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All Journal Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Quantum Wellness : Jurnal Ilmu Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Razoki Razoki
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Evaluasi Drug Related Problems (DRPs) pada Pasien Penyakit Jantung di Poli Penyakit dalam RSU Royal Prima Marelan Innaya Sabrina Sirait; Razoki Razoki; Nerly Juli Pranita Simanjuntak
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.6968

Abstract

Heart disease is the leading cause of death in Indonesia. The use of complex drugs in the treatment of heart disease increases the risk of Drug Related Problems (DRPs), especially due to the many comorbidities and drug interactions. The purpose of this study was to determine the incidence of Drug Related Problems (DRPs) in heart disease patients at the internal medicine clinic of Royal Prima Marelan Hospital. This study is a retrospective descriptive study of 50 outpatients diagnosed with heart disease in the period January-June 2024. Data obtained from medical records and patient prescriptions were analyzed to identify the types of DRPs based on the PCNE classification. Drug interactions were the most prevalent type of DRP (95,7%), with severity levels classified as moderate (80,5%), minor (12,6%), and major (4,4%). The most frequent interactions occurred between clopidogrel and omeprazole (major). Most patients were male (60%) and aged between 40-55 years (54%).
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Glory Stevi Natasia Saragih; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7052

Abstract

Microencapsulation is a technology that uses controlled release of active ingredients to increase bioavailability and reduce gastrointestinal irritation. This study aims to evaluate the microencapsulation formulation of ethanol extract of papaya leaf (Carica papaya L.) by testing its stability, moisture content, and floating in the stomach and intestinal medium. Mardikasari et al (2020) showed the release of chitosan-alginate microencapsulation of 8,811 mg/L (acid) and 79,908 mg/L (base). Microencapsulation was performed by adding sodium alginate and chitosan as polymers, CaCl2 as a cross-linking, and three variations of extract concentration in F1 without extract, F2 of 0,25%, F3 of 0,5%, and F4 of 0,75%. The results showed that all formulas remained stable during the storage cycle in terms of color, aroma, taste, and texture. The average moisture content of the microencapsulated formulations was 24%, 20,5%, 28%, and 18,7%. The microencapsulated preparations were able to maintain their stability in the acidic conditions in the stomach, but showed a decrease in floating under acidic conditions in the intestine.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.) Rika Mai Dinasari Br Sembiring; Razoki Razoki; Erida Novriani; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7054

Abstract

This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
Studi Kualitatif : Analisis Faktor-Faktor yang Mempengaruhi Pengobatan Pasien TB di Puskesmas Sentosa Baru Veronika Bertua Simanjuntak; Erida Novriani; Razoki Razoki
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4751

Abstract

Tuberculosis (TB) is a global health problem, with Indonesia having the second highest number of cases in the world. Although morbidity and mortality rates from TB are still high, the disease is curable with proper treatment. The success of TB therapy can be influenced by various factors such as patient compliance, knowledge about TB, patient motivation, family support, education level, socioeconomic conditions, access to health facilities, the role of health workers, drug side effects, and comorbidities. This study aims to analyze the factors that influence the successful treatment of TB patients at Puskesmas Sentosa Baru. This study used a qualitative method with a cross-sectional descriptive approach, this study involved 15 TB patients who were interviewed in depth until the data reached the point of saturation, as well as observation and documentation. From the results of the research conducted, it was found that the factors that influence the success of patient treatment at Sentosa Baru Health Center are the level of patient compliance, level of knowledge, and patient motivation. Patients who have a better understanding of the disease tend to be more disciplined in undergoing therapy, while family support is a strong driver in improving patient adherence to treatment. Therefore, increased education, monitoring of adherence, and more intensive social support are needed so that patients can complete treatment optimally and break the chain of TB transmission.
Evaluasi Formulasi Sediaan Mikroenkapsulasi Ekstrak Etanol Herba Seledri (Apium graveolens L.) Najwa Aisyah; Razoki Razoki; Hariyadi Dharmawan Syahputra
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 2 (2026): Mei: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i2.6629

Abstract

Celery (Apium graveolens L.) is an herbal plant containing bioactive compounds such as flavonoids, alkaloids, tannins, saponins, and triterpenoids that have the potential to lower blood glucose levels. However, the stability and absorption of its active compounds still need to be developed. One effort to improve the stability and effectiveness of the extract is through microencapsulation technology. This study aims to formulate and evaluate the physical characteristics of microencapsulated preparations containing celery herb ethanol extract. The method used includes making the extract by maceration technique using 80% ethanol, then formulation using alginate and chitosan polymers with ionic gelation method using CaCl2 solution. Evaluation of the preparation includes stability test, water content and adhesion test on the gastric mucosa. The results showed that the microcapsules remained stable, there were no physical changes after six cycles. The adhesion test showed that the extract concentration of 0% (blank) had the highest adhesion ability and the lowest water content was 0.25%.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Salam (Syzygium Polyanthum) Rahma Yulina Al-Farini; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.4894

Abstract

Ethanol extract of bay leaves is known to have pharmacological activities such as anti-inflammatory, antihypertensive, and antidiabetic. However, its stability and solubility are still challenges. Therefore, a microencapsulation-based delivery system with floating characteristics that can last longer in the stomach was developed. This study aims to evaluate floating microencapsulation preparations containing ethanol extract of bay leaves (Syzygium polyanthum) as an effort to increase the effectiveness and bioavailability of active substances orally. The results showed that microencapsulation had a total floating of more than 4 hours with a water content of 0.47% -2.14%. Stability tests showed no significant changes in physical and chemical characteristics after cycling tests.
Co-Authors Afriliani Br Sitepu Anggun Pratiwi Cut Inssy Mulun Daimah Wirdatus Sanaun Harahap Devin Rio Alvaro Elfia Neswita Elfia Neswita Enjelina Br Hutapea Erida Novriani Glory Stevi Natasia Saragih Hariyadi Dharmawan Syahputra Innaya Sabrina Sirait Jecika Stefany Br Tumanggor Kevin Wijaya Muhammad Yunus Najwa Aisyah Nerly Juli Pranita Simanjuntak Rahma Yulina Al-Farini Ricky Martino Rika Mai Dinasari Br Sembiring Roy Indrianto Bangar Simran Kaur Stefanus Rio Pendamenta Tarigan Veronika Bertua Simanjuntak