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Riki Siswandi
Departemen Klinik Reproduksi Dan Patologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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VENTRAL MEDIAN AND LATERAL FLANK APPROACH FOR OVARIOHYSTERECTOMY IN CAT Bella Vera; Riki Siswandi; Raden Harry Soehartono
Jurnal Kedokteran Hewan Vol 17, No 1 (2023): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i1.29418

Abstract

This study was conducted to compare Ventral Median Approach (OHM) and Lateral Flank Approach (OHF) for feline ovariohysterectomy (OH). Fifteen healthy local female cats (Felis catus) with body weights ranged 2-4 kg and aged 1-2 years were divided into two groups, OHM (n= 8) and OHF (n= 7). Prior to OH, the cats were anesthethized using ketamine-xylazine and the sugery was performed by the same operator. The wound scoring showed a significantly higher difference in the OHM group on day 3 and 4 post-surgery. Scores of erythematous, swelling and dehiscence showed no significant differences. The 4Avet pain scale was significantly higher in OHF at the 2, 6, and 12-hours post surgery. The pain response was evaluated using baseline tactile Semmes-Weinstein Monofilaments and was significantly higher in OHF than OHM on day 1 to day 5 post surgery. Blood hematology, blood glucose and wound healing duration did not differ significantly between groups. The OHF approach showed greater post-operative pain than the OHM approach. Wound dehiscence was observed in two cats (25%) in OHM group from day 4 post-operative. The OHM approach showed a greater risk of complications than the OHF group and therefore requires better post-operative care. The OHF group showed a smaller risk of complications but requires better post-operative analgesic therapy.
Perubahan Aktivitas Listrik Jantung pada Tikus yang Diberi Latihan Fisik Aerobik Serta Henti Latih William .; Dewi Irawati Soeria Santoso; Isdoni .; Riki Siswandi
Jurnal Kedokteran Meditek Vol. 21 No. 55 Januari - April 2015
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v21i55.1199

