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All Journal Buletin Udayana Mengabdi E-Journal Obstetric & Gynecology Udayana WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Reproduksi ISM (Intisari Sains Medis) : Jurnal Kedokteran Andalas obstetrics and gynecology journal Science Midwifery International Journal of Social Service and Research Aesculapius Medical Journal Warmadewa Minesterium Medical Journal
A A G Raka Budayasa, A A G Raka
Universitas Warmadewa
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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HUBUNGAN ANTARAPENYAKIT PERIODONTAL PADA IBU HAMIL DENGAN ANGKA KEJADIAN PERSALINAN PRETERM Budayasa, A A G Raka
E-Journal Obstetric & Gynecology Udayana Vol 3, No 2 (2015)
Publisher : E-Journal Obstetric & Gynecology Udayana

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Abstract

Latar belakang: Sampai saat ini mortalitas dan morbiditas neonatus pada bayi preterm masih sangat tinggi. Dibandingkan dengan bayi baru lahir cukup bulan, bayi preterm terutama yang lahir dengan usia kehamilan < 32 minggu, mempunyai resiko kematian 70 kali lebih tinggi, karena mereka mempunyai kesulitan untuk beradaptasi dengan kehidupan di luar rahim. Pada banyak kasus penyebab utama dari persalinan preterm belum diketahui. Pada tahun-tahun terakhir, infeksi-infeksi rongga mulut juga berkontribusi terhadap persalinan preterm, ketuban pecah dini atau korioamnionitis. Offenbacher dkk (1996), pertama sekali melaporkan penyakit periodontal sebagai faktor resiko yang bermakna secara statistik mempengaruhi persalinan preterm.   Tujuan: Untuk mengetahui hubungan antara penyakit periodontal pada wanita hamil dengan angka kejadian persalinan preterm.   Rancangan Penelitian: Penelitian ini merupakan penelitian cross-sectional analitik. Subyek penelitian sebesar 60 ibu hamil yang dibagi menjadi dua kelompok, 30 ibu hamil preterm inpartu dan 30 ibu hamil preterm tidak inpartu. Subyek dipilih secara consecutive sampling. Pada subyek penelitian dilakukan evaluasi semua gigi kecuali molar III menggunakan pemeriksaan Probing Depth dan Bleeding On Probing, pencatatan adanya kalkulus, dan selanjutnya hasil diinterpretasikan menurut CPITN, 1997 (WHO). Evaluasi dilakukan di Poli Gigi dan Mulut RSUP Sanglah dan RSUD Gianyar.   Hasil: Karakteristik subyek penelitian tidak berbeda bermakna antara kedua kelompok sehingga pengaruhnya dapat diabaikan. Penyakit periodontal pada ibu hamil ditemukan memiliki hubungan dengan persalinan preterm melalui uji Chi-square dengan nilai rasio prevalen 2,30 (IK 95% 1,69-3,13, p = 0,011).   Simpulan: Pada penelitian ini disimpulkanpenyakit periodontal pada ibu hamil berhubungan dengan angka kejadian persalinan preterm yaitu pada ibu hamil dengan penyakit periodontal maka kejadian persalinan preterm adalah 2 kali lebih tinggi dibandingkan ibu hamil yang tidak menderita penyakit periodontal sebelum dan selama hamil.   Kata Kunci : penyakitperiodontal, persalinan preterm
PERBEDAAN KADAR INTERLEUKIN-8 SERUM PADA PERSALINAN PRETERM DAN PERSALINAN ATERM Raka Budayasa, A A G
E-Journal Obstetric & Gynecology Udayana Vol 2, No 3 (2014)
Publisher : E-Journal Obstetric & Gynecology Udayana

