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All Journal El-Hayah : Jurnal Biologi EGALITA SAINSTIS Indonesian Journal of Cancer Chemoprevention Science and Technology Indonesia Jurnal Biodjati Journal of Islamic Medicine CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Nurlaili Susanti
Maulana Malik Ibrahim State Islamic University, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Phytochemical, Metabolite Compound, and Antioxidant Activity of Clinacanthus nutans Leaf Extract from Indonesia Nurlaili Susanti; Arifa Mustika; Junaidi Khotib; Roihatul Muti’ah; Maftuchah Rochmanti
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.38-44

Abstract

The antioxidant properties from medicinal plants have protective effects against oxidative stress-linked diseases. Their antioxidant capacities are related to phenolic compounds, including phenols and flavonoids. Clinacanthus nutans, a native to Asia, including Malaysia, Thailand, and Indonesia, are used for treating diabetes and other diseases, but the exploration of the plant in Indonesia is still limited. Therefore, this study aimed to reveal the phytochemical constituents, metabolic compounds, and antioxidant activity of C. nutans extracts. Dried leaf powder was extracted with 70% ethanol and aqueous, each extract was subjected to qualitative phytochemical screening. Subsequently, total phenolic and flavonoid content was calculated using Folin-Ciocalteu and AlCl3 colorimetric assay. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The profiles of phenolic and flavonoid compounds of 70% ethanolic extract were investigated by LC MS/MS. Phytochemical screening showed that the extracts contain phenolic, flavonoid, tannin, and saponin. The total phenolic content of the 70% ethanol and aqueous extract was 4.14±1.9% mgGAE/g and 3.89±3.2% mgGAE/g, respectively. Meanwhile, the total flavonoid content obtained was 0.19±1.0% mgQE/g and 0.03±0.5% mgQE/g for 70% ethanol and aqueous extracts, respectively. Both extracts showed high antioxidant activity, with DPPH IC50 30.57 ????g/mL for 70% ethanol and 37.24 ????g/mL for aqueous extract. LC-MS/MS analysis of 70% ethanol extract revealed 5 phenolic and 3 flavonoid compounds, where DL-glutamic monohydrate and Boesenbergin B were the most dominant based on the percentage of area under the curve. C. nutans originating from Indonesia can be a good source of natural antioxidants because 70% ethanol and aqueous extract show high phytochemical content and antioxidant activity.
In Silico Analysis Effect of Potential Antidiabetic from Dandang Gendis Extract on Aldose Reductase, Glucokinase, and GSK3β for Type 2 Diabetes Mellitus Safira Raissa Dwi Putri; Irda Bella; Siti Khaerunnisa; Nurlaili Susanti; Arifa Mustika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42288

Abstract

Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Various epidemiological studies have shown a trend of increasing incidence and prevalence of diabetes mellitus in various parts of the world. Therefore, diabetes mellitus is currently a global health threat. Dandang gendis (Clinacanthus nutans) is a widely used plant as a traditional herbal treatment in Indonesia, and it has been proven that the ethanol extract of dandang gendis leaves shows an antidiabetic effect. This research aims to determine the compatibility among the flavonoid compounds in C. nutans with Aldose reductase, glucokinase, and GSK3β target drugs for type 2 diabetes mellitus using in silico method.Methods: 45 compounds were obtained from multiple sources. The screening method used Lipinski’s rule of five and Pyrx until 8 compounds were selected. Avogadro, AutoDock 4.2, and Biovia Discovery Studio 2016 were used for molecular docking and visualization analysis.Results: Molecular docking results demonstrate that the ligand-protein interaction’s binding energy was -7.31 to 35.25 kcal/mol for 1AH3, -7.55 to 0.15 kcal/mol for 1V4S, and -7.99 to -2.85 kcal/mol for 3D0E.Conclusion: We can conclude that flavonoid compounds Apigenin, Vitexin, 3,3-di-O-Methylellagic Acid, and Clinacoside C show a high binding affinity with Aldose Reductase, Glucokinase, and GSK3β proteins and have the potential to be oral antidiabetic drug compounds for Diabetes Mellitus. However, its binding affinity has not been able to exceed that of the native ligand of the protein. Further research is needed to determine the significant efficacy and potential as an antidiabetic.
Integrasi KeIslaman Dalam Kurikulum Clinical Skills PSPD Uin Maulana Malik Ibrahim Malang Riskiyah, Riskiyah; Susanti, Nur Laili
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.20677

