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All Journal Majalah Kedokteran Bandung Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JFIOnline Jurnal Buana Farma Kartika : Jurnal Ilmiah Farmasi
Elin Yulinah Sukandar
Sekolah Farmasi, Institut Teknologi Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet, Yuliet; Sukandar, Elin Yulinah; Adnyana, I Ketut
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.15416/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
Co-Authors . Endarti . Patonah Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Afrillia Nuryanti Garmana Aisyah, Salmanda Anam, M. Khairul Ardiansyah, Muhamad Asep Abdul Rahman Asep Gana Suganda Asri Wulandari Astuti, Niken Juni Cahyono, Nur Sidik Candra candra Daryono Hadi Tjahjono Evi Sovia Faizal Hermanto Hernandi, Baso I Ketut Adnyana Irawan, Wira Irda Fidrianny Iwang Soediro Joseph I. Sigit Joseph Iskendiarso Sigit Kuatrina, Kuatrina Kusmaningati, Suswini Kusmaningati, Suswini L Broto S Kardono Lucy Dewi N. Sasongko Narvikasari, Suci Neng Fisheri Kurniati Puput Ayu Perdana, Puput Ayu Putra , Erwin Ekadharma Putri, Mareta Ananda Redya Hernawati, Redya Rini Syafriani Ririn Sinaga, Ririn RR. Ella Evrita Hestiandari Setiani, Nur Asni Sheba, Shiane Hanako Siftiani, Nindy Dwi Siti Nur Aeni, Siti Nur Solihah, Puspa Sari Dewi Suci Nar Vikasari, Suci Nar Sujiatmo, Afifah Bambang Sumartin, Yunita Suryani Suryani Tommy Apriantono Yani Mulyani Yulia Ratnawati, Yulia Yuliet Yuliet