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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Applied Agricultural Science and Technology kawanad Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Soraya Riyanti
Universitas Jenderal Achmad Yani
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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 1 
Isolasi Sinensetin dari Kumis Kucing (Orthosiphon aristatus Blume miq.) Varietas Putih Fahrauk Faramayuda; Soraya Riyanti; Adella Shindy Pratiwi; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 2 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i2.48084

Abstract

Kumis kucing mengandung metabolit sekunder sinensetin yang termasuk ke dalam golongan senyawa flavonoid. Sinensetin berpotensi sebagai agen antivirus dan imunomodulator.  Tujuan penelitian ini adalah standardisasi tanaman kumis kucing varietas putih dan upaya produksi senyawa sinensetin. Ekstraksi dilakukan dengan metoda maserasi. Tahap pemisahan lanjutan dilakukan dengan metoda ekstraksi cair-cair, kromatografi kolom dan kromatografi cair vakum. Hasil ekstraksi cair-cair terpilih tiga fraksi  yaitu fraksi air, etil asetat dan n-heksana. Sebanyak 2,08 gram fraksi etil asetat dilanjutkkan pada tahap pemisahan lanjutan menggunakan kromatografi cair vakum dengan fasa diam silika gel H60 dan fasa gerak n-heksana dan etil asetat. Hasil dari kromatografi cair vakum diperoleh sebanyak 11 subfraksi. Penggabungan dilakukan pada subfraksi 8-11 yang terdeteksi adanya senyawa sinensetin, selanjutnya terhadap subfraksi gabungan dilakukan pemisaahan lanjutan dengan kromatografi kolom. Hasil pemisahan dengan kromatografi kolom diperoleh subfraksi sebanyak 142 vial. Pada subfraksi hasil kromatografi kolom nomor 91-114 terdeteksi adanya isolat sinensetin. Kromatografi lapis tipis preparatif (KLTP) gabungan subfraksi kromatografi kolom 91-114 (SFK) menunjukkan adanya senyawa sinensetin. Berdasarkan hasil pemeriksaan kemurnian dengan menggunakan KLT 2 dimensi dan analisis profil spektrum UV isolat diduga senyawa sinensetin. 
Comparison of Polyphenol Levels of Callus and Wild Type of Cat's Whiskers Plant ( Orthosiphon aristatus (Blume) Miq.) Purple Varieties Fahrauk Faramayuda; Soraya Riyanti; Ari Sri Widyaswari; Zaini Alfahmi; Sultan Salahudin Jamal; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
Journal of Applied Agricultural Science and Technology Vol. 6 No. 2 (2022): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.608 KB) | DOI: 10.55043/jaast.v6i2.51

Abstract

The cat's whiskers plant ( Orthosiphon aristatus (Blume) Miq) that grows in Indonesia has white flowers, purple flowers, and white flowers with purple patterns. The quality of the secondary metabolite content of each cat's whiskers plant is different because it depends on environmental influences such as rainfall or soil mineral content. Plant tissue culture methods such as callus culture or cell culture are used to overcome these obstacles because these methods do not depend on the environment and can produce secondary metabolites such as those produced by the original plant. Cat's whiskers contain the main secondary metabolite compounds: rosmarinic acid, eupatorin, and sinensetin. Rosmarinic acid belongs to the phenolic group, while sinensetin and eupatorin are flavonoids. This study aimed to determine the total levels of polyphenols and flavonoids in purple cat whiskers and determine the ratio of secondary metabolites of cat whiskers callus with wild-type plants—determination of polyphenol content using Folin Ciocalteau reagent. Determining flavonoid levels is based on colorimetry using AlCl 3 reagent, specific for flavone and flavonol compounds. The levels of polyphenols contained in the ethanolic extract of callus and cat whiskers of the purple variety were 16.056 ± 0.204 mgQE/g and 30.780 ± 0.425 mgQE/g, while the polyphenol content of the callus ethyl acetate extract and the purple variety of cat whiskers leaves was 15,489 ± 0.425 mgQE/g and 13,262 ± 0.044 mgQE/g. The levels of flavonoids contained in the ethanol extract of the cat whiskers leaf were 1.39±0.03 mgQE/g and callus 0.16±0.02 mgQE/g in the ethyl acetate extract of the leaves of the cat whiskers 2.16±0.012 mgQE/g and callus 2.24±0.010 mgQE/g. The polyphenols and flavonoids in the callus ethyl acetate extract were more significant than the ethyl acetate extract of the purple variety ( wild type ) cat whiskers leaf.
Sosialisasi Penanganan Pasca Panen Bahan Baku Rempah Obat Tradisional Fahrauk Faramayuda; Soraya Riyanti; Akhirul Kahfi Syam; Ari Sri Windyaswari; Yeni Karlina; Remare Halomoan Limbong; Anggita Esa Putri Fitrichia; Ananda Tunjung Pertiwi; Trialisa Aprilia; Ema Mutya; Renti Mutiara Dewi; Dwi Ayu Pratiwi; Usi Septiani; Esanda Zulfi Amedea; Yesi Wulandari; Adinda Fitriani; Ami Soega Dwigantina
Kawanad : Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 2 (2022): October
Publisher : Yayasan Kawanad

