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Riki Siswandi
Departemen Klinik Reproduksi Dan Patologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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AKTIVITAS ANTIINFLAMASI SENYAWA AKTIF DAUN JAWER KOTOK (Plectranthus scutellarioides (L.)R.Br.) MELALUI INHIBISI Siklooksigenase-2 SECARA IN SILICO Maharani, Alya Rizqi; Purwono, Rini Madyastuti; Siswandi, Riki; Nurkarimah, Dona Astari; Farhamzah
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1343

Abstract

Inflammation is the body’s response to harmful stimuli, and it plays a crucial role in boosting immunity. However, if inflammation is not managed properly, it can lead to degenerative diseases. This research aims to analyze the potential of Plectranthus scutellarioides (L.) R. Br. leaves as an anti-inflammatory agent. The study employs an in silico molecular docking method, using the active compound from the plant as the test ligand and the COX-2 receptor as the target. The results indicate that the test ligand, Antosianin, shows the best interaction as an inhibitor of the target receptor, as demonstrated by its superior affinity energy value compared to the other test ligands.
SURVEI TATA LAKSANA TERAPI CAIRAN OLEH DOKTER HEWAN PRAKTISI HEWAN KECIL DI PROVINSI DKI JAKARTA DAN JAWA BARAT Bensa, Matilde Surtini; Soehartono, Raden Harry; Siswandi, Riki
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.91727

Abstract

ABSTRACT This survey research was conducted to identify the understanding of small animal veterinarians regarding fluid therapy. Survey was directed to the members of Indonesian Veterinary Medical Association (IVMA) in DKI Jakarta and West Java Province between January 29 and March 25, 2023. The survey questionnaire consisted of 8 questions about the respondent's identity and 39 questions focusing on knowledge about fluid therapy. The sample size using the Slovin method is 290 respondents. Questions focused mainly on knowledge about types, indication, procedures, side effects of fluid therapy, and difficulties when administering fluid therapy. Validity test and reliability test were applied to assess questionnaire effectivity. The results show that almost all respondents had isotonic crystalloid fluid therapy in their clinic (Ringer's Lactate [286/290] and NaCl 0.9% [290/290]). Both fluids are often given either subcutaneously (NaCl 0.9% [81%]; Ringer's Lactate [19%]) or intravenously (NaCl 0.9% [48%]; Ringer's Lactate [46%]). Both fluids also often used also for maintenance (NaCl 0.9% [70%]; Ringer's Lactate [27%]) and for shock resuscitation of dogs (NaCl 0.9% [30%]; Ringer's Lactate [57%]) and cats (NaCl 0.9% [32%]; Ringer's Lactate [57%]). To increase the use of fluid therapy in dogs and cats, veterinarian practitioners' understanding and knowledge regarding fluid therapy is very necessary.  ABSTRAK Penelitian ini bertujuan untuk mengidentifikasi pemahaman dokter hewan praktik mengenai terapi cairan. Survei dilakukan kepada anggota Perhimpunan Dokter Hewan Indonesia (PDHI) Provinsi DKI Jakarta dan Jawa Barat dimulai sejak tanggal 29 Januari 2023 hingga  25 Maret 2023. Kuesioner survei dengan terdiri dari 8 pertanyaan tentang identitas responden dan 39 pertanyaan yang difokuskan pada pengetahuan tentang terapi cairan. Perhitungan jumlah responden dilakukan dengan metode Slovin berjumlah 290 responden dengan selang kepercayaan 5%. Pertanyaan difokuskan pada pengetahuan tentang jenis, indikasi,  tata laksana, efek samping dan kesulitan saat pemberian terapi cairan. Sebelum di edarkan, kuesioner telah lulus uji validitas dan uji reliabilitas. Hasil penelitian menunjukkan bahwa hampir semua responden  memiliki terapi cairan kristaloid isotonik yaitu Ringer Laktat (RL) (286/290) dan NaCl 0,9% (290/290). Kedua cairan tersebut sering diberikan secara intravena (NaCl 0,9% [48%]; RL [46%]) maupun secara subkutan (NaCl 0,9% [81%]; RL [19%]). Responden memilih NaCl 0,9% [70%] dan RL [27%]) untuk rumatan. Pilihan cairan pada resusitasi syok pasien anjing adalah NaCl 0,9% (30%) dan RL (57%) dan pada pasien kucing adalah NaCl 0,9% (32%) dan RL (57%). Sebanyak 29% responden merasa perhitungan asupan terapi cairan sebagai tantangan terbesar diikuti dengan perhitungan suplementasi Kalium (28%). Walaupun demikian lebih dari 54% responden melaporkan jarang menemukan efek samping dari pemberian terapi cairan. Untuk meningkatkan keefektifan  penggunaan terapi cairan pada anjing dan kucing sangat diperlukan pendidikan berkelanjutan  terkait terapi cairan.
Modulatory Effect of Electroacupuncture on Isoflurane Anaesthesia in Cats Wahyuni, Sri; Soehartono, R Harry; Siswandi, Riki
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.297-307

