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All Journal Majalah Kedokteran Bandung Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JFIOnline Jurnal Buana Farma Kartika : Jurnal Ilmiah Farmasi
Elin Yulinah Sukandar
Sekolah Farmasi, Institut Teknologi Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Antibacterial activity of ethanolic extract and fraction of leaves of singawalang (Petiveria alliaceae) against resistant bacteria Mulyani, Yani; Sukandar, Elin Yulinah; Adnyana, I Ketut
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.342 KB) | DOI: 10.14499/indonesianjpharm0iss0pp293-29

Abstract

One  of the plants  that grow  in Indonesia,  and  still does  not  use widely  is singawalang  (Petiveria  alliaceae)  from  Phytolaceae  family.  Traditional   herbal medicine  preparations  contained  of  Petiveria  alliacea  in  the  Caribbean,  Latin America,  West  Africa  and  other  regions  for  hundreds  years  has  been  used  to treat  pain,  colds,  inflammation,  tumor,  bacterial  and  fungal   infection,hyperlipidemia,  diabetes and  other  diseases.  This  study  aims to determine  the antibacterial  activity  of  singawalang  growth  in  Indonesia  against  resistant bacteria  to  antibiotics.  The  minimum  inhibitory  concentration   (MIC)  and minimum  bactericidal  concentration(MBC)  were  determined  by  microdilution broth method and type of antibacterial action were determined by observing the profile of bacterial growth curve. Ethanol extract of dried leaves showed activity against bacteria i.e. MRSA (Methicillin-Resistant Staphylococcus aureus), MRCNS (Methicillin-Resistant  Coagulase-Negative  Staphylococci),  VRE  (VancomycinResistant  Enterococcus).   Further  studies  conducted  by  reviewing  the  type  of work  by  looking  at the  growth curve  and  the observed changes  in cell walls by scanning  electron  microscopy  (SEM)  at  MRCNS  (Methicillin-Resistant Staphylococcus  coagulase-Negative).  The  results  showed  that  ethanol  extracts and  all  fractions  showed  good  antibacterial  activity  against  resistant  bacteria, are  bacteriostatic  hexane  fraction  until  the  concentration  of  8  MIC  and  change the morphology of the cell wall of MRCNS.Key words:Singawalang, Antibacteria, Broth Microdilution, bacterial growth curve, SEM 
In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet, Yuliet; Sukandar, Elin Yulinah; Adnyana, I Ketut
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.15416/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
EFEK ANTIDIABETES HERBA CIPLUKAN (Physalis angulata LINN.) PADA MENCIT DIABETES DENGAN INDUKSI ALOKSAN Sutjiatmo, Afifah B.; Sukandar, Elin Yulinah; Ratnawati, Yulia; Kusmaningati, Suswini; Wulandari, Asri; Narvikasari, Suci
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Antidiabetic effects of water extract of ciplukan (Physalis angulata L.) herbs has been done with the test method of alloxan diabetes induction. Water extract was fractionated using n-hexane, ethyl acetate and water.The results showed that ciplukan water extract dose of 10 mg/kgbw and the water fraction dose of  4.84 mg/kgbw have similar effect with glibenclamide dose of  0.65 mg/kgbw. The phytochemical screening showed that ciplukan water extract contains alkaloids, flavonoids, saponins, polyphenols, steroids and triterpenoids, monoterpenoids and sesquiterpenoids. ABSTRAK Telah dilakukan uji efek antidiabetes ekstrak air herba Ciplukan (Physalis angulata L.) dengan metode uji diabetes induksi  aloksan. Selanjutnya ekstrak air difraksinasi dengan pelarut n-heksan, etil asetat dan air. Hasil uji membuktikan bahwa ekstrak air herba ciplukan dosis 10 mg/kgbb dan fraksi air 4,84 mg/kgbb mempunyai efek antidiabetes yang sama dengan pembanding glibenklamid dosis 0,65mg/kgbb. Hasil penapisan fitokimia menunjukkan bahwa simplisia dan ekstrak air herba ciplukan mengandung alkaloid, flavonoid, saponin, polifenol, steroid dan triterpenoid, monoterpenoid dan seskuiterpenoid.
Ekstrak Daun Binahong Mencegah Kenaikan Kolesterol Darah pada Tikus yang Diberi Pakan Lemak Tinggi Rahman, Asep Abdul; Kurniati, Neng Fisheri; Sukandar, Elin Yulinah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Abstract