Abstract

AbstrakLatar Belakang: Latihan fisik aerobik telah lama diketahui memberikan pengaruh yang baik kepada tubuh,  latihan fisik aerobik yang rutin dan dalam jangka waktu lama dapat membuat jantung mengalami remodeling. Proses remodeling ini bukan hanya terjadi pada struktur tetapi juga pada kelistrikan jantung, beberapa studi menunjukkan remodeling listrik jantung yang terjadi mengakibatkan berbagai bentuk aritmia, dan belum banyak yang diketahui tentang remodeling listrik jantung setelah henti latih.Metode: Pemeriksaan EKG dilakukan pada tikus Wistar jantan yang telah menjalani latihan fisik aerobik  selama empat minggu dan 12 minggu. Pemeriksaan EKG juga dilakukan lagi setelah empat minggu periode henti latih. Kecepatan alat treadmill yang digunakan adalah 20 m/menit, dengan lama durasi latihan selama 20 menit dengan diselingi masa istirahat selama 90 detik setiap lima menit tikus tersebut berlari.Hasil: Tidak terdapat perbedaan bermakna untuk voltase dan durasi gelombang P pada semua kelompok perlakuan. Terjadi peningkatan voltase gelombang R pada kelompok latihan fisik aerobik empat minggu dan 12 minggu (p<0,05). Tidak terdapat perbedaan bermakna untuk voltase gelombang R pada kelompok henti latih. Terdapat pemanjangan durasi segmen dan interval PR pada kelompok latihan fisik aerobik empat minggu dan 12 minggu (terutama pada kelompok latihan fisik aerobik 4 minggu dengan p<0,05). Tidak terdapat perbedaan bermakna durasi segmen dan interval PR pada kelompok henti latih. Terjadi pemanjangan durasi repolarisasi ventrikel (durasi gelombang T, interval QT) pada kelompok latihan fisik aerobik empat minggu dan 12 minggu (terutama pada kelompok latihan fisik aerobik 4 minggu, p<0,05). Tidak terdapat perbedaan bermakna untuk durasi gelombang T, interval QT pada kelompok henti latih. Terjadi penurunan frekuensi denyut jantung istirahat pada kelompok latihan fisik aerobik empat minggu dan 12 minggu (terutama pada kelompok latihan fisik empat minggu, p<0,05). Tidak terdapat perbedaan bermakna untuk frekuensi denyut jantung istirahat pada kelompok henti latih.Kesimpulan: Terjadi perubahan aktivitas listrik jantung (interval QT, interval PR, durasi gelombang T dan voltase gelombang R), perubahan frekuensi denyut jantung istirahat tikus Wistar jantan setelah latihan fisik aerobik selama empat minggu dan 12 minggu. Henti latih mengembalikan perubahan aktivitas listrik jantung dan perubahan frekuensi denyut jantung istirahat tersebut.Kata kunci: Aktivitas listrik jantung, EKG, latihan fisik aerobik, henti latih    AbstractBackground: Aerobic training have long been known to give a good impact to body, aerobic training if been done routinely and with long period of time will make remodeling process to the heart. This remodeling process is not only occur in structure but also in heart electrical activity, several study reveal that this electrical activity may cause many form of aritmia, there also evidence that structural remodeling that also cause electrical changes is a persistent process, if structural remodeling persistent process, what will happen to heart electrical activity of this persistent structural remodeling after detraining is still less known. Methods: Electrocardiogram (ECG) is conducted in male Wistar rat that have completed 4 weeks, 12 weeks aerobic training, 4 weeks and 12 weeks aerobic training with 4 weeks detraining. The speed that been use is 20 m/minute with 20 minute training duration and 90 second intermitten resting interval for every 5 minute training. Results: There is no difference for P wave voltage and duration in all groups. R wave voltage is increase in 4, 12 weeks aerobic training group (p < 0.05). There is no significant difference for R wave voltage in detraining group. PR segment and interval is prolonged in 4, 12 weeks aerobic training group (especially in 4 weeks aerobic training group, p < 0.05). There is no significant difference for PR segment and interval in detraining group. Ventricular repolarization time (T wave duration, QT interval) is prolonged in 4, 12 weeks aerobic training group (especially in 4 weeks aerobic training group, p < 0.05). There is no significant difference for T wave duration and QT interval in detraining group. Resting heart rate is lower in 4, 12 weeks aerobic training group (especially in 4 weeks aerobic training group, p<0.05). There is no significant difference for resting heart rate in detraining group.Conclusion: Male Wistar rat heart electrical activity (QT interval, PR interval, T wave duration time and R wave voltage) and resting heart rate change after 4 weeks and 12 weeks aerobic training. Detraining restore that changes. Keywords: Heart electrical activity, Electrocardiogram (ECG), Aerobic training, Detraining Keywords: Heart electrical activity, ECG, Aerobic training, Detraining
Koinfeksi Fasciola dan Paramphistomum pada Kerbau Lumpur (Bubalus bubalis) di Kabupaten Sumba Timur Saukhan, Ghiandra Naufal Syazily; Satrija, Fadjar; Murtini, Sri; Suprayogi, Agik; Siswandi, Riki; Soehartono, R. Harry
Acta VETERINARIA Indonesiana Vol. 11 No. 1 (2023): Maret 2023
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.11.1.17-25

Abstract

Kerbau lumpur (Bubalus bubalis) merupakan ternak yang memegang peranan dalam kehidupan ekonomi dan sosial masyarakat Kabupaten Sumba Timur. Salah satu penyakit yang hingga kini masih menjadi masalah kesehatan pada ternak, termasuk kerbau, adalah infeksi Trematoda. Penelitian ini bertujuan mengidentifikasi jenis cacing Trematoda yang menginfeksi serta mengukur prevalensi dan intensitas infeksinya. Metode filtrasi bertingkat digunakan untuk mendeteksi keberadaan Trematoda pada penelitian ini. Hasil pemeriksaan 105 sampel tinja kerbau asal Kabupaten Sumba Timur menunjukkan sebanyak 17/105 (16,19%) kerbau mengalami Trematodosis yang disebabkan oleh infeksi tunggal Fasciola gigantica (0,95%; rataan telur tiap gram tinja [TTGT] 1,00) dan Paramphistomum sp. (14,29%; rataan TTGT 2,26), serta infeksi campuran (koinfeksi) kedua Trematoda tersebut (0,95%; rataan TTGT 2,45). Prevalensi infeksi Trematoda kerbau betina (17,33%) ditemukan jauh lebih tinggi dibandingkan dengan kerbau jantan (13,33%). Umur dan jenis kelamin diketahui tidak berasosiasi nyata (p > 0,05) dengan kejadian dalam penelitian ini. Intensitas infeksi Trematoda pada penelitian ini dikategorikan ringan, dengan rataan geometrik 2,18 TTGT. Temuan ini menunjukkan bahwa kerbau lumpur di Kabupaten Sumba Timur terinfeksi oleh cacing Trematoda, sehingga diperlukan upaya pengendalian untuk mencegah kerugian akibat infeksi tersebut.
AKTIVITAS ANTIINFLAMASI SENYAWA AKTIF DAUN JAWER KOTOK (Plectranthus scutellarioides (L.)R.Br.) MELALUI INHIBISI Siklooksigenase-2 SECARA IN SILICO Maharani, Alya Rizqi; Purwono, Rini Madyastuti; Siswandi, Riki; Nurkarimah, Dona Astari; Farhamzah
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1343

