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All Journal PROFESI || JURNAL KESEHATAN PROFESIONAL ISLAMI Buletin Kebun Raya Indonesian Journal of Biotechnology Biosaintifika: Journal of Biology & Biology Education Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia
Yuli Widiyastuti
Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Badan Litbang Kesehatan, Kementerian Kesehatan RI Jl. Raya Lawu, Tawangmangu, Karanganyar, Jawa Tengah, Tel.: (0271) 697010, Fax.: (0271) 697451
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Medicinal Plants used for Antihypercholesterolemia in Ethnic Groups of Celebes Island, Indonesia: Pemanfaatan Tumbuhan Obat sebagai Antihiperkolesterolemia di Berbagai Etnis di Pulau Sulawesi, Indonesia Rahmawati, Nuning; Haryanti, Sari; Yanti Marfuatush Sholikhah, Ika; Subositi, Dyah; Widodo, Harto; Mujahid, Rohmat; Widiyastuti, Yuli
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.1025

Abstract

This study aimed to identify the utilization of medicinal plants used by selected traditional healers who met inclusion criteria to treat high cholesterol levels in ethnic groups of Celebes Island, Indonesia. Data collection was carried out through interviews, observation, and sample collection. This study revealed 67 concoction information and identified the use of 48 plant species distributed in 32 families among 39 healers in 20 ethnic groups in Celebes Island. Peperomia pellucida (L.) Kunth (UV=0.21), lamiaceae (15.63%), and leaves (57.35%) were determined as the most prominent species, family, and plant part used. The most widely prescribed rule of use is internal administration (94.03%) with a frequency of 3x1 per day (44.78%) for a week to a month (56.72%). However, conservation efforts need to be initiated immediately since more than 50% of healers made no cultivation efforts
Whole-genome sequencing of endophytic Bacillus cereus ELSZ6 isolated from Smilax zeylanica L. reveals antimicrobial potential against multidrug-resistant pathogens Zuhri, Rozana; Retnaningrum, Endah; Widiyastuti, Yuli; Susidarti, Ratna Asmah
Indonesian Journal of Biotechnology Vol 31, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.116786

Abstract

The increasing global prevalence of multidrug-resistant (MDR) bacterial infections has intensified the search for new antibacterial agents from underexplored natural sources. Endophytic bacteria associated with medicinal plants are recognized as potential producers of bioactive secondary metabolites. This study aims to isolate and characterize antibacterial endophytic bacteria from Smilax zeylanica collected in Bukit Duabelas National Park, Jambi, Indonesia. Endophytic bacteria were isolated from roots, stems, leaves and rhizomes using a surface sterilization method, which was validated by a final rinse test which showed no microbial growth. Antibacterial activity was screened using a dual culture assay on Nutrient Agar against methicillin-resistant Staphylococcus aureus (MRSA) WS 29 and Escherichia coli RES 22-2020, followed by phenotypic and genomic characterization. A total of 45 endophytic bacterial strains were obtained, of which seven exhibited inhibitory activity against both pathogens. Strain ELSZ6 showed the strongest inhibition and was characterized as Gram-positive, rod-shaped, and endospore-forming. Whole genome sequencing identified the strain as Bacillus cereus (6.3 Mbp; 50× coverage). Genome mining using antiSMASH revealed several biosynthetic gene clusters associated with secondary metabolites, including bacillibactin, zwittermicin A and petrobactin. The findings indicate that strain ELSZ6 represents a potential candidate for further investigation as a source of antibacterial compounds for use against MDR bacteria.
Co-Authors Dyah Subositi Gharsina Ghaisani Yumni Harto Widodo, Harto KRISNA KHARISMA PERTIWI M. Nur Rahman Marfuatush Sholikhah, Ika Yanti Nanang Fakhrudin, Nanang Nuning Rahmawati Ratna Asmah Susidarti Retnaningrum, Endah Rohmat Mujahid, Rohmat Rozana Zuhri Sari Haryanti Sholikhah, Ika Yanti M. Yanti Marfuatush Sholikhah, Ika