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56347/kjpkm.v1i2.52

Abstract

Community service activities carried out by students of Universitas Jenderal Achmad Yani were carried out on August 29, 2022, taking place in a medicinal plant garden, Faculty of Pharmacy, Universitas Jenderal Achmad Yani which was attended by UMKM Spice Nusantara Bandung participants. The socialization carried out was the presentation and delivery of post-harvest processing materials (wet sorting, washing, drying, and dry sorting) and the standardization of traditional raw materials. Conventional medicine is a form of treatment efforts in the community to support health which is currently being recommended by the government. Communities can use the toga as an economical and efficient measure to maintain body immunity because the community can obtain and use the toga quickly and simply to maintain family health. The postharvest process greatly determines the existence of active compounds that are efficacious for treatment. Incorrect postharvest management can change, reduce, or destroy the active substance of a plant into a substance that has no therapeutic effect and can even endanger health. The results of the participant's level of understanding were carried out post-test with the results of what is the purpose of post-harvest processing (100%), the sequence of post-harvest processing (80%), what is the general drying temperature (100%), a medicinal plant has good quality and efficacy then we need to know (80%), and what is the function of the washing process (90%) with the conclusion that socialization activities can significantly increase the knowledge of participants from MSMEs regarding planting, post-harvest processing, and the properties of medicinal plants significantly.
PEMANTAUAN KUALITAS JAMU PEGAL LINU YANG BEREDAR DI KOTA CIMAHI Soraya Riyanti; Okky Irnawati Sutardi; Julia Ratnawati
Kartika : Jurnal Ilmiah Farmasi Vol 1 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v1i1.22

Abstract

Jamu pegal linu merupakan salah satu obat tradisional yang banyak dikonsumsi oleh masyarakat Indonesia. Berdasarkan Peraturan Menteri Kesehatan RI No.246/Menkes/Per/V/1990 BAB V Pasal 23 bahwa segala jenis obat tradisional dilarang mengandung bahan kimia hasil isolasi atau sintetik yang berkhasiat obat. Penelitian ini merupakan penelitian survey yang bersifat deskriptif. Objek penelitian adalah lima merk jamu pegal linu yang diperoleh dari beberapa toko jamu yang beredar di daerah Cimahi. Pengujian kualitas jamu pegal linu meliputi parameter spesifik, non spesifik dan pemeriksaan lain, sedangkan untuk mengidentifikasi bahan kimia obat dilakukan dengan metode reaksi warna. Dari lima merk jamu yang dianalisis, empat sampel memenuhi persyaratan kualitas, sedangkan satu sampel tidak memenuhi karena tidak mencantumkan nomor kode produksi dan bahkan mengandung bahan kimia obat berupa metampiron. Tetapi dari empat sampel tersebut, dua diantaranya tidak mencantumkan nomor kode produksi. Jaminan keamanan, kemanfaatan, dan mutu jamu adalah hak asasi konsumen, sehingga diharapkan Dinas Kesehatan setempat dan BPOM dapat melaksanakan pemantauan dan pengawasan terhadap obat-obat tradisional yang beredar di daerah Cimahi.
ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY Fahrauk Faramayuda; Soraya Riyanti; Totik Sri Mariani; Rizka Khoirunnisa Guntina; Winda Nur Halimah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.977

Abstract

 One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.
Co-Authors Adella Shindy Pratiwi Adinda Fitriani Akhirul Kahfi Syam Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Ari Sri Widyaswari Ari Sri Windyaswari Dwi Ayu Pratiwi Elfahmi Elfahmi, Elfahmi Ema Mutya Esanda Zulfi Amedea Fahrauk Faramayuda, Fahrauk Julia Ratnawati Okky Irnawati Sutardi Remare Halomoan Limbong Renti Mutiara Dewi Rizka Khoirunnisa Guntina Sukrasno Sukrasno Sukrasno Sukrasno Sultan Salahudin Jamal Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Trialisa Aprilia Usi Septiani Winda Nur Halimah Yeni Karlina Yesi Wulandari Zaini Alfahmi