Abstract

This study aimed to evaluate the combination of electroacupuncture (EA) and isoflurane as an anesthetic regimen in domestic cats. A total of 15 cats were divided into two groups, namely tiletamine-zolazepam (TZ) (n = 5) and EA (n = 10). Atropine was used as a premedication, injected 5 min before the induction of TZ. Approximately 10 min after induction, endotracheal intubation was applied, and cats were connected to isoflurane anesthesia. EA was applied to the EA group during the first 10 min of the total 30 min under isoflurane maintenance. Furthermore, the acupuncture points ST-36 and SP-6 were used at a frequency of 80 Hz and an intensity of 4 mA. The quality of anesthesia was evaluated by several parameters, including isoflurane requirements, anesthesia quality, cardiovascular function, and respiratory function. Data were collected every 10 min for a total of 30 min from the time of isoflurane application, followed by analysis using a t-test with Welch’s correction. The results showed that there was a significant reduction in isoflurane requirement in EA group, as indicated by the area under the curve (AUC) (p = 0.0003). Isoflurane concentration at 10 min was significantly lower in EA group (1.25 ± 0.71) than in TZ group (2.1 ± 0.22). It was also significantly lower at 20 min in EA group (1.05 ± 0.79) than in TZ group (1.8 ± 0.27). In conclusion, the addition of EA effectively reduced isoflurane requirements while maintaining a similar quality and safety of anesthesia in both groups.
Antitumor activity of Typhonium flagelliforme Ethanol Extract Nanoemulsion in DMBA-Induced Sprague Dawley Rats Rini, Dian Cipta; Priosoeryanto, Bambang Pontjo; Riki Siswandi; Sutardi, Lina Noviyanti
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.167-174

Abstract

Tumors are a leading cause of disease-related deaths in humans and companion animals, including dogs and cats. Typhonium flagelliforme, recognized in Indonesian traditional medicine, exhibits notable antitumor properties, such as inhibiting tumor cell proliferation and enhancing immune response. This study aimed to formulate T. flagelliforme into a nanoemulsion to improve its antitumor eflects and assess its efficacy in Sprague Dawley rats induced with the carcinogen 7,12-dimethylbenz (a) anthracene (DMBA). The nanoemulsion was formulated using the inversion phase method, and its particle size and stability were analyzed using SEM. Phytochemical screening identified active compounds, and toxicity was assessed using the brine shrimp lethality test. In vivo experiments involved five rat groups: untreated (NTC), nanoemulsion solvent (Solv), and three treatment groups receiving 25 μg/kg (TF25), 50 μg/kg (TF50), and 100 μg/kg (TF100) doses of the nanoemulsion, administered via intralesional injection. Results showed significant tumor size reduction in treatment groups compared to controls (p<0.05), with TF25 exhibiting the most eflective antiproliferative activity. Increased body weight across groups indicated low toxicity. The study concludes that T. flagelliforme nanoemulsion eflectively reduces tumor size and angiogenesis, demonstrating its potential as an antitumor agent. 
Efektivitas penggunaan iopamidol sebagai bahan kontras gastrointestinal pada kucing Siswandi, Riki; Bermani, Fadeli; Prastiwi, Nurul Anjar; Bensa, Matilde Surtini; Rahmiati, Dwi Utari; ., Gunanti; Noviana, Deni
ARSHI Veterinary Letters Vol. 6 No. 3 (2022): ARSHI Veterinary Letters - Agustus 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.3.57-58

Abstract

Iopamidol merupakan media kontras yang larut dalam air dan bersifat non-ionik. Tulisan ini melaporkan efektifitas penggunaan iopamidol pada seekor kucing domestik jantan berusia 3 tahun, memiliki bobot badan 6 kg, yang dibawa oleh pemiliknya ke klinik dengan keluhan tidak defekasi selama 5 hari dan memiliki nafsu makan yang baik. Pemeriksaan penunjang dilakukan dengan radiografi kontras gastrointestinal dengan menggunakan iopamidol. Pengambilan x-ray dilakukan pada menit ke-0, 30, 60, 150 dan 240. Motilitas gastrointestinal dievaluasi dengan penilaian semi kuantitatif. Kucing terlihat tidak mengalami gangguan motilitas lambung dan usus halus, namun obstruksi ditemukan pada usus besar. Tidak terlihat adanya efek samping maupun komplikasi dari penggunaan iopamidol baik selama prosedur maupun sampai hari ke 5 setelah prosedur. Iopamidol dinilai dapat dijadikan sebagai bahan kontras gastrointestinal.
A SURVEY ON ANESTHESIA MANAGEMENT PRACTICE BY SMALL ANIMAL VETERINARIAN IN DKI JAKARTA AND WEST JAVA PROVINCES Khalifah, Hadid; Soehartono, Raden Harry; Siswandi, Riki
Jurnal Kedokteran Hewan Vol 18, No 3 (2024): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i3.36348