Abstract

Inflammation is the body’s response to harmful stimuli, and it plays a crucial role in boosting immunity. However, if inflammation is not managed properly, it can lead to degenerative diseases. This research aims to analyze the potential of Plectranthus scutellarioides (L.) R. Br. leaves as an anti-inflammatory agent. The study employs an in silico molecular docking method, using the active compound from the plant as the test ligand and the COX-2 receptor as the target. The results indicate that the test ligand, Antosianin, shows the best interaction as an inhibitor of the target receptor, as demonstrated by its superior affinity energy value compared to the other test ligands.
SURVEI TATA LAKSANA TERAPI CAIRAN OLEH DOKTER HEWAN PRAKTISI HEWAN KECIL DI PROVINSI DKI JAKARTA DAN JAWA BARAT Bensa, Matilde Surtini; Soehartono, Raden Harry; Siswandi, Riki
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.91727

Abstract

ABSTRACT This survey research was conducted to identify the understanding of small animal veterinarians regarding fluid therapy. Survey was directed to the members of Indonesian Veterinary Medical Association (IVMA) in DKI Jakarta and West Java Province between January 29 and March 25, 2023. The survey questionnaire consisted of 8 questions about the respondent's identity and 39 questions focusing on knowledge about fluid therapy. The sample size using the Slovin method is 290 respondents. Questions focused mainly on knowledge about types, indication, procedures, side effects of fluid therapy, and difficulties when administering fluid therapy. Validity test and reliability test were applied to assess questionnaire effectivity. The results show that almost all respondents had isotonic crystalloid fluid therapy in their clinic (Ringer's Lactate [286/290] and NaCl 0.9% [290/290]). Both fluids are often given either subcutaneously (NaCl 0.9% [81%]; Ringer's Lactate [19%]) or intravenously (NaCl 0.9% [48%]; Ringer's Lactate [46%]). Both fluids also often used also for maintenance (NaCl 0.9% [70%]; Ringer's Lactate [27%]) and for shock resuscitation of dogs (NaCl 0.9% [30%]; Ringer's Lactate [57%]) and cats (NaCl 0.9% [32%]; Ringer's Lactate [57%]). To increase the use of fluid therapy in dogs and cats, veterinarian practitioners' understanding and knowledge regarding fluid therapy is very necessary.  ABSTRAK Penelitian ini bertujuan untuk mengidentifikasi pemahaman dokter hewan praktik mengenai terapi cairan. Survei dilakukan kepada anggota Perhimpunan Dokter Hewan Indonesia (PDHI) Provinsi DKI Jakarta dan Jawa Barat dimulai sejak tanggal 29 Januari 2023 hingga  25 Maret 2023. Kuesioner survei dengan terdiri dari 8 pertanyaan tentang identitas responden dan 39 pertanyaan yang difokuskan pada pengetahuan tentang terapi cairan. Perhitungan jumlah responden dilakukan dengan metode Slovin berjumlah 290 responden dengan selang kepercayaan 5%. Pertanyaan difokuskan pada pengetahuan tentang jenis, indikasi,  tata laksana, efek samping dan kesulitan saat pemberian terapi cairan. Sebelum di edarkan, kuesioner telah lulus uji validitas dan uji reliabilitas. Hasil penelitian menunjukkan bahwa hampir semua responden  memiliki terapi cairan kristaloid isotonik yaitu Ringer Laktat (RL) (286/290) dan NaCl 0,9% (290/290). Kedua cairan tersebut sering diberikan secara intravena (NaCl 0,9% [48%]; RL [46%]) maupun secara subkutan (NaCl 0,9% [81%]; RL [19%]). Responden memilih NaCl 0,9% [70%] dan RL [27%]) untuk rumatan. Pilihan cairan pada resusitasi syok pasien anjing adalah NaCl 0,9% (30%) dan RL (57%) dan pada pasien kucing adalah NaCl 0,9% (32%) dan RL (57%). Sebanyak 29% responden merasa perhitungan asupan terapi cairan sebagai tantangan terbesar diikuti dengan perhitungan suplementasi Kalium (28%). Walaupun demikian lebih dari 54% responden melaporkan jarang menemukan efek samping dari pemberian terapi cairan. Untuk meningkatkan keefektifan  penggunaan terapi cairan pada anjing dan kucing sangat diperlukan pendidikan berkelanjutan  terkait terapi cairan.
Modulatory Effect of Electroacupuncture on Isoflurane Anaesthesia in Cats Wahyuni, Sri; Soehartono, R Harry; Siswandi, Riki
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.297-307