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Abstract

Persalinan preterm adalah persalinan yang terjadi antara usia kehamilan 20 sampai 37 minggu dihitung dari hari pertama haid terakhir. Interleukin-8 (IL-8) mengambil peran dalam terjadinya persalinan preterm melalui proses pematangan servik. Pada persalinan aterm, terjadi proses serupa tetapi sekresi interleukin-8 lebih tinggi pada persalinan preterm. Untuk mengetahui perbedaan kadar interleukin-8 pada persalinan preterm dan persalinan aterm. Penelitian ini merupakan desain cross sectional analitik dengan 68 sampel, dimana 29sampel dengan persalinan preterm dan 39sampel dengan persalinan aterm.Kadar interleukin-8 diperiksa di Laboratorium Prodia Denpasar. Uji analisis yang digunakan adalah dengan t-independent sample test dengan tingkat kemaknaan ?= 0,05. Rerata kadar interleukin-8 pada kelompok persalinan pretermadalah 23,56 ± 10,69 pg/ml, sedangkan pada kelompok persalinan aterm sebesar 12,19 ± 5,79 pg/ml.Analisis kemaknaan dengan t-independent sample test didapatkan nilai p = 0,001. Hal ini berarti bahwa rerata kadar interleukin-8 pada kedua kelompok berbeda bermakna. Berdasarkan hasil penelitian didapatkan bahwa kadar interleukin-8 serum pada persalinan preterm lebih tinggi daripada persalinan aterm dan perbedaan tersebut secara statistik bermakna. 
Cervical Hemangioma In Pregnancy I Putu Bagus Mulyana Yoga; Anak Agung Gede Raka Budayasa
International Journal of Social Service and Research Vol. 2 No. 2 (2022): International Journal of Social Service and Research (IJSSR)
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v2i2.83

Abstract

Hemangioma in the uterine cevix is a rare case, especially during pregnancy. Hemangioma is a benign tumor, but it can cause complication namely antepartum bleeding, preterm labour, and severe, life threatening complication such as disseminated intravascular coagulation (DIC). Histopathology examination is needed to diagnose hemangioma, and to differentiate this disease with other pathological condition. Conservative therapy was chosen as the main option rather than surgical therapy. The case report explain about 2 cases with cervical hemangioma in the uterine in 2 pregnant women. In the case 1 we presented a 27 years old primigravida, 29th weeks gestational age, with antepartum bleeding. A cervical biopsy was done and the histopathological examination reveal a capillary hemangioma within the uterine cervix. The patient was followed up with medications, and a caesarean section was planned to deliver the baby. In the case 2, a 30 years old multigravida with complained of postpartum bleeding. The clinical manifestation of cervical hemanioma in pregnancy was similar with other pathological condition, such as cervical cancer. A better understanding in pathogenesis and histopathological examination is important to differentiate hemangioma and other pathological condition in uterine cervix. Therapeutic modality was still debated, because of the limitation of literature about hemangioma cervix, especially in pregnant women
Syphillis In Pregnancy: A Literature Review I Putu Bagus Mulyana Yoga; Anak Agung Gede Raka Budayasa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3578.855 KB) | DOI: 10.36418/syntax-literate.v7i5.7113

Abstract

Syphilis is a bacterial sexually transmitted disease (STI) caused by Treponema pallidum. Syphilis can be transmitted through sexual contact, blood transfusion and vertical transmission from mother-to-child. Syphilis in pregnancy that is left untreated might lead to miscarriage, stillbirth, neonatal death, premature birth, low birth weight, and congenital syphilis. Syphilis in pregnancy, although results in high morbidity and mortality, is actually preventable through early screening and treatment. Diagnosis of syphilis in pregnancy is made through history taking, physical examination, laboratory testing and radiology. Screening for syphilis in pregnant women is important as many people with syphilis are often asymptomatic or experience very mild symptoms. Screening can be done in the first trimester using non-treponemal tests such as rapid plasma regain (RPR) or Venereal Disease Research Laboratory (VDRL), and can then be confirmed with treponemal tests such as (Treponema pallidum haemagglutination assay (TPHA) or fluorescent treponemal antibody absorption (FTA-ABS). All pregnant women who are tested positive for syphilis should promptly receive Benzathin penicillin G as the first-line treatment. Screening and treatment of syphilis in early pregnancy may help reduce morbidity and mortality of congenital syphilis.
PEMBERDAYAAN MASYARAKAT DALAM DETEKSI DINI KEHAMILAN RISIKO TINGGI PADA KELOMPOK IBU HAMIL DAN PENUNGGU PASIEN RS SANJIWANI A.A. Raka Budayasa; Dewa Made Sadguna; DAP Niti Widari; DAP Sri Masyeni
Buletin Udayana Mengabdi Vol 20 No 2 (2021): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.621 KB) | DOI: 10.24843/BUM.2021.v20.i02.p12

