAGAI DETEKSI LESI PRAKANKER SERVIKS PADA WANITA PEKERJA SEKSUAL TIDAK LANGSUNG DI HOTSPOT X KECAMATAN PAYUNG SEKAKI PEKANBARU Monaliza "; Wiwit Ade Fidiawati; Amru Sofian
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 1 (2016): Wisuda Februari 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTCervical cancer is a malignancy in the cervix who occupy the highest rank as the most common disease in women in the world. This disease can be detected earlier with Visual Inspection with Acetic Acid (VIA) examination. This paper describes an overview of VIA as the detection of cervical precancerous lesions in the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru. This disease can be detected early with inspection Visual Inspection Acetate (VIA) is a simple examination with the outward appearance of 3-5% acetic acid on the cervix. This study aims to clarify the picture VIA examination as the detection of precancerous cervical lesions and determine the characteristics of the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru. The method used is descriptive observational. Population of research are all in the indirect Female Sex Workers (FSW) at hotspot X District Payung Sekaki Pekanbaru and samples were taken using total sampling. Results of this study found respondents with positive results VIA (acethowhite) as many as 14 people (45.16%). The conclusion from this study is that the majority of indirect Female Sex Workers (FSW) at hotspot X have tested negative VIA.Key words : VIA, Cervical cancer, Indirect Female Sex Workers, Hotspot X
The Effect of Fasting Sunnah Mondays and Thursdays on Body Composition, Blood Pressure, and Blood Glucose Levels Bebasari, Eka; Sofian, Amru; Pratama, Bayu Fajar
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5500

Abstract

Fasting is a form of non-pharmacological intervention to improve health. One of the sunnah fastings that is often done is fasting Monday and Thursday. There is still little research on the benefits of this sunnah fasting. This study is a quasi-experimental study to determine the effect of sunnah fasting on Mondays and Thursdays on body composition, blood pressure, and blood glucose levels. The research subjects were 19 Riau University students who were willing to fast every Monday and Thursday for 4 consecutive weeks (8 days of fasting), were healthy, and did not smoke. Measurement of research parameters was carried out before and after fasting. The results of this study showed differences in the average values of body composition (weight, body mass index, upper arm circumference, waist circumference, waist-hip ratio), systolic blood pressure, diastolic blood pressure, and blood glucose levels before and after fasting. The results of statistical analysis with paired t-test there were significant differences in the average values of upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels before and after fasting (p 0.05), but there was no significant difference in body weight, index body mass, waist-to-hip ratio, and systolic blood pressure before and after fasting (p 0.05). There is an effect of Monday and Thursday sunnah fasting on upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels.
Genetic variations of the L2 gene in human papillomavirus (HPV) type 16 from cervical cancer patients in Sumatra region, Indonesia Savira, Maya; Farniga, Arnaldi; Ilmiah, Zidny; Rachmadina, Rachmadina; Rini, Ika A.; Kemal, Rahmat A.; Mahargyarani, Azza E.; Admiral, Muhammad Z.; Sofian, Amru; Razali, Renardy R.; Suhaimi, Donel; Putra, Andani E.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1653

Abstract

The L2 protein, a minor capsid component of human papillomavirus (HPV), plays a critical role in the HPV life cycle by packaging the viral genome with the L1 protein and facilitating DNA transport to the nucleus. Identifying genetic variations in the L2 gene is essential for improving vaccine development, diagnostic accuracy, and understanding viral evolution, potentially contributing to more effective HPV vaccines. The aim of this study was to investigate the genetic variation of the L2 gene in cervical cancer specimens collected from patients in Riau Province, Indonesia. A single-center, cross-sectional study was conducted at Arifin Achmad General Hospital, Riau Province, involving cervical cancer patients with confirmed HPV16 infection between January 2018 and August 2020. Demographic, clinical, and risk factor data were collected through structured interviews and direct assessments. Cervical biopsy specimens were collected, and viral DNA was extracted for L2 gene amplification using polymerase chain reaction (PCR). Sequencing was conducted on PCR products, followed by single-nucleotide polymorphism (SNP) identification through alignment with the HPV16 reference genome. The amplification and sequencing of the HPV16 L2 gene from 22 cervical cancer specimens revealed 36 SNPs, including 31 nonsynonymous and five synonymous mutations. High-frequency mutations were observed at nucleotide positions 4,074 and 4,177, each detected in 95.45% of the samples. Notable insertions were found at positions 3,668–3,669 and 4,275–4,276, indicating substantial sequence variation. Phylogenetic analysis grouped the sequences into three clusters, with most belonging to sub-lineage A2 (European), while others aligned with A4 (Asian) and East Asian lineages. The observed genetic diversity in the HPV16 L2 gene may reflect regional viral evolution and has potential implications for future vaccine development.
Co-Authors Ade, Wiwit Admiral, Muhammad Z. Awanda Herman Azizah " Bayu Fajar Pratama Dhini Aiyuli Novri Dhini Aiyulie Novri Dimas Pramita Nugraha Donel S Dyah Astrid Astrid Ega Rahman Evsya Eka Bebasari Fadilla Rizki Putri Farniga, Arnaldi Fatmawati " Fifia Chandra Gerry Pratama Hendra Perkasa Ika A. Rini, Ika A. Ilmiah, Zidny Kemal, Rahmat A. Mahargyarani, Azza E. Mardhiah Gaffar Maya Savira Monaliza " Nursida Islami, Nursida Ovinitha, Sarah Putra, Andani E. Putri Deas H Rachmadina, Rachmadina Rahmadani, Fetty Try Razali, Renardy R. Riyan M Darundryo Sindy Oktaviani Suyanto " Trigen Yulis Rahmat Yulis Tryanda Ferdyansyah Vicennia Serly Wiwit Ade Wiwit Ade Fidiawati Yanti Ernalia