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All Journal El-Hayah : Jurnal Biologi EGALITA SAINSTIS Indonesian Journal of Cancer Chemoprevention Science and Technology Indonesia Jurnal Biodjati Journal of Islamic Medicine CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Nurlaili Susanti
Maulana Malik Ibrahim State Islamic University, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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In Silico Analysis Effect of Potential Antidiabetic from Dandang Gendis Extract on Aldose Reductase, Glucokinase, and GSK3β for Type 2 Diabetes Mellitus Safira Raissa Dwi Putri; Irda Bella; Siti Khaerunnisa; Nurlaili Susanti; Arifa Mustika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42288

Abstract

Introduction: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Various epidemiological studies have shown a trend of increasing incidence and prevalence of diabetes mellitus in various parts of the world. Therefore, diabetes mellitus is currently a global health threat. Dandang gendis (Clinacanthus nutans) is a widely used plant as a traditional herbal treatment in Indonesia, and it has been proven that the ethanol extract of dandang gendis leaves shows an antidiabetic effect. This research aims to determine the compatibility among the flavonoid compounds in C. nutans with Aldose reductase, glucokinase, and GSK3β target drugs for type 2 diabetes mellitus using in silico method.Methods: 45 compounds were obtained from multiple sources. The screening method used Lipinski’s rule of five and Pyrx until 8 compounds were selected. Avogadro, AutoDock 4.2, and Biovia Discovery Studio 2016 were used for molecular docking and visualization analysis.Results: Molecular docking results demonstrate that the ligand-protein interaction’s binding energy was -7.31 to 35.25 kcal/mol for 1AH3, -7.55 to 0.15 kcal/mol for 1V4S, and -7.99 to -2.85 kcal/mol for 3D0E.Conclusion: We can conclude that flavonoid compounds Apigenin, Vitexin, 3,3-di-O-Methylellagic Acid, and Clinacoside C show a high binding affinity with Aldose Reductase, Glucokinase, and GSK3β proteins and have the potential to be oral antidiabetic drug compounds for Diabetes Mellitus. However, its binding affinity has not been able to exceed that of the native ligand of the protein. Further research is needed to determine the significant efficacy and potential as an antidiabetic.
Integrasi KeIslaman Dalam Kurikulum Clinical Skills PSPD Uin Maulana Malik Ibrahim Malang Riskiyah, Riskiyah; Susanti, Nur Laili
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.20677

Abstract

Background: A medical education curriculum that integrates Islamic content is necessary for Muslim doctors. Implementing Islamic integration in medical science must be reflected in curriculum development and learning. Objective: This research aims to determine how Islamic integration is implemented in the CSL curriculum in the Medical Education Study Program at UIN Maulana Malik Ibrahim Malang. Method: This research used a qualitative phenomenological with purposive sampling. In-depth interviews were conducted with 16 people, namely ten students and six lecturers, at the UIN Malang Medical Education Study Program. Results: The results of the research found six themes, including Islamic integration was still lacking in the CSL curriculum; Islamic values material that needed to be integrated into the CSL curriculum; Forms of activities that incorporate Islamic values into the CSL curriculum; Needed to include Islamic integration in the assessment OSCE; There needed to be a guidebook in the form of a CSL module that contains the theory and practice of Islamic integration; Prepared lecturers as role models for doctors who apply Islamic values in the CSL curriculum. Conclusion: The integration of Islam in the CSL curriculum still has many shortcomings that need to be improved.
Paradigma dokter ulul albab, sebuah pendekatan integratif dalam pendidikan kedokteran modern Susanti, Nurlaili
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.32211

Abstract

Sejarah mencatat bahwa ilmu kedokteran berkembang sangat pesat pada masa kejayaan Islam. Tokoh-tokoh dokter muslim menjadi pakar dalam berbagai ilmu pengetahuan termasuk ilmu kedokteran dan karya-karyanya menjadi rujukan pengobatan di berbagai belahan dunia. Capaian tersebut menjadi bukti bahwa integrasi keilmuan dengan nilai keislaman telah menghantarkan pada peradaban Islam yang tinggi. Universitas Islam Negeri Maulana Malik Ibrahim Malang bercita-cita melahirkan sosok ilmuwan besar seperti Ibnu Sina seiring dengan idealisme dan filosofi pengembangan keilmuan Universitas. Oleh karena itu, dikembangkanlah paradigma dokter ulul albab sebagai karakteristik yang tercermin pada lulusannya. Ulasan ini disusun berdasarkan pada kajian literatur dan pemikiran mendalam yang bertujuan untuk memberikan gambaran mengenai karakteristik dan metodologi dokter ulul albab. Karakteristik dokter ulul albab tercermin dalam empat pilar yaitu kedalaman spiritual, keluhuran akhlak, keluasan ilmu, dan kematangan profesional. Metodologi pembelajarannya digambarkan sebagai metafora pohon ilmu dimana akar, batang, ranting, daun dan buah menggambarkan pendekatan integratif dalam proses pembelajaran yang tercermin dalam kurikulum.
Integrasi Nilai Islam dalam Kurikulum Pendidikan Kedokteran Susanti, Nurlaili; Riskiyah, Riskiyah
Journal of Islamic Medicine Vol 6, No 1 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i1.15693

