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Cystatin C Serum Level and the Severity of Preeclampsia Winarto, Abraham; Suparman, Eddy; Wantania, John
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.577 KB) | DOI: 10.32771/inajog.v4i3.434

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Objective: Determining the cystatin C serum level among normotensive, mild preeclamptic, severe preeclamptic pregnant women and their relationship with the severity of preeclampsia. Method: The study was held using cross sectional design in Prof. Dr. RD Kandou Hospital in Manado and its network hospitals. We did on 51 samples at term pregnant women, consisting of 17 samples for each group in normotensive, mild preeclampsia, and severe preeclampsia. The data were analyzed using SPSS version 22.0 software through ANOVA and Kruskal Wallis statistical test. Result: The mean cystatin C serum concentration in normotensive pregnant women, mild preeclampsia, and severe preeclampsia were 0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical test showed the significant association between cystatin C level and severity of preeclampsia (p
The Prevalence and Risk Factors of Stress Urinary Incontinence in Postpartum Pratiwi, Renny; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.713 KB) | DOI: 10.32771/inajog.v4i3.438

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Objective: To know the incidence of stress urinary incontinence in postpartum and determine the relationship among age, parity, infant birth weight, mode of delivery, episiotomy and perineum rupture. Method: This study used cross sectional analytic design. Qualified subjects from inclusion criteria were interviewed by researchers using pre-defined MESA questioner. Subjects with stress urinary incontinence were found from the questionnaire result. The acquired data was measured and analyzed using SPSS v. 22.0 software and discussed using available literature. Result: From 162 subjects, 36 cases (22.22%) had stress urinary incontinence, 47.22% aging ? 35 years old, 72.22% had multiple pregnancies, 88.89% had per vaginal delivery. Using multivariate logistic regression test, we found there was a relationship between stress urinary incontinence with age and parity (p 35 years old and multiple parities. Keywords: multiple parities, post-partum, stress urinary incontinence
Heat Shock Protein 70 (HSP 70) Level in Threatened Abortion Utomo, Bram M; Suparman, Eddy; Mamengko, Linda M
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.75 KB) | DOI: 10.32771/inajog.v4i4.445

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Objective: To determine the level of Heat Shock Protein 70 (HSP 70) in threatened abortion compared with normal pregnancy. Method: This was a cross-sectional analytic study design conducted to examine the HSP 70 level on 25 subjects of pregnant women with
The Menopausal Symptoms of Paramedics at a Tertiary Care Center Kumaat, Toar A; Loho, Maria F T; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.837 KB) | DOI: 10.32771/inajog.v5i4.562

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Objective: To assess paramedic menopausal symptoms on theinpatient unit and outpatient unit.Methods: This was a cross sectional study. Data collect by fill thequestioner, the questioner fill by menopausal paramedic on Prof. Dr.R. D. Kandou Manado Hospital from October 2016 to January 2017.Data were analyzed using SPSS 22.0 for Windows.Results: Of 60 paramedics, 30 were divided to inpatient unit andthe other 30 were divided to outpatient unit. By the menopauserating scale, somatic and urogenital complaint in statistical testhave no significant differences. Psychology complaint with a moderatecomplaints on inpatient unit have 19 paramedic (63%) and12 paramedic (40%) on outpatient paramedic, in statistical havea significant differences (x2=9.62, p=0.022). On the total scoremenopausal complaints, the moderate complaints 18 paramedic(60%) on the inpatient unit and the minor complaints 21 paramedic(70%) on the outpatient unit, in statistical have a significantdifferences (x2=6.97, p=0.031).Conclusion: There is no significant difference in somatic andurogenital complaints on paramedic inpatient unit and outpatientunit. There is a significant difference in psychological complaintsand total score menopausal complaints on paramedic inpatientunit and outpatient unit.[Indones J Obstet Gynecol 2017; 5-4: 208-212]Keywords: menopause, menopause rating scale, paramedic
Relationship between Vaginal Sialidase Levels with Threatened of Preterm Labour Sulistyo, Bambang; Warouw, Najoan N; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.271 KB) | DOI: 10.32771/inajog.v6i1.753