Abstract

Kehamilan risiko tinggi adalah kehamilan yang harus dideteksi sejak dini karena dapat menimbulkan terjadinya bahaya atau komplikasi baik terhadap ibu ataupun janin. Kompilkasi dapat terjadi selama kehamilan, pada masa persalinan atau masa nifas. Keadaan ini dapat terjadi sebagai akibat atau komplikasi dari kehamilan atau disebabkan oleh suatu kondisi yang dimiliki ibu dari sebelum hamil. Kehamilan risiko tinggi merupakan penyebab terbanyak kematian pada ibu hamil. Oleh karena itu untuk mengurangi bahaya atau komplikasi akibat kehamilan risiko timggi, pengabdian ini bertujuan untuk membantu ibu hamil beserta penunggu pasien untuk dapat mengenali tanda-tanda kehamilan risiko tinggi sehingga angka kesakita dan kematian untuk ibu hamil dan jani dapat diturunkan. Kegiatan diawali dengan sosialisasi serta koordinasi dengan kelompok mitra, focus group discussion serta pelaksanaan kegiatan kemiteraan kepada masyarakat (PKM). Kegiatan PKM diawali dengan pre-test untuk mengukur tingkat pengetahuan ibu dan penunggu pasien, lalu penyuluhan mengenai kehamilan risiko tinggi dengan pamphlet, serta video. Pada akhir pelaksanaan PKM dilaksanakan post-test untuk mengetahui peningkatan pengetahuan mitra. Output serta outcome PKM dievaluasi dari peningkatan pengetahuan mitra, kedatangan ibu dalam perawatan ante natalcare serta penurunan komplikasi akibat kehamilan risiko tinggi. Peningkatan pengetahuan mitra ditemukan sebesar 90% dalam pengenalan gejala kehamilan risiko tinggi, dan frekuensi antenatal care. Evalausi keberhasilan PKM akan dilaksanakan dari penurunan kasus kehamilan risiko tinggi serta penurunan kesakitan dan kematian ibu hamil.
Management of pregnant women with Refractory Immune Thrombocytopenia Purpura (ITP) receiving eltrombopag therapy at Sanjiwani Hospital, Gianyar, Indonesia Anak Agung Raka Budayasa; Cokorda Gede Angga Ary Nugraha
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.032 KB) | DOI: 10.15562/ism.v12i1.958

Abstract

Background: Immune Thrombocytopenia Purpura (ITP) is an autoimmune disease characterized by a low level of platelets in the blood caused by accelerated platelet destruction or disruption of the thrombopoiesis due to antibodies to platelets. Drugs with similar functions to thrombopoietins (TPO) such as eltrombopag and romiplostim have been widely used and have been shown to be quite successful in treating ITP in nonpregnant patients. This case study aims to evaluate eltrombopag therapy's role in managing the refractory ITP in pregnant women.Case Presentation: A 25-year-old patient, a housewife, presented to the obstetrics clinic at Sanjiwani Hospital for the first time at a gestational age of 13 weeks for her third pregnancy, with a history of two abortions. ITP was diagnosed in 2017 during the second abortion treatment. The platelet examination results were between 32,000-66,000/?l, with platelet count during delivery planning at 34 weeks of 41,000/?l. The patient was diagnosed with chronic refractory ITP and was considered for second-line drug administration. Intravenous Immunoglobulin Therapy (IVIG) and anti-D administration as second-line drugs were not possible due to cost. The patient was given 50 mg eltrombopag per day for a week. The platelet counts increased to 202,000/?l a week after therapy. The patient then underwent vaginal delivery with a baby weight of 2,850 gram, Apgar Score of 8-10. The baby was exclusively breastfed and subjected to clinical monitoring and laboratory tests. The patient's clinical condition was favorable and the platelets fell to 20,000/?l nineteen days after delivery.Conclusion: In this case, the patient with chronic ITP refractory to steroid therapy showed an immediate response to eltrombopag. However, the platelet level decreased two weeks after the treatment cessation. More studies are needed on the use of eltrombopag in pregnant women.
Relationship Between Maternal Age, Education, and Parity in The Incidence of Spontaneous Abortion in Bali I Made Wira Supanji; Anak Agung Raka Budayasa; Pande Ayu Naya Kasih Permatananda; Putu Nita Cahyawati; Anak Agung Sri Agung Aryastut
Science Midwifery Vol 10 No 4 (2022): October: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i4.710

