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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Cendekia Journal of Pharmacy Jurnal Farmamedika (Pharmamedica Journal) Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian kepada Masyarakat Natural Sciences Engineering and Technology Journal
Ilham Kuncahyo
Department Of Pharmacy Sciences, Faculty Of Pharmacy, Universitas Setia Budi Surakarta, Surakarta, Indonesia
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Optimasi Carbopol 940 dan Gliserin dalam Formula Gel Lendir Bekicot (Achatina fulica Ferr) sebagai Antibakteri Staphylococcus aureus dengan Metode Simplex Lattice Design Arsiaty Sumule; Ilham Kuncahyo; Fransiska Leviana
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.5640

Abstract

Lendir bekicot (Achatina fulica Ferr) mengandung protein achasin, suatu senyawa dengan aktivitas antibakteri yang mendukung proses penyembuhan luka. Selain itu, peptida mytimacin-AF pada lender bekicot diketahui menghambat pertumbuhan Staphylococcus aureus ATCC 25923. Lendir bekicot kurang praktis jika digunakan secara langsung sehingga perlu dikembangkan menjadi bentuk sediaan gel. Penelitian ini bertujuan untuk mengetahui proporsi optimum campuran carbopol 940 dengan gliserin dalam formula gel dan mengevaluasi aktivitas antibakteri formula optimum terhadap S. aureus ATCC 25923. Gel lendir bekicot dibuat tiga formula dengan komposisi carbopol 940 dan gliserin masing-masing sebesar 1; 1,5; dan 2%, serta 15; 14,5; dan 14%. Semua formula diuji sifat fisiknya selama empat minggu, meliputi organoleptis, homogenitas, viskositas, daya sebar, daya lekat, dan pergeseran viskositas. Hasil uji dioptimasi dengan metode simplex lattice design menggunakan program Design Expert 8.0.6.1. Formula optimum yang diperoleh dievaluasi sifat fisiknya selama empat minggu, sedangkan aktivitas antibakterinya diuji dengan menggunakan metode difusi sumuran. Hasil penelitian menunjukkan formula optimum gel lendir bekicot dengan proporsi campuran carbopol 940 dan gliserin masing-masing 1,123 dan 14,877%. Formula optimum memiliki aktivitas antibakteri terhadap S. aureus dengan diameter zona hambat sebesar 1,73 cm.
Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method Muhimmatul Khoiriyah; Jason Merari Perangirangin; Ilham Kuncahyo
Natural Sciences Engineering and Technology Journal Vol. 2 No. 2 (2022): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v2i2.21

Abstract

Fenofibrate is a drug that can be used to treat hyperlipidemia where the drug is included in the category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes the need to improve the drug delivery system (DDS) made using the solid lipid nanoparticle (SLN) method. SLN fenofibrate can be made using the high shear homogenization method by determining the formula using Factorial 22 Design Expert 12. The formula is made with a concentration of 0.31-1.25% GMS and 1.25-2% Tween-40, then SLN fenofibrate is made by mixing all ingredients until an emulsion is formed and continued with the SLN critical parameter test. From the test results, the critical parameters of SLN fenofibrate for the particle size of 8 formulas 490; 561; 601; 697; 916; 1040; 1818, and 2410 nm. The results obtained for the polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, and 0.65. The zeta potential value of the 8 formulas obtained successive values of 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, and 8.8 mV. Calculation of the efficiency of the SLN fenofibrate drug obtained successive values of 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, and 87.82%. The SLN method can improve drugs that are included in the Biopharmaceutical classification system class II category with the distribution of test results in the particle size range, and the adsorbed drug is more than 70%.
In vitro Naringenin SNEDDS Release Test by Dissolution Gendis Purno Yudanti; Ilham Kuncahyo; Endang Diyah Ikasari
Natural Sciences Engineering and Technology Journal Vol. 3 No. 1 (2023): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v3i2.29

