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All Journal International Journal of Public Health Science (IJPHS) journal of internal medicine Biomolecular and Health Science Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Narra J The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Titong Sugihartono
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Oxidative Stress and the Severity of Gastroesophageal Reflux Disease: Is There Any Correlation? Imro'ati, Tri Asih; Sugihartono, Titong; Widodo, Budi; Nefertiti, Eva Pravitasari; Wibawa, I Dewa Nyoman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202445-52

Abstract

Background: Oxidative stress plays a crucial role in the inflammatory response of the oesophageal epithelium; hence, therapies that affect oxidative stress may be a new approach in GERD management.  The objective is to analyze and determine the correlation between Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI) with severity of GERD.Methods: This is an observational analytic study using a cross-sectional design,that  conducted at the Endoscopic Unit of three hospitals in Surabaya, which held from June 2020 to March 2021. The 18 to 60 years old subjects who meet the GERD-Q score 8-18 and not meet the exclusion criteria undergo an endoscopic examination to determine the GERD severity and blood test. Data analysis was using the Spearman rank correlation test.Results: This study indicates that most subjects are women, with mean age 39.31±10.99 years, most are GERD grade A, the mean value of TOS, TAS, ISO respectively is 5.18±1.60, 1.58±0.18, and 3.36±1.35. The laboratory test results show insignificant different based on GERD degree.  There is a non-significant positive correlation between TOS and GERD severity, a significant negative correlation  between TAS and  GERD severity, and a significant positive correlation between OSI and GERD severity (respectively, r = 0.121, p = 0.266 vs r = -0.323, p = 0.044 vs r = 0.345, p = 0.033).Conclusion:  The TAS and OSI may be correlated to the GERD severity but still need further investigations. 
Co-Authors Adaninggar PN Agung Pranoto Alshawsh, Mohammed A. Amie Vidyani Budi W Budi Widodo Budi Widodo Denny Vianto Dwitama Adiwinoto, Robert Fauziah Diayu Retnaningtyas Heasty Oktaricha Herry Purbayu I Dewa Nyoman Wibawa Imro'ati, Tri Asih Iswan A Nusi Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Iswan Abbas Nusi Martino Handoyo Muhammad Miftahussurur Nefertiti, Eva Pravitasari Pangestu Adi PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Ronald Pratama Adiwinoto Setiawan, Poernomo B Soelistijo, Soebagijo Adi Supriadi Supriadi Tanaya, Willa M. Thamrin, Husin Ulfa Kholili Ummi Maimunah Vasa Adi Wisnu Wardana Wessels, Firda I. Widodo, Budi Widodo, Budi