Abstract

Abortion is one of the problems in the world that affects the health, morbidity, and mortality of pregnant women. The purpose of this study was to examine the relationship between maternal age during pregnancy, education, and maternal parity in the incidence of spontaneous abortion at the Sanjiwani Hospital, Gianyar. This research was a retrospective and cross-sectional analytic study. The inclusion criteria were pregnant women who performed prenatal care at the Obstetrics Gynecology section of the Sanjiwani Hospital Gianyar, were clearly diagnosed with abortion (incomplete, complete, insipient) and/or non-abortion, and had complete pregnancy data. This study succeeded in collecting 79 data on pregnant women who met the inclusion and exclusion criteria. From the 79 data, 39 pregnant women experienced spontaneous abortion, and 40 pregnant women did not experience abortion. The results of bivariate analysis using chi-square showed a significant relationship between the age of pregnant women, education, and parity in the incidence of spontaneous abortion with a P value <0.05. This research is expected to be the basis of health promotion for pregnant women in order to increase the understanding of risk factors of spontaneous abortion and be able to take appropriate prevention.
Peripartum Cardiomyopathy: A Case Management Series At Sanjiwani Hospital Grace Eva; Anak Agung Gede Raka Budayasa; Anak Agung Gede Indrayana Putra; Ketut Erna Bagiari
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 1 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.320-329.2023

Abstract

Introduction: In Peripartum Cardiomyopathy (PPCM), heart function will generally return to normal a fewmonths after delivery, but in some cases poor outcomes might occur, therefore early detection and managementare crucial. This case series study aims to get an overview of PPCM cases in a type-B referral hospital in Gianyar,Bali.Case Presentation: This study presents 3 cases of PPCM that showed symptom onset in the antepartum period(the third trimester of pregnancy). Two out of three cases were nulliparous with maternal age <30 years, andwent through a Cesarean Section. All three cases underwent treatment in the Intensive Care Unit and showedimprovement in their condition.Discussion: Until now, the heterogeneity of PPCM diagnostic criteria has become an obstacle to its treatment,thus the reported incidence tends to be low. This is likely due to the diagnosis of PPCM which is an exclusiondiagnosis from other causes of heart failure. Echocardiography and NT-ProBNP examinations should be done,which, although not specific, may lead to a diagnosis of PPCM when combined with a thorough patient history.The availability of supporting examination modalities in many regions in Indonesia are varied thus referrals areusually needed, resulting in the delay of PPCM cases management.Conclusion: All pregnant women who experience dyspnea during the third trimester of pregnancy, along with afamily history of heart disease, need to undergo close examination and supervision due to the suspicion of PPCM.Early detection and treatment are the main key to successful management of PPCM cases
Peripartum Cardiomyopathy: A Case Management Series At Sanjiwani Hospital Eva, Grace; Raka Budayasa, Anak Agung Gede; Indrayana Putra, Anak Agung Gede; Bagiari, Ketut Erna
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.320-329.2023

