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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya MANDALA of Health Disease Prevention and Public Health Journal Jurnal Penelitian Pendidikan Prosiding 2nd Seminar Nasional IPTEK Terapan (SENIT) 2017 Universa Medicina Jurnal Gizi Klinik Indonesia Journal Of Holistic Nursing Science Herb-Medicine Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Evy Sulistyoningrum
Department Of Histology, Faculty Of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : MANDALA of Health

 1 
PERUBAHAN SELULER DAN MOLEKULER PADA NEFROPATI DIABETIK Sulistyoningrum, Evy
MANDALA of Health Vol 7, No 1 (2014): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Diabetic nehropathy is the most prevalent complication of diabetes mellitus. Hiperglycemia in diabetes mellitus activates several pathways leading to PKC activation. This activation then induce molecular changes involving many growth factors and cytokines. Various growth factors and cytokines further induce extracellular matrix accumulation and mesangial cell expansion leading to glomerular hypertrophy and sclerosis. This changes affects renal function in filtering albumin and further damage can cause abnormal renal function and lead to renal failure
TINJAUAN HISTOLOGIS PEMBULUH DARAH TIKUS PUTIH (Rattus norvegicus) DIABETES YANG DIBERI REBUSAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpha (Scheff.) Boerl.) Sulistyoningrum, Evy; Kautsari, Septina; Susatyo, Priyo
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Prevalence of Diabetes Mellitus among adult in Indonesia reached 4,1% in 1995 and projected to 6,5% in 2025. Complication of diabetes mellitus which come earlier and widely distributed yis atherosclerosis.Atherosklerosis can lead to other serious complications such as gangrene, stroke, cardiomiopathy, andcoronary artery diseases. This research was aimed to know the effect of Mahkota dewa (Phaleriamacrocarpha (Scheff.) Boerl.) boiled water to regeneration of aorta’s atherosclerosis post diabetic inductionwith alloxan. The research was conduct in four weeks to 25male albino rats (Rattus norvegicus) 3 monthaged, 120-180 grama weighed. The subjects was divided into five groups:positive control, negative control,A, B and C. A, B and C groups was treated Mahkota dewa boiled water with 4,5%, 9%, and 13,5%concentration respectively. The drug was administered orally. III, IV, and V groups are injected by alloxan toinduce diabetes. Atherosclerosis frequency was counted from histological section stained with Haematoxylineosin.Statistical analysis using Chi square analysis showed that Mahkota Dewa boiled water significantlyreduced atherosclerosis frequency in aorta. It can be concluded that Mahkota dewa (P.macrocarpha(Scheff.) Boerl.) regenerates atherosclerosis injury in diabetic blood vessel.
TINJAUAN MOLEKULAR DAN ASPEK KLINIS RESISTENSI INSULIN Sulistyoningrum, Evy
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Insulin resistance is defined by an unresponsive condition in the target organ that normallyresponded to insulin hormone. Insulin resistance play a major role in many serious health problem such asmetabolic syndrome, type II diabetes, polycistic ovarii syndrome, cancer and cardiovascular diseases. Themechanism of insulin resistance is still unclearly understood. Researchers postulated two mechanism ofinsulin resistance, based on inflammatory theory and obesity theory. These two causes of insulin resistancehave different mechanism of action. Clinical diagnosis of insulin resistance can be performed by clampmethod and minimal model of frequency sampled intravenous glucose tolerance test (FSIVGTT) but thesegold standard diagnosis are very invasive. Non-invasive methods for diagnosing insulin resistance can beperformed by using various formulas derived from base examination in glucose and insulin plasma level.One of the formulas which have high sensitivity and specificity is HOMA-IR index (Homeostasis ModelAssessment-Insulin Resistance). Different characteristic of population required different cut-off fordetermining insulin resistant condition.
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
Co-Authors Adrian Nugraha Putra Agus Prastowo Agus Prastowo Ariadne Tiara Hapsari Ariadne Tiara Hapsari Aulia, Afkar Azzahra, Fathimah Cleopatra, Neysa Nurprahutri Darajati, Irene Titin Diah Krisnansari Diah Krisnansari Dicky Bramantyo agung Prakoso, Dicky Bramantyo agung Eman Sutrisna Erika Maharani Fajar Wahyu Pribadi Fitranto Arjadi Herlin Fitriana Kurniawati Herlina Nindyastuti Ika Fidianingsih Ira Puspitawati Kharisma, Muhammad Mus topa Mustofa Mustofa Muttaqqin, Habib Zahar Zaki Narantika, Shindy Galuh Novyan Lusiyana Nur Signa Aini Gumilas Nurvita Pranasari, Nurvita Panggabean, Andre Stefanus Priyo Susatyo Qurrotu Aini Rosmelia Rosmelia Septina Kautsari, Septina Setiawati Setiawati Supriyati . Supriyati, Endah Susiana Candrawati Yulia Wardhani, Yulia