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Objective: To investigate the association between vaginalsialidase levels and threatened of preterm labor.Methods: A cross sectional study design was used. Subjects weredivided into two groups; the first group were pregnant women withthreatened of preterm labour, whereas the second were pretermpregnant women in Prof. Dr. R.D. Kandou Manado hospitals andnetwork hospitals, during the period between August 2016 andOctober 2016. Data were analyzed with SPSS version 20 to see thesignificancy levels.Results: From the 16 pregnant women with threatened ofpreterm labor and 16 pregnant women with preterm pregnant,the statistical t test showed that there were significant differencesaverage level of sialidase vagina between the threatened ofpreterm labor and preterm pregnant group (p = 0.000).Conclusion: There is a relationship between the incidencethreatened of preterm labor with vaginal sialidase levels.Keywords: bacteria, threat of preterm labour, vaginal sialidase
Malondialdehyde Levels in Preeclampsia before and after Delivery Rumopa, Harold; Wagey, Freddy W.; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.193 KB) | DOI: 10.32771/inajog.v6i3.777

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  Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.   Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).   Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia
The Associated of Serum Inhibin A Levels in Severe Preeclampsia Lumentut, Anatasia M; Kaeng, Junneke J; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.763 KB) | DOI: 10.32771/inajog.v7i1.824

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Objective: to prove the associated of serum Inhibin A levels in severe preeclampsia. Method: this study was an observational analytic research with cross-sectional design. The subject of this study consists of 23 samples of normotensive pregnancy and 23 of samples severe preeclampsia who meet the inclusion and exclusion criteria.This study was conducted and evaluated fromSeptember 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine University of Sam Ratulangi Prof. Dr. R. D. Kandou Hospital Manado and satellite hospitals. Samples were analyzed using ELISA method at Prodia laboratory. Data were analyzed with SPSS version 20.0 Result: Mean serum Inhibin A levels in normotensive pregnancy is 477,22pg/ml while mean in severe preeclampsiais 2712,39 pg/ml with p value = 0,000. Conclusion: Levels of serum Inhibin A in severe preeclampsia significantly higher compared to normotensive pregnancy. Keywords: inhibin A, normotensi, severe preeclampsia     Tujuan:  untuk membuktikan hubungan kadar inhibin A serum pada preeclamsia berat. Metode: penelitian ini merupakan studi analitik observasional dalam bentuk desain potong lintang. Dilakukan pemeriksaan kadar Inhibin A serum pada 46 sampel ibu hamil yang memenuhi kriteria inklusi dan eksklusi, terdiri atas 23 kelompok preeclamsia berat dan 23 kelompok kehamilan normotesi. Penelitian dilaksanakan dan dievaluasi sejak bulan September 2016 sampai Desember 2016 di Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sam Ratulangi / RSU Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring. Analisis sampel dilakukan di Laboratorium Prodia Jakartamenggunakan metode ELISA. Data dianalisis denganSPSS versi 20.0. Hasil: rerata kadar Inhibin A serum pada kelompok kehamilan normotesi yaitu 477,22 pg/mlsedangkan rerata pada kelompok preeklamsia berat yaitu  271,.39 pg/ml dengan nilai p=,.000. Kesimpulan: kadar Inhibin A serum pada preeclampsia berat lebih tinggi secara bermakna dibandingkan dengan kehamilan normotensi. Kata kunci: inhibin A, normotensi, preeclamsia berat
Relationship of Retinol Binding Protein Four Serum Level on Endometrial Hyperplasia and Endometrial Carcinoma Limy, Ivan; Suparman, Eddy; Tendean, Hermie M. M.
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.974 KB) | DOI: 10.32771/inajog.v6i4.849