Binahong (Anredera cordifolia (Ten.) v. Steenis) leaves empirically have been used to lower cholesterol levels. In this study, preventive activity of ethanol extracts will be tested on the animals fed with a high-cholesterol chow. Hypercholesterolemic animal model established by orally administering high-cholesterol chow, pure cholesterol, cholic acid, and propiltiourasil. The test animals were divided into 5 groups, including the positive control group, ethanol extract of binahong leaves at doses of 50 mg/kg bw, 100 mg/kg bw, and 200 mg/kg bw; and simvastatin at dose of 36 mg/kg bw. Extract was given at the same time as hypercholesterol induction. Lipid profiles were measured at the time before the induction, 15 days and 29 days after induction. Index of atherogenic was also calculated. The results showed that level of cholesterol and LDL of extract binahong at dose of 50 mg/kg (109.17±26.60 mg/dL and 55.78±23.92 mg/dL, respectively) had significant difference compared to a positive control group (p < 0.05). Furthermore, binahong extract at dose of 50 mg/kg bb had the lowest atherogenic index (0,68±0,27) and aorta thickening (150.60±41.72 μm) compared to other extracts at day 15 of induction. In conclusion, extract binahong at dose of 50 mg/kg bw rat gives the best effect to prevent the increase of cholesterol and LDL level on wistar male rats fed with a high-cholesterol chow.
PROFIL AIR KELAPA (Cocos nucifera L.) VARIETAS GENJAH SALAK SEBAGAI PENGGANTI MINUMAN ISOTONIK Syafriani, Rini; Sukandar, Elin Yulinah; Apriantono, Tommy; Sigit, Joseph Iskendiarso
JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Vol 1, No 1 (2016)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.664 KB) | DOI: 10.5614/jskk.2016.1.1.2

Abstract

Telah diuji profil dari air kelapa (Cocos nucifera L.) sebagai pengganti minuman isotonik melalui uji diuretik, kadar natrium dan kalium dalam urin tikus jantan. Uji diuretik dilakukan pada tikus dengan pembanding minumanisotonik dan furosemida dengan menggunakan metode Lipschitz. Tikus dibagi menjadi 4 kelompok yaitu kelompok kontrol negatif, kelompok yang diberi 5 mL/kg bb air kelapa genjah salak, kelompok yang diberi5 mL/kg bb minuman isotonik, dan kelompok furosemida dengan dosis 25 mg/kg bb. Pada proses pengujian, setiap tikus diberi larutan NaCl 0,9% sebagai loading dose secara oral dengan dosis 50 mL/kg bb. Pengamatan yang dilakukan meliputi pencatatan volume urin yang diekskresikan setiap 60 menit selama 5 jam dan 24 jam, kemudian dihitung volume rata-rata urin kumulatifnya. Parameter lain yang diamati adalah kadar natrium dan kalium di dalam urin. Hasil menunjukkan volume urin kumulatif kelompok air kelapa genjah salak tidak berbeda dengan kelompok minuman isotonik dan kelompok furosemida, dan berbeda bermakna terhadap kelompok kontrol negatif dengan volume urin kelompok air kelapa genjah salak lebih tinggi secara bermakna dibanding kelompok kontrol negatif (p<0,05). Hasil menunjukkan kadar natrium dalam urin kelompok air kelapa genjah salak tidak berbeda dengan kelompok minuman isotonik dan kelompok furosemida, dan berbeda bermakna terhadap kontrol negatif dengan kadar natrium lebih tinggi secara bermakna dibanding kelompok kontrol negatif (p<0,05). Hasil menunjukkan kadar kalium dalam urin semua kelompok tidak berbeda bermakna. Kesimpulan dari penelitian ini adalah bahwa air kelapa genjah salak dosis 5 mL/kg bb mempunyai efek diuretik dan efek saluretik dan dapat digunakan sebagai pengganti minuman isotonik.
PENGARUH AIR KELAPA (COCOS NUCIFERA L.) VARIETAS GENJAH SALAK DAN MINUMAN ISOTONIK TERHADAP PERUBAHAN AMPLITUDO JANTUNG TIKUS INDUKSI HIPERTENSI Syafriani, Rini; Sukandar, Elin Yulinah; Apriantono, Tommy; Sigit, Joseph Iskendiarso
JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Vol 1, No 2 (2016)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.298 KB) | DOI: 10.5614/jskk.2016.1.2.2