Abstract

Introduction: In Peripartum Cardiomyopathy (PPCM), heart function will generally return to normal a fewmonths after delivery, but in some cases poor outcomes might occur, therefore early detection and managementare crucial. This case series study aims to get an overview of PPCM cases in a type-B referral hospital in Gianyar,Bali.Case Presentation: This study presents 3 cases of PPCM that showed symptom onset in the antepartum period(the third trimester of pregnancy). Two out of three cases were nulliparous with maternal age <30 years, andwent through a Cesarean Section. All three cases underwent treatment in the Intensive Care Unit and showedimprovement in their condition.Discussion: Until now, the heterogeneity of PPCM diagnostic criteria has become an obstacle to its treatment,thus the reported incidence tends to be low. This is likely due to the diagnosis of PPCM which is an exclusiondiagnosis from other causes of heart failure. Echocardiography and NT-ProBNP examinations should be done,which, although not specific, may lead to a diagnosis of PPCM when combined with a thorough patient history.The availability of supporting examination modalities in many regions in Indonesia are varied thus referrals areusually needed, resulting in the delay of PPCM cases management.Conclusion: All pregnant women who experience dyspnea during the third trimester of pregnancy, along with afamily history of heart disease, need to undergo close examination and supervision due to the suspicion of PPCM.Early detection and treatment are the main key to successful management of PPCM cases
Non-Invasive Prenatal Testing with Next Generation Sequencing Methods in Birth Defect Pregnancy: A Pilot Study Anom Suardika; Anak Agung Ngurah Jaya Kusuma; Ni Gusti Ayu Manik Ermayanti; Endang Sri Widiyanti; I Gusti Ngurah Agung Satria Wibawa; Divika Silvana; Anak Agung Gede Raka Budayasa; Ni Nyoman Ayu Dewi; I Made Jawi; H. Sunny Sun; Yen-An Tang
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3753

Abstract

BACKGROUND: Identification of cell-free foetal DNA (cffDNA) in maternal blood, combined with next-generation sequencing (NGS) advancement, has paved the way for non-invasive prenatal screening to detect foetal aneuploidies. However, there is limited evidence on its diagnostic accuracy when compared with gold-standard invasive tests specifically in pregnancies complicated by birth defects in Indonesia. This study was conducted to evaluate the precision of non-invasive prenatal testing (NIPT) using NGS and ultrasound findings compared with the established benchmarks of amniocentesis and neonatal karyotyping through G-banding analysis, which is an invasive procedures, in a private laboratory setting for pregnancies with birth defect.METHODS: An observational cohort study involving pregnant women with foetal birth defects in central nervous system, facial, heart, gastrointestinal tract, urinary tract abnormalities and suspected Down Syndrome was conducted. The foetal birth defects were identified in the first trimester with ultrasound screening. Venous blood was drawn from the mother for NGS-based NIPT examination. As a gold standard, amniocentesis or neonatal G-banding karyotyping was conducted.RESULTS: Using G-banding karyotyping as gold standard, the results indicated that NIPT using the NGS method and ultrasound findings achieved 100% sensitivity, 100% specificity, and 100% accuracy in detecting trisomy 13, 18, and 21, as well as foetal sex chromosome abnormalities. Additionally, a case of tetrasomy 9p was identified through G-banding karyotyping, which was associated with multiple clinical abnormalities.CONCLUSION: NIPT with NGS methods and ultrasound findings demonstrated 100% accuracy for the screening of trisomy 13, 18, and 21 in birth defect pregnancy, which is comparable with G-banding analysis as a gold standard. Therefore, this suggest that these approaches offer a safe early detection, highly accurate alternative in high risk setting, compared to invasive procedure in Indonesia where access to such testing may be limited. KEYWORDS: G-banding karyotyping, next generation sequencing, non-invasive prenatal testing
Co-Authors Anak Agung Gede Indrayana Putra Anak Agung Ngurah Jaya Kusuma Anak Agung Sri Agung Aryastut Anom Suardika Asri Lestarini Cahyawati, Putu Nita Cokorda Gede Angga Ary Nugraha Dewa Nyoman Sadguna, Dewa Nyoman Divika Silvana Endang Sri Widiyanti Eva, Grace Grace Eva H. Sunny Sun I Gusti Ayu Sri Anjani I Gusti Ngurah Agung Satria Wibawa I Made Adi Putra Wiguna I Made Adi Putra Wiguna I Made Jawi I Made Wira Supanji I Putu Bagus Mulyana Yoga I Wayan Rusdiarna Eka Putra Indrayana Putra, Anak Agung Gede Kennedy Winartan Ketut Erna Bagiari Ketut Erna Bagiari, Ketut Erna Made Surya Pramana Ni Gusti Ayu Manik Ermayanti Ni Nyoman Ayu Dewi Ni Putu Diah Witari, Ni Putu Pande Ayu Naya Kasih Permatananda Putu Devi Gema Partamayani Putu Indah Budi Apsari Sintya Sevadani Sintya Sevadani Sri Masyeni, Dewa Ayu Putri Widari, Dewa Ayu Putu Niti Yen-An Tang