Abstract

Background: A medical education curriculum that integrates Islamic content is necessary for Muslim doctors. Implementing Islamic integration in medical science must be reflected in curriculum development and learning. Objective: This research aims to determine how Islamic integration is implemented in the CSL curriculum in the Medical Education Study Program at UIN Maulana Malik Ibrahim Malang. Method: This research used a qualitative phenomenological with purposive sampling. In-depth interviews were conducted with 16 people, namely ten students and six lecturers, at the UIN Malang Medical Education Study Program. Results: The results of the research found six themes, including Islamic integration was still lacking in the CSL curriculum; Islamic values material that needed to be integrated into the CSL curriculum; Forms of activities that incorporate Islamic values into the CSL curriculum; Needed to include Islamic integration in the assessment OSCE; There needed to be a guidebook in the form of a CSL module that contains the theory and practice of Islamic integration; Prepared lecturers as role models for doctors who apply Islamic values in the CSL curriculum. Conclusion: The integration of Islam in the CSL curriculum still has many shortcomings that need to be improved.
Paradigma dokter ulul albab, sebuah pendekatan integratif dalam pendidikan kedokteran modern Susanti, Nurlaili
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.32211

Abstract

Sejarah mencatat bahwa ilmu kedokteran berkembang sangat pesat pada masa kejayaan Islam. Tokoh-tokoh dokter muslim menjadi pakar dalam berbagai ilmu pengetahuan termasuk ilmu kedokteran dan karya-karyanya menjadi rujukan pengobatan di berbagai belahan dunia. Capaian tersebut menjadi bukti bahwa integrasi keilmuan dengan nilai keislaman telah menghantarkan pada peradaban Islam yang tinggi. Universitas Islam Negeri Maulana Malik Ibrahim Malang bercita-cita melahirkan sosok ilmuwan besar seperti Ibnu Sina seiring dengan idealisme dan filosofi pengembangan keilmuan Universitas. Oleh karena itu, dikembangkanlah paradigma dokter ulul albab sebagai karakteristik yang tercermin pada lulusannya. Ulasan ini disusun berdasarkan pada kajian literatur dan pemikiran mendalam yang bertujuan untuk memberikan gambaran mengenai karakteristik dan metodologi dokter ulul albab. Karakteristik dokter ulul albab tercermin dalam empat pilar yaitu kedalaman spiritual, keluhuran akhlak, keluasan ilmu, dan kematangan profesional. Metodologi pembelajarannya digambarkan sebagai metafora pohon ilmu dimana akar, batang, ranting, daun dan buah menggambarkan pendekatan integratif dalam proses pembelajaran yang tercermin dalam kurikulum.
Integrasi Nilai Islam dalam Kurikulum Pendidikan Kedokteran Susanti, Nurlaili; Riskiyah, Riskiyah
Journal of Islamic Medicine Vol 6, No 1 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i1.15693

Abstract

Background: Medical education has a strategic role in producing professional doctors who will provide quality health services to the community. A medical education curriculum that integrates Islamic content is needed to strengthen professionalism as a Muslim doctor. Objective: This study examines the implementation of Islamic integration in several Islamic Medical Faculties in Indonesia. Methods: This research is qualitative research with a phenomenological approach. The research subject was taken by purposive sampling. The research subjects are the Faculty of Medicine under the State Islamic Religious College (PTKIN). Data collection techniques were carried out through document studies and interviews. Results: Each Faculty of Medicine has the concept of implementing Islamic integration in medical education with different approaches and ways. Conclusion: The implementation of the integration of Islam in medical science is reflected in curriculum development, learning activities, and assessments Keyword :Medical education, muslim doctor, Islamic value, integration, curriculum.
Co-Authors AA Sudharmawan, AA Abdul Hakim Ach. Nashichuddin Arifa Mustika Arifa Mustika Ermin Rachmawati Ermin Rachmawati Irda Bella Junaidi Khotib Muhammad Ragib Mustofa Muhammad Zainuddin Rahmi Annisa Riskiyah Riskiyah riskiyah, Riskiyah - Risma Aprinda Kristanti Rochmanti, Maftuchah Rochmanti Roihatul Mutiah Roihatul Muti’ah Safira Raissa Dwi Putri Siti Khaerunnisa Yen Yen Ari Indrawijaya