Abstract

Penelitian ini mengevaluasi pengaruh dari air kelapa (Cocos nucifera L) dan minuman isotonik terhadap perubahan amplitudo pada tikus yang diinduksi hipertensi. Tikus jantan galur Wistar dibagi menjadi lima kelompok yaitu kelompok kontrol negatif, kelompok aquades, kelompok air kelapa, kelompok minuman isotonik, dan kelompok obat. Tikus diinduksi hipertensi dengan pemberian NaCl selama 14 hari, kemudian diterapi dengan pemberian bahan uji pada masing-masing kelompok selama 14 hari tanpa menghentikan induksi. Amplitudo jantung diukur sebelum induksi (h0), awal terapi (h14), dan akhir terapi (h28) dengan menggunakan alat tail cuff. Ketika diinduksi hipertensi, amplitudo jantung tikus semua kelompok mengalami peningkatan. Ketika tikus kelompok air kelapa diterapi dengan air kelapa dan tikus kelompok minuman isotonik diterapi dengan minuman isotonik, amplitudo memperlihatkan penurunan. Kelompok minuman isotonik memperlihatkan penurunan amplitudo yang signifikan (p=0,02) dibandingkan kelompok air kelapa dan obat. Hasil penelitian menunjukkan air kelapa genjah salak dapat menurunkan amplitudo tetapi minuman isotonik paling mendekati optimum atau paling baik dalam menurunkan amplitudo pada kondisi hipertensi dibandingkan dengan air kelapa (Cocos nucifera L.).
Ekstrak Daun Binahong Mencegah Kenaikan Kolesterol Darah pada Tikus yang Diberi Pakan Lemak Tinggi Rahman, Asep Abdul; Kurniati, Neng Fisheri; Sukandar, Elin Yulinah
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.021 KB) | DOI: 10.35617/jfi.v8i2.516

Abstract

Binahong (Anredera cordifolia (Ten.) v. Steenis) leaves empirically have been used to lower cholesterol levels. In this study, preventive activity of ethanol extracts will be tested on the animals fed with a high-cholesterol chow. Hypercholesterolemic animal model established by orally administering high-cholesterol chow, pure cholesterol, cholic acid, and propiltiourasil. The test animals were divided into 5 groups, including the positive control group, ethanol extract of binahong leaves at doses of 50 mg/kg bw, 100 mg/kg bw, and 200 mg/kg bw; and simvastatin at dose of 36 mg/kg bw. Extract was given at the same time as hypercholesterol induction. Lipid profiles were measured at the time before the induction, 15 days and 29 days after induction. Index of atherogenic was also calculated. The results showed that level of cholesterol and LDL of extract binahong at dose of 50 mg/kg (109.17±26.60 mg/dL and 55.78±23.92 mg/dL, respectively) had significant difference compared to a positive control group (p < 0.05). Furthermore, binahong extract at dose of 50 mg/kg bb had the lowest atherogenic index (0,68±0,27) and aorta thickening (150.60±41.72 μm) compared to other extracts at day 15 of induction. In conclusion, extract binahong at dose of 50 mg/kg bw rat gives the best effect to prevent the increase of cholesterol and LDL level on wistar male rats fed with a high-cholesterol chow.
EFEK ANTIDIABETES HERBA CIPLUKAN (Physalis angulata LINN.) PADA MENCIT DIABETES DENGAN INDUKSI ALOKSAN Sutjiatmo, Afifah B.; Sukandar, Elin Yulinah; Ratnawati, Yulia; Kusmaningati, Suswini; Wulandari, Asri; Narvikasari, Suci
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.52