Abstract

Naringenin is the main flavanone in grapefruit which has anti-inflammatory, anti-cancer, hepatoprotective and antilipid peroxidation effects. Its low solubility in water causes dissolution and low bioavailability when taken orally. This study aims to increase the solubility and bioavailability of naringenin by using the SNEDDS technique. Initial characterization to determine the optimum formula was carried out using the D-optimal mixture design method, namely by optimizing the composition of SNEDDS which consisted of triacetin as the oil phase, tween 80 as surfactant and transcutol P as cosurfactant as an independent factor and SNEDDS characterization included emulsification time, drug loading, size globules and percent transmittance in response. The optimization results showed that the optimum formula was obtained at the composition of 10% triacetin, 70% tween 80 and 20% transcutol P. The dissolution test showed that the SNEDDS of naringenin was capable of dissolution (Q30) of 87,50% ±1,73 at the 30th minute and the f2 value of 28,93 so it can be concluded that the dissolution profile between the SNEDDS of naringenin and the naringenin capsules is not identical.
PELATIHAN PEMBUATAN BALSEM STIK GONDOPURO DI WILAYAH KERTEN LAWEYAN SURAKARTA YANG BERPOTENSI SEBAGAI USAHA MANDIRI WARGA Siti Aisiyah; Reslely Harjanti; Vivin Nopiyanti; Titik Sunarni; Suhartinah Suhartinah; Ilham Kuncahyo
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2: Juli 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v3i2.6008

Abstract

Potensi penggunaan metil salisilat untuk pereda nyeri otot yang digunakan secara topikal sangat besar di Indonesia. Bentuk balsem stik merupakan inovasi yang muncul dikarenakan adanya keluhan tidak nyaman dan lengket pada tangan saat diaplikasikan. Sehingga sediaan balsem yang dianggap kuno oleh sebagian orang, kini semakin elegan dengan dibuat dalam bentuk mini stik yang praktis digunakan. Kegiatan pengabdian kepada masyarakat ini dilakukan dengan metode penyuluhan dan pelatihan kepada kader PKK di wilayah Kerten Laweyan Surakarta. Penggunaan bahan-bahan yang murah dan mudah diperoleh serta dengan pengembangan label kemasan, maka hasil pelatihan yang sudah dilakukan dinilai mempunyai potensi untuk dikembangkan sebagai usaha mandiri warga.
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing Syaiful Choiri; Dwi Larasati; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.2150

Abstract

Herein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions.
PENGARUH UKURAN HOST CAMPURAN AVICEL PH 101 DAN LAKTOSA TERHADAP MUTU FISIK DAN DISOLUSI TABLET CAMPURAN INTERAKTIF GLIMEPIRID Ilham Kuncahyo; Aliya Faiza Amalia; Agus Gunawan; Raden Roro Sri Wulandari
Jurnal Farmamedika (Pharmamedica Journal) Vol. 10 No. 2 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i2.451

Abstract

Permasalahan utama pembuatan tablet obat dosis kecil adalah homogenitas. Campuran interaktif merupakan salah satu teknik pembuatan untuk mengatasi hal tersebut. Penelitian ini bertujuan untuk mengeksplorasi pengaruh ukuran host terhadap mutu fisik dan disolusi tablet campuran interaktif glimepirid. Glimepirid merupakan obat kelas II dalam Sistem Klasifikasi Biofarmasi (BCS) yaitu mempunyai permeabilitas tinggi tetapi kelarutan rendah. Campuran interaktif menggunakan zat aktif micronized yang melekat pada host yang merupakan komponen pembawa berukuran lebih besar untuk keseragaman kandungan tablet, mengurangi risiko segregasi, dan mempercepat proses disolusi. Penelitian menggunakan ukuran host yang berbeda yaitu F1 dengan 18/40 mesh, F2 20/40 mesh dan F3 30/40 mesh. Host dibuat dengan mencampurkan Avicel PH 101 dan laktosa (1:1) dan digranulasi dengan pengikat PVP. Ketiga formula dikompresi menggunakan metode kempa langsung dan diuji mutu fisik tablet meliputi : kerapuhan, kekerasan, waktu hancur, dan disolusi. Hasil analisis varian (one-way ANOVA) menunjukkan bahwa ukuran host secara signifikan mempengaruhi mutu fisik tablet. Formula 3 dengan ukuran host 30/40 mesh menghasilkan tablet campuran interaktif glimepirid yang lebih keras, mengurangi kerapuhan, serta mempercepat laju disolusi dibandingkan formula 1 (18/40 mesh) dan formula 2 (20/40 mesh).
PENGARUH VARIASI KONSENTRASI AVICEL PH 101 DAN LAKTOSA SEBAGAI HOST DALAM PEMBUATAN TABLET CAMPURAN INTERAKTIF GLIMEPIRID MENGGUNAKAN METODE KEMPA LANGSUNG Muhammad Agung Nugroho; Ilham Kuncahyo; Reslely Harjanti
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p80-91