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Abstract Objective : To determine the relationship of elevated serum retinol binding protein 4 with abnormal uterine bleeding Methods : This study was an observational quantitative with cross sectional methods, with all women who had abnormal uterine bleeding caused either by endometrial carcinoma or endometrial hyperplasia at RSUP Prof.DR.RD Kandou, and affiliation hospitals from November 2016 until April 2017. Data were analyzed With SPSS version 2.0 to see the significancy level. Results: Of 26 research subjects, 23 subjects with endomtrial hyperplasia and 3 subjects with endometrial carcinoma. From the total of 26 malignancy and hyperplasia diagnoses, 21 had IMT> 25 and 23 were diagnosed with Endometrial Hyperplasia and 3 Carcinoma Endometrium. 18 subjects had elevated serum RBP4 levels, with 15 people with endometrial hyperplasia and 3 with endometrial carcinoma. With the Fischer Exact test statistic, serum retinol binding protein 4 levels were found in both endometrial hyperplasia and endometrial carcinoma p = 1.00, meaning no significant difference for the occurrence of abnormal uterine bleeding. Conclusion: There was no significant association between serum retinol binding protein 4 between endomterium carcinoma and endometrial hyperplasia. Keywords: abnormal uterine bleeding, endometrial carcinoma, endometrial hyperplasia, serum retinol binding protein 4   Abstrak Tujuan : Mengetahui adanya hubungan peningkatan kadar serum retinol binding protein 4 pada hyperplasia endomterium dengan carcinoma endometrium Metode : Penelitian ini adalah jenis kuantitatif observasional secara potong lintang, dengan semua perempuan yang mengalami perdarahan uterus abnormal yang disebabkan oleh hiperplasia endometrium atau carcinoma endometrium di Bagian Kebidanan dan Kandungan Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai November 2016 sampai April 2017.Data dianalisa dengan SPSS versi 2.0 untuk melihat tingkat kemaknaannya. Hasil : Dari 26 subjek penelitian, 23 subjek dengan hyperplasia endomtrium dan 3 subjek dengan carcinoma endometrium. Didapatkan data penelitian dari total keganasan diagnosa  dan hiperplasia sejumlah 26 orang, sebanyak 21 orang memiliki IM T>25 dan sebanyak 23 orang didiagnosa dengan Hiperplasia Endometrium dan 3 orang karsinoma Endometrium. Didapatkan sebanyak 18 subyek penelitian mengalami peningkatan kadar serum RBP 4, dengan 15 orang yang mengalami hiperplasia endometrium dan 3 orang dengan karsinoma endometrium. Dengan uji statistik Fischer Exact test, didapatkan kadar serum retinol binding protein 4 baik pada hiperplasia endometrium dengan karsinoma endometrium p=1.00, mengartikan tidak mempunyai perbedaan bermakna untuk terjadinya perdarahan uterus abnormal. Kesimpulan : Tidak terdapat hubungan bermakna kadar serum retinol binding protein 4 antara karsinoma endomterium dengan hiperplasia endometrium. Kata kunci : hiperplasia endometrium , kadar serum retinol binding protein 4, karsinoma endometrium, perdarahan uterus abnormal
Gambaran persalinan prematur pada kehamilan remaja di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari – 31 Desember 2015 Ondang, Marnie Ch.; Suparman, Eddy; Tendean, Hermie M.M.
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.2.2016.14487

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Abstract: According to WHO, about 13 millions babies were born prematurely in this world, and less than 1 million premature babies die every year. Around 14 million teenagers become mothers every year and more than 90% of young mothers were in developing countries. Rate of premature birth around 10-20% in Indonesia in 2009 which causes Indonesia becomes the big 5 of the most premature births. According to Riskesdas in 2013 pregnancy in the age 10-54 years in Indonesia was 2,68% higher in cities than in suburban/villages. From women aged 10-54 there are 0.02% pregnant women under 15 years old. This was a descriptive retrospective, study using medical record data of the patients who had premature labour among teenagers acording to age, education, job, marital status, parity, health, head presentation. The results showed that of 31 cases of premature labours in teenagers, 22 cases or 70.96% of them are delivered by women age 18 to 19-year-old, the last education level they had in average is high school which is 64.51%, the majority of them, 93.54% are working as housewives, 83.87% are married, 25 cases or 80.64% of them are primigravida, the highest factors of premature baby, 12.90 % is the ruptured amnion which happened far before the due date of the baby’s delivery, and 90.32% of the case is baby’s head in facing-down position. Conclusion: Premature labours were mostly found in the age group of 18 to 19-year-old with ruptured of amnion long before the baby’s delivery as the highest complication factor, and utmost cases with the baby’s head is in facing-down position.Keywords: preterm labor, teenagers. Abstrak: Menurut WHO ± 13 juta bayi lahir prematur di dunia, dan >1 juta bayi yang lahir prematur meninggal setiap tahunnya. Sekitar 14 juta anak remaja wanita menjadi ibu setiap tahun dan lebih dari 90% dari para ibu muda berada di negara berkembang. Angka kelahiran prematur berkisar 10-20% di Indonesia pada tahun 2009 yang menyebabkan Indonesia masuk dalam peringkat kelima dengan kelahiran prematur terbesar. Berdasarkan Riskesdas 2013 kehamilan umur 10-54 tahun di Indonesia adalah 2,68%, di perkotaan lebih tinggi dibanding perdesaan. Di antara wanita umur 10-54 tahun terdapat kehamilan umur <15 tahun (0,02%). Jenis penelitian ialah deskriptif retrospektif, menggunakan data rekam medik pasien yang melahirkan prematur pada usia remaja berdasarkan umur, pendidikan, pekerjaan, status perkawinan, paritas, penyakit/penyulit, presentasi kepala. Dari 31 kasus persalinan prematur pada remaja, didapatkan paling sering pada usia 18-19 tahun sebanyak 22 kasus (70,96%), pendidikan terakhir terbanyak SMA (64,51%), pekerjaan terbanyak IRT (93,54%), dengan status menikah (83,87%) dan jumlah primigravida 25 kasus (80,64%). Penyakit/penyulit persalinan terbanyak Ketuban Pecah Dini (12,90%) dengan presentasi letak kepala (90,32%). Simpulan: Persalinan prematur pada remaja paling sering ditemukan pada kelompok usia 18-19 tahun dan penyulit tertinggi yaitu ketuban pecah dini dengan jenis presentasi kepala tinggi. Kata kunci: persalinan prematur, kehamilan remaja.
HUBUNGAN ANTARA STRES DENGAN POLA MENSTRUASI PADA MAHASISWI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO ANGKATAN 2010 Saerang, Anster; Suparman, Eddy; Lengkong, Rudy A.
e-CliniC Vol 2, No 3 (2014): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v2i3.5759

