Garuda - Garba Rujukan Digital

Peripheral iridectomy procedure in angle closure glaucoma Masitha Dewi Sari
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Objective : To report angle closure glaucoma cases treated by peripheral iridectomy.Methods : A 42 year-old woman come to Ophthalmology Departement,Adam Malik Hospital with chief complaint of pain in the right eye for 1 week. Visual acuity in the right eye no light perception and eye pressure 21 mmHg. On examination found sklerektasis, shallow anterior chamber, posterior synechial, slightly cloudy cornea and the lens . Patient is diagnosed absolute angle closure glaucoma and treated by peripheral iridectomy procedure.Result : Pain and Intraocular pressure were reduced after sugical iridectomy.Conclusion : In Absolute glaucoma cases without complain does not require any treatment. The goal of surgical procedure is important to minimizing pain.

Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Eva Imelda; Ulfa Fitria; Ulmiza Putri Mutia; Syahrul Syahrul; Masitha Dewi Sari; Sarra Mutiara Adev; Alya Mutiara Adev; Zakiaturrahmi Zakiaturrahmi; Navneet Shamsundar Toshniwal
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.

AUROLAB AQUEOUS DRAINAGE IMPLANT IN YOUNG ADULT WITH NEOVASCULAR GLAUCOMA AND TUBERCULOSIS HISTORY: A CASE REPORT Barii Hafidh Pramono; Masitha Dewi Sari; Aslim D. Sihotang
Majalah Oftalmologi Indonesia Vol 49 No 1 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i1.100170

Introduction: Neovascular glaucoma (NVG) is historically known as rubeotic glaucoma, from “rubeosis iridis” that refers to the iris neovascularization. One of several causes that lead to rubeosis iridis is changes in Pigment Epithelium-Derived Growth Factor (PEDF) that may be caused by Mycobacterium tuberculosis. The influence of NVG may cause intraocular pressure (IOP) to rise rapidly. It can be decreased by Aurolab Aqueous Drainage Implant (AADI). Case Report: A 34-year-old male complained of left eye pain and sudden decreased vision for the past 2 months. He had been diagnosed with tuberculosis since 8 months ago. The patient’s blood pressure, blood sugar, cholesterol, and triglycerides were within normal limit. Diabetes Mellitus (-). Human Immunodeficiency Virus (-). Visual acuity of left eye was hand movement. The pupil was dilated and non-reactive, anterior chamber depth is shallow, and rubeosis iridis (+). IOP is 60 mmHg. Medical management was failed to decrease the IOP. Funduscopy image showed cup-disc ratio was 0,7. Ganglion cell complex parameters showed 80,91. On the next day after AADI implantation surgery, the patient’s left eye IOP was reduced to 10 mmHg. On the 14th day post operative visual acuity was 2 meter counting finger. The anterior segment of the conjunctiva bulbi was hyperemic and conjunctival injection was reduced. The camera oculi anterior showed remainder of the implant. In the iris, rubeosis iridis disappeared, pupil was dilated, IOP was increased to 12 mmHg Discussion: Neovascular glaucoma was caused by the growth of the fibrovascular membrane on the surface of the iris and the anterior chamber angle. The three most common causes of neovascular glaucoma were diabetes mellitus, central retinal vein occlusion, and carotid artery occlusion. Conclusion:AADI is a safe and effective option for patients with neovascular glaucoma following tuberculosis.

ASSOCIATION BETWEEN ESTROGEN LEVELS WITH INTRAOCULAR PRESSURE IN PRIMARY OPEN ANGLE GLAUCOMA PATIENT: Oral Presentation - Observational Study - Resident Alvin Rambe; Masitha Dewi Sari; Fithria Aldy; Taufik Ashar
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/697gtq43

Introduction & ObjectivesThere are studies that state that estrogen deficiency can exacerbate visual disturbances in glaucomapatients. To determine the relationship between estrogen levels and intraocular pressure (IOP) inpatients with POAG. MethodsThis study used a case-control design in 30 POAG patients who came to the OphthalmologyPolyclinic at the University of North Sumatra Hospital and Network Hospital. The data collectionmethod in this study used a consecutive sampling technique starting from February 2022 until thesample was filled. The inclusion criteria in this study were all women with POAG who were ?40years old and willing to be the research sample. The exclusion criteria for this study were patientswith a history of secondary glaucoma or a history of optic nerve disease, a history of ocular surgery(except cataracts), a history of orbital trauma, menstrual disorders, or currently on hormonaltherapy, a history of systemic or autoimmune disease. Data is then collected and analyzed. ResultsOf the 30 patients with POAG, the majority were aged 45-65 years (46.7%) with an average age of55.87(±12.91) years and had suffered from POAG for an average of 1.62(±2.08) years. The averagepatient had an intraocular pressure of 25.07(±6.12) mmHg, MD -12.99(±8.28) dB, VCDR0.78(±0.13) mm, and estrogen levels 2.47(±2.11) pg/dL. There was no significant relationshipbetween estrogen levels and intraocular pressure (p=0.851). ConclusionThere was no significant association between estrogen levels and intraocular pressure in patientswith POAG.

