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Journal : Jurnal Kesehatan

Literatur Review : Rapid Immunochromatography Sebagai Metode Skrining Kanker Serviks Berbasis Deteksi Onkoprotein HPV pada Urin Ika Rahmawati Sutejo; Kiky Martha Arieska
Jurnal Kesehatan Vol 8 No 3 (2020): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-kes.v8i3.164

Abstract

Cervical cancer is still become main health problem especially in development country. This cancer is the second most common cancer in Indonesian women. It commonly caused by infection of Human Papillomavirus (HPV) type 16 and 18. Actually if cervical cancer was detected earlier, it shows better respond therapy than other cancers, but this opportunity is not supported by appropiate screening methods. Nowadays, pap smear and IVA are commonly used for detect cervical cancer but they only recommend for women who have had sexual intercourse. Both of them also require medical expertise and pap smear is highly cost. Based on these problem, this paper describes novel method for cervical cancer screening by using rapid immunochromatography kit which is more applicative, noninvasive, and affordable. This paper was a literature review (library research). Data obtained through the search engine using keywords: "Cervical Cancer", "HPV", "Urine", "Screening", “Lateral flow test”, and "Rapid immunochromatography". The references were taken from reliable journal in the range of 2009 to 2019. Data was also taken from textbooks and the health institution official sites which support the analysis. This method detect the presence of oncoprotein E6 & E7 of HPV-16 and HPV-18 in urinusing antigen-antibody binding principle. Sensitivity and specificity test done by comparing the results of the kit with the results of pap smear tests as a standard screening method and PCR HPV test on urinsamples. We conclude that with further protocol development and standardization to achieve clinical sensitivity, this kit is a solution for noninvasive detection of high risk cervical cancer so that treatment can be do immediately and the mortality rate due to cervical cancer can be reduced as much as possible.  
Co-Authors Adistha Eka Noveyani Adji, Novan Krisno Ain Yuanita Insani Al Munawir Alief Ilman Zaelany Alief Ilman Zaelany Anaditya Wahyu Kumudhaningsih Anang Dwi Atmoko Ancah Marchianti Angga Mardro Raharjo Annafira Yuniar Annafira Yuniar Arif, Dina Rizky Amalia Arifah Nur Hasanah Avita Lukmawati Baskoro Adi Prayitno Brilliant Givya Ariansari Cholis Abrori, Cholis Diana Chusna Mufida Dimas Zabirrurohman Putra Dini Agustina Dwita Aryadina Rachmawati EDY MEIYANTO Edy Meiyanto Edy Meiyanto Edy Meiyanto ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Fauqi Amalia Fuad Adi Prasetyo Hairrudin Hairrudin Handayani, Sri Hazmi Dwinanda Nurqistan Hazmi Dwinanda Nurqistan Heni Fatmawati Heri Puguh Widodo Herwandhani Putri Herwandhani Putri Herwandhani Putri Herwandhani Putri Hilyatul Fadliyah I Nyoman Insan Parisudha Ida Srisurani Wiji Astuti Imama Rasyada Imama Rasyada Jenie, Riris Istighfari Jenie, Riris Istighfari Kiky Martha Ariesaka Kiky Martha Arieska Kristianingrum Dian Sofiana Laila Auliya Noviyanti Lailatul Maghfiroh M. Ali Shodikin Meirizky Zulharini Mudzakkir Taufiqurrqhman Ni Nyoman Yuniasih Nunung Nurhasanah Nur Hasyimiyyah Nurfahimi, Yudriani Nurul Indah Saffanah Pratikno, Dela Putri Puput Sagita Mey Sandra Putra Uta, Diego Rafi Putri, Herwandhani Rakhmat Ramadhani Rayyan, Muhammad Isra Rafidin Rini Riyanti septa surya wahyudi, septa surya Septyawati, Ratna Siti Marissa Aisyah Sugiyanta Sugiyanta Tristira Urvina Viddi Agustian Rosyidi Viddi Rosyidi Viddy Agustian Rosyidi Wiwien Sugih Utami Yasmin Auralia Putri Zahrah Febianti