Abstract

Antidiabetic effects of water extract of ciplukan (Physalis angulata L.) herbs has been done with the test method of alloxan diabetes induction. Water extract was fractionated using n-hexane, ethyl acetate and water.The results showed that ciplukan water extract dose of 10 mg/kgbw and the water fraction dose of  4.84 mg/kgbw have similar effect with glibenclamide dose of  0.65 mg/kgbw. The phytochemical screening showed that ciplukan water extract contains alkaloids, flavonoids, saponins, polyphenols, steroids and triterpenoids, monoterpenoids and sesquiterpenoids. ABSTRAK Telah dilakukan uji efek antidiabetes ekstrak air herba Ciplukan (Physalis angulata L.) dengan metode uji diabetes induksi  aloksan. Selanjutnya ekstrak air difraksinasi dengan pelarut n-heksan, etil asetat dan air. Hasil uji membuktikan bahwa ekstrak air herba ciplukan dosis 10 mg/kgbb dan fraksi air 4,84 mg/kgbb mempunyai efek antidiabetes yang sama dengan pembanding glibenklamid dosis 0,65mg/kgbb. Hasil penapisan fitokimia menunjukkan bahwa simplisia dan ekstrak air herba ciplukan mengandung alkaloid, flavonoid, saponin, polifenol, steroid dan triterpenoid, monoterpenoid dan seskuiterpenoid.
UJI AKTIVITAS EKSTRAK BEBERAPA TUMBUHAN TERHADAP MYCOBACTERIUM TUBERCULOSIS GALUR SENSITIF DAN RESISTEN Garmana, Afrillia Nuryanti; Sukandar, Elin Yulinah; Fidrianny, Irda
Acta Pharmaceutica Indonesia Vol 36, No 3 & 4 (2011)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Telah diteliti aktivitas ekstrak etanol batang bratawali (Tinospora tuberculata Beumee), ekstrak etanol daun binahong (Anredera cordifolia (Ten.) Steenis), ekstrak etanol rimpang kencur (Kaempferia galanga L.), dan ekstrak etanol rimpang temu putih (Curcuma zedoaria (Berg.)) terhadap Mycobacterium tuberculosis galur sensitif (H37Rv) dan resisten (HE dan SR). Ekstrak diuji pada konsentrasi 10, 20, 50, dan 100 ?g/mL media dengan metode pengenceran agar. Bakteri diinokulasikan pada media yang mengandung larutan ekstrak atau obat pembanding kemudian diinkubasi pada 37°C lalu diamati setiap minggu mulai minggu keempat sampai minggu kedelapan. Dari keempat ekstrak yang diuji, hanya ekstrak etanol rimpang kencur yang dapat menghambat pertumbuhan M. tuberculosis galur HE dan SR pada konsentrasi 100 ?g/mL media.Kata kunci : aktivitas antituberkulosis, Mycobacterium tuberculosis, Tinospora tuberculata Beumee, Anredera cordifolia (Ten.) Steenis, Kaempferia galanga L., Curcuma zedoaria (Berg.)
EFEK PENAMBAHAN EKSTRAK ETANOL HERBA CIPLUKAN (PHYSALIS ANGULATA L) SEBAGAI SUPLEMEN TERAPI PADA RHEUMATOID ARTRITIS Vikasari, Suci Nar; Sujiatmo, Afifah Bambang; Sukandar, Elin Yulinah; Wahyuningsih, Sri; Solihah, Puspa Sari Dewi; Suryani, Suryani; Aisyah, Salmanda; Kuatrina, Kuatrina; Astuti, Niken Juni; Siftiani, Nindy Dwi
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.667

Abstract

Rheumatoid arthritis is an autoimmune disease characterized with chronic joint inflammation. Chronic inflammation leads to liver function abnormality. Previous study showed that Physalis angulata L. had antiinflammatory, hepatoprotector, and immunosupressan effect. This research aims was to evaluate the effect of ethanol extract of P.angulata as adjuvant on liver function of RA animals model. Animals was induced with 0.1 mL complete freund adjuvant (CFA) intraplantar. The dose of P.angulata extract was 50 mg/kg bw po. The extract was given for 10 days as adjuvant of 0.1125 mg/kg bw methotrexate. Evaluation of liver function consisted of measurement of aminotransferase (AST and ALT), alanine phosphatase (ALP), organ index, and histology. The result showed that CFA could increase the level of AST and ALP and decrease the level of ALT and organ index of control group. The extract of P.angulata as adjuvant of methotrexate could decrease the level of AST and ALP and increase the level of ALT and organ index compare to control group, but could not reach its normal value. Histology showed that the extract also could improve liver regeneration. The extract of P.angulata at dose of 50 mg/kg bw used as adjuvant could improve liver function of RA animals model. 
Co-Authors . Endarti . Patonah Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Afrillia Nuryanti Garmana Aisyah, Salmanda Anam, M. Khairul Ardiansyah, Muhamad Asep Abdul Rahman Asep Gana Suganda Asri Wulandari Astuti, Niken Juni Cahyono, Nur Sidik Candra candra Daryono Hadi Tjahjono Evi Sovia Faizal Hermanto Hernandi, Baso I Ketut Adnyana Irawan, Wira Irda Fidrianny Iwang Soediro Joseph I. Sigit Joseph Iskendiarso Sigit Kuatrina, Kuatrina Kusmaningati, Suswini Kusmaningati, Suswini L Broto S Kardono Lucy Dewi N. Sasongko Narvikasari, Suci Neng Fisheri Kurniati Puput Ayu Perdana, Puput Ayu Putra , Erwin Ekadharma Putri, Mareta Ananda Redya Hernawati, Redya Rini Syafriani Ririn Sinaga, Ririn RR. Ella Evrita Hestiandari Setiani, Nur Asni Sheba, Shiane Hanako Siftiani, Nindy Dwi Siti Nur Aeni, Siti Nur Solihah, Puspa Sari Dewi Suci Nar Vikasari, Suci Nar Sujiatmo, Afifah Bambang Sumartin, Yunita Suryani Suryani Tommy Apriantono Yani Mulyani Yulia Ratnawati, Yulia Yuliet Yuliet