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All Journal Edulitics (Education, Literature, and Linguistics) Journal Jurnal Respirologi Indonesia ENGLISH EDUCATION: JOURNAL OF ENGLISH TEACHING AND RESEARCH Narra J Edulitics (Education, Literature, and Linguistics) Journal SYARIAH DARUSSALAM : JURNAL ILMIAH KESYARIAHAN DAN SOSIAL MASYARAKAT At Tasyri'i Jurnal Prodi Perbankan Syariah Langua: Journal of Linguistics, Literature, and Language Education INTERACTION: Jurnal Pendidikan Bahasa
Akhmad Syaikhu
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Religion Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Differences in White Blood Cells, Neutrophil-to-Lymphocyte Ratio, Tumor Necrosis Factor-α based on Procalcitonin Level in Community-Acquired Pneumonia Patients Sutanto, Yusup Subagio; Apriningsih, Hendrastutik; Syaikhu, Akhmad; Siregar, Sihsusetyaningtyas Tiominar
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.632

Abstract

Background: Community-acquired pneumonia (CAP) is a respiratory infectious disease caused by bacteria, viruses, or fungi. Procalcitonin (PCT) levels will rise, especially in bacterial infection. PCT examination in CAP can help to confirm the diagnosis and anticipate complications. CAP is diagnosed by symptoms, vital signs, laboratory tests, and radiographic investigations. Inflammatory biomarkers are required for predicting causative microorganisms, guiding antibiotic therapy, and determining severity. The purpose of this study is to compare NLR, WBC, and TNF-α levels in CAP patients dependent on PCT level.Methods: This was an analytical cross-sectional study involving 43 CAP patients admitted to Universitas Sebelas Maret (UNS) Hospital and Moewardi Regional General Hospital Surakarta between February and March 2023. Patients were separated into two groups based on PCT levels: those with levels ≤0.12 ng/mL and >0.12 ng/mL. All patients provided a blood sample for NLR, WBC, TNF-α, and PCT testing. The independent t-test and Mann-Whitney tests were performed for statistical analysis of two unpaired groups, and the Chi-square or Fisher exact test was utilized for ordinal categorical data. If the value of P<0.05, the result is statistically significant.Results: NLR and TNF-α levels were higher in the PCT group >0.12 ng/mL and statistically significant with a value of P=0.001. WBC levels in the PCT group >0.12 ng/mL were higher, but the difference was not statistically significant (P=0.096).Conclusion: The NLR value, WBC, and TNF-α levels were found to be higher in the group with PCT >0.12 ng/mL. 
Co-Authors Abdur Rohman Abu Fanani Adhiputri, Artrien Apriningsih, Hendrastutik Atiq Mohammad Romdlon Budi Rahmat Hakim Fathur Rohim Fathur Rohim Frank, Ahmad Hapsari, Brigitta DA. Kurniasari, Atika Rahma Machfud Muhamad Sodiq marwoto marwoto Mashunah Hanafi Mochammad Imron Awalludin Muhajir Muhajir Novita Qurrotul Aini, Fahria Reviono Reviono Riyantoro, Septian Fiktor Siregar, Sihsusetyaningtyas Tiominar SURYAWATI, BETTY Sutanto, Yusup S. Thoriqussuud Thoriqussuud, Muhammad Yusup Subagio Sutanto