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All Journal e-Journal Pustaka Kesehatan Jurnal Riset Kimia Pharmacon Warta Pengabdian JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Cendekia : Jurnal Pengabdian Masyarakat Journal of Tropical Ethnobiology Jurnal PkM (Pengabdian kepada Masyarakat)
Indah Yulia Ningsih
University Of Jember
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : e-Journal Pustaka Kesehatan

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Gambaran Histopatologi Organ Jantung Tikus Putih Jantan Galur Wistar (Rattus norvegicus) dalam Uji Toksisitas Akut Kombinasi Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lmk.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Novia Hilma; Nuri Nuri; Endah Puspitasari; Indah Yulia Ningsih
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7574

Abstract

Jati belanda leaves (Guazuma ulmifolia Lmk.) and Roselle petals (Hibiscus sabdariffa L.) have been known for their activity as antihyperlipidemia with different mechanisms. Combination of these plants was expected to has a synergy effect in reducing cholesterol. However, the toxicity of jati belanda leaves and roselle petals extract combination must be investigated for knowing its safety. Based on the acute toxicity test, the LD50 value of jati belanda leaves and roselle petals extract combination was >5,000 mg/kg bw. It was classified as category 5 or unclassified. This research aimed to study about its effect in cardiac by cardiac histopathology examinations of the rats. The result showed that there was no cardiac histopathology changes of the rats at doses 5,000 mg/kg bw. Keywords: jati belanda leaves, roselle petals, acute toxicity, cardiac histopathology
Pengaruh Pemberian Kombinasi Ekstrak Etanol Daun Sidaguri (Sida rhombifolia L.) dan Rimpang Jahe Merah (Zingiber officinale Rosc.) pada Mencit Jantan Hiperurisemia Kinanthi Putri Rizki; Siti Muslichah; Indah Yulia Ningsih
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7566

Abstract

This study aimed to determine the effect of the combination of sidaguri leaves and red ginger rhizome extracts in uric acid levels of hyperuricemic male mice. Thirty-six mice were divided into nine groups including normal group, the positive control (+), negative control (-), extracts of four treatment groups with a variety of combinations and two groups of single extract. Hyperuricemia induction was performed by administering mixture melinjo 10% of the standard feed mice for 7 days dan potassium oxonate 250 mg/kg BB intraperitoneally at 2 hours before blood sampling. The results showed that the combination dose of sidaguri leaves of 50 mg/kg BB and red ginger rhizome 400 mg/kg BB had higher antihyperuricemia activity than other combinations in lowering uric acid levels of mice. Compounds may have antihyperuricemic activity were flavonoids, alkaloids, saponins, tannins, and terpenoids. Keywords: sidaguri leaves, red ginger rhizome, antihyperuricemic activity, uric acid
Co-Authors Annisa Ragdha Eka Nuryuanda Auralia Putri Pratama Bambang Kuswandi Bawon Triatmoko Debi Listiayana Dedi Irawanto Dewi Dianasari Dianasari, Dewi Ema Desia Prajitiasari Ema Rachmawati Endah Puspitasari Endah Puspitasari Evi Umayah Ulfa Fauzia Ken Nasititi Ika Barokah Suryaningsih Jacinda Na’ilahafitra Kinanthi Putri Rizki Lisa Kusuma Wardhani Mochammad Amrun Hidayat Nasititi, Fauzia Ken Novia Hilma Noviani Tri Wahyuning Nuri Nuri Nuri Nuri Rismatul Khoiroh Siti Muslichah Yuniatin Hasanah