Abstract

Glimepirid is an antidiabetic drug from the sulfonylurea class with low solubility, thus requiring a formulation approach to improve its bioavailability. This study aimed to examine the effect of varying concentrations of avicel pH 101 and lactose as carrier (host) materials on the physical properties and dissolution profile of glimepirid tablets prepared using the direct compression method. Three formulas were developed with avicel pH 101:lactose ratios: F1 (1:0.5), F2 (1:1), and F3 (1.5:1). Quality evaluation included tests of granule flow properties (angle of repose and flow time) and physical tablet tests (content uniformity, hardness, friability, disintegration time, and dissolution) based on the Indonesian Pharmacopoeia. ANOVA statistical analysis showed significant differences between formulas (p < 0.05). The results indicated that variations in avicel pH 101 and lactose concentrations affected the physical quality and dissolution profile of the tablets. Formula 1 had the fastest disintegration time and the highest drug release. Formula 2 demonstrated the best content uniformity, good powder flow, and stable dissolution. Formula 3 produced the hardest tablets with the lowest friability but required longer disintegration time. Formula 2 was considered the most optimal and is recommended for further development of glimepirid tablets.
PENGARUH KOMBINASI BAHAN PELICIN MAGNESIUM STEARAT DAN TALK DALAM PEMBUATAN TABLET GLIMEPIRID DENGAN TEKNIK PENCAMPURAN INTERAKTIF Ilham Kuncahyo; Siti Aisiyah; Shabrina Nindya Hutami; RR Sri Wulandari

Publisher :

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v10i2.419

Abstract

Homogeneity is one of the primary challenges in the formulation of tablets containing low-dose drugs such as glimepiride. The interactive mixing technique, in which the drug is adhered to a host carrier, has been developed as an innovative approach to address this issue. One of the essential excipients required in tablet manufacturing is a lubricant. The use of micronized lubricants, namely magnesium stearate and talc, plays a critical role in determining the outcome of the compression process of interactive mixture tablets. This study aimed to investigate the effect of magnesium stearate and talc as lubricants on the physical quality and dissolution behavior of glimepiride interactive mixture tablets. Five formulations were prepared using different proportions of magnesium stearate and talc: F1 (magnesium stearate : talc) = 1,25 : 0,75; F2 = 0,5 : 1,5; F3 = 0,25 : 1,25; F4 = 1,5 : 0,5; and F5 = 1 : 1. The host carrier was prepared by mixing Avicel PH 101 and lactose in a 1:1 ratio, followed by granulation using polyvinylpyrrolidone (PVP) as a binder. The lubricants were then blended with the host particles onto which glimepiride had been adhered, and the mixture was subsequently compressed using the direct compression method. The resulting tablets were evaluated for physical quality parameters, including friability, hardness, disintegration time, and dissolution. The data obtained from each formulation were statistically analyzed using SPSS version 12.0. The results demonstrated that all five formulations met the homogeneity requirements, with coefficient of variation (CV) values of less than 5%. The combination of magnesium stearate and talc significantly affected the physical quality and dissolution behavior of glimepiride interactive mixture tablets. Formula 4, which contained the highest proportion of magnesium stearate and the lowest proportion of talc compared to F1, F2, F3, and F5, produced tablets with greater hardness, reduced friability, prolonged disintegration time, and a slower dissolution rate.
Co-Authors Agus Gunawan Aliya Faiza Amalia Arsiaty Sumule Dwi Larasati Endang Diyah Ikasari Fransiska Leviana Gendis Purno Yudanti Jason Merari Peranginangin Muhammad Agung Nugroho Muhimmatul Khoiriyah Raden Roro Sri Wulandari Reslely Harjanti Reslely Harjanti RR Sri Wulandari Shabrina Nindya Hutami Siti Aisiyah Siti Aisiyah Suhartinah Syaiful Choiri Titik Sunarni Vivin Nopiyanti