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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Pengabdian kepada Masyarakat Natural Sciences Engineering and Technology Journal
Ilham Kuncahyo
Department Of Pharmacy Sciences, Faculty Of Pharmacy, Universitas Setia Budi Surakarta, Surakarta, Indonesia
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Optimasi Carbopol 940 dan Gliserin dalam Formula Gel Lendir Bekicot (Achatina fulica Ferr) sebagai Antibakteri Staphylococcus aureus dengan Metode Simplex Lattice Design Arsiaty Sumule; Ilham Kuncahyo; Fransiska Leviana
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5640

Abstract

Lendir bekicot (Achatina fulica Ferr) mengandung protein achasin, suatu senyawa dengan aktivitas antibakteri yang mendukung proses penyembuhan luka. Selain itu, peptida mytimacin-AF pada lender bekicot diketahui menghambat pertumbuhan Staphylococcus aureus ATCC 25923. Lendir bekicot kurang praktis jika digunakan secara langsung sehingga perlu dikembangkan menjadi bentuk sediaan gel. Penelitian ini bertujuan untuk mengetahui proporsi optimum campuran carbopol 940 dengan gliserin dalam formula gel dan mengevaluasi aktivitas antibakteri formula optimum terhadap S. aureus ATCC 25923. Gel lendir bekicot dibuat tiga formula dengan komposisi carbopol 940 dan gliserin masing-masing sebesar 1; 1,5; dan 2%, serta 15; 14,5; dan 14%. Semua formula diuji sifat fisiknya selama empat minggu, meliputi organoleptis, homogenitas, viskositas, daya sebar, daya lekat, dan pergeseran viskositas. Hasil uji dioptimasi dengan metode simplex lattice design menggunakan program Design Expert 8.0.6.1. Formula optimum yang diperoleh dievaluasi sifat fisiknya selama empat minggu, sedangkan aktivitas antibakterinya diuji dengan menggunakan metode difusi sumuran. Hasil penelitian menunjukkan formula optimum gel lendir bekicot dengan proporsi campuran carbopol 940 dan gliserin masing-masing 1,123 dan 14,877%. Formula optimum memiliki aktivitas antibakteri terhadap S. aureus dengan diameter zona hambat sebesar 1,73 cm.
Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method Muhimmatul Khoiriyah; Jason Merari Perangirangin; Ilham Kuncahyo
Natural Sciences Engineering and Technology Journal Vol. 2 No. 2 (2022): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v2i2.21

Abstract

Fenofibrate is a drug that can be used to treat hyperlipidemia where the drug is included in the category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes the need to improve the drug delivery system (DDS) made using the solid lipid nanoparticle (SLN) method. SLN fenofibrate can be made using the high shear homogenization method by determining the formula using Factorial 22 Design Expert 12. The formula is made with a concentration of 0.31-1.25% GMS and 1.25-2% Tween-40, then SLN fenofibrate is made by mixing all ingredients until an emulsion is formed and continued with the SLN critical parameter test. From the test results, the critical parameters of SLN fenofibrate for the particle size of 8 formulas 490; 561; 601; 697; 916; 1040; 1818, and 2410 nm. The results obtained for the polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, and 0.65. The zeta potential value of the 8 formulas obtained successive values of 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, and 8.8 mV. Calculation of the efficiency of the SLN fenofibrate drug obtained successive values of 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, and 87.82%. The SLN method can improve drugs that are included in the Biopharmaceutical classification system class II category with the distribution of test results in the particle size range, and the adsorbed drug is more than 70%.
In vitro Naringenin SNEDDS Release Test by Dissolution Gendis Purno Yudanti; Ilham Kuncahyo; Endang Diyah Ikasari
Natural Sciences Engineering and Technology Journal Vol. 3 No. 1 (2023): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v3i2.29

Abstract

Naringenin is the main flavanone in grapefruit which has anti-inflammatory, anti-cancer, hepatoprotective and antilipid peroxidation effects. Its low solubility in water causes dissolution and low bioavailability when taken orally. This study aims to increase the solubility and bioavailability of naringenin by using the SNEDDS technique. Initial characterization to determine the optimum formula was carried out using the D-optimal mixture design method, namely by optimizing the composition of SNEDDS which consisted of triacetin as the oil phase, tween 80 as surfactant and transcutol P as cosurfactant as an independent factor and SNEDDS characterization included emulsification time, drug loading, size globules and percent transmittance in response. The optimization results showed that the optimum formula was obtained at the composition of 10% triacetin, 70% tween 80 and 20% transcutol P. The dissolution test showed that the SNEDDS of naringenin was capable of dissolution (Q30) of 87,50% ±1,73 at the 30th minute and the f2 value of 28,93 so it can be concluded that the dissolution profile between the SNEDDS of naringenin and the naringenin capsules is not identical.
PELATIHAN PEMBUATAN BALSEM STIK GONDOPURO DI WILAYAH KERTEN LAWEYAN SURAKARTA YANG BERPOTENSI SEBAGAI USAHA MANDIRI WARGA Siti Aisiyah; Reslely Harjanti; Vivin Nopiyanti; Titik Sunarni; Suhartinah Suhartinah; Ilham Kuncahyo
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2: Juli 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v3i2.6008

Abstract

Potensi penggunaan metil salisilat untuk pereda nyeri otot yang digunakan secara topikal sangat besar di Indonesia. Bentuk balsem stik merupakan inovasi yang muncul dikarenakan adanya keluhan tidak nyaman dan lengket pada tangan saat diaplikasikan. Sehingga sediaan balsem yang dianggap kuno oleh sebagian orang, kini semakin elegan dengan dibuat dalam bentuk mini stik yang praktis digunakan. Kegiatan pengabdian kepada masyarakat ini dilakukan dengan metode penyuluhan dan pelatihan kepada kader PKK di wilayah Kerten Laweyan Surakarta. Penggunaan bahan-bahan yang murah dan mudah diperoleh serta dengan pengembangan label kemasan, maka hasil pelatihan yang sudah dilakukan dinilai mempunyai potensi untuk dikembangkan sebagai usaha mandiri warga.
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing Syaiful Choiri; Dwi Larasati; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.2150

Abstract

Herein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions.
Co-Authors Arsiaty Sumule Dwi Larasati Endang Diyah Ikasari Fransiska Leviana Gendis Purno Yudanti Jason Merari Peranginangin Muhimmatul Khoiriyah Reslely Harjanti Siti Aisiyah Suhartinah Syaiful Choiri Titik Sunarni Vivin Nopiyanti