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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology PROFESI || JURNAL KESEHATAN PROFESIONAL ISLAMI Buletin Kebun Raya Biosaintifika: Journal of Biology & Biology Education Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia
Yuli Widiyastuti
Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Badan Litbang Kesehatan, Kementerian Kesehatan RI Jl. Raya Lawu, Tawangmangu, Karanganyar, Jawa Tengah, Tel.: (0271) 697010, Fax.: (0271) 697451
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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ISOLASI SENYAWA 2-GERANIL-2’,3,4,4’-TETRAHIDROKSI DIHIDROKALKON DARI DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) DENGAN FLASH COLUMN CHROMATOGRAPHY: Isolation of 2-Geranyl-2',3,4,4'-Tetrahydroxy Dihydrochalcone from Breadfruit Leaf (Artocarpus altilis (Park.) Fosberg) Using Flash Column Chromatography Yumni, Gharsina Ghaisani; Pertiwi, Krisna Kharisma; Widiyastuti, Yuli; Fakhrudin, Nanang
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.599

Abstract

Breadfruit is one of the Indonesian plants traditionally used in medication. The main active compound in breadfruit leaves is a geranylated flavonoid namely 2-geranyl-2',3,4,4'-tetrahydroxy dihydrochalcone (GTD). Previous study showed that the separation and isolation of GTD from sukun leaves is time consuming and laborious as it requires a long procedure (extraction, liquid-liquid partition, Vacuum Liquid Chromatography (VCC), Sephadex Column Chromatography (SCC), and preparative Thin Layer Chromatography (TLC). This process is ineffective and inefficient. Thus, the more effective and shorter method of isolation is needed. This study aimed to isolate GTD from breadfruit leaves utilizing flash column chromatography (FCC). The breadfruit leaves were extracted using ethanol and the extract was partitioned with the solvent n-hexane: ethyl acetate: methanol: water (3:1:3:1). The lower phase containing GTD was subjected to VCC and the fraction containing GTD was purified with FCC (using n-hexane, ethyl acetate, and methanol in a gradient polarity as mobile phases; and silica gel as a solid phase) to isolate GTD. The isolated GTD was analyzed by thin-layer chromatography (TLC) and purity was determined using high-performance liquid chromatography. This method was able to produce 138 mg of GTD (purity of 88.49 %) from 15 g of breadfruit leaf extract (0.92% yield). This study demonstrated that GTD, a main bioactive compound of breadfruit leaves, could be effectively isolated by using FCC instead of SCC and preparative TLC.
Medicinal Plants used for Antihypercholesterolemia in Ethnic Groups of Celebes Island, Indonesia: Pemanfaatan Tumbuhan Obat sebagai Antihiperkolesterolemia di Berbagai Etnis di Pulau Sulawesi, Indonesia Rahmawati, Nuning; Haryanti, Sari; Yanti Marfuatush Sholikhah, Ika; Subositi, Dyah; Widodo, Harto; Mujahid, Rohmat; Widiyastuti, Yuli
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.1025

Abstract

This study aimed to identify the utilization of medicinal plants used by selected traditional healers who met inclusion criteria to treat high cholesterol levels in ethnic groups of Celebes Island, Indonesia. Data collection was carried out through interviews, observation, and sample collection. This study revealed 67 concoction information and identified the use of 48 plant species distributed in 32 families among 39 healers in 20 ethnic groups in Celebes Island. Peperomia pellucida (L.) Kunth (UV=0.21), lamiaceae (15.63%), and leaves (57.35%) were determined as the most prominent species, family, and plant part used. The most widely prescribed rule of use is internal administration (94.03%) with a frequency of 3x1 per day (44.78%) for a week to a month (56.72%). However, conservation efforts need to be initiated immediately since more than 50% of healers made no cultivation efforts
Co-Authors Adi, M Bakti Samsu Dian Susanti Dyah Subositi Gharsina Ghaisani Yumni Harto Widodo, Harto KRISNA KHARISMA PERTIWI M. Nur Rahman Marfuatush Sholikhah, Ika Yanti Nanang Fakhrudin, Nanang Nuning Rahmawati Putra, Aditya Dwi Permana Rizal Maarif Rukmana, Rizal Maarif Rohmat Mujahid, Rohmat Safrina, Devi Sari Haryanti Sholikhah, Ika Yanti M. Usman Siswanto Wijaya, Nur Rahmawati Yanti Marfuatush Sholikhah, Ika