Abstract

his study was designated to the members of the Indonesian Veterinary Medical Association (IVMA) in DKI Jakarta and West Java Province between May and August 2023. The sample size was calculated with the Slovin method which covered 260 respondents with a significance level of 5.4%. Questions was focused mainly on the respondents identity, perianesthesia procedures, and anesthesia topic for continuing professional development. The majority of respondents performed 5 cases of anesthesia per week in dogs (76.9%) and cats (36.2%). Preanesthesia physical examination was carried out by 96% of respondents. Premedication was always given to dogs (66.2%) and cats (63.5%). IV catheter placement was always given in 41.2% of dogs and frequently in 38.5% of cats. Atropine was the most widely used premedication agent (88%) and meloxicam mainly used for analgesic (57%). The induction agent widely used was ketamine (34), while the maintenance agent was isoflurane in dogs (43.5%) and ketamine in cats (37.3%). The anesthesia monitoring tools that are widely used were thermometers (89.6%) and pulse oximeters (38.8%). As conclusion, the majority of respondents were considered to have understood anesthesia management in accordance with recommendations, however, this understanding could be improved through continuing education.
THE EFFECTIVENESS OF COMBINATION OF SNAKEHEAD FISH, TEMULAWAK, AND MENIRAN EXTRACTS ON POST OVARIOHYSTERECTOMY WOUND HEALING IN CATS Bermani, Fadeli; Soehartono, Raden Harry; Berlian, Guntur; Siswandi, Riki
Jurnal Kedokteran Hewan Vol 18, No 1 (2024): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i1.34542

Abstract

This study aims to determine the effectiveness of combination of snakehead fish, ginger and meniran extract (GTM) on healing wounds after ovariohysterectomy (OH) in cats. Twenty healthy female cats aged 1-4 years, weighed 2-4 kg were divided into three groups with different doses of GTM and compared with the group without treatment (n= 5 cats/group). The GTM dose was extrapolated from the human dose using allometric scaling, with the basal dose for G:T:M were 40:3.2:4.8 mg/kg BW (group 1, GTM1x). Treatment groups 2 (GTM2x) and 3 (GTM4x) were given a dose of GTM that was multiplied by 2 and 4 of the basal doses, respectively. OH was performed via a flank approach with the same operator and anesthesia. Discharge, swelling and erythema scores were significantly lower on days 3, 4 and 5 post-operativeamong all GTM groups compared with control. Pain evaluation using Baseline Tactile Semmes Monofilaments showed significantly lower in GTM2x and GTM4x compared to GTM1x and control. The 4A-vet pain scale showed lower pain in GTM2x from 1 to 5 days postoperative. The number of leukocytes, erythrocytes and platelets was in the normal range indicates the absence of postoperative infection. Postoperative albumin levels showed a significantly higher difference in GTM2x compared to control. The treatment given GTM2x showed the fastest healing interval (3.20.44 days). The combination of GTM can reduce pain, reduce wound scores and accelerate post-OH wound healing with the most effective dose was GTM2x. ________________________________________________________________
VENTRAL MEDIAN AND LATERAL FLANK APPROACH FOR OVARIOHYSTERECTOMY IN CAT Vera, Bella; Siswandi, Riki; Soehartono, Raden Harry
Jurnal Kedokteran Hewan Vol 17, No 1 (2023): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i1.29418