Abstract

Background: Medical education has a strategic role in producing professional doctors who will provide quality health services to the community. A medical education curriculum that integrates Islamic content is needed to strengthen professionalism as a Muslim doctor. Objective: This study examines the implementation of Islamic integration in several Islamic Medical Faculties in Indonesia. Methods: This research is qualitative research with a phenomenological approach. The research subject was taken by purposive sampling. The research subjects are the Faculty of Medicine under the State Islamic Religious College (PTKIN). Data collection techniques were carried out through document studies and interviews. Results: Each Faculty of Medicine has the concept of implementing Islamic integration in medical education with different approaches and ways. Conclusion: The implementation of the integration of Islam in medical science is reflected in curriculum development, learning activities, and assessments Keyword :Medical education, muslim doctor, Islamic value, integration, curriculum.
Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells Mutiah, Roihatul; Mustofa, Muhammad Ragib; Indrawijaya, Yen Yen Ari; Hakim, Abdul; Annisa, Rahmi; Susanti, Nurlaili; Nashichuddin, Ach; Zainuddin, Muhammad
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp71-79

Abstract

Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry
Aktivitas Antimikroba Ekstrak Rimpang Jeringau (Acorus calamus) Terhadap Pertumbuhan Candida albicans Susanti, Nurlaili
Jurnal Biodjati Vol 1 No 1 (2016): Jurnal Biodjati, Volume I, Nomor 1, November 2016
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v1i1.1037

Abstract

Abstrak. Infertilitas adalah ketidakmampuan seorang wanita berusia lebih dari 35 tahun untuk hamil setelah mencoba kurang lebih selama 6 bulan, dengan hubungan seksual yang normal dan tanpa menggunakan kontrasepsi. WHO memperkirakan bahwa 8-12% dari pasangan di seluruh dunia memiliki masalah dalam kehamilan. Baru-baru ini, manajemen infertilitas dengan cara operasi, obat-obatan, dibantu teknologi reproduksi (fertilisasi in-vitro / IVF) selain mahal, tidak selalu berhasil. Saat ini, banyak orang menggunakan herbal dalam pengobatan berbagai penyakit. Madura dikenal sebagai salah satu etnis yang memiliki pengetahuan tentang obat tradisional atau "herbal" terutama yang berkaitan dengan keharmonisan perkawinan. Rimpang Jeringau (Acorus Calamus) adalah salah satu bahan baku "Jamu Subur Kandungan" yang mengatasi masalah infertilitas perempuan. Penelitian ini menguji aktivitas antimikroba Jeringau Rimpang (Acorus Calamus) untuk menghambat pertumbuhan Candida albicans. Hasil penelitian ini diharapkan menjadi dasar untuk standardisasi dan saintification dari "Jamu Subur Kandungan". Uji aktivitas antimikroba dari ekstrak Jeringau Rimpang (Acorus Calamus) menunjukkan penghambatan pertumbuhan Candida albicans dengan Konsentrasi Hambat Minimum (KHM) sebesar 0,5%.Abstrak : Acorus calamus, Antimicrobial activity, Candida albicans Abstract. Infertility is the inability of a woman over 35 years to pregnant after trying for at least 6 months, with normal sexual intercourse and without use birth control. WHO estimates that 8-12% of couples worldwide have problems in pregnancy. Recently, management of infertility with surgery, medicine, assisted reproductive technology (in-vitro fertilization/IVF) in addition to expensive, not always successfully. Currently, many people use herbs in the treatment of various diseases. Madura is known as one of the ethnic that have knowledge of traditional medicine or "herbal" especially related to marital harmony. Rhizome of Jeringau (Acorus Calamus) is one of the raw materials of "Jamu Subur Kandungan" which overcome the problem of female infertility. This study examined the antimicrobial activity of Jeringau Rhizomes (Acorus Calamus) to inhibit the growth of Candida albicans. The results of this study are expected to be the basic for standardization and saintification of "Jamu Subur Kandungan". Antimicrobial activity test of Jeringau Rhizome Extract (Acorus Calamus) showed inhibition of Candida albicans growth with Minimum Inhibitory Concentration (MIC) at 0.5%.Key words : Acorus calamus, Antimicrobial activity, Candida albicans
Co-Authors AA Sudharmawan, AA Abdul Hakim Ach. Nashichuddin Arifa Mustika Arifa Mustika Ermin Rachmawati Ermin Rachmawati Irda Bella Junaidi Khotib Muhammad Zainuddin Mustofa, Muhammad Ragib Rahmi Annisa Riskiyah Riskiyah riskiyah, Riskiyah - Risma Aprinda Kristanti Rochmanti, Maftuchah Rochmanti Roihatul Mutiah Roihatul Muti’ah Safira Raissa Dwi Putri Siti Khaerunnisa Yen Yen Ari Indrawijaya