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All Journal Pendidikan Dasar KEMBARA Jurnal Ilmiah Ekonomi Islam Dinamisia: Jurnal Pengabdian Kepada Masyarakat Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Ilmiah Edunomika (JIE) Journal of Stem Cell Research and Tissue Engineering KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Budimas : Jurnal Pengabdian Masyarakat Language and Education Journal JEBDEKER: Jurnal Ekonomi, Manajemen, Akuntansi, Bisnis Digital, Ekonomi Kreatif, Entrepreneur BASA Journal of Language & Literature Asian Management and Business Review Golden Childhood Education Journal (GCEJ) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Prosiding Seminar Nasional Hasil Penelitian Sains, Teknik dan Aplikasi Industri Fakultas Teknik Universitas Lampung Jurnal Indonesia Sosial Teknologi Electrician : Jurnal Rekayasa dan Teknologi Elektro Business and Investment Review Ezra Science Bulletin Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi Emitor: Jurnal Teknik Elektro Jurnal Riset Multidisiplin Edukasi Journal of Studies in Academic, Humanities, Research, and Innovation Indonesian Journal of Economics, Business, Accounting, and Management As-Sulthan Journal of Education
Sumadi
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Journal : Journal of Stem Cell Research and Tissue Engineering

 1 
DEVELOPMENT OF STEM CELL-BASED CANCER THERAPY STRATEGIES Sumadi; Warda, Rizki Zeillatul
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67760

Abstract

Cancer remains one of the leading causes of death worldwide, with various treatment options available depending on the type and stage of the disease. Traditional therapies, such as surgery, radiotherapy, chemotherapy, and immunotherapy, have shown varying degrees of success, but each has its limitations. Recently, stem cell therapies have emerged as a promising alternative, offering more targeted treatments with fewer side effects. Stem cells, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs), have demonstrated potential in cancer therapy through mechanisms like tumor site targeting, paracrine signaling, and gene delivery. MSCs, in particular, are of interest due to their ability to migrate to tumor sites and release exosomes that can influence tumor growth, angiogenesis, and metastasis. Modified MSCs have been engineered to deliver anticancer agents or "suicide" genes, providing a more focused approach to tumor treatment. Moreover, MSCs have shown promise in addressing challenges like drug resistance and recurrence in cancer. However, their effectiveness depends on factors such as exosome composition and the tumor microenvironment. Despite the challenges, stem cell-based therapies, including MSC-derived exosomes, represent a novel strategy to enhance the specificity and efficacy of cancer treatments. This review explores current advances in stem cell-based cancer therapies, highlighting their potential, ongoing research, and the need for further studies to optimize these approaches for clinical application.
UTILIZATION OF STEM CELL THERAPY AS A NEW APPROACH TO OVERCOME REPRODUCTIVE DISEASES IN WOMEN Warda, Rizki Zeillatul; Sumadi
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67758

Abstract

The human body contains approximately 37.2 trillion cells, each specialized to perform specific functions within tissues and organs. Stem cells, particularly mesenchymal stem cells (MSCs), have emerged as a promising therapeutic option for various medical conditions due to their regenerative and differentiation capabilities. Female infertility, which significantly impacts quality of life, often results from reproductive disorders such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. Conventional treatments like hormone therapy are limited by long-term risks, including heart disease and cancer, while assisted reproductive technologies are hindered by ethical, safety, and financial concerns. This review explores MSC-based therapies as innovative alternatives for addressing female reproductive disorders. MSCs demonstrate potential in regenerating ovarian cells, restoring hormonal balance, and repairing uterine tissue. For POF, MSC therapy replenishes ovarian cells, improves hormone levels, and restores function. In PCOS, MSCs reduce inflammation and fibrosis while enhancing ovarian function. Endometriosis management benefits from MSCs' ability to repair endometrial damage and improve uterine receptivity. MSCs also show efficacy in reducing fibrosis and increasing vascularization in Asherman syndrome and repairing placental damage in preeclampsia by mitigating oxidative stress and inflammation. This review synthesizes findings from recent studies to highlight MSCs' role in advancing gynecological medicine, presenting them as a safe, effective, and sustainable therapeutic approach for treating infertility and enhancing reproductive health.
Co-Authors Adheizka, Finandra Afri Yudamson Alferidho Arif Anang Santoso Anisa Ulya Darajat Arisa, Musliana Nur Aulin Nuha, Gardina Aulya Putri, Ramadhani Badri Atul Fikriyah Budi Murtiyasa Buhani* Cahyani, Andini Septiara Cholis Abrori, Cholis D Permatasari Daffa, Muhammad De Laurent, Defant Dewi Muliasari Dewi Yuli Trisnawati Dian Wahyuningsih Dina Helianti Djoko Apriono Dwi Imam Efendi Effendi, Agsendo Muhammad Ekayati, Ifa Aristia Sandra Eko Triyanto emir nasrullah Emir Nasrullah Eri Ramadhan F Luziana Fatihah Wari Nurjanah Firdausi Nuzula Apriliyana Gigih Forda Nama Hadi Samanto Hamala, Nanda Rizky Helmy Fitriawan Hendi Hidayat Herlinawati Izza Azzahra Kendall Malik khoiriyah, soviyatul Lasmi Lina Aulia Hikmah Marimin , Maulana, Aditha Satria Muhammad Ifan Saputra Munawaroh, Ayu Muqorobin Nopreza, M. Andi Alwi Nurchasanah Pertiwi, Novia Ayu Sekar Pratama, Yogi Putra, Muhammad Raihan Rakha Rahmad Washinton Ramlan Setiawan RESTI UTAMI Rina Nursabrina Rosdiana Rosita Dewi Rosyida Hanifa Zara Ruaidah Setyawan, FX Arinto Sheilla Rachmania, Sheilla Siti Fatimatuz Zahro Siti Muliatul Afifah Suharso Suhartini Suhendra, Nanang Syaiful Alam Syfa Meisyin Nisa Tawakkal, M. Iqbal Tho’in, Muhammad Tino Feri Efendi Tira Nur Fitria Tira Nur Fitria, Tira Nur Umi Murdika WAHYUDI Warda, Rizki Zeillatul Wayan Denny Putra Wijaya Widiastuti, Yuanita Yulinartati Yustin Henina Oktaviani Zulfa Khoirul Ummah Zulfi, M.Ridho