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Abstract: Adolescence is a period that very sensitive and vulnerable to stress that caused by more rapid physical maturation process than the psychosocial maturation. Stress involves the neuroendocrinology system as a system that has a large role in the female reproduction and therefore contributes to menstrual pattern. Ongoing stress can lead to depression. The prevalence of stress on women is 2 times higher than man. This research aims to determine whether there is a correlation between stress and menstrual pattern on female college student in Medical Faculty 2010 of Sam Ratulangi University Manado. Methods: Design of this research is using analytical observational methods with cross sectional approach. The sampling technique that used is total sampling and 90 respondents that appropriate with the specified criteria and the collecting data technique is using DASS 42 questionnaires. Results: Data obtained most about stress level characteristics is at the normal group which is 54 respondents (60 %) and the fewest is at very severe stress group which is 2 respondents (2,2 %). Data on the characteristics of menstrual cycle, respondents that obtained in regular category is 69 respondents (76,7 %) and in negative category is 21 respondents (23,3,%). Conclusion: There is a correlation between stress level and menstrual cycle on the female college student in Medical Faculty 2010 of Sam Ratulangi University Manado. It is proved by the result of the research which is obtained that most of respondents had a normal stress level with the number of 54 respondents (60 %) and most of respondents had regular menstrual cycle with the number of 69 respondents (76,7 %). Keywords : Stress, menstrual cycle.     Abstrak: Masa remaja merupakan masa sangat sensitif dan rawan terhadap stres yang disebabkan proses pematangan fisiknya lebih cepat dari pematangan psikososial. Stres melibatkan sistem neuroendokrinologi sebagai sistem yang besar peranannya dalam reproduksi wanita sehingga berpengaruh terhadap pola menstruasi.Stres yang berkelanjutan dapat menyebabkan depresi.Prevalensi depresi pada wanita 2 kali lebih tinggi dibanding pria.Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan antara stres dengan pola menstruasi pada mahasiswi Fakultas Kedokteran Universitas Sam Ratulangi Manado Angkatan 2010. Metode: Desain penelitian menggunakan metode obsevasional analitik dengan pendekatan cross sectional. Teknik sampling yang digunakan adalah total sampling dan 90 responden yang sesuai dengan kriteria yang ditentukan dan teknik pengumpulan data menggunakan kuesioner DASS 42. Hasil: Data didapatkan paling banyak mengenai karakteristik tingkat stress yaitu pada kelompok normal sebanyak 54 responden (60%) dan paling sedikit pada kelompok stress sangat parah 2 responden (2,2%). Data mengenai karakteristik siklus haid, responden penelitian didapatkan pada kategori teratur dengan jumlah 69 responden (76,7%) dan pada ketegori negatif 21 responden (23,3%). Simpulan: Terdapat hubungan antara tingkat stres dengan siklus haid pada mahasiswi Fakultas Kedokteran Universitas Sam ratulangi Manado.Dibuktikan dengan hasil penelitian dimana terdapat sebagian besar responden mengalami tingkat stres normal dengan jumlah 54 responden (60%) dan sebagian besar responden mengalami siklus haid teratur dengan jumlah 69 responden (76,7%). Kata kunci: Stres, pola menstruasi.