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All Journal Best Journal (Biology Education, Sains and Technology) Jurnal Penelitian Farmasi dan Herbal Jurnal Pengabdian Masyarakat Putri Hijau
Masria Phetheresia Sianipar
Institut Kesehatan Deli Husada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi Sediaan Gel Ekstrak Etanol Daun Kitolod (Isotoma longiflora L.) Terhadap Penyembuhan Luka Bakar Pada Kelinci (Oryctolagus cuniculus) Masria Phetheresia Sianipar; Delima Marsauli Simorangkir
BEST Journal (Biology Education, Sains and Technology) Vol 5, No 1 (2022): Juni 2022
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v5i1.5246

Abstract

Luka bakar adalah luka yang terjadi akibat kontak permukaan tubuh dengan benda yang menghasilkan panas atau zat yang terbakar. Salah satu tanaman yang dapat menyembuhkan luka bakar adalah daun kitolod. Daun kitolod memiliki senyawa saponin dan flavonoid yang berfungsi sebagai anti bakteri dan meningkatkan pertumbuhan jaringan baru sehingga mempercepat penyembuhan luka. Metode untuk mengetahui efektivitas sediaan gel ekstrak etanolik kitolod (Isotoma longiflora L.) terhadap penyembuhan luka bakar. Metode penelitian dilakukan secara eksperimental, sampel diekstraksi dengan cara maserasi menggunakan pelarut etanol 96%. Ekstrak kental yang diperoleh sebagai zat aktif dibuat menjadi sediaan gel dengan konsentrasi 5%, 7,5% dan 10%. Persiapan pengujian meliputi uji organoleptik, uji homogenitas, pengamatan pH, uji dispersi, uji adhesi dan pengamatan penyembuhan luka. Pengujian sediaan gel luka bakar dilakukan selama 14 hari dengan 5 kelompok yaitu kontrol positif (preparat pasaran), kontrol negatif (basis gel), dan preparat gel EEDK 5%, 7,5% dan 10%. Hasil penelitian menunjukkan bahwa ekstrak daun kitolod dapat diformulasikan sebagai sediaan gel yang homogen, tidak berubah warna, dan memiliki pH yang stabil. Pengamatan terhadap penyembuhan luka bakar menunjukkan bahwa sediaan yang beredar di pasaran lebih efektif dan tidak jauh berbeda dengan gel EEDK 10% dengan perbandingan penutupan luka hari ke-14 sebesar 0,20 dan 0,25 cm. Ekstrak etanol daun kitolod 10% dalam sediaan gel paling efektif dalam penyembuhan luka bakar dibandingkan ekstrak etanol daun kitolod 5% dan 7,5%.
FORMULASI SEDIAAN SALEP KOMBINASI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN KERSEN (Muntingia calabura L.)TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS JANTAN PUTIH TAHUN 2022 masria phetheresia sianipar
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1066

Abstract

Background: Wounds are damage to part of body tissue or damage to tissue components, where there are damaged or missing tissue substances. Jackfruit leaves (Artocarpus heterophyllus Lam.) contain secondary metabolites, namely, flavonoids, saponins and tannins. Flavonoids function as antibacterial and reduce inflammation in wounds. Saponins to trigger the formation of collagen. While the tannins function as an antibacterial. Cherry leaves (Muntingia calabura L.) contain several active compounds such as flavonoids, saponins, and tannins. Compounds that function as anti-inflammatory are flavonoids. These compounds can accelerate wound healing because it has anti-inflammatory activity. Objective: to determine the concentration of the combination ointment of jackfruit leaf and cherry leaf ethanol extract in the form of an ointment that is most effective in healing open wounds. Method : Experimentally. Samples using jackfruit and cherry leaves were taken purposively, extracted by maceration using 96% ethanol as a solvent made in the form of a thick extract. Then the thick extract was made into an ointment with a ratio of 1:2, 2:1 and 2:2 as well as positive control (bacitracin ointment), negative control (ointment base). open wound for 14 days. Results: The results of the open wound healing study had the best effectiveness, namely bacitracin ointment (0 cm), a combination ointment of jackfruit leaf and cherry ethanol extract 2:2 (0.10 cm), 1:2 (0.25 cm) and 2 :1 (0.28 cm) then ointment base (0.55 cm). Conclusion : The preparation of ointment combination of jackfruit leaf ethanol extract and 2:2 cherry is more effective in the treatment of open wounds.
EDUKASI PENGGUNAAN ANTIBIOTIK PADA SISWA/SISWI SMA NEGERI 1 STM HILIR, JLN. PENDIDIKAN DUSUN I TALUN KENAS, KEC. SINEMBAH TANJUNG MUDA HILIR, KAB. DELI SERDANG, SUMATERA UTARA Pintata Sembiring; Masria Sianipar; Sri Sudewi Pratiwi Sitio; Yunita Syahputri Damanik; Efrata Sembiring
Jurnal Pengabdian Masyarakat Putri Hijau Vol 3 No 3 (2023): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v3i3.1342