Abstract

This study was conducted to compare Ventral Median Approach (OHM) and Lateral Flank Approach (OHF) for feline ovariohysterectomy (OH). Fifteen healthy local female cats (Felis catus) with body weights ranged 2-4 kg and aged 1-2 years were divided into two groups, OHM (n= 8) and OHF (n= 7). Prior to OH, the cats were anesthethized using ketamine-xylazine and the sugery was performed by the same operator. The wound scoring showed a significantly higher difference in the OHM group on day 3 and 4 post-surgery. Scores of erythematous, swelling and dehiscence showed no significant differences. The 4Avet pain scale was significantly higher in OHF at the 2, 6, and 12-hours post surgery. The pain response was evaluated using baseline tactile Semmes-Weinstein Monofilaments and was significantly higher in OHF than OHM on day 1 to day 5 post surgery. Blood hematology, blood glucose and wound healing duration did not differ significantly between groups. The OHF approach showed greater post-operative pain than the OHM approach. Wound dehiscence was observed in two cats (25%) in OHM group from day 4 post-operative. The OHM approach showed a greater risk of complications than the OHF group and therefore requires better post-operative care. The OHF group showed a smaller risk of complications but requires better post-operative analgesic therapy.
IDENTIFIKASI GOLONGAN DARAH DAN KEMUNGKINAN HUBUNGANNYA DENGAN WARNA RAMBUT PADA KUCING DOMESTIK INDONESIA (Felis familiaris) g, Gunanti; Endrawati, Dwi; Supriadi, Helny Rosita; Siswandi, Riki; Agungpriyono, Srihadi
Jurnal Kedokteran Hewan Vol 7, No 1 (2013): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v7i1.571

Abstract

Penelitian ini bertujuan mengetahui distribusi penyebaran golongan darah A, B, dan AB dan mengetahui kemungkinan hubungan antaragolongan darah dengan kemunculan pola warna rambut pada kucing domestik di Indonesia. Pada penelitian ini digunakan 50 ekor kucing domestik yang berasal dari daerah Bogor dan Bekasi. Pemeriksaan golongan darah kucing dilakukan dengan identifikasi golongan darah dengan kit antibodi monoklonal Shigeta(Jepang). Hasil penelitian menunjukkan bahwa semua kucing domestik yang diteliti bergolongan darah A dan tidak diperoleh tanda-tanda adanya hubungan antara golongan darah dengan warna rambut. Terdapat sembilan kemunculan warna rambut yang terdiri atas warna tunggal, kombinasi dua warna, dan kombinasi tiga warna.
Perbandingan Teknik Ovariektomi dan Ovariohisterektomi pada Anjing Lokal Indonesia Siswandi, Riki; Soehartono, R. Harry; Kale, Nadya Daramuli
JURNAL KAJIAN VETERINER Vol 13 No 2 (2025): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v13i2.21273

Abstract

Gonadectomy is a common procedure to control dog populations and prevent reproductive diseases. Ovariectomy (OVE) and ovariohysterectomy (OH) are the primary techniques, although their relative efficiency remains under debate. This study compared both methods based on hematological parameters, surgical duration, blood loss, wound healing, progesterone levels, body weight, and postoperative behavior in female dogs. This experiment were using 14 female domestic dogs were divided into OVE and OH groups. Surgeries were performed under general anesthesia, and outcomes were analyzed statistically. Postoperatively, hematocrit and erythrocyte counts significantly decreased in OH group (p<0.05), while white blood cell counts were higher than in OVE (p<0.05), indicating stronger inflammatory response. OVE had a shorter surgical time (56.18 ± 7.10 min vs. 84.41 ± 24.28 min), lower blood loss (4.91 ± 2.60 g vs. 46.02 ± 39.06 g), and faster wound healing (4.57 ± 0.76 days vs. 5.91 ± 1.24 days) (p<0.05). There was no significant differencs in progesterone level one month post surgery between the OVE and OH groups (0.67 ± 0.30 ng/mL and 0.48 ± 0.29 ng/mL, respectively). Likewise, no significant difference were observed in body weight gain, as well as in grooming, sleeping, drinking, exploration and play behaviours between the groups after nine weeks of observation. In conclusion, both techniques effectively reduce plasma progesterone concentration and support body weight gain, but OVE offers greater surgical efficiency, faster recovery, and fewer hematological alterations, highlighting its potential as the optimal technique for sterilizing.
Co-Authors Agik Suprayogi Anita Rahmayanti Bambang Pontjo Priosoeryanto Basrul Hanafi Bella Vera Bensa, Matilde Surtini Berlian, Guntur Bermani, Fadeli Deni Noviana Dwi Endrawati Dwi Endrawati Dwi Utari Rahmiati Ega Iftahul Rizky Farhamzah Gunanti . Helny Rosita Supriadi Helny Rosita Supriadi I Gusti Ngurah Sudisma Isdoni Bustaman Kale, Nadya Daramuli Khalifah, Hadid Lina Noviyanti Sutardi Madyastuti, Rini Maharani, Alya Rizqi Mokhamad Fakhrul Ulum, Mokhamad Muhammad Abhi Purnomosidi Nurkarimah, Dona Astari Peter Ian Limas Prastiwi, Nurul Anjar Rini, Dian Cipta Rismala Dewi Santoso, Dewi Irawati Soeria Saukhan, Ghiandra Naufal Syazily sri murtini . Sri Wahyuni Srihadi Agungpriyono vera, bella William .