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All Journal Pendidikan Dasar KEMBARA Pendas : Jurnah Ilmiah Pendidikan Dasar Journal of Stem Cell Research and Tissue Engineering Language and Education Journal JEBDEKER: Jurnal Ekonomi, Manajemen, Akuntansi, Bisnis Digital, Ekonomi Kreatif, Entrepreneur Golden Childhood Education Journal (GCEJ) Prosiding Seminar Nasional Hasil Penelitian Sains, Teknik dan Aplikasi Industri Fakultas Teknik Universitas Lampung Electrician : Jurnal Rekayasa dan Teknologi Elektro Business and Investment Review Ezra Science Bulletin Emitor: Jurnal Teknik Elektro Indonesian Journal of Economics, Business, Accounting, and Management As-Sulthan Journal of Education
Sumadi
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Arts Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Veterinary Other

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Journal : Journal of Stem Cell Research and Tissue Engineering

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DEVELOPMENT OF STEM CELL-BASED CANCER THERAPY STRATEGIES Sumadi; Warda, Rizki Zeillatul
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67760

Abstract

Cancer remains one of the leading causes of death worldwide, with various treatment options available depending on the type and stage of the disease. Traditional therapies, such as surgery, radiotherapy, chemotherapy, and immunotherapy, have shown varying degrees of success, but each has its limitations. Recently, stem cell therapies have emerged as a promising alternative, offering more targeted treatments with fewer side effects. Stem cells, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs), have demonstrated potential in cancer therapy through mechanisms like tumor site targeting, paracrine signaling, and gene delivery. MSCs, in particular, are of interest due to their ability to migrate to tumor sites and release exosomes that can influence tumor growth, angiogenesis, and metastasis. Modified MSCs have been engineered to deliver anticancer agents or "suicide" genes, providing a more focused approach to tumor treatment. Moreover, MSCs have shown promise in addressing challenges like drug resistance and recurrence in cancer. However, their effectiveness depends on factors such as exosome composition and the tumor microenvironment. Despite the challenges, stem cell-based therapies, including MSC-derived exosomes, represent a novel strategy to enhance the specificity and efficacy of cancer treatments. This review explores current advances in stem cell-based cancer therapies, highlighting their potential, ongoing research, and the need for further studies to optimize these approaches for clinical application.
UTILIZATION OF STEM CELL THERAPY AS A NEW APPROACH TO OVERCOME REPRODUCTIVE DISEASES IN WOMEN Warda, Rizki Zeillatul; Sumadi
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67758

Abstract

The human body contains approximately 37.2 trillion cells, each specialized to perform specific functions within tissues and organs. Stem cells, particularly mesenchymal stem cells (MSCs), have emerged as a promising therapeutic option for various medical conditions due to their regenerative and differentiation capabilities. Female infertility, which significantly impacts quality of life, often results from reproductive disorders such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. Conventional treatments like hormone therapy are limited by long-term risks, including heart disease and cancer, while assisted reproductive technologies are hindered by ethical, safety, and financial concerns. This review explores MSC-based therapies as innovative alternatives for addressing female reproductive disorders. MSCs demonstrate potential in regenerating ovarian cells, restoring hormonal balance, and repairing uterine tissue. For POF, MSC therapy replenishes ovarian cells, improves hormone levels, and restores function. In PCOS, MSCs reduce inflammation and fibrosis while enhancing ovarian function. Endometriosis management benefits from MSCs' ability to repair endometrial damage and improve uterine receptivity. MSCs also show efficacy in reducing fibrosis and increasing vascularization in Asherman syndrome and repairing placental damage in preeclampsia by mitigating oxidative stress and inflammation. This review synthesizes findings from recent studies to highlight MSCs' role in advancing gynecological medicine, presenting them as a safe, effective, and sustainable therapeutic approach for treating infertility and enhancing reproductive health.
Co-Authors Afri Yudamson Alferidho Arif Anang Santoso Arisa, Musliana Nur Badri Atul Fikriyah Buhani* Cahyani, Andini Septiara D Permatasari Daffa, Muhammad De Laurent, Defant Dwi Imam Efendi Effendi, Agsendo Muhammad Ekayati, Ifa Aristia Sandra Eko Triyanto Emir Nasrullah F Luziana Firdausi Nuzula Apriliyana Gigih Forda Nama Helmy Fitriawan Hendi Hidayat Herlinawati Izza Azzahra Kendall Malik khoiriyah, soviyatul Muhammad Ifan Saputra Nanda Rizky Hamala Nurchasanah Pertiwi, Novia Ayu Sekar Pratama, Yogi Rahmad Washinton Ramlan Setiawan Rina Nursabrina Ruaidah Setyawan, FX Arinto Siti Fatimatuz Zahro Siti Muliatul Afifah Suharso Syaiful Alam Ulya Darajat, Anisa Umi Murdika WAHYUDI Warda, Rizki Zeillatul Wayan Denny Putra Wijaya Widiastuti, Yuanita Zulfi, M.Ridho