Abstract

Overuse of antibiotics has the potentiall for irrational use. This is one of the factorss that cause resistances. WHO in the field of antimicrobial resistance:According to the Global Surveillance Report, Southeast Asia has the highest level of antimicrobial resistance in the world, especially against methicillin-resistant Staphylococcus aureus (Ministry of Health, 2015). Results of the AMRIN (Antimicrobial Resistance in Indonesia) study conducted from 2000 to 2005 showed that approximately 43% of E. coli are resistant to various types of antibiotics, including: ampicillin (34%), co-trimoxazole (29%), chloramphenicol (25%) (Minister of Health of the Republic, 2015). Irrational use is a major factor in high antibiotic resistance rates. Lack off publicc knowledges about antibiotics can affect attitudes and healths behaviorss, including irrationall use of antibiotics. Knowledge plays an important rolee in shaping beliefs and attitudess about certain behaviors, such as behavior when taking antibioticss. Education level is thought to have a significant impact on this behavior (Ivoryanto, 2017). Keywords : antibiotics, resistance, student
STOP SELF-MEDICATION SEMBARANGAN: BIJAK MENGGUNAKAN OBAT SEJAK REMAJA PUTRI ANGGITA ANGGITA; masria phetheresia sianipar; nurul dahlia harahap; Nina Irmayani Harahap; Elysa .
Jurnal Pengabdian Masyarakat Putri Hijau Vol. 6 No. 3 (2026): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v6i3.3101

Abstract

Irrational self-medication, including the misuse of antibiotics and corticosteroids, is a serious health problem among adolescents that may lead to antimicrobial resistance, adverse effects, and delayed diagnosis. A Community Service Program (PKM) titled “Stop Self-Medication Sembarangan: Bijak Menggunakan Obat Sejak Remaja” was carried out by pharmacy professional students of Deli Husada Health Institute on May 23, 2026, at SMA ISTIQLAL Deli Tua. The program aimed to improve health literacy among Grade 11 students regarding rational drug use, the risks of unprescribed antibiotic and corticosteroid use, and the role of pharmacists. An interactive school-based counseling method was used with leaflets, brochures, and educational videos, accompanied by pre-test and post-test evaluations. The activity was attended by 70 students with high enthusiasm. Evaluation results showed a significant improvement in knowledge, from an average pre-test score of 30% to a post-test score of 90%. A total of 10 questions were raised during the discussion session, with a 100% participation rate. In conclusion, school-based health education is effective in improving adolescent health literacy, and pharmacists play a key role as agents of change in fostering rational medication behavior among youth.
Uji Aktivitas Anti Oksidan Fraksi Etil Asetat Bunga Kecombrang (Etlingera elatior) Dengan Metode DPPH Lidia Klorida Barus; Sofia Eliasari Bangun; Masria Phetheresia Sianipar
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.12798

Abstract

Abstrak Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan fraksi etil asetat bunga jahe obor (Etlingera elatior) menggunakan metode DPPH. Penelitian ini dilakukan secara eksperimental melalui ekstraksi dan fraksinasi sampel, kemudian dilakukan pengujian menggunakan spektrofotometri UV-Vis untuk menentukan nilai IC50. Hasil penelitian menunjukkan potensi antioksidan yang kuat dari fraksi tersebut. Penelitian ini menggunakan metode eksperimental yang dilakukan di laboratorium. Sampel bunga jahe obor diekstraksi menggunakan etanol 96%, kemudian difraksinasi dengan pelarut n-heksana, etil asetat, dan etanol. Pengujian aktivitas antioksidan dilakukan menggunakan metode DPPH dan dianalisis menggunakan spektrofotometri UV-Vis untuk menentukan nilai IC50 fraksi etil asetat. Hasil penelitian menunjukkan bahwa fraksi etil asetat bunga jahe obor memiliki aktivitas antioksidan yang sangat kuat. Nilai IC50 yang diperoleh berada di bawah 50 µg/mL, menunjukkan kemampuan yang tinggi dalam menangkal radikal bebas. Aktivitas ini dikonfirmasi melalui pengujian DPPH dan analisis menggunakan spektrofotometri UV-Vis. Kesimpulan dari penelitian ini adalah fraksi etil asetat dari bunga jahe obor memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 kurang dari 50 µg/mL. Rekomendasi untuk penelitian lebih lanjut meliputi isolasi senyawa aktif spesifik dan pengembangan potensi bunga jahe obor sebagai bahan dasar untuk produk herbal atau suplemen kesehatan alami dan aman
PENETAPAN KADAR AKRILAMIDA PADA MAKANAN HEWANI DAN NABATI PANGGANG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Sofia Eliasari Br Bangun; Sulasmi Sulasmi; Masria Phetheresia Sianipar
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2943

Abstract

This study aimed to determine the acrylamide levels in animal-based (grilled chicken and grilled fish) and plant-based (grilled Cilembu sweet potato) foods using the UV-Vis spectrophotometry method. Acrylamide is a carcinogenic compound formed in foods heated to high temperatures. The samples were tested qualitatively and quantitatively. Qualitative tests confirmed the presence of acrylamide in all three samples. Quantitative measurement was performed at a maximum wavelength of 267 nm and showed the average acrylamide levels in grilled Cilembu sweet potato, grilled chicken, and grilled fish were 51.3964 mcg/g, 38.1875 mcg/g, and 32.1383 mcg/g, respectively. The highest level was found in the grilled Cilembu sweet potato due to its higher carbohydrate content. Although the detected levels are below the daily toxic limit set by BPOM, excessive long-term consumption is not recommended. The method validation test showed results that met the requirements for linearity (r = 0.995) , accuracy (recovery range 101.58% - 106.33%) , and precision (RSD < 2%) , with LOD and LOQ values of 0.4111 and 1.3703, respectively. It was concluded that the UV-Vis spectrophotometry method is effective for the analysis of acrylamide in grilled food samples.
Co-Authors Delima Marsauli Simorangkir Efrata Sembiring Elysa . Lidia Klorida Barus Nina Irmayani Harahap nurul dahlia harahap Pintata Sembiring PUTRI ANGGITA ANGGITA Sitio, Sri Sudewi Pratiwi Sofia Eliasari Br Bangun Sulasmi Sulasmi Yunita Syahputri Damanik