Abstract

This study aimed to evaluate the combination of electroacupuncture (EA) and isoflurane as an anesthetic regimen in domestic cats. A total of 15 cats were divided into two groups, namely tiletamine-zolazepam (TZ) (n = 5) and EA (n = 10). Atropine was used as a premedication, injected 5 min before the induction of TZ. Approximately 10 min after induction, endotracheal intubation was applied, and cats were connected to isoflurane anesthesia. EA was applied to the EA group during the first 10 min of the total 30 min under isoflurane maintenance. Furthermore, the acupuncture points ST-36 and SP-6 were used at a frequency of 80 Hz and an intensity of 4 mA. The quality of anesthesia was evaluated by several parameters, including isoflurane requirements, anesthesia quality, cardiovascular function, and respiratory function. Data were collected every 10 min for a total of 30 min from the time of isoflurane application, followed by analysis using a t-test with Welch’s correction. The results showed that there was a significant reduction in isoflurane requirement in EA group, as indicated by the area under the curve (AUC) (p = 0.0003). Isoflurane concentration at 10 min was significantly lower in EA group (1.25 ± 0.71) than in TZ group (2.1 ± 0.22). It was also significantly lower at 20 min in EA group (1.05 ± 0.79) than in TZ group (1.8 ± 0.27). In conclusion, the addition of EA effectively reduced isoflurane requirements while maintaining a similar quality and safety of anesthesia in both groups.
Antitumor activity of Typhonium flagelliforme Ethanol Extract Nanoemulsion in DMBA-Induced Sprague Dawley Rats Rini, Dian Cipta; Priosoeryanto, Bambang Pontjo; Riki Siswandi; Sutardi, Lina Noviyanti
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.167-174

Abstract

Tumors are a leading cause of disease-related deaths in humans and companion animals, including dogs and cats. Typhonium flagelliforme, recognized in Indonesian traditional medicine, exhibits notable antitumor properties, such as inhibiting tumor cell proliferation and enhancing immune response. This study aimed to formulate T. flagelliforme into a nanoemulsion to improve its antitumor eflects and assess its efficacy in Sprague Dawley rats induced with the carcinogen 7,12-dimethylbenz (a) anthracene (DMBA). The nanoemulsion was formulated using the inversion phase method, and its particle size and stability were analyzed using SEM. Phytochemical screening identified active compounds, and toxicity was assessed using the brine shrimp lethality test. In vivo experiments involved five rat groups: untreated (NTC), nanoemulsion solvent (Solv), and three treatment groups receiving 25 μg/kg (TF25), 50 μg/kg (TF50), and 100 μg/kg (TF100) doses of the nanoemulsion, administered via intralesional injection. Results showed significant tumor size reduction in treatment groups compared to controls (p<0.05), with TF25 exhibiting the most eflective antiproliferative activity. Increased body weight across groups indicated low toxicity. The study concludes that T. flagelliforme nanoemulsion eflectively reduces tumor size and angiogenesis, demonstrating its potential as an antitumor agent. 
Co-Authors Agik Suprayogi Anita Rahmayanti Bambang Pontjo Priosoeryanto Basrul Hanafi Bella Vera Bensa, Matilde Surtini Deni Noviana Dwi Endrawati Dwi Utari Rahmiati Ega Iftahul Rizky Fadeli Bermani Farhamzah Gunanti . Gunanti . Helny Rosita Supriadi I Gusti Ngurah Sudisma Isdoni Bustaman Lina Noviyanti Sutardi Madyastuti, Rini Maharani, Alya Rizqi Matilde Surtini Bensa Mokhamad Fakhrul Ulum, Mokhamad Muhammad Abhi Purnomosidi Nurkarimah, Dona Astari Nurul Anjar Prastiwi Peter Ian Limas Rini, Dian Cipta Rismala Dewi Santoso, Dewi Irawati Soeria Saukhan, Ghiandra Naufal Syazily sri murtini . Sri Wahyuni Srihadi Agungpriyono William .