The Role of Tumor Necrosis Factor (TNF) Alpha with Visual Field Defects in Primary Open Angle Glaucoma (POAG): Oral Presentation - Observational Study - Resident Muhammad Hendy Hasudungan Hutabarat; Masitha Dewi Sari
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/19xr0h91

Introduction & ObjectivesGlaucoma is a group of progressive optic neuropathy disease characterized by degeneration ofretinal ganglion cells. This causes changes in the optic nerve and loss of visual field. Several studieshave revealed that there is a role for TNF Alpha in glaucoma cases. To determine the role TumorNecrosis Factor (TNF) Alpha Levels between visual field defects in Primary Open-angle Glaucomapatients. MethodsThis study is Observational Analytical with cross sectional data collection method. Examination ofthe field of view using the Humphrey visual field perimetry. ResultsThe sample of this research was 30 people with 16 (53.3%) male and 14 people (46.7%) female.Using the Spearman correlation test, it showed that there was no significant correlation betweenTNF alpha and field of view (p = 0.119). ConclusionTNF Alpha level was not significantly related to visual field defects.

DIABETES DURATION AND RETINAL NERVE FIBER LAYER THICKNESS RELATED DEGREE OF DIABETIC RETINOPATHY: Oral Presentation - Observational Study - Resident Felanda Ahsanu Nadia; Masitha Dewi Sari; Delfi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/857sg474

Introduction & ObjectivesDiabetic retinopathy is an ocular complication of diabetes mellitus (DM). Several studies have shownthat neurodegenerative changes in the retina occur earlier than microvascular changes.Measurement of retinal nerve fiber layer thickness can detect neurodegeneration at an early stage.This study aims to analyze the relationship of diabetes duration and retinal nerve fiber layerthickness with degree of diabetic retinopathy in type 2 diabetes mellitus patients. MethodsThis research was analytic observational research with cross-sectional design. The sample was type2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University ofSumatera Utara General Hospital. The sample were then analyzed with the Kruskal Wallis test tofind relationship of diabetes duration and retinal nerve fiber layer thickness with degree of diabeticretinopathy in type 2 diabetes mellitus patients. ResultsThe sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabeticretinopathy as the control group. The mean duration of having DM in the group of patients with mildNPDR was 5.33 years, with moderate NPDR was 9.13 years and with PDR was 15.33 years. Usingthe Kruskal Wallis test revealed that there was no significant relationship between degree ofdiabetic retinopathy with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111),temporal RNFL (p=0.064), nasal RNFL (p=0.535). ConclusionThere was a significant difference between diabetes duration with degree of diabetic retinopathy butno significant between retinal nerve fiber layer thickness with degree of diabetic retinopathy.

The Relationship between Diabetic Retinopathy Degree with Visual Acuity and Retinal Nerve Fiber Layer Thickness in Type 2 Diabetes Mellitus Patients Felanda Ahsanu Nadia; Masitha Dewi Sari
Sumatera Medical Journal Vol. 5 No. 3 (2022): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v5i3.9190

Introduction: Diabetic retinopathy is an ocular complication of diabetes mellitus (DM), and is one of the leading causes of visual impairment and blindness worldwide.. More than one third of people with diabetes have signs of diabetic retinopathy. Methods: This was an analytic observational study with cross-sectional design. The sample was type 2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University of Sumatera Utara General Hospital from September 2021-December 2021. The sample were then analyzed with the Mann-Whitney and Kruskal Wallis test to find the relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients. Results: The sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabetic retinopathy as the control group. The mean visual acuity in subjects with mild diabetic retinopathy was 0.65+0.48. Average visual acuity in subjects with the degree of moderate diabetic retinopathy was 0.83+0.46. The mean visual acuity in subjects with a proliferative degrees diabetic retinopathy was 0.77+0.64. Mann Whitney test revealed no statistically significant relationship between the degree of diabetic retinopathy and visual acuity (p=0.734). Using the Kruskal Wallis test revealed that there was no significant relationship between the degree of retinopathy diabetic with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111), temporal RNFL (p=0.064), nasal RNFL (p=0.535). Discussion: Controlling blood glucose levels becomes more important than the duration of diabetes in preventing the development of retinopathy. Most patients are advised to have an HbA1c of 7% or lower, and for certain patients it is recommended to be lower than6.5%. Diabetic retinopathy slowly damages the retinal blood vessels or the optic nerve layer, leading to leakage, thus resulting in accumulation of fluid containing lipid and blood in the retina which will gradually lead to visual impairment, and even blindness. Conclusion: There is no significant relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients.

Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Imelda, Eva; Fitria, Ulfa; Mutia, Ulmiza Putri; Syahrul, Syahrul; Sari, Masitha Dewi; Adev, Sarra Mutiara; Adev, Alya Mutiara; Zakiaturrahmi, Zakiaturrahmi; Toshniwal, Navneet Shamsundar
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.

Relationships Between Age of Onset, Seizure Frequency, And Disease Duration with Cognitive Function in Epilepsy Patients at the Neurology Clinic of H. Adam Malik Central Hospital, Medan Malau, Tamara Betanya; Ritarwan, Kiking; Muzasti, Riri Andri; Sari, Masitha Dewi; Anggreiny
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 1 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i1.14894

Background: Cognitive function disorders often occur in individuals with epilepsy. The decline in cognitive function in epilepsy patients can be caused by various factors, including age of onset, seizure frequency, and duration of the disease. This study aims to investigate the relationship between the age of onset, seizure frequency, and disease duration on the cognitive function of epilepsy patients at the Neurology Outpatient Clinic of Haji Adam Malik General Hospital in Medan Method: The chosen research design is a cross-sectional analytic. The study was conducted at the neurology outpatient clinic of the Adam Malik Central General Hospital in Medan. The samples used were patients diagnosed with epilepsy at the Neurology Outpatient Clinic of Adam Malik Central General Hospital in Medan, aged 18-65 years, and without any other medical conditions aside from epilepsy. The study involved 35 subjects.Result: The majority of the research subjects are aged 18-45 years (94.3%), with more males (51.4%) than females. Most have a high school education background (48.6%), and the largest group is unemployed (62.9%). The most common age group at onset is 0-18 years (48.6%). The majority of subjects experience seizures in the rare category (less than 1 time per month) at 62.9%. Most subjects have a disease duration of less than 15 years (65.7%). The majority of epilepsy patients at the Neurology Outpatient Clinic of H. Adam Malik Hospital (52.1%) have abnormal cognitive function based on the MoCA-Ina test results. Statistical analysis was conducted using the chi-square test and multivariate analysis with logistic regression. The chi-square test results revealed a significant relationship between age of onset and cognitive function (p=0,008), a significant relationship between seizure frequency and cognitive function (p=0,004), and a significant relationship between disease duration and cognitive function (p=0,012). The multivariate analysis results indicated that disease duration had a significant relationship with cognitive function, with an odds ratio of 0,081 (p-value=0,037, 95% CI 0,008-0,862).Conclusion: There is a relationship between age of onset, seizure frequency, and disease duration with the cognitive function of epilepsy patients at the Neurology Outpatient Clinic of Haji Adam Malik General Hospital in Medan

Correlation Between Axial Length and Amplitude of Accommodation in Myopia Patients Angie, Evelyn; Amra, Aryani Atiyatul; Sari, Masitha Dewi
Journal of Public Health and Pharmacy Vol. 4 No. 3: NOVEMBER 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i3.5576

Background: Myopia is the most common refractive disorder and is a global concern because it can cause more serious eye problems. Excessive prolonged axial growth of the eyeball can lead to myopia. The amplitude of accommodation is the strength of the eye accommodation during the minimum and maximum accommodation conditions. Based on the above data, the researchers wanted to assess the relationship between eyeball length and accommodation amplitude in myopia patients. Method: The research was conducted at the Hospital of Prof CPL University of North Sumatra from November 2023 to March 2024. Data analysis was done analytically and presented in the form of data tabulation. Result: This study included 54 myopia patients, 27 males and 27 females, who visited the eye clinic. The mean age of the subjects was (52%). The mean age of the subjects was 23 years old with the youngest being 22 years old and the oldest being 24 years old. The mean of axial length for mild myopia, moderate myopia and severe myopia were 24.51 cm, 25.75 cm and 28.38 cm respectively. The lowest NPA value was found in severe myopia (27.33 cm) and the highest in mild myopia (43 cm). The lowest NPC value was found in mild myopia (36.61 cm) and the highest in severe myopia (38.56 cm). There was a significant relationship between eyeball length and accommodation amplitude with a Spearman correlation value of -0.685 as well as after cycloplegic administration with a Spearman correlation value of 0.438. NPA values showed an increase when receiving spherical correction, whether accompanied by cycloplegics or not, and a decrease when not receiving spherical correction. NPC values showed a decrease in all treatments. Conclusion: There is a correlation between axial length and amplitude of accomodation values (NPA and NPC) in patients with myopia.

Title

Found 10 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 10 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 10 Documents
Search